Cellular protection using Flt3 and PI3Kα inhibitors demonstrates multiple mechanisms of oxidative glutamate toxicity

Phosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death

(2013) A M Brennan-Minnella et al.   Cell Death & Disease

AIF depletion provides neuroprotection through a preconditioning effect

(2012) Eva-Maria Öxler et al.   APOPTOSIS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Pyrroloquinoline quinone rescues hippocampal neurons from glutamate-induced cell death through activation of Nrf2 and up-regulation of antioxidant genes

(2012) Q. Zhang et al.   GENETICS AND MOLECULAR RESEARCH

Glutamate Induces Mitochondrial Dynamic Imbalance and Autophagy Activation: Preventive Effects of Selenium

(2012) Santosh Kumari et al.   PLoS One

H2O2 Production Downstream of FLT3 Is Mediated by p22phox in the Endoplasmic Reticulum and Is Required for STAT5 Signalling

(2012) John F. Woolley et al.   PLoS One

MetaboLab - advanced NMR data processing and analysis for metabolomics

(2011) Christian Ludwig et al.   BMC BIOINFORMATICS

Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications

(2011) Shinichiro Takahashi   Journal of Hematology & Oncology

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

(2011) Theonie Anastassiadis et al.   NATURE BIOTECHNOLOGY

Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma

(2011) H. S. Venkatesh et al.   NEURO-ONCOLOGY

The Structure of Human 5-Lipoxygenase

(2011) N. C. Gilbert et al.   SCIENCE

Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons

(2010) S Tobaben et al.   CELL DEATH AND DIFFERENTIATION

Activation of p38 MAPK Is Required in Monocytic and Neuronal Cells for HIV Glycoprotein 120-Induced Neurotoxicity

(2010) K. E. Medders et al.   JOURNAL OF IMMUNOLOGY

Oxidative Stress-Induced Necrotic Cell Death via Mitochondira-Dependent Burst of Reactive Oxygen Species

(2009) Kyungsun Choi et al.   CURRENT NEUROVASCULAR RESEARCH

Mechanism of glutamate-induced neurotoxicity in HT22 mouse hippocampal cells

(2009) Masayuki Fukui et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Metabolomic Profiling of Drug Responses in Acute Myeloid Leukaemia Cell Lines

(2009) Stefano Tiziani et al.   PLoS One

Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML

(2008) A. Sallmyr et al.   BLOOD

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

(2008) Veronique Nogueira et al.   CANCER CELL

Bid-induced release of AIF from mitochondria causes immediate neuronal cell death

(2008) S Landshamer et al.   CELL DEATH AND DIFFERENTIATION

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA