IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs

Dual regulation of HMGB1 by combined JNK1/2–ATF2 axis with miR-200 family in nonalcoholic steatohepatitis in mice

(2018) Xin Chen et al.   FASEB JOURNAL

MicroRNA-466 inhibits tumor growth and bone metastasis in prostate cancer by direct regulation of osteogenic transcription factor RUNX2

(2017) Melissa Colden et al.   Cell Death & Disease

MiR-34a Inhibits Breast Cancer Proliferation and Progression by Targeting Wnt1 in Wnt/β-Catenin Signaling Pathway

(2016) Wentao Si et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Inositol-Requiring Enzyme 1 Facilitates Diabetic Wound Healing Through Modulating MicroRNAs

(2016) Jie-Mei Wang et al.   DIABETES

XBP1s Is an Anti-lipogenic Protein

(2016) Hilde Herrema et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomal miR-24-3p impedes T-cell function by targetingFGF11and serves as a potential prognostic biomarker for nasopharyngeal carcinoma

(2016) Shu-Biao Ye et al.   JOURNAL OF PATHOLOGY

MicroRNA-23b regulates nasopharyngeal carcinoma cell proliferation and metastasis by targeting E-cadherin

(2016) JUN-YING WANG et al.   Molecular Medicine Reports

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

The microRNA-23b/-27b cluster suppresses prostate cancer metastasis via Huntingtin-interacting protein 1-related

(2016) M A Rice et al.   ONCOGENE

Up-regulation of FGFBP1 signaling contributes to miR-146a-induced angiogenesis in human umbilical vein endothelial cells

(2016) Hua-yu Zhu et al.   Scientific Reports

Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar diet

(2015) Xiaoying Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing

(2015) J. Peschek et al.   EMBO REPORTS

miR-155 targets Caspase-3 mRNA in activated macrophages

(2015) Rebecca De Santis et al.   RNA Biology

S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction

(2015) L. Yang et al.   SCIENCE

MiR-146a-5p suppresses activation and proliferation of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis through directly targeting Wnt1 and Wnt5a

(2015) Jinghua Du et al.   Scientific Reports

MitomiRs in human inflamm-aging: A hypothesis involving miR-181a, miR-34a and miR-146a

(2014) Maria Rita Rippo et al.   EXPERIMENTAL GERONTOLOGY

Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts Endoplasmic Reticulum Stress-induced Hepatic Steatosis

(2014) Shan Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development

(2014) Lars Maegdefessel et al.   Nature Communications

Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1 Splicing and RIDD

(2014) Arvin B. Tam et al.   Cell Reports

Thrombospondin-1/CD36 pathway contributes to bone marrow-derived angiogenic cell dysfunction in type 1 diabetes via Sonic hedgehog pathway suppression

(2013) Jie-Mei Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis

(2013) Quan Qiu et al.   EMBO JOURNAL

The Adaptive Endoplasmic Reticulum Stress Response to Lipotoxicity in Progressive Human Nonalcoholic Fatty Liver Disease

(2013) April D. Lake et al.   TOXICOLOGICAL SCIENCES

Endoplasmic Reticulum Stress in Nonalcoholic Fatty Liver Disease

(2012) Michael J. Pagliassotti   Annual Review of Nutrition

MicroRNA-19a and -19b regulate cervical carcinoma cell proliferation and invasion by targeting CUL5

(2012) Xue-Mei Xu et al.   CANCER LETTERS

Metformin lowers the threshold for stress-induced senescence: A role for the microRNA-200 family and miR-205

(2012) Sílvia Cufí et al.   CELL CYCLE

The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling

(2012) Suneng Fu et al.   Cell Metabolism

IRE1α-XBP1s Induces PDI Expression to Increase MTP Activity for Hepatic VLDL Assembly and Lipid Homeostasis

(2012) Shiyu Wang et al.   Cell Metabolism

Silencing of Lipid Metabolism Genes through IRE1α-Mediated mRNA Decay Lowers Plasma Lipids in Mice

(2012) Jae-Seon So et al.   Cell Metabolism

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IRE1  Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

(2012) J.-P. Upton et al.   SCIENCE

Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model

(2012) Jin-Sook Lee et al.   TOXICOLOGY LETTERS

The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis

(2011) Kezhong Zhang et al.   EMBO JOURNAL

miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response

(2011) Bogdan Mateescu et al.   NATURE MEDICINE

PPARα Is Regulated by miR-21 and miR-27b in Human Liver

(2011) Katsuhiko Kida et al.   PHARMACEUTICAL RESEARCH

MicroRNA-21 targets peroxisome proliferators-activated receptor-  in an autoregulatory loop to modulate flow-induced endothelial inflammation

(2011) J. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes

(2010) Sarah Hummasti et al.   CIRCULATION RESEARCH

S-Nitrosylation of β-Catenin by eNOS-Derived NO Promotes VEGF-Induced Endothelial Cell Permeability

(2010) Sébastien Thibeault et al.   MOLECULAR CELL

Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility

(2010) E H Jeninga et al.   ONCOGENE

A Phos-Tag-Based Approach Reveals the Extent of Physiological Endoplasmic Reticulum Stress

(2010) Liu Yang et al.   PLoS One

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice

(2009) Bo Wang et al.   HEPATOLOGY

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

Effect of dietary fat to produce non-alcoholic fatty liver in the rat

(2009) Umbreen Ahmed et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease

(2007) Puneet Puri et al.   GASTROENTEROLOGY