Article
Cell Biology
Ping Pang, Zhezhe Qu, Shuting Yu, Xiaochen Pang, Xin Li, Yuelin Gao, Kuiwu Liu, Qian Liu, Xiuzhu Wang, Yu Bian, Yingqi Liu, Yingqiong Jia, Zhiyong Sun, Hanif Khan, Zhongting Mei, Xiaoqian Bi, Changhao Wang, Xinda Yin, Zhimin Du, Weijie Du
Summary: The study demonstrates that Mettl14 attenuates cardiac I/R injury by activating Wnt/beta-catenin in an m6A-dependent manner, providing a novel therapeutic target for ischemic heart disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Chun Tang, Xuehui Wang, Changle Ji, Wenfang Zheng, Yunhe Yu, Xiaochong Deng, Xiqian Zhou, Lin Fang
Summary: The study demonstrated that miR-640 suppresses the tumorigenesis of breast cancer cells by regulating the Wnt/β-catenin signaling pathway, making it a potential novel target for targeted therapy in breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuri Lee, Hai-long Piao, Jongchan Kim
Summary: The Wnt signaling pathway is crucial for regulating various cellular processes, and dysregulation of this pathway has been linked to human diseases, including cancer. In this study, researchers aimed to identify the deubiquitinases (DUBs) that regulate the pathway through the essential component LEF1. They discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to increased interaction with beta-catenin. This study suggests that OTUD7B may serve as a potential therapeutic target in diseases where Wnt signaling is dysregulated, such as cancer.
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Article
Medicine, Research & Experimental
Ying Li, Yu Wang, Qinguang Zou, Shouqing Li, Fan Zhang
Summary: KLF3 is overexpressed in gastric cancer and promotes its growth and metastasis by activating the WNT/B-catenin signaling pathway. Inhibition of KLF3 could be a potential therapeutic target for patients with gastric cancer.
LABORATORY INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Hua Liu, Xianhu Yue, Gang Zhang
Summary: The study revealed that downregulation of miR-146a inhibited osteoporosis in the jawbones of OVX rats by activating the Wnt/beta-catenin signaling pathway, leading to improvements in bone density, enzyme levels, and osteoclast numbers.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Orthopedics
Bashan Zhang, Rong Li, Wenfeng Wang, Xueming Zhou, Beijing Luo, Zinian Zhu, Xibo Zhang, Aijiao Ding
Summary: The missense mutations WNT1 c.110T>C and c.505G>T were found to affect the proliferation and osteogenic phenotype of MC3T3-E1 cells, possibly through inhibition of the WNT1/beta-catenin signaling pathway. This study provides new insights into the molecular mechanisms underlying the development of OI associated with these mutations.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Cell Biology
Hang Tian, Lei Hou, Yumei Xiong, Qiuju Cheng
Summary: The study showed that DEX can inhibit OC development by upregulating miR-185 expression and deactivating the SOX9/Wnt/beta-catenin signaling pathway. MiR-185 targeted SOX9, and interfering with miR-185 expression affected HO-8910 cell proliferation, invasion, migration, and apoptosis. SOX9 knockdown repressed OC development and the Wnt/beta-catenin pathway.
Article
Biotechnology & Applied Microbiology
Tao Xueqin, Mei Jinhong, Huang Yuping
Summary: INHBA is highly expressed in breast cancer cells and acts as an oncogene by activating the Wnt/beta-catenin pathway, providing a potential therapeutic target for the treatment of breast cancer.
Article
Medicine, Research & Experimental
Di Zhang, Xiaofeng Liu, Yun Li, Li Sun, Shu-Shu Liu, Yue Ma, Huan Zhang, Xin Wang, Yue Yu
Summary: The study revealed that miR-586 functions as an oncogene promoting breast cancer proliferation and metastasis, while LINC01189 acts as a tumor suppressor inhibiting cancer progression. The interaction and feedback loop between the two are involved in the regulation of Wnt/β-catenin signaling and breast cancer development.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Virology
Anwesha Banerjee, Mamta Chawla-Sarkar, Anupam Mukherjee
Summary: The significance of the Wnt/beta-catenin signaling cascade in Rotavirus (RV) infection has been investigated in this study. miRNAs have been found to be capable of suppressing RV infection by targeting the intermediates of the Wnt signaling pathway. These findings highlight the role of the Wnt signaling cascade in RV infection and suggest miR-192 family and miR-181a as potential antivirals against RV infection.
Review
Pharmacology & Pharmacy
Xue Hu, Qiang Zhang, Wanying Xing, Wan Wang
Summary: This mini-review discusses the modulation of the Wnt/beta-catenin signaling pathway in triple-negative breast cancer, focusing on the involvement of lncRNAs and miRNAs in its regulation and their impact on breast cancer pathogenesis, proliferation, migration, and malignancy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Zheng Qin, Yupei Li, Jiameng Li, Luojia Jiang, Zhuyun Zhang, Kaixi Chang, Qinbo Yang, Shanshan Chen, Ruoxi Liao, Baihai Su
Summary: This study found that exosomal STAT1 derived from HP-treated HUVECs can promote VSMC calcification. Activation of the Wnt/beta-catenin pathway may be a potential mechanism of exosome-promoted VSMC calcification.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Xinbing Yang, Yajing Du, Lulu Luo, Xinru Xu, Shizheng Xiong, Xueni Yang, Li Guo, Tingming Liang
Summary: Dysregulated expression of specific non-coding RNAs (ncRNAs) has been strongly linked to tumorigenesis, cancer progression, and therapeutic resistance. Recent evidence suggests that ncRNAs can interact with the Wnt/beta-catenin signaling pathway, influencing the expression of Wnt target genes in cancer cells. This review aims to unravel the complex associations between ncRNAs and the Wnt/beta-catenin signaling pathway and explore their potential implications for cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yansen Xiao, Min Cong, Jiatao Li, Dasa He, Qiuyao Wu, Pu Tian, Yuan Wang, Shuaixi Yang, Chenxi Liang, Yajun Liang, Jili Wen, Yingjie Liu, Wenqian Luo, Xianzhe Lv, Yunfei He, Dong-Dong Cheng, Tianhao Zhou, Wenjing Zhao, Peiyuan Zhang, Xue Zhang, Yichuan Xiao, Youcun Qian, Hongxia Wang, Qiang Gao, Qing-Cheng Yang, Qifeng Yang, Guohong Hu
Summary: The study reveals that tumor-secreted protease CTSC promotes breast-to-lung metastasis by regulating recruitment of neutrophils and formation of neutrophil extracellular traps.
Article
Oncology
Zheng Li, Yaming Li, Xiaolong Wang, Qifeng Yang
Summary: The study identified PPP2R2B as a strong tumor suppressor in TNBC, with downregulated expression in TNBC tissues compared to normal breast tissues. Low PPP2R2B expression was associated with shorter survival time and could play a key role in breast cancer initiation and progression. PPP2R2B was also found to be related to specific immune cells and immune inhibitor genes.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Dianwen Han, Lijuan Wang, Bing Chen, Wenjing Zhao, Yiran Liang, Yaming Li, Hanwen Zhang, Ying Liu, Xiaolong Wang, Tong Chen, Chen Li, Xiaojin Song, Dan Luo, Zheng Li, Qifeng Yang
Summary: The study revealed that the USP1/WDR48 complex can enhance TGF-beta-induced EMT and migration in TNBC cells by stabilizing TAK1 in vitro.
Article
Biochemistry & Molecular Biology
Tong Chen, Xiaolong Wang, Chen Li, Hanwen Zhang, Ying Liu, Dianwen Han, Yaming Li, Zheng Li, Dan Luo, Ning Zhang, Meizhu Zheng, Bing Chen, Lijuan Wang, Wenjing Zhao, Qifeng Yang
Summary: The study found that the novel circRNA circHIF1A was significantly overexpressed in TNBC, associated with metastasis, poor prognosis, and the TNBC subtype. CircHIF1A modulated the expression of NFIB and FUS via a positive feedback loop, leading to activation of the AKT/STAT3 signaling pathway. CircHIF1A may serve as a potential biomarker for breast cancer diagnosis and a therapeutic target for TNBC treatment.
Article
Gastroenterology & Hepatology
Lijuan Wang, Ning Zhang, Dianwen Han, Peng Su, Bing Chen, Wenjing Zhao, Ying Liu, Hanwen Zhang, Guohong Hu, Qifeng Yang
Summary: The study revealed that MTDH expression in colonic lamina propria macrophages is correlated with the severity of inflammatory colitis. MTDH-/- mice were protected against DSS-induced colitis, but adoptive transfer of MTDH wild-type monocytes partially restored susceptibility. TLR stimulation induced MTDH expression and absence of MTDH suppressed inflammatory cytokine production by macrophages.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Medicine, General & Internal
Tao Sun, Hanwen Zhang, Wei Gao, Qifeng Yang
Summary: The study assessed the sensitivity, specificity, and experience of freehanded CNB in outpatient settings for breast cancer diagnosis. Results showed that taking 2 tissue strips by CNB was as reliable as taking six strips in distinguishing malignancy from benignancy without the aid of US. Four tissue strips obtained by CNB showed good accuracy in assessing ER, PR, HER2 status, and tumor grade compared to surgical specimens. Two tissue strips obtained by CNB were accurate in differentiating malignancy from benignancy, but at least 4 strips are recommended for overall conformity of pathological biomarkers.
Review
Oncology
Yajie Wang, Fangzhou Ye, Yiran Liang, Qifeng Yang
Summary: Breast cancer brain metastasis is a common cause of death among breast cancer patients, with poor prognosis due to limited permeability of the blood-brain barrier and lack of effective treatments. While the sequence of metastasis events is accepted, the underlying mechanisms remain to be fully elucidated.
BRITISH JOURNAL OF CANCER
(2021)
Article
Biotechnology & Applied Microbiology
Yaming Li, Zekun Wang, Peng Su, Yiran Liang, Zheng Li, Hanwen Zhang, Xiaojin Song, Dianwen Han, Xiaolong Wang, Ying Liu, Jingwen Yang, Bing Chen, Lijuan Wang, Wenjing Zhao, Qifeng Yang
Summary: The protein-coding ability of circRNAs in TNBC has not been well understood. This study identified a circRNA called circ-EIF6, which was associated with poorer prognosis and clinicopathological characteristics in TNBC patients. Functional experiments showed that circ-EIF6 promoted proliferation and metastasis of TNBC cells, mediated by encoding a novel peptide called EIF6-224aa that interacted with MYH9, leading to activation of the Wnt/β-catenin pathway.
Article
Cell Biology
Xue Kong, Juan Li, Yanru Li, Weili Duan, Qiuchen Qi, Tiantian Wang, Qifeng Yang, Lutao Du, Haiting Mao, Chuanxin Wang
Summary: In this study, a novel lncRNA AC073352.1 was identified to be significantly upregulated in breast cancer tissues and associated with poor prognosis. AC073352.1 was found to promote breast cancer cell migration and invasion by interacting with the protein YBX1, leading to enhanced metastasis and angiogenesis in breast cancer. This lncRNA may serve as a promising biomarker for prognosis and a potential therapeutic target in breast cancer.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Yingjie Liu, Peiyuan Zhang, Qiuyao Wu, Houqin Fang, Yuan Wang, Yansen Xiao, Min Cong, Tingting Wang, Yunfei He, Chengxin Ma, Pu Tian, Yajun Liang, Lun-Xiu Qin, Qingcheng Yang, Qifeng Yang, Lujian Liao, Guohong Hu
Summary: This study reveals the regulatory role of lncRNA NR2F1-AS1 in metastatic dormancy, promoting tumor dissemination but inhibiting proliferation in mesenchymal-like breast cancer stem-like cells. This connection between BCSC plasticity and metastatic dormancy highlights the importance of lncRNA in these processes.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Tingting Liu, Hongyue Wang, Zhiyong Liu, Jing Zhang, Yan Liu, Lin Zhang, Chunhui Zheng, Fei Liu, Chuanqiang Hou, Baojiang Li
Summary: TNBC stem cells were screened using phage display to identify specific binding clones, which were then synthesized into polypeptides labeled with FITC. The specificity of these polypeptides to BCSCs was confirmed in vitro and in vivo, providing a foundation for targeted therapy and further research on BCSCs.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Xiaolong Wang, Chen Li, Tong Chen, Wenhao Li, Hanwen Zhang, Dong Zhang, Ying Liu, Dianwen Han, Yaming Li, Zheng Li, Dan Luo, Ning Zhang, Qifeng Yang
Summary: In this study, gene expression profiles and clinical information of breast cancer patients were analyzed to identify prognostic biomarkers. A risk score formula involving five novel biomarkers was constructed and validated in both TCGA entire cohort and an independent validation cohort. In vitro assays demonstrated the significant impact of these biomarkers on breast cancer progression, highlighting their potential for personalized management.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dong Zhang, Yingnan Wang, Qifeng Yang
Summary: The study identified and validated a 10-CpG-based prognostic signature in breast cancer patients, showing correlation with immune characteristics. High-risk patients exhibited upregulated immune-inhibited oncogenic pathways, higher TP53 mutations, and lower responsiveness to treatments.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Letter
Oncology
Ya Wang, Jiahao Liu, Jiali Li, Huayi Li, Xiong Li, Long Qiao, Jie Yang, Tian Fang, Shaoqi Chen, Jingjing Ma, Junxiang Wan, Xingrui Li, Lin Zhang, Yun Xia, Yaqun Wu, Tao Xu, Jun Shao, Yaojun Feng, Ihab R. Kamel, Qifeng Yang, Zhen Li, Qinglei Gao
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Bing Chen, Yuting Sang, Xiaojin Song, Dong Zhang, Lijuan Wang, Wenjing Zhao, Yiran Liang, Ning Zhang, Qifeng Yang
Summary: The study confirmed that CAF-derived exosomes significantly promoted the proliferation and metastasis of breast cancer cells through miR-500a-5p. MiR-500a-5p was transferred from CAFs to cancer cells and promoted proliferation and metastasis by binding to USP28.