Review
Nutrition & Dietetics
Maurice C. J. M. Konings, Sabine Baumgartner, Ronald P. P. Mensink, Jogchum Plat
Summary: Non-Alcoholic Fatty Liver Disease (NAFLD) is characterized by the accumulation of hepatic free cholesterol. Research suggests that certain miRNAs (miR122, 34a, 132, and 21) are associated with NAFLD and cholesterol metabolism, potentially playing a role in NAFLD development. Additionally, miRNAs 122, 34a, and 379 may be used as part of a panel of biomarkers for early detection of NAFLD.
Article
Medicine, Research & Experimental
Liangying Ye, Dan Zhao, Yangzhi Xu, Jiaen Lin, Jiahui Xu, Kunyuan Wang, Zhanhui Ye, Yufeng Luo, Shiming Liu, Hui Yang
Summary: The study identified 381 lncRNAs highly expressed in NAFLD and even higher in NASH. A novel LncRNA-gm9795 was found to be significantly upregulated in NASH animal and cell models. The research indicated that gm9795 promotes inflammatory response in NASH through NF-kB and JNK pathways.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Fasiha Kanwal, Jay H. Shubrook, Zobair Younossi, Yamini Natarajan, Elisabetta Bugianesi, Mary E. Rinella, Stephen A. Harrison, Christos Mantzoros, Kim Pfotenhauer, Samuel Klein, Robert H. Eckel, Davida Kruger, Hashem El-Serag, Kenneth Cusi
Summary: There are significant management gaps between clinical guidelines and practice in patients with NAFLD and NASH, and there is no single global guiding strategy for their management. An international conference convened experts in gastroenterology, hepatology, endocrinology, and primary care providers to discuss promising approaches for clinical practice and prepare a comprehensive, unified strategy for the care of NAFLD/NASH patients. Participants also identified specific high-yield targets for clinical research and called for a unified, international public health response to NAFLD and NASH.
Letter
Gastroenterology & Hepatology
Amandeep Singh, Rajat Garg, Rocio Lopez, Naim Alkhouri
Summary: This study aims to develop a simple noninvasive fibrosis score to detect advanced fibrosis in patients with diabetes and compare its performance with other fibrosis scores.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Endocrinology & Metabolism
Fasiha Kanwal, Jay H. Shubrook, Zobair Younossi, Yamini Natarajan, Elisabetta Bugianesi, Mary E. Rinella, Stephen A. Harrison, Christos Mantzoros, Kim Pfotenhauer, Samuel Klein, Robert H. Eckel, Davida Kruger, Hashem El-Serag, Kenneth Cusi
Summary: NAFLD and NASH are common conditions with significant management gaps, lacking a single global guiding strategy. The American Gastroenterological Association, along with professional associations, convened an international conference to develop a comprehensive, unified strategy for primary care providers and specialists, calling for a unified international public health response to NAFLD and NASH.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Gastroenterology & Hepatology
Stefania Grimaudo, Paola Dongiovanni, Jussi Pihlajamaki, Mohammed Eslam, Hannele Yki-Jarvinen, Rosaria Maria Pipitone, Guido Baselli, Calogero Camma, Vito Di Marco, Marco Enea, Miriam Longo, Grazia Pennisi, Daniele Prati, Rossella Zito, Anna Ludovica Fracanzani, Antonio Craxi, Jacob George, Stefano Romeo, Luca Valenti, Salvatore Petta
Summary: The NR1H4 gene rs35724 C allele is protective against severity of steatosis, steatohepatitis, and liver fibrosis, but is associated with higher total circulating cholesterol levels. Patients carrying the NR1H4 rs35724 C allele show increased hepatic mRNA levels of FXR and genes involved in bile acid synthesis. This suggests that increased hepatic FXR expression due to the NR1H4 rs35724 C allele may have potential therapeutic implications for NAFLD.
LIVER INTERNATIONAL
(2021)
Article
Environmental Sciences
Norma David, Jean-Philippe Antignac, Marine Roux, Philippe Marchand, Sophie Michalak, Frederic Oberti, Isabelle Fouchard, Adrien Lannes, Odile Blanchet, Paul Cales, Etienne B. Blanc, Jerome Boursier, Clemence M. Canivet
Summary: This study found a significant association between PFHpA and liver steatosis in NAFLD, possibly through beta-oxidation and biosynthesis of fatty acids.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Immunology
Bing Sun, Ranteng Zhang, Zicong Liang, Aoqiang Fan, Dongmei Kang
Summary: The study demonstrates that hyperoside has a protective effect against high-fat diet-induced NAFLD and regulates macrophage polarization, alleviating hepatic steatosis, insulin resistance, and inflammatory responses. It shows that hyperoside may have therapeutic potential in preventing the pathological progression of NAFLD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Marc-Olivier Deguise, Chantal Pileggi, Yves De Repentigny, Ariane Beauvais, Alexandra Tierney, Lucia Chehade, Jean Michaud, Maica Llavero-Hurtado, Douglas Lamont, Abdelmadjid Atrih, Thomas M. Wishart, Thomas H. Gillingwater, Bernard L. Schneider, Mary-Ellen Harper, Simon H. Parson, Rashmi Kothary
Summary: The Smn(2B/-) mouse model rapidly develops microvesicular steatohepatitis, providing an opportunity to study the pathogenesis of NAFLD. While not a typical NAFLD/NASH model, it offers a reliable, low-cost, and early-onset model for both adult and pediatric populations.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yueqi Zhang, Yue Luo, Xinhui Liu, Matti Kiupel, Aimin Li, Hongbing Wang, Qing-Sheng Mi, Hua Xiao
Summary: This study reveals a novel mechanism for the onset of NAFLD/NASH and HCC initiated by NCOA5-deficient macrophages, suggesting the NCOA5-PF4 axis in macrophages as a potential target for developing preventive and therapeutic interventions against NAFLD/NASH and HCC.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2024)
Review
Chemistry, Medicinal
Navid Omidkhoda, Sina Mahdiani, A. Wallace Hayes, Gholamreza Karimi
Summary: This article summarizes in vitro and in vivo studies on the effect of natural bioactive compounds on NAFLD through the LKB1/AMPK signaling pathway, providing clues for finding new therapeutic agents for NAFLD management.
PHYTOTHERAPY RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Magnus Holmer, Mattias Ekstedt, Patrik Nasr, Robin Zenlander, Axel Wester, Federica Tavaglione, Stefano Romeo, Stergios Kechagias, Per Stal, Hannes Hagstrom
Summary: The study found that the PNPLA3 G/G genotype is associated with an increased rate of severe liver disease in patients with NAFLD, while overall mortality is not affected by any genetic variant.
LIVER INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Grazia Pennisi, Rosaria Maria Pipitone, Daniela Cabibi, Marco Enea, Manuel Romero-Gomez, Mauro Vigano, Elisabetta Bugianesi, Vincent Wai-Sun Wong, Anna Ludovica Fracanzani, Giada Sebastiani, Annalisa Berzigotti, Francesca Di Salvo, Antonino Giulio Giannone, Claudia La Mantia, Giulia Lupo, Rossana Porcasi, Federica Vernuccio, Rossella Zito, Vito Di Marco, Calogero Camma, Antonio Craxi, Victor de Ledinghen, Stefania Grimaudo, Salvatore Petta
Summary: The presence of a cholestatic pattern in patients with NAFLD predicts a higher risk of major liver-related outcomes independently from other features of liver disease.
LIVER INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Stephen A. Harrison, Rohit Loomba, Julie Dubourg, Vlad Ratziu, Mazen Noureddin
Summary: Nonalcoholic fatty liver disease is a spectrum of diseases that may progress to nonalcoholic steatohepatitis (NASH) and potentially lead to severe liver conditions. The prevalence of NASH has increased along with the rise in obesity and type 2 diabetes. Efforts have been made to develop effective treatments, with promising results in recent clinical trials.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Obstetrics & Gynecology
Iliana Doycheva, David A. Ehrmann
Summary: Polycystic ovary syndrome (PCOS) is frequently associated with nonalcoholic fatty liver disease (NAFLD) and obstructive sleep apnea. Women with PCOS have a higher risk of NAFLD compared to healthy weight-matched controls, independent of body mass index. Insulin resistance and hyperandrogenemia play a central role in the development of NAFLD. Timely diagnosis of NAFLD is important as it can progress to nonalcoholic steatohepatitis and advanced liver fibrosis, leading to liver-related mortality. NAFLD is also associated with increased risks of type 2 diabetes, cardiovascular events, overall mortality, and extrahepatic cancers.
FERTILITY AND STERILITY
(2022)
Article
Oncology
Jing Tang, Liang Li, Wentao Huang, Chengjun Sui, Yingcheng Yang, Ximeng Lin, Guojun Hou, Xin Chen, Jing Fu, Shengxian Yuan, Shao Li, Wen Wen, Shanhua Tang, Dan Cao, Mengchao Wu, Lei Chen, Hongyang Wang
Article
Oncology
Liang Li, Jianguo Chen, Xin Chen, Jing Tang, Huan Guo, Xiaofeng Wang, Ji Qian, Guijuan Luo, Fangping He, Xiaomei Lu, Yibo Ding, Yingchen Yang, Wentao Huang, Guojun Hou, Ximeng Lin, Qin Ouyang, Hengyu Li, Ruoyu Wang, Feng Jiang, Rui Pu, Jianhua Lu, Mudan Jin, Yexiong Tan, Frank J. Gonzalez, Guangwen Cao, Mengchao Wu, Hao Wen, Tangchun Wu, Li Jin, Lei Chen, Hongyang Wang
Review
Oncology
Liang Li, Hongyang Wang
Article
Gastroenterology & Hepatology
Liang Li, Jing Tang, Baohua Zhang, Wen Yang, Miyang LiuGao, Ruoyu Wang, Yexiong Tan, Jianling Fan, Yanxin Chang, Jing Fu, Feng Jiang, Caiyang Chen, Yingcheng Yang, Jin Gu, Dingming Wu, Linna Guo, Dan Cao, Hengyu Li, Guangwen Cao, Mengchao Wu, Michael Q. Zhang, Lei Chen, Hongyang Wang
Article
Gastroenterology & Hepatology
Liang Li, Lei Chen, Liang Hu, Yuan Liu, Han-Yong Sun, Jing Tang, Yu-Jie Hou, Yan-Xin Chang, Qian-Qian Tu, Gen-Sheng Feng, Feng Shen, Meng-Chao Wu, Hong-Yang Wang
Article
Virology
Liang Hu, Lei Chen, Liang Li, HanYong Sun, GuangZhen Yang, YanXin Chang, QianQian Tu, MengChao Wu, HongYang Wang
JOURNAL OF VIROLOGY
(2011)
Article
Multidisciplinary Sciences
Xin-wei Yang, Jue Yang, Liang Li, Xiao-bo Man, Bao-hua Zhang, Feng Shen, Meng-chao Wu
Article
Multidisciplinary Sciences
Xin-wei Yang, Jue Yang, Liang Li, Xing-zhou Yan, Bao-hua Zhang, Feng Shen, Meng-chao Wu
Article
Gastroenterology & Hepatology
Yanping Wei, Xin Chen, Chi Liang, Yan Ling, Xinwei Yang, Xiaofei Ye, Hailing Zhang, Pinghua Yang, Xiuliang Cui, Yibing Ren, Xianglei Xin, Hengyu Li, Ruoyu Wang, Wenjing Wang, Feng Jiang, Suiyi Liu, Jing Ding, Baohua Zhang, Liang Li, Hongyang Wang
Letter
Gastroenterology & Hepatology
Liang Li, Yanpin Wei, Hongyang Wang
Article
Multidisciplinary Sciences
Pinghua Yang, Fengliang Song, Xinwei Yang, Xingzhou Yan, Xinyu Huang, Zhengjun Qiu, Zhijian Wen, Chi Liang, Xianglei Xin, Zhengqin Lei, Kecheng Zhang, Jue Yang, Hu Liu, Hongcheng Wang, Shijun Xiang, Liang Li, Baohua Zhang, Hongyang Wang
Summary: Through biomarker discovery, training, and validation, we have identified a combination of miRNAs that can evaluate the risk of gallbladder carcinoma. This biomarker outperforms standard markers and can be used for early diagnosis. It is also associated with clinicopathological features and prognosis, and regulates cell functions and signaling pathways. This biomarker combination has potential for noninvasive diagnosis, screening, and prognosis prediction for gallbladder carcinoma.
Article
Biochemistry & Molecular Biology
Yanping Wei, Xuewu Tang, Yibin Ren, Yun Yang, Fengliang Song, Jingbo Fu, Shuowu Liu, Miao Yu, Jing Chen, Suyang Wang, Kecheng Zhang, Yexiong Tan, Zhipeng Han, Lixin Wei, Baohua Zhang, Zhangjun Cheng, Liang Li, Hongyang Wang
Summary: The study identified potential HMGB1-driven RNA-RNA crosstalk networks in HCC and explored their roles at different stages of the disease, suggesting the potential for RNA-based precision therapy. Interventions against HMGB1 and RICTOR in HCC cells demonstrated the potential to enhance the effectiveness of immunotherapy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Chemistry, Multidisciplinary
Jun Li, Liang Li, Yang Lv, Hao Zou, Yanping Wei, Fei Nie, Wanli Duan, Maidinamu Sedike, Liang Xiao, Mei Wang