An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups

GRIN1 mutation associated with intellectual disability alters NMDA receptor trafficking and function

(2017) Wenjuan Chen et al.   JOURNAL OF HUMAN GENETICS

Channel opening and gating mechanism in AMPA-subtype glutamate receptors

(2017) Edward C. Twomey et al.   NATURE

Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes

(2017) Edward C. Twomey et al.   NEURON

Diverse modes of NMDA receptor positive allosteric modulation: Mechanisms and consequences

(2017) David H. Hackos et al.   NEUROPHARMACOLOGY

A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain

(2017) Tzu-Ming Wang et al.   NEUROPHARMACOLOGY

Role of the Ion Channel Extracellular Collar in AMPA Receptor Gating

(2017) Maria V. Yelshanskaya et al.   Scientific Reports

Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology

(2017) Kevin K. Ogden et al.   PLoS Genetics

Mechanism of NMDA Receptor Inhibition and Activation

(2016) Shujia Zhu et al.   CELL

A Molecular Determinant of Subtype-Specific Desensitization in Ionotropic Glutamate Receptors

(2016) Matthew Alsaloum et al.   JOURNAL OF NEUROSCIENCE

Activation of NMDA receptors and the mechanism of inhibition by ifenprodil

(2016) Nami Tajima et al.   NATURE

Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors

(2016) Feng Yi et al.   NEURON

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function

(2016) David H. Hackos et al.   NEURON

Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs

(2016) Maria V. Yelshanskaya et al.   NEURON

A novel class of negative allosteric modulators of NMDA receptor function

(2015) Brooke M. Katzman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Allosteric modulators of NMDA receptors: multiple sites and mechanisms

(2015) Shujia Zhu et al.   CURRENT OPINION IN PHARMACOLOGY

Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule

(2015) Vojtech Vyklicky et al.   Scientific Reports

NMDA receptor modulators: an updated patent review (2013 – 2014)

(2014) Katie L Strong et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

NMDA receptor structures reveal subunit arrangement and pore architecture

(2014) Chia-Hsueh Lee et al.   NATURE

What do we know about gliotransmitter release from astrocytes?

(2014) D. A. Sahlender et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Organization, control and function of extrasynaptic NMDA receptors

(2014) T. Papouin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Crystal structure of a heterotetrameric NMDA receptor ion channel

(2014) E. Karakas et al.   SCIENCE

Emerging paradigms in GPCR allostery: implications for drug discovery

(2013) Denise Wootten et al.   NATURE REVIEWS DRUG DISCOVERY

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Potentiation of GluN2C/D NMDA Receptor Subtypes in the Amygdala Facilitates the Retention of Fear and Extinction Learning in Mice

(2013) Kevin K Ogden et al.   NEUROPSYCHOPHARMACOLOGY

Novel NMDA receptor modulators: an update

(2012) Rose M Santangelo et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Subunit-Selective Allosteric Inhibition of Glycine Binding to NMDA Receptors

(2012) K. B. Hansen et al.   JOURNAL OF NEUROSCIENCE

GluN1 splice variant control of GluN1/GluN2D NMDA receptors

(2012) Katie M. Vance et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators

(2012) Daniel T. Monaghan et al.   NEUROCHEMISTRY INTERNATIONAL

Access of inhibitory neurosteroids to the NMDA receptor

(2011) Jirina Borovska et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structural and Mechanistic Determinants of a Novel Site for Noncompetitive Inhibition of GluN2D-Containing NMDA Receptors

(2011) K. B. Hansen et al.   JOURNAL OF NEUROSCIENCE

Mechanisms underlying NMDA receptor synaptic/extrasynaptic distribution and function

(2011) Clare M. Gladding et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors

(2011) Erkan Karakas et al.   NATURE

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

(2011) Uwe Rudolph et al.   NATURE REVIEWS DRUG DISCOVERY

New advances in NMDA receptor pharmacology

(2011) Kevin K. Ogden et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors

(2010) Praseeda Mullasseril et al.   Nature Communications

NMDA receptors in clinical neurology: excitatory times ahead

(2008) Lorraine V Kalia et al.   LANCET NEUROLOGY

Recruiting Extrasynaptic NMDA Receptors Augments Synaptic Signaling

(2007) Alexander Z. Harris et al.   JOURNAL OF NEUROPHYSIOLOGY