Role of the Ion Channel Extracellular Collar in AMPA Receptor Gating

Lessons from crystal structures of kainate receptors

(2017) Stine Møllerud et al.   NEUROPHARMACOLOGY

Steered Molecular Dynamics Simulations Predict Conformational Stability of Glutamate Receptors

(2016) Maria Musgaard et al.   Journal of Chemical Information and Modeling

A Molecular Determinant of Subtype-Specific Desensitization in Ionotropic Glutamate Receptors

(2016) Matthew Alsaloum et al.   JOURNAL OF NEUROSCIENCE

Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs

(2016) Maria V. Yelshanskaya et al.   NEURON

A structural biology perspective on NMDA receptor pharmacology and function

(2015) Michael C Regan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

The Hydrophobic Effect Contributes to the Closed State of a Simplified Ion Channel through a Conserved Hydrophobic Patch at the Pore-Helix Crossing

(2015) Michael Yonkunas et al.   Frontiers in Pharmacology

Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States

(2014) Katharina L. Dürr et al.   CELL

Lipid14: The Amber Lipid Force Field

(2014) Callum J. Dickson et al.   Journal of Chemical Theory and Computation

Stargazin promotes closure of the AMPA receptor ligand-binding domain

(2014) David M. MacLean et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural mechanism of glutamate receptor activation and desensitization

(2014) Joel R. Meyerson et al.   NATURE

Perampanel Inhibition of AMPA Receptor Currents in Cultured Hippocampal Neurons

(2014) Chao-Yin Chen et al.   PLoS One

Structure of an agonist-bound ionotropic glutamate receptor

(2014) M. V. Yelshanskaya et al.   SCIENCE

X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism

(2014) L. Chen et al.   SCIENCE

A Conserved Mechanism for Gating in an Ionotropic Glutamate Receptor

(2013) Bryn S. Moore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics of Cleft Closure of the GluA2 Ligand-binding Domain in the Presence of Full and Partial Agonists Revealed by Hydrogen-Deuterium Exchange

(2013) Ahmed H. Ahmed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and gating of tetrameric glutamate receptors

(2013) Alexander I. Sobolevsky   JOURNAL OF PHYSIOLOGY-LONDON

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Functional Insights from Glutamate Receptor Ion Channel Structures

(2012) Janesh Kumar et al.   Annual Review of Physiology

Role of Conformational Dynamics in α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid (AMPA) Receptor Partial Agonism

(2012) Swarna Ramaswamy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of 2-(2-Oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile (Perampanel): A Novel, Noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropanoic Acid (AMPA) Receptor Antagonist

(2012) Shigeki Hibi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Coupled Control of Desensitization and Gating by the Ligand Binding Domain of Glutamate Receptors

(2012) Anna L. Carbone et al.   NEURON

Structural Mechanism of N-Methyl-D-Aspartate Receptor Type 1 Partial Agonism

(2012) Mikko Ylilauri et al.   PLoS One

Characterizing the Energetic States of the GluR2 Ligand Binding Domain Core-Dimer

(2011) Michael Yonkunas et al.   BIOPHYSICAL JOURNAL

Full and Partial Agonism of Ionotropic Glutamate Receptors Indicated by Molecular Dynamics Simulations

(2011) Pekka A. Postila et al.   Journal of Chemical Information and Modeling

Structural landscape of isolated agonist-binding domains from single AMPA receptors

(2011) Christy F Landes et al.   Nature Chemical Biology

The hidden energetics of ligand binding and activation in a glutamate receptor

(2011) Albert Y Lau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Progress report on new antiepileptic drugs: A summary of the Tenth Eilat Conference (EILAT X)

(2010) Meir Bialer et al.   EPILEPSY RESEARCH

On the Mechanisms of α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid (AMPA) Receptor Binding to Glutamate and Kainate

(2010) Michael K. Fenwick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

AMPA Receptor Ligand Binding Domain Mobility Revealed by Functional Cross Linking

(2009) A. J. R. Plested et al.   JOURNAL OF NEUROSCIENCE

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE

Energetics of the Cleft Closing Transition and the Role of Electrostatic Interactions in Conformational Rearrangements of the Glutamate Receptor Ligand Binding Domain†

(2008) Tatyana Mamonova et al.   BIOCHEMISTRY

Ionotropic Glutamate Receptors & CNS Disorders

(2008) Derek Bowie   CNS & Neurological Disorders-Drug Targets

The Activation Gate and Gating Mechanism of the NMDA Receptor

(2008) H.-R. Chang et al.   JOURNAL OF NEUROSCIENCE

Interplay between structural rigidity and electrostatic interactions in the ligand binding domain of GluR2

(2008) Tatyana Mamonova et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS