NMDA receptor modulators: an updated patent review (2013 – 2014)

Correction to Synthesis and Structure Activity Relationship of Tetrahydroisoquinoline-Based Potentiators of GluN2C and GluN2D Containing N-Methyl-d-aspartate Receptors

(2014) Rose M. Santangelo Freel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Structure–Activity Relationship of a Novel Series of GluN2C-Selective Potentiators

(2014) Sommer S. Zimmerman et al.   JOURNAL OF MEDICINAL CHEMISTRY

NMDA receptor structures reveal subunit arrangement and pore architecture

(2014) Chia-Hsueh Lee et al.   NATURE

Distinct Functional and Pharmacological Properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA Receptors

(2014) Kasper B. Hansen et al.   NEURON

Different oxysterols have opposing actions at N-methyl-d-aspartate receptors

(2014) Andrew J. Linsenbardt et al.   NEUROPHARMACOLOGY

Crystal structure of a heterotetrameric NMDA receptor ion channel

(2014) E. Karakas et al.   SCIENCE

Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress Disorder

(2014) Adriana Feder et al.   JAMA Psychiatry

Effect of Bitopertin, a Glycine Reuptake Inhibitor, on Negative Symptoms of Schizophrenia

(2014) Daniel Umbricht et al.   JAMA Psychiatry

Ketamine as Antidepressant? Current State and Future Perspectives

(2013) H. Hasselmann   Current Neuropharmacology

Synthesis and Structure Activity Relationship of Tetrahydroisoquinoline-Based Potentiators of GluN2C and GluN2D Containing N-Methyl-d-aspartate Receptors

(2013) Rose M. Santangelo Freel et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of N-Methyl-D-Aspartate Receptors

(2013) S. M. Paul et al.   JOURNAL OF NEUROSCIENCE

Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain

(2013) Robert J. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Induces Antidepressant-Like Effects Without Ketamine-Like Side Effects

(2013) Jeffrey Burgdorf et al.   NEUROPSYCHOPHARMACOLOGY

Randomized Controlled Crossover Trial of Ketamine in Obsessive-Compulsive Disorder: Proof-of-Concept

(2013) Carolyn I Rodriguez et al.   NEUROPSYCHOPHARMACOLOGY

Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease

(2013) Caitlin M. Neri et al.   PEDIATRIC ANESTHESIA

Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction

(2013) D. T. Balu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Memory in aged mice is rescued by enhanced expression of the GluN2B subunit of the NMDA receptor

(2012) B.L. Brim et al.   BEHAVIOURAL BRAIN RESEARCH

Novel NMDA receptor modulators: an update

(2012) Rose M Santangelo et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Subunit-Selective Allosteric Inhibition of Glycine Binding to NMDA Receptors

(2012) K. B. Hansen et al.   JOURNAL OF NEUROSCIENCE

A single GluN2 subunit residue controls NMDA receptor channel properties via intersubunit interaction

(2012) Beth Siegler Retchless et al.   NATURE NEUROSCIENCE

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-d-aspartate receptors

(2012) Mark W. Irvine et al.   NEUROCHEMISTRY INTERNATIONAL

Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators

(2012) Daniel T. Monaghan et al.   NEUROCHEMISTRY INTERNATIONAL

TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner

(2012) S. Edman et al.   NEUROPHARMACOLOGY

Genetic Overexpression of NR2B Subunit Enhances Social Recognition Memory for Different Strains and Species

(2012) Stephanie A. Jacobs et al.   PLoS One

NMDA Receptor and Schizophrenia: A Brief History

(2012) J. T. Coyle   SCHIZOPHRENIA BULLETIN

Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist

(2011) S McKay et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ketamine as a Novel Antidepressant: From Synapse to Behavior

(2011) J W Murrough   CLINICAL PHARMACOLOGY & THERAPEUTICS

Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines

(2011) Laetitia Mony et al.   EMBO JOURNAL

Molecular basis of NMDA receptor functional diversity

(2011) Pierre Paoletti   EUROPEAN JOURNAL OF NEUROSCIENCE

Structural and Mechanistic Determinants of a Novel Site for Noncompetitive Inhibition of GluN2D-Containing NMDA Receptors

(2011) K. B. Hansen et al.   JOURNAL OF NEUROSCIENCE

Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors

(2011) Erkan Karakas et al.   NATURE

Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid

(2011) Blaise Mathias Costa et al.   NEUROPHARMACOLOGY

Positive emotional learning is regulated in the medial prefrontal cortex by GluN2B-containing NMDA receptors

(2011) J. Burgdorf et al.   NEUROSCIENCE

Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors

(2011) Katie M. Vance et al.   Nature Communications

Triheteromeric NR1/NR2A/NR2B Receptors Constitute the MajorN-Methyl-d-aspartate Receptor Population in Adult Hippocampal Synapses

(2010) Claudia Rauner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visual Experience Induces Long-Term Potentiation in the Primary Visual Cortex

(2010) S. F. Cooke et al.   JOURNAL OF NEUROSCIENCE

Specific Sites within the Ligand-Binding Domain and Ion Channel Linkers Modulate NMDA Receptor Gating

(2010) I. Talukder et al.   JOURNAL OF NEUROSCIENCE

A Novel Family of Negative and Positive Allosteric Modulators of NMDA Receptors

(2010) B. M. Costa et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Identification and Characterization of Novel NMDA Receptor Antagonists Selective for NR2A- over NR2B-Containing Receptors

(2010) E. Bettini et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Control of Assembly and Function of Glutamate Receptors by the Amino-Terminal Domain

(2010) K. B. Hansen et al.   MOLECULAR PHARMACOLOGY

NMDA Receptor Contributions to Visual Contrast Coding

(2010) Michael B. Manookin et al.   NEURON

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors

(2010) Praseeda Mullasseril et al.   Nature Communications

Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit

(2009) Erkan Karakas et al.   EMBO JOURNAL

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE

The N-methyl-d-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats

(2009) Jeffrey Burgdorf et al.   NEUROBIOLOGY OF AGING

Glutamate-based antidepressants: 20 years on

(2009) Phil Skolnick et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors

(2008) Yongneng Yao et al.   EMBO JOURNAL

An Innovative Design to Establish Proof of Concept of the Antidepressant Effects of the NR2B Subunit Selective N-Methyl-D-Aspartate Antagonist, CP-101,606, in Patients With Treatment-Refractory Major Depressive Disorder

(2008) Sheldon H. Preskorn et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral–CA1 synapses in hippocampus

(2008) Xiao-lei Zhang et al.   NEUROPHARMACOLOGY

Antinociceptive action of GLYX-13: an N-methyl-D-aspartate receptor glycine site partial agonist

(2008) Paul L. Wood et al.   NEUROREPORT