The signaling lipid sphingosine 1-phosphate regulates mechanical pain

Comparative transcriptome profiling of the human and mouse dorsal root ganglia

(2018) Pradipta Ray et al.   PAIN

Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination

(2017) Alice Arcourt et al.   NEURON

Specialized Mechanosensory Nociceptors Mediating Rapid Responses to Hair Pull

(2017) Nima Ghitani et al.   NEURON

Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation

(2017) Shaness A. Grenald et al.   PAIN

Nociceptor Sensory Neuron–Immune Interactions in Pain and Inflammation

(2017) Felipe A. Pinho-Ribeiro et al.   TRENDS IN IMMUNOLOGY

Cell-Type-Specific Splicing of Piezo2 Regulates Mechanotransduction

(2017) Marcin Szczot et al.   Cell Reports

Increase in circulating sphingosine-1-phosphate and decrease in ceramide levels in psoriatic patients

(2016) Hanna Myśliwiec et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

KCNQ Potassium Channels Modulate Sensitivity of Skin Down-hair (D-hair) Mechanoreceptors

(2016) Sebastian Schütze et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

(2016) Jeremiah D. Osteen et al.   NATURE

Ablation of Sphingosine 1-Phosphate Receptor Subtype 3 Impairs Hippocampal Neuron Excitability In vitro and Spatial Working Memory In vivo

(2016) Daniela Weth-Malsch et al.   Frontiers in Cellular Neuroscience

Touch Receptors Undergo Rapid Remodeling in Healthy Skin

(2016) Kara L. Marshall et al.   Cell Reports

Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity

(2016) Simon Joost et al.   Cell Systems

S1P-induced airway smooth muscle hyperresponsiveness and lung inflammationin vivo: molecular and cellular mechanisms

(2015) F Roviezzo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases

(2015) Michael S. Donoviel et al.   FASEB JOURNAL

Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3

(2015) Chao Li et al.   Journal of Neuroinflammation

A map of the distribution of sphingosine 1-phosphate in the spleen

(2015) Willy D Ramos-Perez et al.   NATURE IMMUNOLOGY

HTR7 Mediates Serotonergic Acute and Chronic Itch

(2015) Takeshi Morita et al.   NEURON

RNA-Seq Analysis of Human Trigeminal and Dorsal Root Ganglia with a Focus on Chemoreceptors

(2015) Caroline Flegel et al.   PLoS One

CD11b+Ly6G−myeloid cells mediate mechanical inflammatory pain hypersensitivity

(2015) Nader Ghasemlou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin

(2015) Claudia Nussbaum et al.   Nature Communications

Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment

(2015) Antonio Checa et al.   Scientific Reports

Activated platelets release sphingosine 1-phosphate and induce hypersensitivity to noxious heat stimuli in vivo

(2015) Daniela Weth et al.   Frontiers in Neuroscience

Identification of Spinal Circuits Transmitting and Gating Mechanical Pain

(2014) Bo Duan et al.   CELL

The Development and Maintenance of Paclitaxel-induced Neuropathic Pain Require Activation of the Sphingosine 1-Phosphate Receptor Subtype 1

(2014) Kali Janes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Peripheral KCNQ Channels Attenuates Inflammatory Pain

(2014) Hiroki Hayashi et al.   Molecular Pain

Characterizing Human Stem Cell–derived Sensory Neurons at the Single-cell Level Reveals Their Ion Channel Expression and Utility in Pain Research

(2014) Gareth T Young et al.   MOLECULAR THERAPY

Piezo2 is the major transducer of mechanical forces for touch sensation in mice

(2014) Sanjeev S. Ranade et al.   NATURE

Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors

(2014) Srdjan Maksimovic et al.   NATURE

Piezo2 is required for Merkel-cell mechanotransduction

(2014) Seung-Hyun Woo et al.   NATURE

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

Population of sensory neurons essential for asthmatic hyperreactivity of inflamed airways

(2014) D. Trankner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer’s disease pathogenesis

(2014) Timothy A Couttas et al.   Acta Neuropathologica Communications

The Ion Channel TRPA1 Is Required for Chronic Itch

(2013) S. R. Wilson et al.   JOURNAL OF NEUROSCIENCE

Sphingosine-1-Phosphate-Induced Nociceptor Excitation and Ongoing Pain Behavior in Mice and Humans Is Largely Mediated by S1P3 Receptor

(2013) M. Camprubi-Robles et al.   JOURNAL OF NEUROSCIENCE

A ‘toothache tree’ alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain

(2013) Makoto Tsunozaki et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mechanical Sensitization of Cutaneous Sensory Fibers in the Spared Nerve Injury Mouse Model

(2013) Amanda K Smith et al.   Molecular Pain

Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond

(2013) Gregory T. Kunkel et al.   NATURE REVIEWS DRUG DISCOVERY

The Star-Nosed Mole Reveals Clues to the Molecular Basis of Mammalian Touch

(2013) Kristin A. Gerhold et al.   PLoS One

Sphingosine 1-Phosphate Mediates Hyperalgesia via a Neutrophil-Dependent Mechanism

(2013) Amanda Finley et al.   PLoS One

Shaping the landscape: Metabolic regulation of S1P gradients

(2012) Ana Olivera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model

(2012) Qin Zheng et al.   PAIN

TRPA1 Mediates Mechanical Sensitization in Nociceptors during Inflammation

(2012) Richard C. Lennertz et al.   PLoS One

Functional significance of M-type potassium channels in nociceptive cutaneous sensory endings

(2012) Gayle M. Passmore et al.   Frontiers in Molecular Neuroscience

TRPC1 contributes to light-touch sensation and mechanical responses in low-threshold cutaneous sensory neurons

(2011) Sheldon R. Garrison et al.   JOURNAL OF NEUROPHYSIOLOGY

TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch

(2011) Sarah R Wilson et al.   NATURE NEUROSCIENCE

TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat

(2011) Joris Vriens et al.   NEURON

Genetic Evidence for Involvement of Neuronally Expressed S1P1 Receptor in Nociceptor Sensitization and Inflammatory Pain

(2011) Norbert Mair et al.   PLoS One

Sphingosine-1-phosphate Lyase Deficiency Produces a Pro-inflammatory Response While Impairing Neutrophil Trafficking

(2010) Maria L. Allende et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Regularity of Sustained Firing Reveals Two Populations of Slowly Adapting Touch Receptors in Mouse Hairy Skin

(2010) Scott A. Wellnitz et al.   JOURNAL OF NEUROPHYSIOLOGY

SKI-II, an Inhibitor of Sphingosine Kinase, Ameliorates Antigen-Induced Bronchial Smooth Muscle Hyperresponsiveness, but Not Airway Inflammation, in Mice

(2010) Yoshihiko Chiba et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Activation of Voltage-Gated KCNQ/Kv7 Channels by Anticonvulsant Retigabine Attenuates Mechanical Allodynia of Inflammatory Temporomandibular Joint in Rats

(2010) Wen Xu et al.   Molecular Pain

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

TRPA1 Modulates Mechanotransduction in Cutaneous Sensory Neurons

(2009) K. Y. Kwan et al.   JOURNAL OF NEUROSCIENCE

Phenotyping sensory nerve endings in vitro in the mouse

(2009) Katharina Zimmermann et al.   Nature Protocols

Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers

(2008) Rebecca L. Shaner et al.   JOURNAL OF LIPID RESEARCH

Behavioral differentiation between itch and pain in mouse

(2008) Steven G. Shimada et al.   PAIN

The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain

(2008) B. Abrahamsen et al.   SCIENCE