Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3

Investigating the molecular mechanisms through which FTY720-P causes persistent S1P1receptor internalization

(2014) David A Sykes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sphingolipids: Important Players in Multiple Sclerosis

(2014) Ramona Halmer et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Sphingosine-1-Phosphate: Boon and Bane for the Brain

(2014) Gerhild van Echten-Deckert et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Development and Maintenance of Paclitaxel-induced Neuropathic Pain Require Activation of the Sphingosine 1-Phosphate Receptor Subtype 1

(2014) Kali Janes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Discovery, design and synthesis of a selective S1P3 receptor allosteric agonist

(2013) Miguel Guerrero et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sphingosine-1-Phosphate-Induced Nociceptor Excitation and Ongoing Pain Behavior in Mice and Humans Is Largely Mediated by S1P3 Receptor

(2013) M. Camprubi-Robles et al.   JOURNAL OF NEUROSCIENCE

Fingolimod: Direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy

(2013) Aran Groves et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain

(2013) Daniela Salvemini et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Sphingosine-1-phosphate receptors as emerging targets for treatment of pain

(2012) Sandra P. Welch et al.   BIOCHEMICAL PHARMACOLOGY

Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: Review of sphingosine kinase inhibitors

(2012) K. Alexa Orr Gandy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Reassessment of the pharmacology of Sphingosine-1-phosphate S1P3receptor ligands using the DiscoveRx PathHunter™ and Ca2+release functional assays

(2012) DM Riddy et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor

(2012) Chao Li et al.   JOURNAL OF NEUROPHYSIOLOGY

Knockdown of the sphingosine-1-phosphate receptor S1PR1reduces pain behaviors induced by local inflammation of the rat sensory ganglion

(2012) Wenrui Xie et al.   NEUROSCIENCE LETTERS

Expression of sphingosine 1-phosphate receptors in the rat dorsal root ganglia and defined single isolated sensory neurons

(2012) J. S. Kays et al.   PHYSIOLOGICAL GENOMICS

Nerve growth factor enhances the excitability of rat sensory neurons through activation of the atypical protein kinase C isoform, PKMζ

(2011) Y. H. Zhang et al.   JOURNAL OF NEUROPHYSIOLOGY

Sphingosine-1-Phosphate Modulates Vascular Permeability and Cell Recruitment in Acute Inflammation In Vivo

(2011) F. Roviezzo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats

(2011) Tim Doyle et al.   PAIN

Genetic Evidence for Involvement of Neuronally Expressed S1P1 Receptor in Nociceptor Sensitization and Inflammatory Pain

(2011) Norbert Mair et al.   PLoS One

Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery

(2010) KM Mair et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Sphingosine 1-Phosphate Transporter, SPNS2, Functions as a Transporter of the Phosphorylated Form of the Immunomodulating Agent FTY720

(2010) Yu Hisano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Sphingosine 1-Phosphate Receptor, S1PR1, Plays a Prominent But Not Exclusive Role in Enhancing the Excitability of Sensory Neurons

(2010) Xian Xuan Chi et al.   JOURNAL OF NEUROPHYSIOLOGY

Counter-Regulation of Opioid Analgesia by Glial-Derived Bioactive Sphingolipids

(2010) C. Muscoli et al.   JOURNAL OF NEUROSCIENCE

Sphingosine Kinase 1 Induces Tolerance to Human Epidermal Growth Factor Receptor 2 and Prevents Formation of a Migratory Phenotype in Response to Sphingosine 1-Phosphate in Estrogen Receptor-Positive Breast Cancer Cells

(2010) J. S. Long et al.   MOLECULAR AND CELLULAR BIOLOGY

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Sphingosine 1-Phosphate Receptor Signaling

(2009) Hugh Rosen et al.   Annual Review of Biochemistry

Different response patterns of several ligands at the sphingosine-1-phosphate receptor subtype 3 (S1P3)

(2009) M Jongsma et al.   BRITISH JOURNAL OF PHARMACOLOGY

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors

(2009) Florian Mullershausen et al.   Nature Chemical Biology

Sphingosine 1-phosphate chemical biology

(2008) K LYNCH   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Selective activation of G alpha i mediated signalling of S1P3 by FTY720-phosphate

(2008) Sven-Christian Sensken et al.   CELLULAR SIGNALLING

Antinociceptive activity of the S1P-receptor agonist FTY720

(2008) Ovidiu Coste et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lysophospholipid Receptor-Mediated Calcium Signaling in Human Keratinocytes

(2008) Karin Lichte et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Full Pharmacological Efficacy of a Novel S1P1 Agonist That Does Not Require S1P-Like Headgroup Interactions

(2008) P. J. Gonzalez-Cabrera et al.   MOLECULAR PHARMACOLOGY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY