The Development and Maintenance of Paclitaxel-induced Neuropathic Pain Require Activation of the Sphingosine 1-Phosphate Receptor Subtype 1

Second generation S1P pathway modulators: Research strategies and clinical developments

(2013) Marc Bigaud et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Pharmacokinetics and pharmacodynamics of ponesimod, a selective S1P1receptor modulator, in the first-in-human study

(2013) Patrick Brossard et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Novel Agents Targeting Bioactive Sphingolipids for the Treatment of Cancer

(2013) A. Adan-Gokbulut et al.   CURRENT MEDICINAL CHEMISTRY

Emerging Trends in Understanding Chemotherapy-Induced Peripheral Neuropathy

(2013) Jérémy Ferrier et al.   Current Pain and Headache Reports

Endogenous Interleukin-1β in Neuropathic Rats Enhances Glutamate Release from the Primary Afferents in the Spinal Dorsal Horn through Coupling with PresynapticN-Methyl-d-aspartic Acid Receptors

(2013) Xisheng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fingolimod: Direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy

(2013) Aran Groves et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Inhibition of glycogen synthase kinase 3beta activity with lithium prevents and attenuates paclitaxel-induced neuropathic pain

(2013) M. Gao et al.   NEUROSCIENCE

Sphingosine 1-Phosphate Mediates Hyperalgesia via a Neutrophil-Dependent Mechanism

(2013) Amanda Finley et al.   PLoS One

Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain

(2013) Daniela Salvemini et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Sphingosine-1-phosphate receptors as emerging targets for treatment of pain

(2012) Sandra P. Welch et al.   BIOCHEMICAL PHARMACOLOGY

Discovering cytokines as targets for chemotherapy-induced painful peripheral neuropathy

(2012) Xiao-Min Wang et al.   CYTOKINE

The contribution of satellite glial cells to chemotherapy-induced neuropathic pain

(2012) R.A. Warwick et al.   EUROPEAN JOURNAL OF PAIN

Cannabinoid agonist WIN 55,212-2 prevents the development of paclitaxel-induced peripheral neuropathy in rats. Possible involvement of spinal glial cells

(2012) Elisa Burgos et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Controlling murine and rat chronic pain through A3 adenosine receptor activation

(2012) Zhoumou Chen et al.   FASEB JOURNAL

An Oral Sphingosine 1-Phosphate Receptor 1 (S1P1) Antagonist Prodrug with Efficacy in Vivo: Discovery, Synthesis, and Evaluation

(2012) Daniela Angst et al.   JOURNAL OF MEDICINAL CHEMISTRY

Supraspinal Peroxynitrite Modulates Pain Signaling by Suppressing the Endogenous Opioid Pathway

(2012) J. W. Little et al.   JOURNAL OF NEUROSCIENCE

Targeting the Overproduction of Peroxynitrite for the Prevention and Reversal of Paclitaxel-Induced Neuropathic Pain

(2012) T. Doyle et al.   JOURNAL OF NEUROSCIENCE

Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin

(2012) Gary J. Patti et al.   Nature Chemical Biology

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

The Clinically-tested S1P Receptor Agonists, FTY720 and BAF312, Demonstrate Subtype-Specific Bradycardia (S1P1) and Hypertension (S1P3) in Rat

(2012) Ryan M. Fryer et al.   PLoS One

Peroxisome proliferator-activated receptor β/δ agonist GW0742 ameliorates cerulein- and taurocholate-induced acute pancreatitis in mice

(2012) Irene Paterniti et al.   SURGERY

Inhibiting the mTOR Pathway Synergistically Enhances Cytotoxicity in Ovarian Cancer Cells Induced by Etoposide through Upregulation of c-Jun

(2011) H. Itamochi et al.   CLINICAL CANCER RESEARCH

Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway

(2011) Tim Doyle et al.   FASEB JOURNAL

Fingolimod modulates microglial activation to augment markers of remyelination

(2011) Samuel J Jackson et al.   Journal of Neuroinflammation

Behavioral Evidence for the Differential Regulation of p-p38 MAPK and p-NF-κB in Rats with Trigeminal Neuropathic Pain

(2011) Min K Lee et al.   Molecular Pain

The response of spinal microglia to chemotherapy-evoked painful peripheral neuropathies is distinct from that evoked by traumatic nerve injuries

(2011) F.Y. Zheng et al.   NEUROSCIENCE

Characterization of oxaliplatin-induced chronic painful peripheral neuropathy in the rat and comparison with the neuropathy induced by paclitaxel

(2011) W.H. Xiao et al.   NEUROSCIENCE

Sphingosine-1-phosphate acting via the S1P1 receptor is a downstream signaling pathway in ceramide-induced hyperalgesia

(2011) Tim Doyle et al.   NEUROSCIENCE LETTERS

Genetic Evidence for Involvement of Neuronally Expressed S1P1 Receptor in Nociceptor Sensitization and Inflammatory Pain

(2011) Norbert Mair et al.   PLoS One

Chemotherapy-induced neuropathic pain

(2011) Paul Farquhar-Smith   Current Opinion in Supportive and Palliative Care

Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation

(2010) Ashley J. Snider et al.   BIOCHIMIE

2-Imino-thiazolidin-4-one Derivatives as Potent, Orally Active S1P1Receptor Agonists

(2010) Martin H. Bolli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Differential responses of human microglia and blood-derived myeloid cells to FTY720

(2010) Bryce A. Durafourt et al.   JOURNAL OF NEUROIMMUNOLOGY

The Sphingosine 1-Phosphate Receptor, S1PR1, Plays a Prominent But Not Exclusive Role in Enhancing the Excitability of Sensory Neurons

(2010) Xian Xuan Chi et al.   JOURNAL OF NEUROPHYSIOLOGY

Counter-Regulation of Opioid Analgesia by Glial-Derived Bioactive Sphingolipids

(2010) C. Muscoli et al.   JOURNAL OF NEUROSCIENCE

Sphingosine-1-phosphate receptors: Zooming in on ligand-induced intracellular trafficking and its functional implications

(2010) Dennis Verzijl et al.   MOLECULES AND CELLS

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Pathophysiology and Animal Models of Cancer-Related Painful Peripheral Neuropathy

(2010) G. J. Bennett   ONCOLOGIST

Peripheral inflammation induces tumor necrosis factor dependent AMPA receptor trafficking and Akt phosphorylation in spinal cord in addition to pain behavior

(2010) Jeong Il Choi et al.   PAIN

Biological Roles of Acid and Neutral Sphingomyelinases and Their Regulation by Nitric Oxide

(2010) Cristiana Perrotta et al.   PHYSIOLOGY

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

(2010) J. W. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of cellular redox state underlies antagonism between oxaliplatin and cetuximab in human colorectal cancer cell lines

(2009) Laetitia Dahan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Enkephalins, dynorphins, and β-endorphin in the rat dorsal horn: An immunofluorescence colocalization study

(2009) Juan Carlos G. Marvizón et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Direct intra-tumoral injection of zinc-acetate halts tumor growth in a xenograft model of prostate cancer

(2009) Maulik R Shah et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia

(2009) D. Nayak et al.   NEUROSCIENCE

MAP kinase and pain

(2008) Ru-Rong Ji et al.   BRAIN RESEARCH REVIEWS

Sphingosine 1-Phosphate Modulates Spinal Nociceptive Processing

(2008) Ovidiu Coste et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antinociceptive activity of the S1P-receptor agonist FTY720

(2008) Ovidiu Coste et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Spinal Ceramide Modulates the Development of Morphine Antinociceptive Tolerance via Peroxynitrite-Mediated Nitroxidative Stress and Neuroimmune Activation

(2008) M. M. Ndengele et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Full Pharmacological Efficacy of a Novel S1P1 Agonist That Does Not Require S1P-Like Headgroup Interactions

(2008) P. J. Gonzalez-Cabrera et al.   MOLECULAR PHARMACOLOGY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY