Article
Agronomy
Zhongling WU, Jiehua QIU, Huanbin SHI, Chuyu LIN, Jiangnan YUE, Zhiquan LIU, Wei XIE, Naweed I. N. Aqvi, Yanjun KOU, Zeng TAO
Summary: This study reveals the essential role of the core subunits of PRC2 in the pathogenicity of Magnaporthe oryzae to rice. These subunits are required for the establishment of H3K27me3 modification, which is involved in the transcriptional regulation of numerous genes. Interestingly, the de-repression of genes associated with H3K27me3 modification is closely related to effector-mediated host immunity and host environment adaption.
Article
Genetics & Heredity
Janet Lesley Brown, Joshua D. Price, Maksim Erokhin, Judith A. Kassis
Summary: Polycomb group proteins, including Pho, Spps, Cg, and GAF, are recruited to Polycomb response elements (PREs) to silence key developmental genes in Drosophila. Pho has been considered as a central player in PcG recruitment, but recent studies have revealed that PcG proteins can still bind to PREs without Pho. This study demonstrates that Pho binding sites are required for the activity of PREs in transgenes, and that multiple PREs and chromatin environment can compensate for the loss of Pho binding sites. These findings highlight the multiple mechanisms involved in PcG recruitment in Drosophila.
Article
Biochemistry & Molecular Biology
Jing Xu, Xiaolu Zhao, Fengbiao Mao, Venkatesha Basrur, Beatrix Ueberheide, Brian T. Chait, C. David Allis, Sean D. Taverna, Shan Gao, Wei Wang, Yifan Liu
Summary: In this study, the EZL1 complex in the protist Tetrahymena thermophila was characterized, revealing its essential role in histone methylation, heterochromatin formation, and genome rearrangement. The interaction between the EZL1 complex and EMA1, as well as PDD1, reinforces its chromatin association and contributes to the dynamic distribution of Polycomb bodies in Tetrahymena development. These findings provide a molecular mechanism linking RNAi and Polycomb repression, ultimately regulating nuclear bodies and genome organization.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Yu Zhang, Min Ma, Meng Liu, Aiqing Sun, Xiaoyun Zheng, Kunpeng Liu, Chunmei Yin, Chuanshun Li, Cizhong Jiang, Xiaoyu Tu, Yuda Fang
Summary: This study reveals that the Arabidopsis cohesin subunits SCC3 and SYN4 are involved in the establishment of H2Aub1 through their direct or indirect interaction with BMI1A/B/C subunits of PRC1.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Satoshi Kaito, Atsushi Iwama
Summary: Polycomb repressive complexes play a crucial role in maintaining hematopoietic stem cells and mutations in corresponding genes are associated with hematologic malignancies, leading to resistance to chemotherapy and poor prognosis. Recent studies have revealed that these gene mutations are druggable targets, and inhibitors have shown therapeutic efficacy for tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Min Gao, Yongwen Li, Peijun Cao, Hongyu Liu, Jun Chen, Shirong Kang
Summary: This paper reviews the importance of PRC2 in the development and progression of lung cancer, and explores its role in tumor immunity, cellular behavior regulation, and drug treatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Ludivine Raby, Pamela Volkel, Shaghayegh Hasanpour, Julien Cicero, Robert-Alain Toillon, Eric Adriaenssens, Isabelle Van Seuningen, Xuefen Le Bourhis, Pierre-Olivier Angrand
Summary: This study reports on a zebrafish line with a null allele of eed, a key component of PRC2, and reveals severe defects in digestive organs and brain neuronal differentiation in homozygous eed-deficient mutants, leading to death. Additionally, loss of PRC2 function in zebrafish increases larval activity and highlights its potential as a model for studying human pathologies linked to PRC2 dysfunction and reduced H3K27me3 levels.
Review
Genetics & Heredity
Pooja Flora, Gil Dalal, Idan Cohen, Elena Ezhkova
Summary: Resident stem cells in adult tissues play a crucial role in maintaining, repairing, and regenerating tissues throughout organisms' lifetimes. The process of stem cell renewal and differentiation is tightly regulated, with epigenetic regulators such as polycomb group proteins playing a key role in maintaining homeostasis and regenerative balance in adult tissues.
Article
Plant Sciences
Tianqing Zhu, Jiwen Hu, Xiaowei Yang, Lisheng Kong, Juanjuan Ling, Junhui Wang, Sanping An
Summary: This study characterizes the PRC2 core component genes in the conifer species P. abies, revealing their involvement in cell reprogramming during seed and embryo development. These findings may contribute to a better understanding of embryonic potential and development in conifers.
Review
Biochemistry & Molecular Biology
Akhil Gargey Iragavarapu, Liqi Yao, Vignesh Kasinath
Summary: Polycomb repressive complexes are a family of chromatin modifier enzymes critical for regulating gene expression and maintaining cell-type identity. PRC2 acts as both a reader and writer of histone H3 lysine 27 trimethylation, serving as a marker for transcription repression and heterochromatin boundaries. Recent structural studies have provided insights into the roles of Polycomb cofactor proteins in mediating crosstalk between histone modifications and the recruitment of PRC2 for methyltransferase activity.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2021)
Article
Oncology
Maksim Erokhin, Olga Chetverina, Balazs Gyorffy, Victor V. Tatarskiy, Vladic Mogila, Alexander A. Shtil, Igor B. Roninson, Jerome Moreaux, Pavel Georgiev, Giacomo Cavalli, Darya Chetverina
Summary: PRC2 is a complex involved in transcriptional repression through histone methylation, with dysregulation linked to tumor development. This study analyzed clinical correlations of PRC2 subunit genes in tumor samples, identifying cancer types responsive to PRC2 inhibition and potential sensitivity markers for PRC2-targeting drugs.
Article
Biochemistry & Molecular Biology
Shirish Shukla, Weijiang Ying, Felicia Gray, Yiwu Yao, Miranda L. Simes, Qingjie Zhao, Hongzhi Miao, Hyo Je Cho, Paula Gonzalez-Alonso, Alyssa Winkler, George Lund, Trupta Purohit, EunGi Kim, Xiaotian Zhang, Joshua M. Ray, Shihan He, Caroline Nikolaidis, Juliano Ndoj, Jingya Wang, Lukasz Jaremko, Mariusz Jaremko, Russell J. H. Ryan, Monica L. Guzman, Jolanta Grembecka, Tomasz Cierpicki
Summary: Novel compounds targeting PRC1 have been developed to modulate its activity and induce differentiation in leukemia cells.
NATURE CHEMICAL BIOLOGY
(2021)
Article
Plant Sciences
Adji Baskoro Dwi Nugroho, Sujeong Kim, Sang Woo Lee, Dong-Hwan Kim
Summary: Polycomb group proteins (PcG) are important for developmental programs in plants. CLF, a PcG component in Arabidopsis, has a homolog in Brassica rapa ssp. trilocularis, called BrCLF. BrCLF participates in developmental processes, stress signaling, and stress-responsive metabolism in B. rapa. This study contributes to understanding the molecular mechanism of PcG-mediated regulation in development and stress responses in B. rapa.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Multidisciplinary Sciences
Keke Qu, Kangjing Chen, Hao Wang, Xueming Li, Zhucheng Chen
Summary: This study reports the cryo-electron microscopy structure of NuA4 bound to the nucleosome, shedding light on the assembly of NuA4 and its role in nucleosome recognition and transcription co-activation.
Article
Biotechnology & Applied Microbiology
Shujing Liu, Minerva S. Trejo-Arellano, Yichun Qiu, D. Magnus Eklund, Claudia Koehler, Lars Hennig
Summary: The study demonstrates that H2Aub plays a crucial role in H3K27me3 deposition and is required for PRC1-mediated transcriptional changes in both genes and transposable elements in Marchantia.