Trithorax group proteins: switching genes on and keeping them active

Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions

(2011) Alexander J. Ruthenburg et al.   CELL

Wdr5 Mediates Self-Renewal and Reprogramming via the Embryonic Stem Cell Core Transcriptional Network

(2011) Yen-Sin Ang et al.   CELL

Role for Dpy-30 in ES Cell-Fate Specification by Regulation of H3K4 Methylation within Bivalent Domains

(2011) Hao Jiang et al.   CELL

Chromatin states in pluripotent, differentiated, and reprogrammed cells

(2011) Cynthia L Fisher et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

An MLL/COMPASS subunit functions in the C. elegans dosage compensation complex to target X chromosomes for transcriptional regulation of gene expression

(2011) R. R. Pferdehirt et al.   GENES & DEVELOPMENT

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance

(2011) J. Zuber et al.   GENES & DEVELOPMENT

The Putzig-NURF Nucleosome Remodeling Complex Is Required for Ecdysone Receptor Signaling and Innate Immunity inDrosophila melanogaster

(2011) Sabrina J. Kugler et al.   GENETICS

H3K36 Methylation Antagonizes PRC2-mediated H3K27 Methylation

(2011) Wen Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The COMPASS Family of H3K4 Methylases in Drosophila

(2011) M. Mohan et al.   MOLECULAR AND CELLULAR BIOLOGY

A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression

(2011) Kevin C. Wang et al.   NATURE

Crystal structure of the trithorax group protein ASH2L reveals a forkhead-like DNA binding domain

(2011) Sabina Sarvan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-wide chromatin occupancy analysis reveals a role for ASH2 in transcriptional pausing

(2011) Sílvia Pérez-Lluch et al.   NUCLEIC ACIDS RESEARCH

The CHD3 Chromatin Remodeler PICKLE and Polycomb Group Proteins Antagonistically Regulate Meristem Activity in the Arabidopsis Root

(2011) E. Aichinger et al.   PLANT CELL

NF-Y Recruits Ash2L to Impart H3K4 Trimethylation on CCAAT Promoters

(2011) Andrea Fossati et al.   PLoS One

Histone code pathway involving H3 S28 phosphorylation and K27 acetylation activates transcription and antagonizes polycomb silencing

(2011) P. N. I. Lau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells

(2011) Y. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for Set1/MLL-Related Components in Epigenetic Regulation of the Caenorhabditis elegans Germ Line

(2011) Tengguo Li et al.   PLoS Genetics

A Higher-Order Complex Containing AF4 and ENL Family Proteins with P-TEFb Facilitates Oncogenic and Physiologic MLL-Dependent Transcription

(2010) Akihiko Yokoyama et al.   CANCER CELL

The PAF Complex Synergizes with MLL Fusion Proteins at HOX Loci to Promote Leukemogenesis

(2010) Andrew G. Muntean et al.   CANCER CELL

The Language of Histone Crosstalk

(2010) Jung-Shin Lee et al.   CELL

Long Noncoding RNAs with Enhancer-like Function in Human Cells

(2010) Ulf Andersson Ørom et al.   CELL

Biphasic MLL takes helm at cell cycle control: Implications in human mixed lineage leukemia

(2010) Han Liu et al.   CELL CYCLE

The Trithorax group protein Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation

(2010) D. Pullirsch et al.   DEVELOPMENT

Methylation and demethylation activities of a C. elegans MLL-like complex attenuate RAS signalling

(2010) Kate Fisher et al.   DEVELOPMENTAL BIOLOGY

A Combined Ex Vivo and In Vivo RNAi Screen for Notch Regulators in Drosophila Reveals an Extensive Notch Interaction Network

(2010) Abil Saj et al.   DEVELOPMENTAL CELL

Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing

(2010) Khairul I. Ansari et al.   FEBS Journal

Menin stimulates homology-directed DNA repair

(2010) A. Gallo et al.   FEBS LETTERS

Prediction of Polycomb target genes in mouse embryonic stem cells

(2010) Yingchun Liu et al.   GENOMICS

Developmentally induced Mll1 loss reveals defects in postnatal haematopoiesis

(2010) T Gan et al.   LEUKEMIA

The H3K27me3 Demethylase dUTX Is a Suppressor of Notch- and Rb-Dependent Tumors in Drosophila

(2010) H. M. Herz et al.   MOLECULAR AND CELLULAR BIOLOGY

Multiple Interactions Recruit MLL1 and MLL1 Fusion Proteins to the HOXA9 Locus in Leukemogenesis

(2010) Thomas A. Milne et al.   MOLECULAR CELL

Polycomb Group Protein Displacement and Gene Activation through MSK-Dependent H3K27me3S28 Phosphorylation

(2010) Simmi Suman Gehani et al.   MOLECULAR CELL

AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia

(2010) Chengqi Lin et al.   MOLECULAR CELL

HIV-1 Tat Assembles a Multifunctional Transcription Elongation Complex and Stably Associates with the 7SK snRNP

(2010) Bijan Sobhian et al.   MOLECULAR CELL

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

(2010) Eric L. Greer et al.   NATURE

Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint

(2010) Han Liu et al.   NATURE

JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

(2010) Diego Pasini et al.   NATURE

Chromatin remodelling during development

(2010) Lena Ho et al.   NATURE

CpG islands influence chromatin structure via the CpG-binding protein Cfp1

(2010) John P. Thomson et al.   NATURE

A unique chromatin signature uncovers early developmental enhancers in humans

(2010) Alvaro Rada-Iglesias et al.   NATURE

Promoter chromatin remodeling of immediate-early genes is mediated through H3 phosphorylation at either serine 28 or 10 by the MSK1 multi-protein complex

(2010) Bojan Drobic et al.   NUCLEIC ACIDS RESEARCH

Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex

(2010) J. D. Pereira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Kinetics of Nucleosome Turnover Determined by Metabolic Labeling of Histones

(2010) R. B. Deal et al.   SCIENCE

MLL2 Is Required in Oocytes for Bulk Histone 3 Lysine 4 Trimethylation and Transcriptional Silencing

(2010) Claudia V. Andreu-Vieyra et al.   PLOS BIOLOGY

GC-Rich Sequence Elements Recruit PRC2 in Mammalian ES Cells

(2010) Eric M. Mendenhall et al.   PLoS Genetics

Alternative Epigenetic Chromatin States of Polycomb Target Genes

(2010) Yuri B. Schwartz et al.   PLoS Genetics

Epigenetic chromatin states uniquely define the developmental plasticity of murine hematopoietic stem cells

(2009) H. Weishaupt et al.   BLOOD

DDB1-CUL4 and MLL1 Mediate Oncogene-Induced p16INK4a Activation

(2009) Y. Kotake et al.   CANCER RESEARCH

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

RAD6-Mediated Transcription-Coupled H2B Ubiquitylation Directly Stimulates H3K4 Methylation in Human Cells

(2009) Jaehoon Kim et al.   CELL

Chromatin Signatures in Multipotent Human Hematopoietic Stem Cells Indicate the Fate of Bivalent Genes during Differentiation

(2009) Kairong Cui et al.   Cell Stem Cell

Recruitment of Polycomb group complexes and their role in the dynamic regulation of cell fate choice

(2009) B. Schuettengruber et al.   DEVELOPMENT

CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing

(2009) F. Tie et al.   DEVELOPMENT

Genetic and epigenetic mechanisms regulating hedgehog expression in the Drosophila wing

(2009) Fernando Bejarano et al.   DEVELOPMENTAL BIOLOGY

Histone H3 lysine 4 (H3K4) methylation in development and differentiation

(2009) Joel C. Eissenberg et al.   DEVELOPMENTAL BIOLOGY

Characterization of DNA damage-dependent cell cycle checkpoints in a menin-deficient model

(2009) Molly C. Kottemann et al.   DNA REPAIR

E2F1 mediates DNA damage and apoptosis through HCF-1 and the MLL family of histone methyltransferases

(2009) Shweta Tyagi et al.   EMBO JOURNAL

The ISWI-containing NURF complex regulates the output of the canonical Wingless pathway

(2009) Haiyun Song et al.   EMBO REPORTS

Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns

(2009) M. P. Schnetz et al.   GENOME RESEARCH

Evolution and pleiotropy of TRITHORAX function in Arabidopsis

(2009) Zoya Avramova   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

A Reconfigured Pattern of MLL Occupancy within Mitotic Chromatin Promotes Rapid Transcriptional Reactivation Following Mitotic Exit

(2009) Gerd A. Blobel et al.   MOLECULAR CELL

Role of the polycomb protein EED in the propagation of repressive histone marks

(2009) Raphael Margueron et al.   NATURE

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

(2009) Gijs van Haaften et al.   NATURE GENETICS

Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling

(2009) Anne-Marie Martinez et al.   NATURE GENETICS

In Brief

(2009)   NATURE REVIEWS NEUROSCIENCE

Su(z)2 Antagonizes Auto-Repression of Myc in Drosophila, Increasing Myc Levels and Subsequent Trans-Activation

(2009) Abid Khan et al.   PLoS One

Gene Regulation and Epigenetic Remodeling in Murine Embryonic Stem Cells by c-Myc

(2009) Chin-Hsing Lin et al.   PLoS One

Fgfr3 Is a Transcriptional Target of Ap2δ and Ash2l-Containing Histone Methyltransferase Complexes

(2009) Cheryl C. Tan et al.   PLoS One

Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance

(2009) A. P. Siebold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MLL5, a trithorax homolog, indirectly regulates H3K4 methylation, represses cyclin A2 expression, and promotes myogenic differentiation

(2009) S. Sebastian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development

(2009) R. L. Montgomery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network

(2009) L. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis

(2009) Stefan Glaser et al.   Epigenetics & Chromatin

Mll5 contributes to hematopoietic stem cell fitness and homeostasis

(2008) Y. Zhang et al.   BLOOD

Loss of Mll5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation

(2008) M. Heuser et al.   BLOOD

Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog Mll5

(2008) V. Madan et al.   BLOOD

Menin Critically Links MLL Proteins with LEDGF on Cancer-Associated Target Genes

(2008) Akihiko Yokoyama et al.   CANCER CELL

Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells

(2008) Xi Chen et al.   CELL

An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells

(2008) Jonghwan Kim et al.   CELL

Association of trxG and PcG proteins with the bxd maintenance element depends on transcriptional activity

(2008) S. Petruk et al.   DEVELOPMENT

The nucleosome remodeling factor (NURF) regulates genes involved in Drosophila innate immunity

(2008) So Yeon Kwon et al.   DEVELOPMENTAL BIOLOGY

A gene-trap strategy identifies quiescence-induced genes in synchronized myoblasts

(2008) Ramkumar Sambasivan et al.   JOURNAL OF BIOSCIENCES

Inv(11)(q21q23) fuses MLL to the Notch co-activator mastermind-like 2 in secondary T-cell acute lymphoblastic leukemia

(2008) M Metzler et al.   LEUKEMIA

SWI/SNF Mediates Polycomb Eviction and Epigenetic Reprogramming of the INK4b-ARF-INK4a Locus

(2008) S. K. Kia et al.   MOLECULAR AND CELLULAR BIOLOGY

Parafibromin, a Component of the Human PAF Complex, Regulates Growth Factors and Is Required for Embryonic Development and Survival in Adult Mice

(2008) P. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular Regulation of H3K4 Trimethylation by Wdr82, a Component of Human Set1/COMPASS

(2008) M. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors

(2008) Fabio Mohn et al.   MOLECULAR CELL

A model for transmission of the H3K27me3 epigenetic mark

(2008) Klaus H. Hansen et al.   NATURE CELL BIOLOGY

A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation

(2008) Shima Nakanishi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Histone H3 Lysine 27-Specific Demethylase Jmjd3 Is Required for Neural Commitment

(2008) Thomas Burgold et al.   PLoS One

ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a

(2008) X. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13

(2008) I. Carrera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-Cell Factor 3 Regulates Embryonic Stem Cell Pluripotency and Self-Renewal by the Transcriptional Control of Multiple Lineage Pathways

(2008) Wai-Leong Tam et al.   STEM CELLS

SWI/SNF-Brg1 Regulates Self-Renewal and Occupies Core Pluripotency-Related Genes in Embryonic Stem Cells

(2008) Benjamin L. Kidder et al.   STEM CELLS

Essential Role of Chromatin Remodeling Protein Bptf in Early Mouse Embryos and Embryonic Stem Cells

(2008) Joseph Landry et al.   PLoS Genetics

Drosophila Kismet Regulates Histone H3 Lysine 27 Methylation and Early Elongation by RNA Polymerase II

(2008) Shrividhya Srinivasan et al.   PLoS Genetics