Deciphering the molecular determinants of cholinergic anthelmintic sensitivity in nematodes: When novel functional validation approaches highlight major differences between the model Caenorhabditis elegans and parasitic species

Synthesis, nematocidal activity and SAR study of novel difluoromethylpyrazole carboxamide derivatives containing flexible alkyl chain moieties

(2017) Xing-Hai Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Functional genomics inBrugia malayireveal diverse muscle nAChRs and differences between cholinergic anthelmintics

(2017) Saurabh Verma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent Duplication and Functional Divergence in Parasitic Nematode Levamisole-Sensitive Acetylcholine Receptors

(2016) Thomas B. Duguet et al.   PLoS Neglected Tropical Diseases

RNA interference in adult Ascaris suum – an opportunity for the development of a functional genomics platform that supports organism-, tissue- and cell-based biology in a nematode parasite

(2015) Ciaran J. McCoy et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Transient effects of levamisole on Brugia malayi microfilariae

(2015) Eman Mostafa et al.   INVERTEBRATE NEUROSCIENCE

Expression of nicotinic acetylcholine receptor subunits from parasitic nematodes in Caenorhabditis elegans

(2015) Megan A. Sloan et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Macrocyclic lactone resistance in Dirofilaria immitis: Failure of heartworm preventives and investigation of genetic markers for resistance

(2015) Catherine Bourguinat et al.   VETERINARY PARASITOLOGY

Functional Characterization of a Novel Class of Morantel-Sensitive Acetylcholine Receptors in Nematodes

(2015) Elise Courtot et al.   PLoS Pathogens

The evolution of pentameric ligand-gated ion-channels and the changing family of anthelmintic drug targets

(2014) ROBIN N. BEECH et al.   PARASITOLOGY

Trichuris suis and Oesophagostomum dentatum Show Different Sensitivity and Accumulation of Fenbendazole, Albendazole and Levamisole In Vitro

(2014) Tina V. A. Hansen et al.   PLoS Neglected Tropical Diseases

Investigation of Acetylcholine Receptor Diversity in a Nematode Parasite Leads to Characterization of Tribendimidine- and Derquantel-Sensitive nAChRs

(2014) Samuel K. Buxton et al.   PLoS Pathogens

Anthelmintic resistance in equine nematodes

(2014) Jacqueline B. Matthews   International Journal for Parasitology-Drugs and Drug Resistance

Nicotinic acetylcholine receptors: A comparison of the nAChRs of Caenorhabditis elegans and parasitic nematodes

(2013) Lindy Holden-Dye et al.   PARASITOLOGY INTERNATIONAL

The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery

(2013) Roz Laing et al.   GENOME BIOLOGY

Selective effect of the anthelmintic bephenium on Haemonchus contortus levamisole-sensitive acetylcholine receptors

(2012) Claude L. Charvet et al.   INVERTEBRATE NEUROSCIENCE

Positive modulation of a Cys-loop acetylcholine receptor by an auxiliary transmembrane subunit

(2012) Thomas Boulin et al.   NATURE NEUROSCIENCE

Effect of combinations of marketed human anthelmintic drugs against Trichuris muris in vitro and in vivo

(2012) Jennifer Keiser et al.   Parasites & Vectors

The development of RNA interference (RNAi) in gastrointestinal nematodes

(2012) MURRAY E. SELKIRK et al.   PARASITOLOGY

Levamisole receptors: a second awakening

(2012) Richard J. Martin et al.   TRENDS IN PARASITOLOGY

Functional reconstitution of Haemonchus contortus acetylcholine receptors in Xenopus oocytes provides mechanistic insights into levamisole resistance

(2011) T Boulin et al.   BRITISH JOURNAL OF PHARMACOLOGY

An inconvenient truth: Global worming and anthelmintic resistance

(2011) Ray M. Kaplan et al.   VETERINARY PARASITOLOGY

The NIH-NIAID Filariasis Research Reagent Resource Center

(2011) Michelle L. Michalski et al.   PLoS Neglected Tropical Diseases

Factors affecting susceptibility to RNA interference in Haemonchus contortus and in vivo silencing of an H11 aminopeptidase gene

(2010) Buddhini Samarasinghe et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Nematode parasite genes: what's in a name?

(2010) Robin N. Beech et al.   TRENDS IN PARASITOLOGY

A suite of genes expressed during transition to parasitic lifestyle in the trichostrongylid nematode Haemonchus contortus encode potentially secreted proteins conserved in Teladorsagia circumcincta

(2010) Alexia Delannoy-Normand et al.   VETERINARY PARASITOLOGY

RNAi and Functional Genomics in Plant Parasitic Nematodes

(2009) M. N. Rosso et al.   Annual Review of Phytopathology

cDNA-AFLP analysis in levamisole-resistant Haemonchus contortus reveals alternative splicing in a nicotinic acetylcholine receptor subunit

(2009) Aymeric Fauvin et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Overcoming macrocyclic lactone resistance in Haemonchus contortus with pulse dosing of levamisole

(2009) Kerri. L. Tyrrell et al.   VETERINARY PARASITOLOGY

The Nicotinic Acetylcholine Receptors of the Parasitic Nematode Ascaris suum: Formation of Two Distinct Drug Targets by Varying the Relative Expression Levels of Two Subunits

(2009) Sally M. Williamson et al.   PLoS Pathogens

Eight genes are required for functional reconstitution of the Caenorhabditis elegans levamisole-sensitive acetylcholine receptor

(2008) T. Boulin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA