Journal
INTERNATIONAL JOURNAL FOR PARASITOLOGY
Volume 45, Issue 11, Pages 673-678Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2015.05.003
Keywords
Ascaris suum; RNA interference; Nematode parasite; Reverse genetics
Categories
Funding
- Biotechnology and Biological Sciences Research Council, UK [BB/H019472/1]
- Department of Employment and Learning for Northern Ireland
- Department of Agriculture and Rural Development for Northern Ireland
- National Institute of Allergy and Infectious Diseases (NIH), USA [R 01 A1 047194]
- Biotechnology and Biological Sciences Research Council [BB/H019472/1, BB/M010392/1] Funding Source: researchfish
- BBSRC [BB/H019472/1, BB/M010392/1] Funding Source: UKRI
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The sustainable control of animal parasitic nematodes requires the development of efficient functional genomics platforms to facilitate target validation and enhance anthelmintic discovery. Unfortunately, the utility of RNA interference (RNAi) for the validation of novel drug targets in nematode parasites remains problematic. Ascaris suum is an important veterinary parasite and a zoonotic pathogen. Here we show that adult A. suum is RNAi competent, and highlight the induction, spread and consistency of RNAi across multiple tissue types. This platform provides a new opportunity to undertake whole organism-, tissue- and cell-level gene function studies to enhance target validation processes for nematode parasites of veterinary/medical significance. (C) 2015 The Authors. Published by Elsevier Ltd.
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