The evolution of pentameric ligand-gated ion-channels and the changing family of anthelmintic drug targets

Crystal structure of a human GABAA receptor

(2014) Paul S. Miller et al.   NATURE

X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors

(2014) Thorsten Althoff et al.   NATURE

Investigation of Acetylcholine Receptor Diversity in a Nematode Parasite Leads to Characterization of Tribendimidine- and Derquantel-Sensitive nAChRs

(2014) Samuel K. Buxton et al.   PLoS Pathogens

Asymmetric Ligand Binding Facilitates Conformational Transitions in Pentameric Ligand-Gated Ion Channels

(2013) David Mowrey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The genomes of four tapeworm species reveal adaptations to parasitism

(2013) Isheng J. Tsai et al.   NATURE

Genomics of Loa loa, a Wolbachia-free filarial parasite of humans

(2013) Christopher A Desjardins et al.   NATURE GENETICS

Characterization of cys-loop receptor genes involved in inhibitory amine neurotransmission in parasitic and free living nematodes

(2013) Robin N. Beech et al.   PARASITOLOGY INTERNATIONAL

Signal Transduction Pathways in the Pentameric Ligand-Gated Ion Channels

(2013) David Mowrey et al.   PLoS One

Gating of Pentameric Ligand-Gated Ion Channels: Structural Insights and Ambiguities

(2013) Corrie J.B. daCosta et al.   STRUCTURE

New advancement in anthelmintic drugs in veterinary medicine

(2013) Christian Epe et al.   TRENDS IN PARASITOLOGY

acr-23 Encodes a Monepantel-Sensitive Channel in Caenorhabditis elegans

(2013) Lucien Rufener et al.   PLoS Pathogens

The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery

(2013) Roz Laing et al.   GENOME BIOLOGY

The genome and developmental transcriptome of the strongylid nematode Haemonchus contortus

(2013) Erich M Schwarz et al.   GENOME BIOLOGY

Structural basis of ligand recognition in 5-HT3 receptors

(2012) Divya Kesters et al.   EMBO REPORTS

The cys-loop ligand-gated ion channel gene family of Tetranychus urticae: Implications for acaricide toxicology and a novel mutation associated with abamectin resistance

(2012) W. Dermauw et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Gating Movement of Acetylcholine Receptor Caught by Plunge-Freezing

(2012) Nigel Unwin et al.   JOURNAL OF MOLECULAR BIOLOGY

ACR-26: A novel nicotinic receptor subunit of parasitic nematodes

(2012) Hayley M. Bennett et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Natural Variation in a Chloride Channel Subunit Confers Avermectin Resistance in C. elegans

(2012) R. Ghosh et al.   SCIENCE

Functional reconstitution of Haemonchus contortus acetylcholine receptors in Xenopus oocytes provides mechanistic insights into levamisole resistance

(2011) T Boulin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Identifying bacterial and archaeal homologs of pentameric ligand-gated ion channel (pLGIC) family using domain-based and alignment-based approaches

(2011) Gloria Rendon et al.   Channels

New insights into the structural bases of activation of Cys-loop receptors

(2011) Cecilia Bouzat   JOURNAL OF PHYSIOLOGY-PARIS

The Haemonchus contortus UNC-49B subunit possesses the residues required for GABA sensitivity in homomeric and heteromeric channels

(2011) Michael V. Accardi et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The Voltage-Gated Potassium Channel Subfamily KQT Member 4 (KCNQ4) Displays Parallel Evolution in Echolocating Bats

(2011) Y. Liu et al.   MOLECULAR BIOLOGY AND EVOLUTION

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

WormBase 2012: more genomes, more data, new website

(2011) K. Yook et al.   NUCLEIC ACIDS RESEARCH

Glutamate-Gated Chloride Channels of Haemonchus contortus Restore Drug Sensitivity to Ivermectin Resistant Caenorhabditis elegans

(2011) Susan K. Glendinning et al.   PLoS One

Annotation of Two Large Contiguous Regions from the Haemonchus contortus Genome Using RNA-seq and Comparative Analysis with Caenorhabditis elegans

(2011) Roz Laing et al.   PLoS One

The cys-loop ligand-gated ion channel gene superfamily of the parasitoid wasp, Nasonia vitripennis

(2010) A K Jones et al.   HEREDITY

Association of ion-channel genotype and macrocyclic lactone sensitivity traits in Haemonchus contortus

(2010) Robin Beech et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Characterization of a novel tyramine-gated chloride channel from Haemonchus contortus

(2010) Vijayaraghava T.S. Rao et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Monepantel Allosterically Activates DEG-3/DES-2 Channels of the Gastrointestinal Nematode Haemonchus contortus

(2010) L. Rufener et al.   MOLECULAR PHARMACOLOGY

Nematode parasite genes: what's in a name?

(2010) Robin N. Beech et al.   TRENDS IN PARASITOLOGY

Phylogenomics of Ligand-Gated Ion Channels Predicts Monepantel Effect

(2010) Lucien Rufener et al.   PLoS Pathogens

Pentameric concatenated (α4)2(β2)3 and (α4)3(β2)2 nicotinic acetylcholine receptors: subunit arrangement determines functional expression

(2009) A-L Carbone et al.   BRITISH JOURNAL OF PHARMACOLOGY

The gating isomerization of neuromuscular acetylcholine receptors

(2009) Anthony Auerbach   JOURNAL OF PHYSIOLOGY-LONDON

Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues

(2009) Pierre-Jean Corringer et al.   JOURNAL OF PHYSIOLOGY-LONDON

A dopamine-gated ion channel (HcGGR3*) from Haemonchus contortus is expressed in the cervical papillae and is associated with macrocyclic lactone resistance

(2009) Vijayaraghava T.S. Rao et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The genome of the blood fluke Schistosoma mansoni

(2009) Matthew Berriman et al.   NATURE

Rhodopsin Molecular Evolution in Mammals Inhabiting Low Light Environments

(2009) Huabin Zhao et al.   PLoS One

A Neuronal Acetylcholine Receptor Regulates the Balance of Muscle Excitation and Inhibition in Caenorhabditis elegans

(2009) Maelle Jospin et al.   PLOS BIOLOGY

The Nicotinic Acetylcholine Receptors of the Parasitic Nematode Ascaris suum: Formation of Two Distinct Drug Targets by Varying the Relative Expression Levels of Two Subunits

(2009) Sally M. Williamson et al.   PLoS Pathogens

Haemonchus contortus Acetylcholine Receptors of the DEG-3 Subfamily and Their Role in Sensitivity to Monepantel

(2009) Lucien Rufener et al.   PLoS Pathogens

The cys-loop ligand-gated ion channel gene superfamily of the nematode, Caenorhabditis elegans

(2008) Andrew K. Jones et al.   INVERTEBRATE NEUROSCIENCE

Divergence Times in Caenorhabditis and Drosophila Inferred from Direct Estimates of the Neutral Mutation Rate

(2008) A. D. Cutter   MOLECULAR BIOLOGY AND EVOLUTION

A new class of anthelmintics effective against drug-resistant nematodes

(2008) Ronald Kaminsky et al.   NATURE

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

(2008) Nicolas Bocquet et al.   NATURE

Broad phylogenomic sampling improves resolution of the animal tree of life

(2008) Casey W. Dunn et al.   NATURE

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

Action potentials contribute to neuronal signaling in C. elegans

(2008) Jerry E Mellem et al.   NATURE NEUROSCIENCE

Eight genes are required for functional reconstitution of the Caenorhabditis elegans levamisole-sensitive acetylcholine receptor

(2008) T. Boulin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA