High mutation rates limit evolutionary adaptation in Escherichia coli

Adaptive tuning of mutation rates allows fast response to lethal stress in Escherichia coli

(2017) Toon Swings et al.   eLife

Growthcurver: an R package for obtaining interpretable metrics from microbial growth curves

(2016) Kathleen Sprouffske et al.   BMC BIOINFORMATICS

Evolution of Mutation Rates in Rapidly Adapting Asexual Populations

(2016) B. H. Good et al.   GENETICS

How Archiving by Freezing Affects the Genome-Scale Diversity ofEscherichia coliPopulations

(2016) Kathleen Sprouffske et al.   Genome Biology and Evolution

Tempo and mode of genome evolution in a 50,000-generation experiment

(2016) Olivier Tenaillon et al.   NATURE

Genetic drift, selection and the evolution of the mutation rate

(2016) Michael Lynch et al.   NATURE REVIEWS GENETICS

Within-host nucleotide diversity of virus populations: Insights from next-generation sequencing

(2015) Chase W. Nelson et al.   INFECTION GENETICS AND EVOLUTION

Fitting Linear Mixed-Effects Models Usinglme4

(2015) Douglas Bates et al.   Journal of Statistical Software

Sustained fitness gains and variability in fitness trajectories in the long-term evolution experiment withEscherichia coli

(2015) Richard E. Lenski et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Weakly Deleterious Mutations and Low Rates of Recombination Limit the Impact of Natural Selection on Bacterial Genomes

(2015) Morgan N. Price et al.   mBio

The Relations Between Recombination Rate and Patterns of Molecular Variation and Evolution in Drosophila

(2014) Brian Charlesworth et al.   Annual Review of Genetics

Experimental evolution and the dynamics of genomic mutation rate modifiers

(2014) Y Raynes et al.   HEREDITY

PAPNC, a novel method to calculate nucleotide diversity from large scale next generation sequencing data

(2014) Wei Shao et al.   JOURNAL OF VIROLOGICAL METHODS

Global epistasis makes adaptation predictable despite sequence-level stochasticity

(2014) S. Kryazhimskiy et al.   SCIENCE

Metabolic Erosion Primarily Through Mutation Accumulation, and Not Tradeoffs, Drives Limited Evolution of Substrate Specificity in Escherichia coli

(2014) Nicholas Leiby et al.   PLOS BIOLOGY

Genetic Diversity in the Interference Selection Limit

(2014) Benjamin H. Good et al.   PLoS Genetics

Mechanisms of Acid Resistance inEscherichia coli

(2013) Usheer Kanjee et al.   Annual Review of Microbiology

Genomic mutation rates that neutralize adaptive evolution and natural selection

(2013) P. J. Gerrish et al.   Journal of the Royal Society Interface

Evaluating evolutionary models of stress-induced mutagenesis in bacteria

(2013) R. Craig MacLean et al.   NATURE REVIEWS GENETICS

Genomic signatures of selection at linked sites: unifying the disparity among species

(2013) Asher D. Cutter et al.   NATURE REVIEWS GENETICS

Normal Mutation Rate Variants Arise in a Mutator (Mut S) Escherichia coli Population

(2013) María-Carmen Turrientes et al.   PLoS One

Long-Term Dynamics of Adaptation in Asexual Populations

(2013) M. J. Wiser et al.   SCIENCE

sigmaS, a major player in the response to environmental stresses inEscherichia coli: role, regulation and mechanisms of promoter recognition

(2013) Paolo Landini et al.   Environmental Microbiology Reports

Genetic background affects epistatic interactions between two beneficial mutations

(2012) Y. Wang et al.   Biology Letters

The Evolution of Low Mutation Rates in Experimental Mutator Populations of Saccharomyces cerevisiae

(2012) Michael J. McDonald et al.   CURRENT BIOLOGY

The Effects of Deleterious Mutations on Evolution at Linked Sites

(2012) Brian Charlesworth   GENETICS

Genomic analysis of a key innovation in an experimental Escherichia coli population

(2012) Zachary D. Blount et al.   NATURE

EcoCyc: fusing model organism databases with systems biology

(2012) Ingrid M. Keseler et al.   NUCLEIC ACIDS RESEARCH

Mutation rate dynamics in a bacterial population reflect tension between adaptation and genetic load

(2012) S. Wielgoss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Molecular Diversity of Adaptive Convergence

(2012) O. Tenaillon et al.   SCIENCE

Competition between high- and higher-mutating strains of Escherichia coli

(2011) C. F. Gentile et al.   Biology Letters

The Balance Between Mutators and Nonmutators in Asexual Populations

(2011) Michael M. Desai et al.   GENETICS

The Lower Bound to the Evolution of Mutation Rates

(2011) Michael Lynch   Genome Biology and Evolution

Negative Epistasis Between Beneficial Mutations in an Evolving Bacterial Population

(2011) A. I. Khan et al.   SCIENCE

Diminishing Returns Epistasis Among Beneficial Mutations Decelerates Adaptation

(2011) H.-H. Chou et al.   SCIENCE

Second-Order Selection for Evolvability in a Large Escherichia coli Population

(2011) R. J. Woods et al.   SCIENCE

Adaptation of experimental yeast populations to stressful conditions in relation to population size

(2010) P. SAMANI et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Rate and effects of spontaneous mutations that affect fitness in mutator Escherichia coli

(2010) S. Trindade et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Genetic linkage and natural selection

(2010) N. H. Barton   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Lethal Mutagenesis: Targeting the Mutator Phenotype in Cancer

(2010) Edward J. Fox et al.   SEMINARS IN CANCER BIOLOGY

Optimization of DNA polymerase mutation rates during bacterial evolution

(2009) E. Loh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Properties of Adaptive Walks in Evolving Populations of Fungus

(2009) Sijmen E. Schoustra et al.   PLOS BIOLOGY

Simultaneous Inference in General Parametric Models

(2008) Torsten Hothorn et al.   BIOMETRICAL JOURNAL

Lethal Mutagenesis of Bacteria

(2008) J. J. Bull et al.   GENETICS

A Simple Formula for Obtaining Markedly Improved Mutation Rate Estimates

(2008) Philip Gerrish   GENETICS

Nitrofurantoin resistance mechanism and fitness cost in Escherichia coli

(2008) L. Sandegren et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli

(2008) Z. D. Blount et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA