Adaptive tuning of mutation rates allows fast response to lethal stress in Escherichia coli

Clonal evolution of glioblastoma under therapy

(2016) Jiguang Wang et al.   NATURE GENETICS

Genetic drift, selection and the evolution of the mutation rate

(2016) Michael Lynch et al.   NATURE REVIEWS GENETICS

Rapid Acquisition of Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus: Role of Hypermutation and Homologous Recombination

(2016) Shigekazu Iguchi et al.   PLoS One

Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance

(2016) Kelley R. Healey et al.   Nature Communications

DNA damage regulation and its role in drug-related phenotypes in the malaria parasites

(2016) Devendra Kumar Gupta et al.   Scientific Reports

Evolution of the Insertion-Deletion Mutation Rate Across the Tree of Life

(2016) Way Sung et al.   G3-Genes Genomes Genetics

Frequency of antibiotic application drives rapid evolutionary adaptation of Escherichia coli persistence

(2016) Bram Van den Bergh et al.   Nature Microbiology

Evidence of a Mild Mutator Phenotype in Cambodian Plasmodium falciparum Malaria Parasites

(2016) Andrew H. Lee et al.   PLoS One

Clinical relevance of Pseudomonas aeruginosa hypermutation in cystic fibrosis chronic respiratory infection

(2015) Antonio Oliver   Journal of Cystic Fibrosis

Fitness trade-offs explain low levels of persister cells in the opportunistic pathogenPseudomonas aeruginosa

(2015) Kristine Stepanyan et al.   MOLECULAR ECOLOGY

Frequency-based haplotype reconstruction from deep sequencing data of bacterial populations

(2015) Sergio Pulido-Tamayo et al.   NUCLEIC ACIDS RESEARCH

Adaptation to High Ethanol Reveals Complex Evolutionary Pathways

(2015) Karin Voordeckers et al.   PLoS Genetics

Acinetobacter baumannii Repeatedly Evolves a Hypermutator Phenotype in Response to Tigecycline That Effectively Surveys Evolutionary Trajectories to Resistance

(2015) Troy G. Hammerstrom et al.   PLoS One

Experimental evolution and the dynamics of genomic mutation rate modifiers

(2014) Y Raynes et al.   HEREDITY

Evolution of Escherichia coli to 42 °C and Subsequent Genetic Engineering Reveals Adaptive Mechanisms and Novel Mutations

(2014) Troy E. Sandberg et al.   MOLECULAR BIOLOGY AND EVOLUTION

Life cycles, fitness decoupling and the evolution of multicellularity

(2014) Katrin Hammerschmidt et al.   NATURE

Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis

(2014) Rasmus Lykke Marvig et al.   NATURE GENETICS

Correcting direct effects of ethanol on translation and transcription machinery confers ethanol tolerance in bacteria

(2014) R. J. F. Haft et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-induced mutagenesis and complex adaptation

(2014) Y. Ram et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mutation rate plasticity in rifampicin resistance depends on Escherichia coli cell–cell interactions

(2014) Rok Krašovec et al.   Nature Communications

Mutation Rates: How Low Can You Go?

(2013) Paul Sniegowski et al.   CURRENT BIOLOGY

SHIFTING FITNESS LANDSCAPES IN RESPONSE TO ALTERED ENVIRONMENTS

(2013) Ryan T. Hietpas et al.   EVOLUTION

A strain ofYersinia pestiswith a mutator phenotype from the Republic of Georgia

(2013) Chythanya Rajanna et al.   FEMS MICROBIOLOGY LETTERS

Evolutionary rescue from extinction is contingent on a lower rate of environmental change

(2013) Haley A. Lindsey et al.   NATURE

Genome dynamics during experimental evolution

(2013) Jeffrey E. Barrick et al.   NATURE REVIEWS GENETICS

A trade-off between oxidative stress resistance and DNA repair plays a role in the evolution of elevated mutation rates in bacteria

(2013) C. Torres-Barcelo et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Long-Term Dynamics of Adaptation in Asexual Populations

(2013) M. J. Wiser et al.   SCIENCE

Mutational Spectrum Drives the Rise of Mutator Bacteria

(2013) Alejandro Couce et al.   PLoS Genetics

Genome Analysis of a Transmissible Lineage of Pseudomonas aeruginosa Reveals Pathoadaptive Mutations and Distinct Evolutionary Paths of Hypermutators

(2013) Rasmus Lykke Marvig et al.   PLoS Genetics

Exploring the combinatorial genomic space inEscherichia colifor ethanol tolerance

(2012) Sergios A. Nicolaou et al.   Biotechnology Journal

Involvement of Mismatch Repair in the Reciprocal Control of Motility and Adherence of Uropathogenic Escherichia coli

(2012) Lauren A. Cooper et al.   INFECTION AND IMMUNITY

Evolutionary rescue and adaptation to abrupt environmental change depends upon the history of stress

(2012) A. Gonzalez et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Evolutionary rescue: an emerging focus at the intersection between ecology and evolution

(2012) A. Gonzalez et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Rate and molecular spectrum of spontaneous mutations in the bacterium Escherichia coli as determined by whole-genome sequencing

(2012) H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutation rate dynamics in a bacterial population reflect tension between adaptation and genetic load

(2012) S. Wielgoss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Balance Between Mutators and Nonmutators in Asexual Populations

(2011) Michael M. Desai et al.   GENETICS

The Lower Bound to the Evolution of Mutation Rates

(2011) Michael Lynch   Genome Biology and Evolution

Bacterial hypermutation: clinical implications

(2011) A. Jolivet-Gougeon et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Adaptation and Evolutionary Rescue in Metapopulations Experiencing Environmental Deterioration

(2011) G. Bell et al.   SCIENCE

Second-Order Selection for Evolvability in a Large Escherichia coli Population

(2011) R. J. Woods et al.   SCIENCE

Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli

(2010) Hani Goodarzi et al.   Molecular Systems Biology

DNA methylation and mutator genes in Escherichia coli K-12

(2010) Martin G. Marinus   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Evolution of the mutation rate

(2010) Michael Lynch   TRENDS IN GENETICS

Fluctuation AnaLysis CalculatOR: a web tool for the determination of mutation rate using Luria-Delbruck fluctuation analysis

(2009) B. M. Hall et al.   BIOINFORMATICS

Genome evolution and adaptation in a long-term experiment with Escherichia coli

(2009) Jeffrey E. Barrick et al.   NATURE

Effect of mutatorP. aeruginosaon antibiotic resistance acquisition and respiratory function in cystic fibrosis

(2009) Agnes Ferroni et al.   PEDIATRIC PULMONOLOGY

Optimization of DNA polymerase mutation rates during bacterial evolution

(2009) E. Loh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diverse Two-Dimensional Input Functions Control Bacterial Sugar Genes

(2008) Shai Kaplan et al.   MOLECULAR CELL

DNA mismatch repair-induced double-strand breaks

(2007) Anetta Nowosielska et al.   DNA REPAIR