Mechanical unfolding reveals stable 3-helix intermediates in talin and α-catenin

Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool

(2017) Jane E. Klann et al.   JOURNAL OF IMMUNOLOGY

Multiplexing molecular tension sensors reveals piconewton force gradient across talin-1

(2017) Pia Ringer et al.   NATURE METHODS

Molecular stretching modulates mechanosensing pathways

(2017) Xian Hu et al.   PROTEIN SCIENCE

Mechanical stability of talin rod controls cell migration and substrate sensing

(2017) Rolle Rahikainen et al.   Scientific Reports

All Subdomains of the Talin Rod Are Mechanically Vulnerable and May Contribute To Cellular Mechanosensing

(2016) Alexander William M. Haining et al.   ACS Nano

Cell–cell junctional mechanotransduction in endothelial remodeling

(2016) Yvonne L. Dorland et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanosensing in cell–matrix adhesions – Converting tension into chemical signals

(2016) Vesa P. Hytönen et al.   EXPERIMENTAL CELL RESEARCH

The mechanical regulation of integrin–cadherin crosstalk organizes cells, signaling and forces

(2016) Keeley L. Mui et al.   JOURNAL OF CELL SCIENCE

LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex

(2016) Thomas Zacharchenko et al.   STRUCTURE

The mechanical response of talin

(2016) Mingxi Yao et al.   Nature Communications

Exome Sequencing of a Pedigree Reveals S339L Mutation in the TLN2 Gene as a Cause of Fifth Finger Camptodactyly

(2016) Hao Deng et al.   PLoS One

Mechano-adaptive sensory mechanism of α-catenin under tension

(2016) Koichiro Maki et al.   Scientific Reports

The mechanotransduction machinery at work at adherens junctions

(2015) B. Ladoux et al.   Integrative Biology

Mutations in CTNNA1 cause butterfly-shaped pigment dystrophy and perturbed retinal pigment epithelium integrity

(2015) Nicole T M Saksens et al.   NATURE GENETICS

The Talin Dimer Structure Orientation Is Mechanically Regulated

(2014) Javad Golji et al.   BIOPHYSICAL JOURNAL

Inherited Cardiomyopathies

(2014) Jeffrey A. Towbin   CIRCULATION JOURNAL

Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion

(2014) Jun Yang et al.   Nature Communications

Actomyosin-dependent formation of the mechanosensitive talin–vinculin complex reinforces actin anchoring

(2014) Corina Ciobanasu et al.   Nature Communications

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

(2014) Mingxi Yao et al.   Scientific Reports

RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover

(2013) Benjamin T. Goult et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Force dependency of biochemical reactions measured by single-molecule force-clamp spectroscopy

(2013) Ionel Popa et al.   Nature Protocols

Talins and kindlins: partners in integrin-mediated adhesion

(2013) David A. Calderwood et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dimer asymmetry defines α-catenin interactions

(2013) Erumbi S Rangarajan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An α-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer

(2012) Ian J Majewski et al.   JOURNAL OF PATHOLOGY

The Crystal Structures of Dystrophin and Utrophin Spectrin Repeats: Implications for Domain Boundaries

(2012) Muralidharan Muthu et al.   PLoS One

Crystal Structure of a Rigid Four-Spectrin-Repeat Fragment of the Human Desmoplakin Plakin Domain

(2011) Hee-Jung Choi et al.   JOURNAL OF MOLECULAR BIOLOGY

Integrin Structure, Activation, and Interactions

(2011) I. D. Campbell et al.   Cold Spring Harbor Perspectives in Biology

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

(2011) Felix Margadant et al.   PLOS BIOLOGY

Crystal structure and functional interpretation of the erythrocyte spectrin tetramerization domain complex

(2010) J. J. Ipsaro et al.   BLOOD

Mutations in Alpha-Actinin-2 Cause Hypertrophic Cardiomyopathy

(2009) Christine Chiu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

(2008) Xian Zhang et al.   NATURE CELL BIOLOGY

How Force Might Activate Talin's Vinculin Binding Sites: SMD Reveals a Structural Mechanism

(2008) Vesa P. Hytönen et al.   PLoS Computational Biology