The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases

Overexpression of SNX7 reduces Aβ production by enhancing lysosomal degradation of APP

(2018) Shaohua Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Defects in ER–endosome contacts impact lysosome function in hereditary spastic paraplegia

(2017) Rachel Allison et al.   JOURNAL OF CELL BIOLOGY

Essential and selective role of SNX12 in transport of endocytic and retrograde cargo

(2017) Amulya Priya et al.   JOURNAL OF CELL SCIENCE

Quantitative proteomic analysis of Parkin substrates in Drosophila neurons

(2017) Aitor Martinez et al.   Molecular Neurodegeneration

Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A

(2017) Katarina Willén et al.   Molecular Neurodegeneration

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling

(2017) Kerrie E. McNally et al.   NATURE CELL BIOLOGY

The retromer complex system in a transgenic mouse model of AD: influence of age

(2017) Jin Chu et al.   NEUROBIOLOGY OF AGING

The Retromer Supports AMPA Receptor Trafficking During LTP

(2017) Paul Temkin et al.   NEURON

Endosomal Traffic Jams Represent a Pathogenic Hub and Therapeutic Target in Alzheimer’s Disease

(2017) Scott A. Small et al.   TRENDS IN NEUROSCIENCES

Sorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1

(2017) Na-Young Kim et al.   Alzheimers Research & Therapy

A comprehensive study of the genetic impact of rare variants in SORL1 in European early-onset Alzheimer’s disease

(2016) Jan Verheijen et al.   ACTA NEUROPATHOLOGICA

Risk factor SORL1: from genetic association to functional validation in Alzheimer’s disease

(2016) Olav M. Andersen et al.   ACTA NEUROPATHOLOGICA

Hereditary Spastic Paraplegia: Clinical and Genetic Hallmarks

(2016) Paulo Victor Sgobbi de Souza et al.   CEREBELLUM

SNX27, a protein involved in down syndrome, regulates GPR17 trafficking and oligodendrocyte differentiation

(2016) Veronica Meraviglia et al.   GLIA

Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice

(2016) Nobutaka Ishizu et al.   HUMAN MOLECULAR GENETICS

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation

(2016) Jordan Follett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50

(2016) Arunas Kvainickas et al.   JOURNAL OF CELL SCIENCE

Mitochondrial dysfunction in Parkinson's disease

(2016) Anindita Bose et al.   JOURNAL OF NEUROCHEMISTRY

SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein

(2016) Timothy Y. Huang et al.   JOURNAL OF NEUROSCIENCE

Genetics of Parkinson's disease

(2016) Christina M. Lill   MOLECULAR AND CELLULAR PROBES

LRRK2 at the interface of autophagosomes, endosomes and lysosomes

(2016) Dorien A. Roosen et al.   Molecular Neurodegeneration

VPS35 regulates cell surface recycling and signaling of dopamine receptor D1

(2016) Chen Wang et al.   NEUROBIOLOGY OF AGING

Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination

(2016) Jose Luis Olmos-Serrano et al.   NEURON

Vps35-dependent recycling of Trem2 regulates microglial function

(2016) Jie Yin et al.   TRAFFIC

Coding mutations inSORL1and Alzheimer disease

(2015) Badri N. Vardarajan et al.   ANNALS OF NEUROLOGY

VPS35pathogenic mutations confer no dominant toxicity but partial loss of function inDrosophilaand genetically interact withparkin

(2015) Bilal R. Malik et al.   HUMAN MOLECULAR GENETICS

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for  -Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

(2015) F.-L. Tang et al.   JOURNAL OF NEUROSCIENCE

SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation

(2015) Tuancheng Feng et al.   MOLECULAR NEUROBIOLOGY

De novo deleterious genetic variations target a biological network centered on Aβ peptide in early-onset Alzheimer disease

(2015) A Rovelet-Lecrux et al.   MOLECULAR PSYCHIATRY

SORL1 rare variants: a major risk factor for familial early-onset Alzheimer’s disease

(2015) G Nicolas et al.   MOLECULAR PSYCHIATRY

Parkinson's disease–associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes

(2015) Wenzhang Wang et al.   NATURE MEDICINE

Retromer in Alzheimer disease, Parkinson disease and other neurological disorders

(2015) Scott A. Small et al.   NATURE REVIEWS NEUROSCIENCE

Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein

(2015) Nripesh Dhungel et al.   NEURON

VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function

(2015) Fu-Lei Tang et al.   Cell Reports

Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation

(2014) Ian J. McGough et al.   CURRENT BIOLOGY

Hereditary spastic paraplegia: Clinical-genetic characteristics and evolving molecular mechanisms

(2014) Temistocle Lo Giudice et al.   EXPERIMENTAL NEUROLOGY

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

(2014) E. Tsika et al.   HUMAN MOLECULAR GENETICS

Coding variants in TREM2 increase risk for Alzheimer's disease

(2014) Sheng Chih Jin et al.   HUMAN MOLECULAR GENETICS

Rapid Mapping of Interactions between Human SNX-BAR Proteins MeasuredIn Vitroby AlphaScreen and Single-molecule Spectroscopy

(2014) Emma Sierecki et al.   MOLECULAR & CELLULAR PROTEOMICS

Vacuolar protein sorting 35 (Vps35) rescues locomotor deficits and shortened lifespan in Drosophila expressing a Parkinson’s disease mutant of Leucine-rich repeat kinase 2 (LRRK2)

(2014) Radek Linhart et al.   Molecular Neurodegeneration

Trafficking regulation of proteins in Alzheimer’s disease

(2014) Shangtong Jiang et al.   Molecular Neurodegeneration

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

(2014) Shichun Tu et al.   Molecular Neurodegeneration

Pharmacological chaperones stabilize retromer to limit APP processing

(2014) Vincent J Mecozzi et al.   Nature Chemical Biology

VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease

(2014) Emiko Miura et al.   NEUROBIOLOGY OF DISEASE

The Use of Pharmacological Retromer Chaperones in Alzheimer’s Disease and other Endosomal-related Disorders

(2014) Diego E. Berman et al.   Neurotherapeutics

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

(2014) G. Kleinberger et al.   Science Translational Medicine

Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy

(2014) Eszter Zavodszky et al.   Nature Communications

Sorting Nexin 27 Regulates Aβ Production through Modulating γ-Secretase Activity

(2014) Xin Wang et al.   Cell Reports

In vivo evidence of pathogenicity of VPS35 mutations in the Drosophila

(2014) Hua-shan Wang et al.   Molecular Brain

Pathogenic Mutation in VPS35 Impairs Its Protection against MPP+ Cytotoxicity

(2013) Fangfang Bi et al.   International Journal of Biological Sciences

A global analysis of SNX27–retromer assembly and cargo specificity reveals a function in glucose and metal ion transport

(2013) Florian Steinberg et al.   NATURE CELL BIOLOGY

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome

(2013) Xin Wang et al.   NATURE MEDICINE

RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk

(2013) David A. MacLeod et al.   NEURON

Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease

(2013) Kurt M. Lucin et al.   NEURON

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

(2013) R. Ghai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prefrontal dopamine signaling and cognitive symptoms of Parkinson’s disease

(2013) Nandakumar S. Narayanan et al.   REVIEWS IN THE NEUROSCIENCES

The Vps35 D620N Mutation Linked to Parkinson's Disease Disrupts the Cargo Sorting Function of Retromer

(2013) Jordan Follett et al.   TRAFFIC

Retromer-mediated endosomal protein sorting: all WASHed up!

(2013) Matthew N.J. Seaman et al.   TRENDS IN CELL BIOLOGY

Clinical Approach to Parkinson's Disease: Features, Diagnosis, and Principles of Management

(2013) J. Massano et al.   Cold Spring Harbor Perspectives in Medicine

The hereditary spastic paraplegia protein strumpellin: Characterisation in neurons and of the effect of disease mutations on WASH complex assembly and function

(2012) Caroline Freeman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules

(2012) Jan R T van Weering et al.   EMBO JOURNAL

Retromer Binds the FANSHY Sorting Motif in SorLA to Regulate Amyloid Precursor Protein Sorting and Processing

(2012) A. W. Fjorback et al.   JOURNAL OF NEUROSCIENCE

The Role of Ceroid Lipofuscinosis Neuronal Protein 5 (CLN5) in Endosomal Sorting

(2012) A. Mamo et al.   MOLECULAR AND CELLULAR BIOLOGY

Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing

(2012) Yonghao Zhao et al.   Molecular Neurodegeneration

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

(2012) Mason A. Israel et al.   NATURE

Down's syndrome and Alzheimer's disease: towards secondary prevention

(2012) Seth Ness et al.   NATURE REVIEWS DRUG DISCOVERY

The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport

(2012) Akhil Bhalla et al.   NEUROBIOLOGY OF DISEASE

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

SNX12 Role in Endosome Membrane Transport

(2012) Véronique Pons et al.   PLoS One

A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease

(2011) Alexander Zimprich et al.   AMERICAN JOURNAL OF HUMAN GENETICS

VPS35 Mutations in Parkinson Disease

(2011) Carles Vilariño-Güell et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology

(2011) Lei Wen et al.   JOURNAL OF CELL BIOLOGY

Biology and pathophysiology of the amyloid precursor protein

(2011) Hui Zheng et al.   Molecular Neurodegeneration

SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors

(2011) Paul Temkin et al.   NATURE CELL BIOLOGY

Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing

(2010) Hirokazu Okada et al.   FASEB JOURNAL

SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane

(2010) Benjamin E.L. Lauffer et al.   JOURNAL OF CELL BIOLOGY

The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics

(2010) M. E. Harbour et al.   JOURNAL OF CELL SCIENCE

Hereditary spastic paraplegias: membrane traffic and the motor pathway

(2010) Craig Blackstone et al.   NATURE REVIEWS NEUROSCIENCE

The BAR Domain Superfamily: Membrane-Molding Macromolecules

(2009) Adam Frost et al.   CELL

A FAM21-Containing WASH Complex Regulates Retromer-Dependent Sorting

(2009) Timothy S. Gomez et al.   DEVELOPMENTAL CELL

Parkinson's disease: from monogenic forms to genetic susceptibility factors

(2009) S. Lesage et al.   HUMAN MOLECULAR GENETICS

The role of tau in neurodegeneration

(2009) Tania F Gendron et al.   Molecular Neurodegeneration

Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo

(2009) Valerie Cullen et al.   Molecular Brain

Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of α-Synuclein and Generation of Its Carboxy-Terminally Truncated Species†

(2008) Daniel Sevlever et al.   BIOCHEMISTRY

Neuronal ceroid lipofuscinoses

(2008) Anu Jalanko et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Novel Sorting Nexin Modulates Endocytic Trafficking and α-Secretase Cleavage of the Amyloid Precursor Protein

(2008) Susanne Schöbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adaptor Protein Sorting Nexin 17 Regulates Amyloid Precursor Protein Trafficking and Processing in the Early Endosomes

(2008) Jiyeon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidemiology of Parkinson’s disease

(2008) Guido Alves et al.   JOURNAL OF NEUROLOGY

Loss of LR11/SORLA Enhances Early Pathology in a Mouse Model of Amyloidosis: Evidence for a Proximal Role in Alzheimer's Disease

(2008) S. E. Dodson et al.   JOURNAL OF NEUROSCIENCE

The ADAM metalloproteinases

(2008) D EDWARDS et al.   MOLECULAR ASPECTS OF MEDICINE

Endosomal sorting and signalling: an emerging role for sorting nexins

(2008) Peter J. Cullen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

LRP1 modulates APP trafficking along early compartments of the secretory pathway

(2008) Elaine Waldron et al.   NEUROBIOLOGY OF DISEASE

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and A  accumulation

(2008) A. Muhammad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA