VPS35pathogenic mutations confer no dominant toxicity but partial loss of function inDrosophilaand genetically interact withparkin

Pathologic and therapeutic implications for the cell biology of parkin

(2015) Rakshita A. Charan et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein

(2015) Nripesh Dhungel et al.   NEURON

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

(2015) Brent J. Ryan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation

(2014) Ian J. McGough et al.   CURRENT BIOLOGY

A new pathway for mitochondrial quality control: mitochondrial-derived vesicles

(2014) A. Sugiura et al.   EMBO JOURNAL

Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control

(2014) Gian-Luca McLelland et al.   EMBO JOURNAL

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

(2014) E. Tsika et al.   HUMAN MOLECULAR GENETICS

PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling

(2014) V. A. Morais et al.   SCIENCE

Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy

(2014) Eszter Zavodszky et al.   Nature Communications

In vivo evidence of pathogenicity of VPS35 mutations in the Drosophila

(2014) Hua-shan Wang et al.   Molecular Brain

The Complex I Subunit NDUFA10 Selectively Rescues Drosophila pink1 Mutants through a Mechanism Independent of Mitophagy

(2014) Joe H. Pogson et al.   PLoS Genetics

The Vps35 D620N Mutation Linked to Parkinson's Disease Disrupts the Cargo Sorting Function of Retromer

(2013) Jordan Follett et al.   TRAFFIC

Retromer-mediated endosomal protein sorting: all WASHed up!

(2013) Matthew N.J. Seaman et al.   TRENDS IN CELL BIOLOGY

The retromer complex - endosomal protein recycling and beyond

(2012) M. N. J. Seaman   JOURNAL OF CELL SCIENCE

A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease

(2011) Alexander Zimprich et al.   AMERICAN JOURNAL OF HUMAN GENETICS

VPS35 Mutations in Parkinson Disease

(2011) Carles Vilariño-Güell et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Recruitment of the endosomal WASH complex is mediated by the extended ‘tail’ of Fam21 binding to the retromer protein Vps35

(2011) Michael E. Harbour et al.   BIOCHEMICAL JOURNAL

VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology

(2011) Lei Wen et al.   JOURNAL OF CELL BIOLOGY

Sorting nexins provide diversity for retromer-dependent trafficking events

(2011) Peter J. Cullen et al.   NATURE CELL BIOLOGY

Control of autophagy as a therapy for neurodegenerative disease

(2011) Harry Harris et al.   Nature Reviews Neurology

Vps35 Mediates Vesicle Transport between the Mitochondria and Peroxisomes

(2010) Emélie Braschi et al.   CURRENT BIOLOGY

The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics

(2010) M. E. Harbour et al.   JOURNAL OF CELL SCIENCE

Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin

(2009) L S Tain et al.   CELL DEATH AND DIFFERENTIATION

The Arp2/3 Activator WASH Controls the Fission of Endosomes through a Large Multiprotein Complex

(2009) Emmanuel Derivery et al.   DEVELOPMENTAL CELL

A FAM21-Containing WASH Complex Regulates Retromer-Dependent Sorting

(2009) Timothy S. Gomez et al.   DEVELOPMENTAL CELL

Positioning mitochondrial plasticity within cellular signaling cascades

(2008) Vincent Soubannier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Wingless secretion promotes and requires retromer-dependent cycling of Wntless

(2008) Fillip Port et al.   NATURE CELL BIOLOGY

Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex

(2008) Xavier Franch-Marro et al.   NATURE CELL BIOLOGY

The Retromer Complex Influences Wnt Secretion by Recycling Wntless from Endosomes to the Trans-Golgi Network

(2007) Tatyana Y. Belenkaya et al.   DEVELOPMENTAL CELL