SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation

Structural biology of presenilin 1 complexes

(2015) Yi Li et al.   Molecular Neurodegeneration

Mint Proteins Are Required for Synaptic Activity-dependent Amyloid Precursor Protein (APP) Trafficking and Amyloid β Generation

(2014) Sarah E. Sullivan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysregulation of protein trafficking in neurodegeneration

(2014) Xin Wang et al.   Molecular Neurodegeneration

Trafficking regulation of proteins in Alzheimer’s disease

(2014) Shangtong Jiang et al.   Molecular Neurodegeneration

Sorting Nexin 27 Regulates Aβ Production through Modulating γ-Secretase Activity

(2014) Xin Wang et al.   Cell Reports

In Vivo Targeting of Adult Neural Stem Cells in the Dentate Gyrus by a Split-Cre Approach

(2014) Ruth Beckervordersandforth et al.   Stem Cell Reports

MIT domain of Vps4 is a Ca2+-dependent phosphoinositide-binding domain

(2013) Naoko Iwaya et al.   JOURNAL OF BIOCHEMISTRY

SNX15 links clathrin endocytosis to the PtdIns3P early endosome independently of the APPL1 endosome

(2013) C. Danson et al.   JOURNAL OF CELL SCIENCE

The Expression of Neuronal Sorting Nexin 8 (SNX8) Exacerbates Abnormal Cholesterol Levels

(2013) Gillian Muirhead et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome

(2013) Xin Wang et al.   NATURE MEDICINE

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase

(2013) Satoru Funamoto et al.   Nature Communications

The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice

(2013) Marguerite Prior et al.   Alzheimers Research & Therapy

Truncation of Ube3a-ATS Unsilences Paternal Ube3a and Ameliorates Behavioral Defects in the Angelman Syndrome Mouse Model

(2013) Linyan Meng et al.   PLoS Genetics

Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons

(2012) Gui-Zhi Yang et al.   JOURNAL OF NEUROCHEMISTRY

FBL2 Regulates Amyloid Precursor Protein (APP) Metabolism by Promoting Ubiquitination-Dependent APP Degradation and Inhibition of APP Endocytosis

(2012) T. Watanabe et al.   JOURNAL OF NEUROSCIENCE

Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing

(2012) Yonghao Zhao et al.   Molecular Neurodegeneration

Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease

(2011) Rohan D. Teasdale et al.   BIOCHEMICAL JOURNAL

Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse

(2011) Keisuke Kuroda et al.   HUMAN MOLECULAR GENETICS

The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease

(2011) Robert Vassar et al.   Alzheimers Research & Therapy

Clathrin-dependent APP endocytosis and Aβ secretion are highly sensitive to the level of plasma membrane cholesterol

(2010) Jack-Christophe Cossec et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sorting of the Alzheimer's Disease Amyloid Precursor Protein Mediated by the AP-4 Complex

(2010) Patricia V. Burgos et al.   DEVELOPMENTAL CELL

Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing

(2010) Hirokazu Okada et al.   FASEB JOURNAL

Impaired spatial working memory and decreased frontal cortex BDNF protein level in dopamine transporter knockout mice

(2009) BingJin Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Novel Role of RanBP9 in BACE1 Processing of Amyloid Precursor Protein and Amyloid β Peptide Generation

(2009) Madepalli K. Lakshmana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

(2009) K. Ghosal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Sorting Nexin Modulates Endocytic Trafficking and α-Secretase Cleavage of the Amyloid Precursor Protein

(2008) Susanne Schöbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adaptor Protein Sorting Nexin 17 Regulates Amyloid Precursor Protein Trafficking and Processing in the Early Endosomes

(2008) Jiyeon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flotillin-Dependent Clustering of the Amyloid Precursor Protein Regulates Its Endocytosis and Amyloidogenic Processing in Neurons

(2008) A. Schneider et al.   JOURNAL OF NEUROSCIENCE

Endosomal sorting and signalling: an emerging role for sorting nexins

(2008) Peter J. Cullen   NATURE REVIEWS MOLECULAR CELL BIOLOGY