A motif within the armadillo repeat of Parkinson’s-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway
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Title
A motif within the armadillo repeat of Parkinson’s-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway
Authors
Keywords
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Journal
Scientific Reports
Volume 8, Issue 1, Pages -
Publisher
Springer Nature
Online
2018-02-16
DOI
10.1038/s41598-018-21931-8
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Note: Only part of the references are listed.- Activation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations
- (2016) Katerina Melachroinou et al. PLoS One
- Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts
- (2016) Giambattista Guaitoli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bcl-2 proteins bid and bax form a network to permeabilize the mitochondria at the onset of apoptosis
- (2016) Robert F Gahl et al. Cell Death & Disease
- Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
- (2016) Martin Steger et al. eLife
- Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy
- (2016) Sangwook Park et al. PLoS One
- Crystal Structure of Human Importin-α1 (Rch1), Revealing a Potential Autoinhibition Mode Involving Homodimerization
- (2015) Hideyuki Miyatake et al. PLoS One
- DED or alive: assembly and regulation of the death effector domain complexes
- (2015) J S Riley et al. Cell Death & Disease
- Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21WAF1/CIP1 expression
- (2015) Dong Hwan Ho et al. Molecular Brain
- Bax Interacting Factor-1 Promotes Survival and Mitochondrial Elongation in Neurons
- (2014) D. B. Wang et al. JOURNAL OF NEUROSCIENCE
- Mutant LRRK2 Toxicity in Neurons Depends on LRRK2 Levels and Synuclein But Not Kinase Activity or Inclusion Bodies
- (2014) G. Skibinski et al. JOURNAL OF NEUROSCIENCE
- Structural and functional in silico analysis of LRRK2 missense substitutions
- (2014) Fernando Cardona et al. MOLECULAR BIOLOGY REPORTS
- Involvement of cardiolipin in tBID-induced activation of BAX during apoptosis
- (2013) Etienne Raemy et al. CHEMISTRY AND PHYSICS OF LIPIDS
- (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD
- (2012) C-Y Chen et al. CELL DEATH AND DIFFERENTIATION
- Biochemical Characterization of Highly Purified Leucine-Rich Repeat Kinases 1 and 2 Demonstrates Formation of Homodimers
- (2012) Laura Civiero et al. PLoS One
- Caspase-8 and Bid: Caught in the act between death receptors and mitochondria
- (2011) Chahrazade Kantari et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system
- (2011) Jie Cui et al. BIOSCIENCE REPORTS
- LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice
- (2011) Martin C. Herzig et al. HUMAN MOLECULAR GENETICS
- LRRK2 Parkinson disease mutations enhance its microtubule association
- (2011) Lauren R. Kett et al. HUMAN MOLECULAR GENETICS
- The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease
- (2011) Zhihua Liu et al. NATURE IMMUNOLOGY
- Expression, purification and preliminary biochemical studies of the N-terminal domain of leucine-rich repeat kinase 2
- (2010) Bin Lu et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Life and death by death receptors
- (2009) Maria Eugenia Guicciardi et al. FASEB JOURNAL
- The Parkinson Disease Protein Leucine-Rich Repeat Kinase 2 Transduces Death Signals via Fas-Associated Protein with Death Domain and Caspase-8 in a Cellular Model of Neurodegeneration
- (2009) C. C.-Y. Ho et al. JOURNAL OF NEUROSCIENCE
- The Fas–FADD death domain complex structure unravels signalling by receptor clustering
- (2009) Fiona L. Scott et al. NATURE
- Protective Effect of Memantine Against Doxorubicin Toxicity in Primary Neuronal Cell Cultures: Influence a Development Stage
- (2009) D. Jantas et al. NEUROTOXICITY RESEARCH
- Dissecting the Signaling Events That Impact Classical Nuclear Import and Target Nuclear Transport Factors
- (2009) Mohamed Kodiha et al. PLoS One
- The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation
- (2008) Elisa Greggio et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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