DED or alive: assembly and regulation of the death effector domain complexes
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
DED or alive: assembly and regulation of the death effector domain complexes
Authors
Keywords
-
Journal
Cell Death & Disease
Volume 6, Issue 8, Pages e1866-e1866
Publisher
Springer Nature
Online
2015-08-27
DOI
10.1038/cddis.2015.213
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Unexpected hepatotoxicity in a phase I study of TAS266, a novel tetravalent agonistic Nanobody® targeting the DR5 receptor
- (2015) Kyriakos P. Papadopoulos et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production
- (2015) C J Kearney et al. CELL DEATH AND DIFFERENTIATION
- A RIPK3–Caspase 8 Complex Mediates Atypical Pro–IL-1β Processing
- (2015) Kenta Moriwaki et al. JOURNAL OF IMMUNOLOGY
- The I-TASSER Suite: protein structure and function prediction
- (2015) Jianyi Yang et al. NATURE METHODS
- Smac mimetics as IAP antagonists
- (2015) Simone Fulda SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
- (2015) Kate E. Lawlor et al. Nature Communications
- The eIF4E/eIF4G Interaction Inhibitor 4EGI-1 Augments TRAIL-Mediated Apoptosis through c-FLIP Down-regulation and DR5 Induction Independent of Inhibition of Cap-Dependent Protein Translation
- (2015) Songqing Fan et al. NEOPLASIA
- Mechanisms and Functions of Inflammasomes
- (2014) Mohamed Lamkanfi et al. CELL
- Getting TRAIL back on track for cancer therapy
- (2014) J Lemke et al. CELL DEATH AND DIFFERENTIATION
- Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming
- (2014) R. Allam et al. EMBO REPORTS
- Die another way – non-apoptotic mechanisms of cell death
- (2014) Stephen W. G. Tait et al. JOURNAL OF CELL SCIENCE
- Caspase-8 Modulates Dectin-1 and Complement Receptor 3–Driven IL-1β Production in Response to β-Glucans and the Fungal Pathogen,Candida albicans
- (2014) Sandhya Ganesan et al. JOURNAL OF IMMUNOLOGY
- FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes
- (2014) P. Gurung et al. JOURNAL OF IMMUNOLOGY
- The Apoptotic Initiator Caspase-8: Its Functional Ubiquity and Genetic Diversity during Animal Evolution
- (2014) Kazuhiro Sakamaki et al. MOLECULAR BIOLOGY AND EVOLUTION
- Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3
- (2014) Huayi Wang et al. MOLECULAR CELL
- Regulated necrosis: the expanding network of non-apoptotic cell death pathways
- (2014) Tom Vanden Berghe et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Necroptosis
- (2014) Andreas Linkermann et al. NEW ENGLAND JOURNAL OF MEDICINE
- Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF- B and MAPK signaling
- (2014) N. H. Philip et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
- (2014) Joanne M. Hildebrand et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death
- (2014) D. Weng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1 production in acute glaucoma
- (2014) W. Chi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Evolution of TNF-induced apoptosis reveals 550 My of functional conservation
- (2014) Steven D. Quistad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intra- and Interdimeric Caspase-8 Self-Cleavage Controls Strength and Timing of CD95-Induced Apoptosis
- (2014) S. M. Kallenberger et al. Science Signaling
- A Plug Release Mechanism for Membrane Permeation by MLKL
- (2014) Lijing Su et al. STRUCTURE
- Differential affinity of FLIP and procaspase 8 for FADD’s DED binding surfaces regulates DISC assembly
- (2014) J. Majkut et al. Nature Communications
- MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates
- (2014) Yves Dondelinger et al. Cell Reports
- Structural basis for the prion-like MAVS filaments in antiviral innate immunity
- (2014) Hui Xu et al. eLife
- Control of Autophagic Cell Death by Caspase-10 in Multiple Myeloma
- (2013) Laurence Lamy et al. CANCER CELL
- Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation
- (2013) Y-H Wu et al. CELL DEATH AND DIFFERENTIATION
- K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter
- (2013) Raúl Muñoz-Planillo et al. IMMUNITY
- Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance
- (2013) Agnieszka Kaczmarek et al. IMMUNITY
- p62/Sequestosome-1 Up-regulation Promotes ABT-263-induced Caspase-8 Aggregation/Activation on the Autophagosome
- (2013) Shengbing Huang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Novel Phosphorylation and Ubiquitination Sites Regulate Reactive Oxygen Species-dependent Degradation of Anti-apoptotic c-FLIP Protein
- (2013) Rachel P. Wilkie-Grantham et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cutting Edge: TLR Signaling Licenses IRAK1 for Rapid Activation of the NLRP3 Inflammasome
- (2013) T. Fernandes-Alnemri et al. JOURNAL OF IMMUNOLOGY
- Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2-Induced Apoptosis
- (2013) J. S. Swers et al. MOLECULAR CANCER THERAPEUTICS
- Fas/CD95-Induced Chemokines Can Serve as “Find-Me” Signals for Apoptotic Cells
- (2013) Sean P. Cullen et al. MOLECULAR CELL
- Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
- (2013) Zhenyu Cai et al. NATURE CELL BIOLOGY
- Hyperthermia enhances mapatumumab-induced apoptotic death through ubiquitin-mediated degradation of cellular FLIP(long) in human colon cancer cells
- (2013) X Song et al. Cell Death & Disease
- Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer
- (2013) J S Riley et al. Cell Death & Disease
- Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis
- (2013) Ricardo Weinlich et al. Cell Reports
- High-definition NMR structure of PED/PEA-15 death effector domain reveals details of key polar side chain interactions
- (2012) Edward C. Twomey et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
- (2012) Liming Sun et al. CELL
- Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis
- (2012) E Kerr et al. CELL DEATH AND DIFFERENTIATION
- IAPs limit activation of RIP kinases by TNF receptor 1 during development
- (2012) Maryline Moulin et al. EMBO JOURNAL
- Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response
- (2012) Xiaomo Jiang et al. IMMUNITY
- Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation
- (2012) Christine Juliana et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis
- (2012) Megan M. Young et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondria and cell signalling
- (2012) Stephen W. G. Tait et al. JOURNAL OF CELL SCIENCE
- Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1 and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner
- (2012) L. Bossaller et al. JOURNAL OF IMMUNOLOGY
- A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death
- (2012) Laura S. Dickens et al. MOLECULAR CELL
- Stoichiometry of the CD95 Death-Inducing Signaling Complex: Experimental and Modeling Evidence for a Death Effector Domain Chain Model
- (2012) Kolja Schleich et al. MOLECULAR CELL
- TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer
- (2012) Francois Gonzalvez et al. MOLECULAR CELL
- Inflammasomes in health and disease
- (2012) Till Strowig et al. NATURE
- Regulation of inflammasome signaling
- (2012) Vijay A K Rathinam et al. NATURE IMMUNOLOGY
- Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium
- (2012) Nirmal Robinson et al. NATURE IMMUNOLOGY
- Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome
- (2012) Sonja I Gringhuis et al. NATURE IMMUNOLOGY
- Central roles of apoptotic proteins in mitochondrial function
- (2012) S M Kilbride et al. ONCOGENE
- Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis
- (2012) J. Zhao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The pantheon of the fallen: why are there so many forms of cell death?
- (2012) Douglas R. Green et al. TRENDS IN CELL BIOLOGY
- Survival Function of the FADD-CASPASE-8-cFLIPL Complex
- (2012) Christopher P. Dillon et al. Cell Reports
- FLIPLinduces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity
- (2011) Cristina Pop et al. BIOCHEMICAL JOURNAL
- MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response
- (2011) Fajian Hou et al. CELL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8
- (2011) M A Laussmann et al. CELL DEATH AND DIFFERENTIATION
- RIG-I RNA Helicase Activation of IRF3 Transcription Factor Is Negatively Regulated by Caspase-8-Mediated Cleavage of the RIP1 Protein
- (2011) Akhil Rajput et al. IMMUNITY
- Mechanisms of necroptosis in T cells
- (2011) Irene L. Ch’en et al. JOURNAL OF EXPERIMENTAL MEDICINE
- cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms
- (2011) Maria Feoktistova et al. MOLECULAR CELL
- The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs
- (2011) Tencho Tenev et al. MOLECULAR CELL
- SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
- (2011) Fuminori Tokunaga et al. NATURE
- Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis
- (2011) Claudia Günther et al. NATURE
- RIP3 mediates the embryonic lethality of caspase-8-deficient mice
- (2011) William J. Kaiser et al. NATURE
- Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis
- (2011) Andrew Oberst et al. NATURE
- SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
- (2011) Fumiyo Ikeda et al. NATURE
- Linear ubiquitination prevents inflammation and regulates immune signalling
- (2011) Björn Gerlach et al. NATURE
- Functional complementation between FADD and RIP1 in embryos and lymphocytes
- (2011) Haibing Zhang et al. NATURE
- Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity
- (2011) J. V. Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Individual caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosis
- (2011) A Mühlethaler-Mottet et al. Cell Death & Disease
- Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy
- (2011) Ahmad R. Safa et al. Cancers
- Activation and Specificity of Human Caspase-10
- (2010) Katherine Wachmann et al. BIOCHEMISTRY
- Ubiquitin-Specific Protease 8 Links the PTEN-Akt-AIP4 Pathway to the Control of FLIPSStability and TRAIL Sensitivity in Glioblastoma Multiforme
- (2010) Amith Panner et al. CANCER RESEARCH
- Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity
- (2010) Wenwen Zeng et al. CELL
- Prognostic Significance of TRAIL Signaling Molecules in Stage II and III Colorectal Cancer
- (2010) D. P. McLornan et al. CLINICAL CANCER RESEARCH
- c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling
- (2010) Jasmin N Dynek et al. EMBO JOURNAL
- Inducible Dimerization and Inducible Cleavage Reveal a Requirement for Both Processes in Caspase-8 Activation
- (2010) Andrew Oberst et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I
- (2010) Yanli Wang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis
- (2010) S. L. Osborn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Solution NMR Investigation of the CD95/FADD Homotypic Death Domain Complex Suggests Lack of Engagement of the CD95 C Terminus
- (2010) Diego Esposito et al. STRUCTURE
- A Novel PTEN-Dependent Link to Ubiquitination Controls FLIPS Stability and TRAIL Sensitivity in Glioblastoma Multiforme
- (2009) A. Panner et al. CANCER RESEARCH
- Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation
- (2009) YoungSik Cho et al. CELL
- Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling
- (2009) Zhaoyu Jin et al. CELL
- Studies of the molecular mechanism of caspase-8 activation by solution NMR
- (2009) N Keller et al. CELL DEATH AND DIFFERENTIATION
- PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability
- (2009) A Kaunisto et al. CELL DEATH AND DIFFERENTIATION
- RIPK1 is not essential for TNFR1-induced activation of NF-κB
- (2009) W W-L Wong et al. CELL DEATH AND DIFFERENTIATION
- The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA
- (2009) Irving C. Allen et al. IMMUNITY
- The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1
- (2009) Paul G. Thomas et al. IMMUNITY
- Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease
- (2009) Andrew Kovalenko et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cutting Edge: TNF- Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation
- (2009) L. Franchi et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
- (2009) F. G. Bauernfeind et al. JOURNAL OF IMMUNOLOGY
- Bacterial Endotoxin Induces the Release of High Mobility Group Box 1 via the IFN- Signaling Pathway
- (2009) J.-H. Kim et al. JOURNAL OF IMMUNOLOGY
- Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction
- (2009) Tobias L. Haas et al. MOLECULAR CELL
- The Fas–FADD death domain complex structure unravels signalling by receptor clustering
- (2009) Fiona L. Scott et al. NATURE
- AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
- (2009) Teresa Fernandes-Alnemri et al. NATURE
- Involvement of linear polyubiquitylation of NEMO in NF-κB activation
- (2009) Fuminori Tokunaga et al. NATURE CELL BIOLOGY
- FLIP-mediated autophagy regulation in cell death control
- (2009) Jong-Soo Lee et al. NATURE CELL BIOLOGY
- Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production
- (2009) Hendrik Poeck et al. NATURE IMMUNOLOGY
- Mechanism of procaspase-8 activation by c-FLIPL
- (2009) J. W. Yu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA
- (2009) T. L. Roberts et al. SCIENCE
- Structural and Biochemical Studies on Procaspase-8: New Insights on Initiator Caspase Activation
- (2009) Nadine Keller et al. STRUCTURE
- Up-regulation of c-FLIPshort by NFAT contributes to apoptosis resistance of short-term activated T cells
- (2008) N. Ueffing et al. BLOOD
- TNF-α Induces Two Distinct Caspase-8 Activation Pathways
- (2008) Lai Wang et al. CELL
- TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis
- (2008) Honghong Sun et al. CELL
- Mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment
- (2008) N Ueffing et al. CELL DEATH AND DIFFERENTIATION
- TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway
- (2008) Marie-Cécile Michallet et al. IMMUNITY
- Inflammasomes: guardians of cytosolic sanctity
- (2008) Mohamed Lamkanfi et al. IMMUNOLOGICAL REVIEWS
- c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation
- (2008) Eugene Varfolomeev et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8
- (2008) Jonathan Maelfait et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Paracaspase MALT1 Controls Caspase-8 Activation during Lymphocyte Proliferation
- (2008) Holli Kawadler et al. MOLECULAR CELL
- cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination
- (2008) Mathieu J.M. Bertrand et al. MOLECULAR CELL
- Identification of RIP1 kinase as a specific cellular target of necrostatins
- (2008) Alexei Degterev et al. Nature Chemical Biology
- Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling
- (2008) Sivakumar Vallabhapurapu et al. NATURE IMMUNOLOGY
- Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK
- (2008) Brian J Zarnegar et al. NATURE IMMUNOLOGY
- Crystal structure of TIPE2 provides insights into immune homeostasis
- (2008) Xu Zhang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Both cIAP1 and cIAP2 regulate TNF -mediated NF- B activation
- (2008) D. J. Mahoney et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells
- (2008) B. D. Bell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started