Structural and functional in silico analysis of LRRK2 missense substitutions

Type II Kinase Inhibitors Show an Unexpected Inhibition Mode against Parkinson’s Disease-Linked LRRK2 Mutant G2019S

(2013) Min Liu et al.   BIOCHEMISTRY

Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations

(2012) Ryan D. Mills et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2

(2012) Renée Vancraenenbroeck et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations

(2012) B. K. Gilsbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetic, Mechanistic, and Structural Modeling Studies of Truncated Wild-Type Leucine-Rich Repeat Kinase 2 and the G2019S Mutant

(2011) Min Liu et al.   BIOCHEMISTRY

Biochemical and molecular features of LRRK2 and its pathophysiological roles in Parkinson's disease

(2011) Won-Gi Seol   BMB Reports

Acute inhibition of TAK1 protects against neuronal death in cerebral ischemia

(2011) M Neubert et al.   CELL DEATH AND DIFFERENTIATION

Phylogenetic and in silico structural analysis of the Parkinson disease-related kinase PINK1

(2011) Fernando Cardona et al.   HUMAN MUTATION

LRRK2 haplotype-sharing analysis in Parkinson's disease reveals a novel p.S1761R mutation

(2011) Oswaldo Lorenzo-Betancor et al.   MOVEMENT DISORDERS

Lrrk2 p.Q1111H substitution and Parkinson’s disease in Latin America

(2011) Ignacio F. Mata et al.   PARKINSONISM & RELATED DISORDERS

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

(2010) R. Jeremy Nichols et al.   BIOCHEMICAL JOURNAL

Sequence feature-based prediction of protein stability changes upon amino acid substitutions

(2010) Shaolei Teng et al.   BMC GENOMICS

Reevaluation of Phosphorylation Sites in the Parkinson Disease-associated Leucine-rich Repeat Kinase 2

(2010) Xiaojie Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signal Transduction Protein Array Analysis Links LRRK2 to Ste20 Kinases and PKC Zeta That Modulate Neuronal Plasticity

(2010) Susanne Zach et al.   PLoS One

LRRK2 and neurodegeneration

(2009) Gabriel Santpere et al.   ACTA NEUROPATHOLOGICA

Leucine-rich repeat kinase 2 mutants I2020T and G2019S exhibit altered kinase inhibitor sensitivity

(2009) Laurie J. Reichling et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of the Autophosphorylation Sites of LRRK2

(2009) Shogo Kamikawaji et al.   BIOCHEMISTRY

LRRK2 in Parkinson’s disease: function in cells and neurodegeneration

(2009) Philip J. Webber et al.   FEBS Journal

LRRK2 in Parkinson’s disease: genetic and clinical studies from patients

(2009) Udhaya Kumari et al.   FEBS Journal

Parkinson's disease: from monogenic forms to genetic susceptibility factors

(2009) S. Lesage et al.   HUMAN MOLECULAR GENETICS

Molecular analyses of the LRRK2 gene in European and North African autosomal dominant Parkinson's disease

(2009) S Lesage et al.   JOURNAL OF MEDICAL GENETICS

Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment

(2009) Christian L. Klein et al.   JOURNAL OF NEUROCHEMISTRY

Regulate Axon Branching by the Cyclic GMP Pathway via Inhibition of Glycogen Synthase Kinase 3 in Dorsal Root Ganglion Sensory Neurons

(2009) Z. Zhao et al.   JOURNAL OF NEUROSCIENCE

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols

Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase

(2008) Katja Gotthardt et al.   EMBO JOURNAL

Investigation of leucine-rich repeat kinase 2

(2008) Vasanti S. Anand et al.   FEBS Journal

The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation

(2008) Elisa Greggio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ancient Origin of the Parkinson Disease Gene LRRK2

(2008) Ignacio Marín   JOURNAL OF MOLECULAR EVOLUTION

Identification of ALK as a major familial neuroblastoma predisposition gene

(2008) Yaël P. Mossé et al.   NATURE

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

(2008) J. Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of FOXO1 by Cdk1 in Cycling Cells and Postmitotic Neurons

(2008) Z. Yuan et al.   SCIENCE