Fibroblast-associated tumour microenvironment induces vascular structure-networked tumouroid

Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment

(2017) Hsieh-Fu Tsai et al.   Journal of the Royal Society Interface

Implementing oxygen control in chip-based cell and tissue culture systems

(2016) Pieter E. Oomen et al.   LAB ON A CHIP

CXCL1-Mediated Interaction of Cancer Cells with Tumor-Associated Macrophages and Cancer-Associated Fibroblasts Promotes Tumor Progression in Human Bladder Cancer

(2016) Makito Miyake et al.   NEOPLASIA

3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained

(2016) Michele Zanoni et al.   Scientific Reports

Drug testing and flow cytometry analysis on a large number of uniform sized tumor spheroids using a microfluidic device

(2016) Bishnubrata Patra et al.   Scientific Reports

Engineering a 3D microfluidic culture platform for tumor-treating field application

(2016) Andrea Pavesi et al.   Scientific Reports

A 3D Poly(ethylene glycol)-based Tumor Angiogenesis Model to Study the Influence of Vascular Cells on Lung Tumor Cell Behavior

(2016) Laila C. Roudsari et al.   Scientific Reports

Akt-Girdin Signaling in Cancer-Associated Fibroblasts Contributes to Tumor Progression

(2015) Y. Yamamura et al.   CANCER RESEARCH

Impact of the spheroid model complexity on drug response

(2015) Oliver Ingo Hoffmann et al.   JOURNAL OF BIOTECHNOLOGY

Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer

(2015) YOSHINORI IMAMURA et al.   ONCOLOGY REPORTS

Spontaneously-forming spheroids as an in vitro cancer cell model for anticancer drug screening

(2015) Maria A. Theodoraki et al.   Oncotarget

Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth

(2015) Kazuyoshi Shiga et al.   Cancers

3D cell culture systems modeling tumor growth determinants in cancer target discovery

(2014) Claudio R. Thoma et al.   ADVANCED DRUG DELIVERY REVIEWS

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

(2014) Rasheena Edmondson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Three-dimensional in vitro tumor models for cancer research and drug evaluation

(2014) Xian Xu et al.   BIOTECHNOLOGY ADVANCES

Three-dimensional models of cancer for pharmacology and cancer cell biology: Capturing tumor complexity in vitro/ex vivo

(2014) John A. Hickman et al.   Biotechnology Journal

The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance

(2014) Gvantsa Kharaishvili et al.   Cancer Cell International

Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment

(2014) D. Herrmann et al.   CARCINOGENESIS

Harnessing developmental processes for vascular engineering and regeneration

(2014) Kyung Min Park et al.   DEVELOPMENT

A three-dimensional in vitro model of tumor cell intravasation

(2014) Seema M. Ehsan et al.   Integrative Biology

Siphon-driven microfluidic passive pump with a yarn flow resistance controller

(2014) Gi Seok Jeong et al.   LAB ON A CHIP

Spheroid formation and invasion capacity are differentially influenced by co-cultures of fibroblast and macrophage cells in breast cancer

(2014) Dorina Rama-Esendagli et al.   MOLECULAR BIOLOGY REPORTS

Three-Dimensional Lung Tumor Microenvironment Modulates Therapeutic Compound Responsiveness In Vitro – Implication for Drug Development

(2014) Jason E. Ekert et al.   PLoS One

3-Dimensional Culture Systems for Anti-Cancer Compound Profiling and High-Throughput Screening Reveal Increases in EGFR Inhibitor-Mediated Cytotoxicity Compared to Monolayer Culture Systems

(2014) Amy L. Howes et al.   PLoS One

Fibroblasts Protect Melanoma Cells from the Cytotoxic Effects of Doxorubicin

(2014) Manoela Tiago et al.   TISSUE ENGINEERING PART A

Tumor-Endothelial Cell Three-dimensional Spheroids: New Aspects to Enhance Radiation and Drug Therapeutics

(2014) Meenakshi Upreti et al.   Translational Oncology

Three-Dimensional In Vitro Co-Culture Model of Breast Tumor using Magnetic Levitation

(2014) Hamsa Jaganathan et al.   Scientific Reports

Engineered Culture Models for Studies of Tumor-Microenvironment Interactions

(2013) David W. Infanger et al.   Annual Review of Biomedical Engineering

Microengineered tumor models: insights & opportunities from a physical sciences-oncology perspective

(2013) Peter DelNero et al.   BIOMEDICAL MICRODEVICES

The tumor microenvironment at a glance

(2013) F. R. Balkwill et al.   JOURNAL OF CELL SCIENCE

A three-dimensional microenvironment alters protein expression and chemosensitivity of epithelial ovarian cancer cells in vitro

(2013) Janet Myungjin Lee et al.   LABORATORY INVESTIGATION

Vascular endothelial growth factor in heart failure

(2013) Ziad Taimeh et al.   Nature Reviews Cardiology

Cancer-Associated Fibroblasts Promote Proliferation of Endometrial Cancer Cells

(2013) Kavita S. Subramaniam et al.   PLoS One

Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

(2012) Maria Vinci et al.   BMC BIOLOGY

Stromal cells in tumor microenvironment and breast cancer

(2012) Yan Mao et al.   CANCER AND METASTASIS REVIEWS

Three-dimensional cell culture: the missing link in drug discovery

(2012) Susan Breslin et al.   DRUG DISCOVERY TODAY

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

(2012) Ravid Straussman et al.   NATURE

Human Lung Cancer Cells Grown in an Ex Vivo 3D Lung Model Produce Matrix Metalloproteinases Not Produced in 2D Culture

(2012) Dhruva K. Mishra et al.   PLoS One

Microfluidic 3D cell culture: potential application for tissue-based bioassays

(2012) XiuJun (James) Li et al.   Bioanalysis

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Fibroblasts Contribute to Melanoma Tumor Growth and Drug Resistance

(2011) Edward H. Flach et al.   MOLECULAR PHARMACEUTICS

Ups and Downs of Guided Vessel Sprouting: The Role of Polarity

(2011) Christina Y. Lee et al.   PHYSIOLOGY

The role of the microenvironment in tumor growth and invasion

(2011) Yangjin Kim et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies

(2011) Vikash P. Chauhan et al.   Annual Review of Chemical and Biomolecular Engineering

3D tumour models: novel in vitro approaches to cancer studies

(2011) Agata Nyga et al.   Journal of Cell Communication and Signaling

Forkhead Box F1 Regulates Tumor-Promoting Properties of Cancer-Associated Fibroblasts in Lung Cancer

(2010) Roy-Akira Saito et al.   CANCER RESEARCH

Origin of carcinoma associated fibroblasts

(2010) Izhak Haviv et al.   CELL CYCLE

The Disintegrin-like and Cysteine-rich domains of ADAM-9 Mediate Interactions between Melanoma Cells and Fibroblasts

(2010) Paola Zigrino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biomaterials offer cancer research the third dimension

(2010) Dietmar W. Hutmacher   NATURE MATERIALS

Autocrine TGF-  and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts

(2010) Y. Kojima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling by members of the TGF-β family in vascular morphogenesis and disease

(2010) Evangelia Pardali et al.   TRENDS IN CELL BIOLOGY

Cancer-associated fibroblasts and tumor growth – bystanders turning into key players

(2009) Arne Östman et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Cancer associated fibroblasts (CAFs) in tumor microenvironment

(2009) Fei Xing   Frontiers in Bioscience-Landmark

Spheroid-based drug screen: considerations and practical approach

(2009) Juergen Friedrich et al.   Nature Protocols