Structural and Functional Basis of the Fidelity of Nucleotide Selection by Flavivirus RNA-Dependent RNA Polymerases

Transcription fidelity and its roles in the cell

(2018) Pamela Gamba et al.   CURRENT OPINION IN MICROBIOLOGY

Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus

(2017) Ignacio de la Higuera et al.   Genome Biology and Evolution

Purification of Zika virus RNA-dependent RNA polymerase and its use to identify small-molecule Zika inhibitors

(2017) Hong-Tao Xu et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Triphosphate Reorientation of the Incoming Nucleotide as a Fidelity Checkpoint in Viral RNA-dependent RNA Polymerases

(2017) Xiaorong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutagen resistance and mutation restriction of St. Louis encephalitis virus

(2017) Sara B Griesemer et al.   JOURNAL OF GENERAL VIROLOGY

Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase

(2017) Rana Abdelnabi et al.   JOURNAL OF VIROLOGY

Attenuation of Foot-and-Mouth Disease Virus by Engineered Viral Polymerase Fidelity

(2017) Devendra K. Rai et al.   JOURNAL OF VIROLOGY

Picornaviral polymerase structure, function, and fidelity modulation

(2017) Olve B. Peersen   VIRUS RESEARCH

A structural view of the RNA-dependent RNA polymerases from the Flavivirus genus

(2017) Guoliang Lu et al.   VIRUS RESEARCH

Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase

(2017) Andre S. Godoy et al.   Nature Communications

Structure and function of the Zika virus full-length NS5 protein

(2017) Baoyu Zhao et al.   Nature Communications

Signatures of Nucleotide Analog Incorporation by an RNA-Dependent RNA Polymerase Revealed Using High-Throughput Magnetic Tweezers

(2017) David Dulin et al.   Cell Reports

Crystal structure of full-lengthZika virusNS5 protein reveals a conformation similar toJapanese encephalitis virusNS5

(2017) Anup K. Upadhyay et al.   Acta Crystallographica Section F-Structural Biology Communications

Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor

(2016) Delia Tarantino et al.   ANTIVIRAL RESEARCH

Mechanisms of viral mutation

(2016) Rafael Sanjuán et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Approved Antiviral Drugs over the Past 50 Years

(2016) Erik De Clercq et al.   CLINICAL MICROBIOLOGY REVIEWS

Design of a Genetically Stable High Fidelity Coxsackievirus B3 Polymerase That Attenuates Virus Growthin Vivo

(2016) Seth McDonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens

(2016) Nicole R. Sexton et al.   JOURNAL OF VIROLOGY

DNA Replication—A Matter of Fidelity

(2016) Rais A. Ganai et al.   MOLECULAR CELL

Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation

(2016) Bo Shu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

(2016) Siew Pheng Lim et al.   PLoS Pathogens

Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface

(2016) Valerie J. Klema et al.   PLoS Pathogens

Structural basis for RNA replication by the hepatitis C virus polymerase

(2015) T. C. Appleby et al.   SCIENCE

Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and Resistance

(2015) Auda Eltahla et al.   Viruses-Basel

A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

(2015) Yongqian Zhao et al.   PLoS Pathogens

Sequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in Mosquitoes

(2015) Greta A. Van Slyke et al.   PLoS Pathogens

RNA Virus Population Diversity, an Optimum for Maximal Fitness and Virulence

(2014) Victoria K. Korboukh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Function Relationships Underlying the Replication Fidelity of Viral RNA-Dependent RNA Polymerases

(2014) Grace Campagnola et al.   JOURNAL OF VIROLOGY

Attenuation of Human Enterovirus 71 High-Replication-Fidelity Variants in AG129 Mice

(2014) T. Meng et al.   JOURNAL OF VIROLOGY

Resistance to nucleotide analogue inhibitors of hepatitis C virus NS5B: mechanisms and clinical relevance

(2014) Matthias Götte   Current Opinion in Virology

Inhibition of viral RNA polymerases by nucleoside and nucleotide analogs: therapeutic applications against positive-strand RNA viruses beyond hepatitis C virus

(2014) Jerome Deval et al.   Current Opinion in Virology

The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication

(2014) Xiao-Dan Li et al.   PLoS Neglected Tropical Diseases

Correlation Between Mutation Rate and Genome Size in Riboviruses: Mutation Rate of Bacteriophage Q 

(2013) K. Bradwell et al.   GENETICS

A Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability andde NovoInitiation Activities

(2013) Siew Pheng Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vaccine-derived Mutation in Motif D of Poliovirus RNA-dependent RNA Polymerase Lowers Nucleotide Incorporation Fidelity

(2013) Xinran Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Motif B Loop in Allosteric Regulation of RNA-Dependent RNA Polymerization Activity

(2013) Damià Garriga et al.   JOURNAL OF MOLECULAR BIOLOGY

Conformational Flexibility of the Dengue Virus RNA-Dependent RNA Polymerase Revealed by a Complex with an Inhibitor

(2013) C. G. Noble et al.   JOURNAL OF VIROLOGY

RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state

(2013) Parag Surana et al.   NUCLEIC ACIDS RESEARCH

NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase

(2013) Z. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Full-Length Japanese Encephalitis Virus NS5 Reveals a Conserved Methyltransferase-Polymerase Interface

(2013) Guoliang Lu et al.   PLoS Pathogens

Residues Arg283, Arg285, and Ile287 in the Nucleotide Binding Pocket of Bovine Viral Diarrhea Virus NS5B RNA Polymerase Affect Catalysis and Fidelity

(2012) E. Curti et al.   JOURNAL OF VIROLOGY

Coxsackievirus B3 mutator strains are attenuated in vivo

(2012) N. F. Gnadig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Motif D of Viral RNA-Dependent RNA Polymerases Determines Efficiency and Fidelity of Nucleotide Addition

(2012) Xiaorong Yang et al.   STRUCTURE

Molecular Basis for Nucleotide Conservation at the Ends of the Dengue Virus Genome

(2012) Barbara Selisko et al.   PLoS Pathogens

The F1 Motif of Dengue Virus Polymerase NS5 Is Involved in Promoter-Dependent RNA Synthesis

(2011) N. G. Iglesias et al.   JOURNAL OF VIROLOGY

Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance

(2011) M. H. Powdrill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viral mutation and substitution: units and levels

(2011) Robert Belshaw et al.   Current Opinion in Virology

Characterization of Dengue Virus Resistance to Brequinar in Cell Culture

(2010) M. Qing et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Long-Range Interaction Networks in the Function and Fidelity of Poliovirus RNA-Dependent RNA Polymerase Studied by Nuclear Magnetic Resonance

(2010) Xiaorong Yang et al.   BIOCHEMISTRY

RNA Sequences and Structures Required for the Recruitment and Activity of the Dengue Virus Polymerase

(2010) Claudia V. Filomatori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the Elongation Complex of Dengue Virus RNA Polymerase

(2010) Zhinan Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Further Insights into the Roles of GTP and the C Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis

(2010) Déborah Harrus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Viral Mutation Rates

(2010) R. Sanjuan et al.   JOURNAL OF VIROLOGY

Structure of Foot-and-Mouth Disease Virus Mutant Polymerases with Reduced Sensitivity to Ribavirin

(2010) C. Ferrer-Orta et al.   JOURNAL OF VIROLOGY

Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase

(2010) P. Gong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fidelity Variants of RNA Dependent RNA Polymerases Uncover an Indirect, Mutagenic Activity of Amiloride Compounds

(2010) Laura I. Levi et al.   PLoS Pathogens

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

RNA polymerase fidelity and transcriptional proofreading

(2009) Jasmin F Sydow et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Antimicrobial Strategies

(2009) Jerome Deval   DRUGS

Nucleic acid polymerases use a general acid for nucleotidyl transfer

(2009) Christian Castro et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural and Functional Studies of the Promoter Element for Dengue Virus RNA Replication

(2008) M. F. Lodeiro et al.   JOURNAL OF VIROLOGY