Structural basis for RNA replication by the hepatitis C virus polymerase

Review article: the efficacy and safety of sofosbuvir, a novel, oral nucleotide NS5B polymerase inhibitor, in the treatment of chronic hepatitis C virus infection

(2014) R. S. Koff   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Molecular and Structural Basis for the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance

(2014) Angela M. Lam et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Polymerases of hepatitis C viruses and flaviviruses: Structural and mechanistic insights and drug development

(2014) Célia Caillet-Saguy et al.   ANTIVIRAL RESEARCH

Infrequent Development of Resistance in Genotype 1–6 Hepatitis C Virus–Infected Subjects Treated With Sofosbuvir in Phase 2 and 3 Clinical Trials

(2014) Evguenia S. Svarovskaia et al.   CLINICAL INFECTIOUS DISEASES

OPTN/SRTR 2012 Annual Data Report: Liver

(2013) W. R. Kim et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Nucleotide Polymerase Inhibitor Sofosbuvir plus Ribavirin for Hepatitis C

(2013) Edward J. Gane et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus

(2012) Angela M. Lam et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Treating hepatitis C: current standard of care and emerging direct-acting antiviral agents

(2012) F. Poordad et al.   JOURNAL OF VIRAL HEPATITIS

Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

(2012) R. T. Mosley et al.   JOURNAL OF VIROLOGY

Two Crucial Early Steps in RNA Synthesis by the Hepatitis C Virus Polymerase Involve a Dual Role of Residue 405

(2012) N. Scrima et al.   JOURNAL OF VIROLOGY

A Comprehensive Structure-Function Comparison of Hepatitis C Virus Strain JFH1 and J6 Polymerases Reveals a Key Residue Stimulating Replication in Cell Culture across Genotypes

(2011) M. Schmitt et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus Nucleotide Inhibitors PSI-352938 and PSI-353661 Exhibit a Novel Mechanism of Resistance Requiring Multiple Mutations within Replicon RNA

(2011) A. M. Lam et al.   JOURNAL OF VIROLOGY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PSI-7851, a Pronucleotide of  -D-2'-Deoxy-2'-Fluoro-2'-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication

(2010) A. M. Lam et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977

(2010) Eisuke Murakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Further Insights into the Roles of GTP and the C Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis

(2010) Déborah Harrus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus

(2010) Michael J. Sofia et al.   JOURNAL OF MEDICINAL CHEMISTRY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase

(2009) P. Simister et al.   JOURNAL OF VIROLOGY

Existence of hepatitis C virus NS5B variants naturally resistant to non-nucleoside, but not to nucleoside, polymerase inhibitors among untreated patients

(2008) S. Le Pogam et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Structural Insights into Mechanisms of Catalysis and Inhibition in Norwalk Virus Polymerase

(2008) Dmitry F. Zamyatkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY