A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

Regulation of Flavivirus RNA synthesis and replication

(2014) Barbara Selisko et al.   Current Opinion in Virology

The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication

(2014) Xiao-Dan Li et al.   PLoS Neglected Tropical Diseases

Nuclear localization of dengue virus (DENV) 1–4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin

(2013) M.Y.F. Tay et al.   ANTIVIRAL RESEARCH

Ten years of dengue drug discovery: Progress and prospects

(2013) Siew Pheng Lim et al.   ANTIVIRAL RESEARCH

Serotype-specific Differences in Dengue Virus Non-structural Protein 5 Nuclear Localization

(2013) Holger Hannemann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability andde NovoInitiation Activities

(2013) Siew Pheng Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An interaction between the methyltransferase and RNA dependent RNA polymerase domains of the West Nile virus NS5 protein

(2013) C. S. E. Tan et al.   JOURNAL OF GENERAL VIROLOGY

The global distribution and burden of dengue

(2013) Samir Bhatt et al.   NATURE

Crystal Structure of the Full-Length Japanese Encephalitis Virus NS5 Reveals a Conserved Methyltransferase-Polymerase Interface

(2013) Guoliang Lu et al.   PLoS Pathogens

The viral RNA capping machinery as a target for antiviral drugs

(2012) François Ferron et al.   ANTIVIRAL RESEARCH

Structural biology of dengue virus enzymes: Towards rational design of therapeutics

(2012) Christian G. Noble et al.   ANTIVIRAL RESEARCH

Dengue Virus Nonstructural Protein 5 Adopts Multiple Conformations in Solution

(2012) Cécile Bussetta et al.   BIOCHEMISTRY

Functional Analysis of Two Cavities in Flavivirus NS5 Polymerase

(2011) Gang Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monoclonal antibodies against dengue NS2B and NS3 proteins for the study of protein interactions in the flaviviral replication complex

(2011) Nicole J. Moreland et al.   JOURNAL OF VIROLOGICAL METHODS

The F1 Motif of Dengue Virus Polymerase NS5 Is Involved in Promoter-Dependent RNA Synthesis

(2011) N. G. Iglesias et al.   JOURNAL OF VIROLOGY

NF90 Binds the Dengue Virus RNA 3′ Terminus and Is a Positive Regulator of Dengue Virus Replication

(2011) Raúl C. Gomila et al.   PLoS One

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Dynamics of the β2-Adrenergic G-Protein Coupled Receptor Revealed by Hydrogen−Deuterium Exchange

(2010) Xi Zhang et al.   ANALYTICAL CHEMISTRY

Hydrogen exchange mass spectrometry for studying protein structure and dynamics

(2010) Lars Konermann et al.   CHEMICAL SOCIETY REVIEWS

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

(2010) Siew Pheng Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

310helices in channels and other membrane proteins

(2010) Ricardo Simão Vieira-Pires et al.   JOURNAL OF GENERAL PHYSIOLOGY

Inhibition of Dengue Virus Polymerase by Blocking of the RNA Tunnel

(2010) P. Niyomrattanakit et al.   JOURNAL OF VIROLOGY

Appraising the Roles of CBLL1 and the Ubiquitin/Proteasome System for Flavivirus Entry and Replication

(2010) M.-D. Fernandez-Garcia et al.   JOURNAL OF VIROLOGY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure and functionality in flavivirus NS-proteins: Perspectives for drug design

(2009) Michela Bollati et al.   ANTIVIRAL RESEARCH

N-Sulfonylanthranilic Acid Derivatives as Allosteric Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase

(2009) Zheng Yin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral Replication

(2009) R. Assenberg et al.   JOURNAL OF VIROLOGY

NS5 of Dengue Virus Mediates STAT2 Binding and Degradation

(2009) J. Ashour et al.   JOURNAL OF VIROLOGY

An adenosine nucleoside inhibitor of dengue virus

(2009) Z. Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure

(2009) M. Issur et al.   RNA

A scintillation proximity assay for dengue virus NS5 2′-O-methyltransferase—kinetic and inhibition analyses

(2008) S LIM et al.   ANTIVIRAL RESEARCH

Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus

(2008) Michela Bollati et al.   JOURNAL OF MOLECULAR BIOLOGY

HD desktop: An integrated platform for the analysis and visualization of H/D exchange data

(2008) Bruce D. Pascal et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

West Nile Virus Methyltransferase Catalyzes Two Methylations of the Viral RNA Cap through a Substrate-Repositioning Mechanism

(2008) H. Dong et al.   JOURNAL OF VIROLOGY

Modification of intracellular membrane structures for virus replication

(2008) Sven Miller et al.   NATURE REVIEWS MICROBIOLOGY