A Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability andde NovoInitiation Activities

Conformational Flexibility of the Dengue Virus RNA-Dependent RNA Polymerase Revealed by a Complex with an Inhibitor

(2013) C. G. Noble et al.   JOURNAL OF VIROLOGY

Crystal Structure of the Full-Length Japanese Encephalitis Virus NS5 Reveals a Conserved Methyltransferase-Polymerase Interface

(2013) Guoliang Lu et al.   PLoS Pathogens

Structural biology of dengue virus enzymes: Towards rational design of therapeutics

(2012) Christian G. Noble et al.   ANTIVIRAL RESEARCH

Dengue Virus Nonstructural Protein 5 Adopts Multiple Conformations in Solution

(2012) Cécile Bussetta et al.   BIOCHEMISTRY

Functional Analysis of Two Cavities in Flavivirus NS5 Polymerase

(2011) Gang Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interstitial Contacts in an RNA-Dependent RNA Polymerase Lattice

(2011) Andres B. Tellez et al.   JOURNAL OF MOLECULAR BIOLOGY

Flexibility between the Protease and Helicase Domains of the Dengue Virus NS3 Protein Conferred by the Linker Region and Its Functional Implications

(2010) Dahai Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

(2010) Siew Pheng Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Dengue Virus Polymerase by Blocking of the RNA Tunnel

(2010) P. Niyomrattanakit et al.   JOURNAL OF VIROLOGY

Crystal Structure of the Dengue Virus Methyltransferase Bound to a 5′-Capped Octameric RNA

(2010) Li Jian Yap et al.   PLoS One

Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites

(2009) Sonja Welsch et al.   Cell Host & Microbe

Crystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral Replication

(2009) R. Assenberg et al.   JOURNAL OF VIROLOGY

The flavivirus polymerase as a target for drug discovery

(2008) Hélène Malet et al.   ANTIVIRAL RESEARCH

Molecular targets for flavivirus drug discovery

(2008) Aruna Sampath et al.   ANTIVIRAL RESEARCH

Mutagenesis of the Dengue Virus Type 2 NS5 Methyltransferase Domain

(2008) Helga Kroschewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY