Interferons: Reprogramming the Metabolic Network against Viral Infection

Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity

(2017) Anthony T. Phan et al.   IMMUNITY

25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model

(2017) Chunfeng Li et al.   IMMUNITY

Cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication

(2017) Jiang Wang et al.   JOURNAL OF GENERAL VIROLOGY

Chikungunya Virus Overcomes Polyamine Depletion by Mutation of nsP1 and the Opal Stop Codon To Confer Enhanced Replication and Fitness

(2017) Bryan C. Mounce et al.   JOURNAL OF VIROLOGY

Glycolysis, Glutaminolysis, and Fatty Acid Synthesis Are Required for Distinct Stages of Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication

(2017) Erica L. Sanchez et al.   JOURNAL OF VIROLOGY

Polyamines and Their Role in Virus Infection

(2017) Bryan C. Mounce et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Cholesterol 25-hydroxylase is an interferon-inducible factor that protects against porcine reproductive and respiratory syndrome virus infection

(2017) Zhongbao Song et al.   VETERINARY MICROBIOLOGY

Targeting Metabolic Reprogramming by Influenza Infection for Therapeutic Intervention

(2017) Heather S. Smallwood et al.   Cell Reports

Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol

(2017) Valeria Cagno et al.   Redox Biology

CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels

(2017) Vera Rocha-Perugini et al.   Nature Microbiology

Interferon-induced sterile alpha motif and histidine/aspartic acid domain-containing protein 1 expression in astrocytes and microglia is mediated by microRNA-181a

(2016) Changzhong Jin et al.   AIDS

Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses

(2016) Bryan C. Mounce et al.   Cell Host & Microbe

Polyamines: Small Molecules with a Big Role in Promoting Virus Infection

(2016) Melody M.H. Li et al.   Cell Host & Microbe

Identification of Interferon-Stimulated Genes with Antiretroviral Activity

(2016) Melissa Kane et al.   Cell Host & Microbe

Polyamine Antagonist Therapies Inhibit Neuroblastoma Initiation and Progression

(2016) N. F. Evageliou et al.   CLINICAL CANCER RESEARCH

Regulation of kynurenine biosynthesis during influenza virus infection

(2016) Lana Gaelings et al.   FEBS Journal

Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a

(2016) Maximilian Riess et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Polyamine Biosynthesis Is a Broad-Spectrum Strategy against RNA Viruses

(2016) Bryan C. Mounce et al.   JOURNAL OF VIROLOGY

Suppression of Kaposi's Sarcoma-Associated Herpesvirus Infection and Replication by 5′-AMP-Activated Protein Kinase

(2016) Fan Cheng et al.   JOURNAL OF VIROLOGY

Characterization of Glycoprotein-Mediated Entry of Severe Fever with Thrombocytopenia Syndrome Virus

(2016) Hideki Tani et al.   JOURNAL OF VIROLOGY

Identification of Interferon-Stimulated Gene Proteins That Inhibit Human Parainfluenza Virus Type 3

(2016) M. A. G. Rabbani et al.   JOURNAL OF VIROLOGY

Oxysterols: An emerging class of broad spectrum antiviral effectors

(2016) David Lembo et al.   MOLECULAR ASPECTS OF MEDICINE

Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection

(2016) Gahl Levy et al.   Nature Chemical Biology

SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activity

(2016) Jenna M Antonucci et al.   NATURE MEDICINE

Reply to SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activity

(2016) Jeongmin Ryoo et al.   NATURE MEDICINE

Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication

(2016) Michelle E. Olsen et al.   mBio

25-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation

(2016) Punya Shrivastava-Ranjan et al.   mBio

Distinct Patterns of Tryptophan Maintenance in Tissues during Kynurenine Pathway Activation in Simian Immunodeficiency Virus-Infected Macaques

(2016) Julia L. Drewes et al.   Frontiers in Immunology

Effects of Interferons and Viruses on Metabolism

(2016) Stephanie Deborah Fritsch et al.   Frontiers in Immunology

Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling

(2015) Autumn G. York et al.   CELL

Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation

(2015) Anggakusuma et al.   HEPATOLOGY

A phase 1 study of the sachet formulation of the oral dual PI3K/mTOR inhibitor BEZ235 given twice daily (BID) in patients with advanced solid tumors

(2015) Johanna C. Bendell et al.   INVESTIGATIONAL NEW DRUGS

Modulation of protein synthesis by polyamines

(2015) Kazuei Igarashi et al.   IUBMB LIFE

CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain

(2015) Junpeng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interferon Lambda Upregulates IDO1 Expression in Respiratory Epithelial Cells After Influenza Virus Infection

(2015) Julie M. Fox et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

MicroRNAs regulate the immunometabolic response to viral infection in the liver

(2015) Ragunath Singaravelu et al.   Nature Chemical Biology

SAMHD1 specifically restricts retroviruses through its RNase activity

(2015) Jongsu Choi et al.   Retrovirology

To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes

(2015) Melody M.H. Li et al.   TRENDS IN CELL BIOLOGY

Stealing the Keys to the Kitchen: Viral Manipulation of the Host Cell Metabolic Network

(2015) Christopher M. Goodwin et al.   TRENDS IN MICROBIOLOGY

Viral activation of cellular metabolism

(2015) Erica L. Sanchez et al.   VIROLOGY

Clinical Implications of Antiviral Resistance in Influenza

(2015) Timothy Li et al.   Viruses-Basel

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Inhibition of Hepatitis B virus replication by SAMHD1

(2014) Zhangming Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rhinovirus Uses a Phosphatidylinositol 4-Phosphate/Cholesterol Counter-Current for the Formation of Replication Compartments at the ER-Golgi Interface

(2014) Pascal S. Roulin et al.   Cell Host & Microbe

Drug analog inhibition of indoleamine 2,3-dioxygenase (IDO) activity modifies pattern recognition receptor expression and proinflammatory cytokine responses early during influenza virus infection

(2014) Julie M. Fox et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Vaccinia Virus Requires Glutamine but Not Glucose for Efficient Replication

(2014) K. A. Fontaine et al.   JOURNAL OF VIROLOGY

Dengue Virus Induces and Requires Glycolysis for Optimal Replication

(2014) Krystal A. Fontaine et al.   JOURNAL OF VIROLOGY

Phosphatidylinositol-4 kinase III beta and oxysterol-binding protein accumulate unesterified cholesterol on poliovirus-induced membrane structure

(2014) Minetaro Arita   MICROBIOLOGY AND IMMUNOLOGY

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction

(2014) Jeongmin Ryoo et al.   NATURE MEDICINE

Endogenous polyamine function—the RNA perspective

(2014) Helen L. Lightfoot et al.   NUCLEIC ACIDS RESEARCH

HIV-1 pathogenicity and virion production are dependent on the metabolic phenotype of activated CD4+ T cells

(2014) Andrea Hegedus et al.   Retrovirology

Inhibition of pathogenic non-enveloped viruses by 25-hydroxycholesterol and 27-hydroxycholesterol

(2014) Andrea Civra et al.   Scientific Reports

Kaposi's Sarcoma Herpesvirus MicroRNAs Induce Metabolic Transformation of Infected Cells

(2014) Ohad Yogev et al.   PLoS Pathogens

New Insights into IDO Biology in Bacterial and Viral Infections

(2014) Susanne V. Schmidt et al.   Frontiers in Immunology

Toll-Like Receptor Agonists Are Potent Inhibitors of Human Immunodeficiency Virus-Type 1 Replication in Peripheral Blood Mononuclear Cells

(2013) Maarten Buitendijk et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Effect of Toll-Like Receptor Agonists on the Formation of Macrophage/Foam Cells upon Acute Peritonitis in Mice

(2013) M. I. Dushkin et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

The Retroviral Restriction Ability of SAMHD1, but Not Its Deoxynucleotide Triphosphohydrolase Activity, Is Regulated by Phosphorylation

(2013) Tommy E. White et al.   Cell Host & Microbe

Host Restriction Factor SAMHD1 Limits Human T Cell Leukemia Virus Type 1 Infection of Monocytes via STING-Mediated Apoptosis

(2013) Alexandre Sze et al.   Cell Host & Microbe

Restrictions to HIV-1 replication in resting CD4+ T lymphocytes

(2013) Xiaoyu Pan et al.   CELL RESEARCH

Toll-like Receptor Agonists Promote Prolonged Triglyceride Storage in Macrophages

(2013) Ying-ling Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of indoleamine 2,3-dioxygenase enhances the T-cell response to influenza virus infection

(2013) J. M. Fox et al.   JOURNAL OF GENERAL VIROLOGY

Restriction of HIV-1 Replication in Primary Macrophages by IL-12 and IL-18 through the Upregulation of SAMHD1

(2013) E. Pauls et al.   JOURNAL OF IMMUNOLOGY

Oxysterol-Binding Protein Family I Is the Target of Minor Enviroxime-Like Compounds

(2013) M. Arita et al.   JOURNAL OF VIROLOGY

SAMHD1 Restricts Herpes Simplex Virus 1 in Macrophages by Limiting DNA Replication

(2013) Eui Tae Kim et al.   JOURNAL OF VIROLOGY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway

(2013) Jiri Polivka et al.   PHARMACOLOGY & THERAPEUTICS

Induction and Role of Indoleamine 2,3 Dioxygenase in Mouse Models of Influenza A Virus Infection

(2013) Lei Huang et al.   PLoS One

Oxysterol-binding proteins: Sterol and phosphoinositide sensors coordinating transport, signaling and metabolism

(2013) Vesa M. Olkkonen et al.   PROGRESS IN LIPID RESEARCH

Evidence for IFNα-induced, SAMHD1-independent inhibitors of early HIV-1 infection

(2013) Caroline Goujon et al.   Retrovirology

Samhd1 knockout mice: modeling retrovirus restriction in vivo

(2013) Li Wu   Retrovirology

Restriction of diverse retroviruses by SAMHD1

(2013) Thomas Gramberg et al.   Retrovirology

IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV

(2013) K. M. Monroe et al.   SCIENCE

Mouse SAMHD1 Has Antiretroviral Activity and Suppresses a Spontaneous Cell-Intrinsic Antiviral Response

(2013) Rayk Behrendt et al.   Cell Reports

Neuraminidase inhibitor resistance in influenza viruses and laboratory testing methods

(2012) Ha T Nguyen et al.   ANTIVIRAL THERAPY

Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?

(2012) Ralph J. DeBerardinis et al.   CELL

Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol

(2012) Su-Yang Liu et al.   IMMUNITY

Suppression of Hepatocyte Proliferation by Hepatocyte Nuclear Factor 4α in Adult Mice

(2012) Jessica A. Bonzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Studies on Tissue and Cellular Distribution of Indoleamine 2,3-Dioxygenase 2

(2012) Masakazu Fukunaga et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

INTERFEROME v2.0: an updated database of annotated interferon-regulated genes

(2012) Irina Rusinova et al.   NUCLEIC ACIDS RESEARCH

Systematic identification of type I and type II interferon-induced antiviral factors

(2012) S.-Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons

(2012) Corine St Gelais et al.   Retrovirology

Metabolic pathways in T cell fate and function

(2012) Valerie A. Gerriets et al.   TRENDS IN IMMUNOLOGY

Envelope Glycoprotein of Arenaviruses

(2012) Dominique J. Burri et al.   Viruses-Basel

AMP-Activated Kinase Restricts Rift Valley Fever Virus Infection by Inhibiting Fatty Acid Synthesis

(2012) Theresa S. Moser et al.   PLoS Pathogens

Systematic review of influenza resistance to the neuraminidase inhibitors

(2011) Kristian Thorlund et al.   BMC INFECTIOUS DISEASES

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

(2011) David C. Goldstone et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

Multifaceted roles for lipids in viral infection

(2011) Nicholas S. Heaton et al.   TRENDS IN MICROBIOLOGY

Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis

(2011) Mathieu Blanc et al.   PLOS BIOLOGY

Divergent Effects of Human Cytomegalovirus and Herpes Simplex Virus-1 on Cellular Metabolism

(2011) Livia Vastag et al.   PLoS Pathogens

Metabolic effects of influenza virus infection in cultured animal cells: Intra- and extracellular metabolite profiling

(2010) Joachim B Ritter et al.   BMC Systems Biology

Hepatitis C virus genotype-3a core protein enhances sterol regulatory element-binding protein-1 activity through the phosphoinositide 3-kinase-Akt-2 pathway

(2010) C. Jackel-Cram et al.   JOURNAL OF GENERAL VIROLOGY

The IFITM Proteins Inhibit HIV-1 Infection

(2010) J. Lu et al.   JOURNAL OF VIROLOGY

Upregulation of indoleamine 2,3-dioxygenase in hepatocyte during acute hepatitis caused by hepatitis B virus-specific cytotoxic T lymphocytesin vivo

(2010) Naoki Iwamoto et al.   LIVER INTERNATIONAL

Temporal Proteome and Lipidome Profiles Reveal Hepatitis C Virus-Associated Reprogramming of Hepatocellular Metabolism and Bioenergetics

(2010) Deborah L. Diamond et al.   PLoS Pathogens

Mammalian polyamine metabolism and function

(2009) Anthony E. Pegg   IUBMB LIFE

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

(2009) Gillian I Rice et al.   NATURE GENETICS

Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity

(2009) C. Guillonneau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

α-Galactosylceramide modulates the induction of indoleamine 2,3-dioxygenase in antigen presenting cells

(2008) Silvia Fallarini et al.   BIOCHEMICAL PHARMACOLOGY

Metabolic disorders and chronic viral disease: The case of HIV and HCV

(2008) L. Slama et al.   DIABETES & METABOLISM

Liver-Specific Hepatocyte Nuclear Factor-4α Deficiency: Greater Impact on Gene Expression in Male than in Female Mouse Liver

(2008) Minita G. Holloway et al.   MOLECULAR ENDOCRINOLOGY

Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy

(2008) Joshua Munger et al.   NATURE BIOTECHNOLOGY

Aggravation of viral hepatitis by platelet-derived serotonin

(2008) Philipp A Lang et al.   NATURE MEDICINE

HIV-Induced Type I Interferon and Tryptophan Catabolism Drive T Cell Dysfunction Despite Phenotypic Activation

(2008) Adriano Boasso et al.   PLoS One

Platelets prevent IFN- / -induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus

(2008) M. Iannacone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA