SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activity

Phosphorylation of mouse SAMHD1 regulates its restriction of human immunodeficiency virus type 1 infection, but not murine leukemia virus infection

(2016) Feifei Wang et al.   VIROLOGY

Low dNTP levels are necessary but may not be sufficient for lentiviral restriction by SAMHD1

(2016) Sarah Welbourn et al.   VIROLOGY

Non-POU Domain-Containing Octamer-Binding Protein Negatively Regulates HIV-1 Infection in CD4+ T Cells

(2015) Corine St. Gelais et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity

(2015) Kyle J. Seamon et al.   NUCLEIC ACIDS RESEARCH

SAMHD1 specifically restricts retroviruses through its RNase activity

(2015) Jongsu Choi et al.   Retrovirology

Phosphorylation of murine SAMHD1 regulates its antiretroviral activity

(2015) Sabine Wittmann et al.   Retrovirology

Identification of Cellular Proteins Interacting with the Retroviral Restriction Factor SAMHD1

(2014) C. St. Gelais et al.   JOURNAL OF VIROLOGY

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction

(2014) Jeongmin Ryoo et al.   NATURE MEDICINE

Structural basis of cellular dNTP regulation by SAMHD1

(2014) X. Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Retroviral Restriction Ability of SAMHD1, but Not Its Deoxynucleotide Triphosphohydrolase Activity, Is Regulated by Phosphorylation

(2013) Tommy E. White et al.   Cell Host & Microbe

Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV Infection

(2013) Junpeng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclease Activity of the Human SAMHD1 Protein Implicated in the Aicardi-Goutières Syndrome and HIV-1 Restriction

(2013) Natalia Beloglazova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of CUL4A Neddylation Causes a Reversible Block to SAMHD1-Mediated Restriction of HIV-1

(2013) H. Hofmann et al.   JOURNAL OF VIROLOGY

Restriction of Virus Infection but Not Catalytic dNTPase Activity Is Regulated by Phosphorylation of SAMHD1

(2013) S. Welbourn et al.   JOURNAL OF VIROLOGY

Mechanism of allosteric activation of SAMHD1 by dGTP

(2013) Xiaoyun Ji et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

SAMHD1 restricts HIV-1 infection in resting CD4+ T cells

(2012) Hanna-Mari Baldauf et al.   NATURE MEDICINE

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons

(2012) Corine St Gelais et al.   Retrovirology

SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4+ T-cells

(2012) Benjamin Descours et al.   Retrovirology

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

(2011) David C. Goldstone et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

Transcriptional Restriction of Human Immunodeficiency Virus Type 1 Gene Expression in Undifferentiated Primary Monocytes

(2009) C. Dong et al.   JOURNAL OF VIROLOGY