Stress proteins in the pathogenesis of spondyloarthritis

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Defective autophagy activity and its association with spinal damage in patients with ankylosing spondylitis

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Brief Report: Functional Interaction of Endoplasmic Reticulum Aminopeptidase 2 and HLA-B27 Activates the Unfolded Protein Response

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Autophagy in the pathogenesis of ankylosing spondylitis

(2016) Francesco Ciccia et al.   CLINICAL RHEUMATOLOGY

IL-23/IL-17 axis in spondyloarthritis-bench to bedside

(2016) Siba P. Raychaudhuri et al.   CLINICAL RHEUMATOLOGY

Ankylosing spondylitis M-CSF-derived macrophages are undergoing unfolded protein response (UPR) and express higher levels of interleukin-23

(2016) Alireza Rezaiemanesh et al.   Modern Rheumatology

Causes and consequences of endoplasmic reticulum stress in rheumatic disease

(2016) Fatemeh Navid et al.   Nature Reviews Rheumatology

Heat shock proteins and their immunomodulatory role in inflammatory arthritis

(2016) Julia Spierings et al.   RHEUMATOLOGY

ERAP2functional knockout in humans does not alter surface heavy chains or HLA-B27, inflammatory cytokines or endoplasmic reticulum stress markers

(2015) Philip C Robinson et al.   ANNALS OF THE RHEUMATIC DISEASES

ERAP2is associated with ankylosing spondylitis inHLA-B27-positive andHLA-B27-negative patients

(2015) Philip C Robinson et al.   ANNALS OF THE RHEUMATIC DISEASES

Endoplasmic Reticulum Stress in Immunity

(2015) Sarah E. Bettigole et al.   Annual Review of Immunology

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(2015) Paul Bowness   Annual Review of Immunology

Membrane-bound heat shock proteins facilitate the uptake of dying cells and cross-presentation of cellular antigen

(2015) Haiyan Zhu et al.   APOPTOSIS

Heat shock response and autophagy—cooperation and control

(2015) Karol Dokladny et al.   Autophagy

Bone Proliferation in Ankylosing Tarsitis Might Involve Mechanical Stress, and Hormonal and Growth Factors

(2015) C. PACHECO-TENA et al.   JOURNAL OF RHEUMATOLOGY

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1

(2015) Adrian Cortes et al.   Nature Communications

Transmission of ER stress response by ATF6 promotes endochondral bone growth

(2015) Zhangyuan Xiong et al.   Journal of Orthopaedic Surgery and Research

IL-23 expression and activation of autophagy in synovium and PBMCs of HLA-B27 positive patients with ankylosing spondylitis. Response to: ‘Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation’ by Cicciaet al

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Bone formation in axial spondyloarthritis

(2014) Rik J. Lories et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

The role of the gut and microbes in the pathogenesis of spondyloarthritis

(2014) Mark Asquith et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Disease-associated polymorphisms in ERAP1 do not alter endoplasmic reticulum stress in patients with ankylosing spondylitis

(2014) T J Kenna et al.   GENES AND IMMUNITY

Whole body hyperthermia treatment increases interleukin 10 and toll-like receptor 4 expression in patients with ankylosing spondylitis: A pilot study

(2014) Dorothea Zauner et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Bone Lineage Proteins in the Entheses of the Midfoot in Patients with Spondyloarthritis

(2014) C. Pacheco-Tena et al.   JOURNAL OF RHEUMATOLOGY

Autophagy, Inflammation and Innate Immunity in Inflammatory Myopathies

(2014) Cristina Cappelletti et al.   PLoS One

Autoantibodies against CD74 in spondyloarthritis

(2013) N T Baerlecken et al.   ANNALS OF THE RHEUMATIC DISEASES

Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation

(2013) Francesco Ciccia et al.   ANNALS OF THE RHEUMATIC DISEASES

Serum levels of novel noggin and sclerostin-immune complexes are elevated in ankylosing spondylitis

(2013) Florence W L Tsui et al.   ANNALS OF THE RHEUMATIC DISEASES

Molecular chaperones as enzymes that catalytically unfold misfolded polypeptides

(2013) Smriti Priya et al.   FEBS LETTERS

The Intracellular Sensor NOD2 Induces MicroRNA-29 Expression in Human Dendritic Cells to Limit IL-23 Release

(2013) Oliver Brain et al.   IMMUNITY

Regulatory Coordination between Two Major Intracellular Homeostatic Systems

(2013) Karol Dokladny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERAP1 structure, function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases

(2013) Carlos Alvarez-Navarro et al.   MOLECULAR IMMUNOLOGY

From undifferentiated SpA to ankylosing spondylitis

(2013) Rubén Burgos-Vargas   Nature Reviews Rheumatology

Increased Levels of IgG Antibodies against Human HSP60 in Patients with Spondyloarthritis

(2013) Astrid Hjelholt et al.   PLoS One

Protective effect of an ERAP1 haplotype in ankylosing spondylitis: investigating non-MHC genes in HLA-B27-positive individuals

(2013) B. F. Bettencourt et al.   RHEUMATOLOGY

IgG subclass antibodies to human and bacterial HSP60 are not associated with disease activity and progression over time in axial spondyloarthritis

(2013) Thomas Carlsen et al.   ARTHRITIS RESEARCH & THERAPY

Review: The Interleukin-23/Interleukin-17 Axis in Spondyloarthritis Pathogenesis: Th17 and Beyond

(2013) Judith A. Smith et al.   Arthritis & Rheumatology

Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA-B27 and relates to subtype specificity in ankylosing spondylitis

(2012) Nigil Haroon et al.   ANNALS OF THE RHEUMATIC DISEASES

Are spondylarthritides related but distinct conditions or a single disease with a heterogeneous phenotype?

(2012) Dominique Baeten et al.   ARTHRITIS AND RHEUMATISM

Heat-shock proteins as endogenous ligands building a bridge between innate and adaptive immunity

(2012) Yasuaki Tamura et al.   Immunotherapy

IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells

(2012) Jonathan P Sherlock et al.   NATURE MEDICINE

Ankylosing spondylitis macrophage production of higher levels of interleukin-23 in response to lipopolysaccharide without induction of a significant unfolded protein response

(2011) Ling Zeng et al.   ARTHRITIS AND RHEUMATISM

Heat shock protein 60 protects skeletal tissue against glucocorticoid-induced bone mass loss by regulating osteoblast survival

(2011) Feng-Sheng Wang et al.   BONE

A case of mistaken identity: HSPs are no DAMPs but DAMPERs

(2011) Willem van Eden et al.   CELL STRESS & CHAPERONES

Spondyloarthritis

(2011) Maxime Dougados et al.   LANCET

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

HLA-B27 subtypes in the spondarthropathies

(2010) I. L. MACLEAN et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci

(2010) John D Reveille et al.   NATURE GENETICS

The HSP60 immune system network

(2010) Francisco J. Quintana et al.   TRENDS IN IMMUNOLOGY

Spondyloarthropathies and bone resorption: A possible role of heat shock protein (Hsp70)

(2009) Tibor Fábián et al.   ACTA PHYSIOLOGICA HUNGARICA

The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection

(2009) M Rudwaleit et al.   ANNALS OF THE RHEUMATIC DISEASES

HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats

(2009) Monica L. DeLay et al.   ARTHRITIS AND RHEUMATISM

Activation of autophagy during glutamate-induced HT22 cell death

(2009) Hansoo Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Evidence for a distinctive pattern of bone formation in enthesophytes

(2008) M Benjamin et al.   ANNALS OF THE RHEUMATIC DISEASES

Heat shock response relieves ER stress

(2008) Yu Liu et al.   EMBO JOURNAL

HSP60 as a Target of Anti-Ergotypic Regulatory T Cells

(2008) Francisco J. Quintana et al.   PLoS One

Upregulation of 78‐kDa glucose‐regulated protein in macrophages in peripheral joints of active ankylosing spondylitis

(2008) W. Dong et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY