Article
Cell Biology
Alireza Rezaiemanesh, Mahdi Mahmoudi, Ali Akbar Amirzargar, Mahdi Vojdanian, Farhad Babaie, Jila Mahdavi, Misagh Rajabinejad, Ahmad Reza Jamshidi, Mohammad Hossein Nicknam
Summary: ER stress in macrophages from AS patients plays a role in the increased production of IL-23. The autophagy pathway is not involved in the modulation of IL-23 production by AS macrophages.
Article
Immunology
Dominique Baeten, Iannis E. Adamopoulos
Summary: This article discusses the pathobiology of axial spondyloarthritis, particularly the role of IL-23/IL-17 axis, and shares relevant lessons learned for translating emerging biological insights into clinical therapeutics.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
James T. Rosenbaum, Michael H. Weisman, Hedley Hamilton, Cassie Shafer, Elin Aslanyan, Richard A. Howard, Kimberly Ogle, John D. Reveille, Kevin L. Winthrop, Dongseok Choi
Summary: HLA-B27 positive patients with axial spondyloarthritis (AxSpA) tend to have lower disease activity compared to HLA-B27 negative patients, as indicated by higher BASDAI scores. HLA-B27 positive patients with mild back pain are more likely to be diagnosed with AxSpA, suggesting a cognitive bias introduced by the HLA-B27 test.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Javier Fernandez-Torres, Yessica Zamudio-Cuevas, Nathalie Montano-Armendariz, Ivan Alejandro Lujan-Juarez, Roberto Sanchez-Sanchez, Karina Martinez-Flores
Summary: The study found that variants of the ERAP1 gene may interact with smoking to increase the risk of AS in patients, especially those carrying the B27 allele.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Immunology
Farhad Babaie, Hamed Mohammadi, Sorayya Salimi, Alireza Ghanavatinegad, Mitra Abbasifard, Mehdi Yousefi, Mehrzad Hajaliloo, Younes Khalili, Sajjad Zamanlou, Roghaiyeh Safari, Maryam Hemmatzadeh, Alireza Rezaiemanesh, Reza Salimi, Behzad Baradaran, Zohreh Babaloo
Summary: This study aimed to evaluate the impact of Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphisms on the expression of Human leukocyte antigen (HLA)-B27-free heavy chains (FHCs) on macrophages and subsequent NK cell activation in Ankylosing spondylitis (AS) patients. Results showed reduced expression of HLA-B27-FHCs on M1 and M2 macrophages in patients with protective ERAP1 genotype. Co-culturing ERAP1-inhibited M1 macrophages with NK cells from patients with protective genotype resulted in downregulation of CD69 and CD107a markers on NK cells and decreased number of IFN-gamma+ NK cells. Inhibiting ERAP1 activity to reduce NK cell activation may have therapeutic potential in treating AS patients.
CLINICAL IMMUNOLOGY
(2023)
Article
Rheumatology
Zhixiu Li, Mohammad Kazim Khan, Sjef M. van der Linden, Bjorn Winkens, Peter M. Villiger, Heinz Baumberger, Hermine van Zandwijk, Muhammad Asim Khan, Matthew A. Brown
Summary: This study found that patients with ankylosing spondylitis (AS) have a higher mortality rate compared to the general population, and healthy individuals carrying the HLA-B27 gene also have a similar risk. Additionally, female patients have a lower life expectancy. However, in the overall European population, the presence of the HLA-B27 gene does not affect survival or the risk of death from cardiovascular disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Cell Biology
Chin-Man Wang, Ming-Kun Liu, Yeong-Jian Jan Wu, Jing-Chi Lin, Jian-Wen Zheng, Jianming Wu, Ji-Yih Chen
Summary: The study examined the impact of ERAP1 allelic variants and their interaction with HLA-B27 on ankylosing spondylitis susceptibility. It discovered multiple ERAP1 SNVs and allelic variants in Taiwanese individuals, and found that ERAP1 variants significantly contribute to the development of AS in a HLA-B27-dependent manner.
Article
Multidisciplinary Sciences
Minkai Song, Xiangyu Wang, Jiawen Gao, Weizhou Jiang, Enguang Bi, Taixue An, Ting Wang, Zishuo Chen, Weilu Liu, Zhanjun Shi, Jun Xiao, Chao Zhang
Summary: This study reveals that the increased expression of circular RNA (circRNA) circIFNGR2 in peripheral blood mononuclear cells is associated with the severity of ankylosing spondylitis (AS). In vitro experiments show that circIFNGR2 promotes macrophage proliferation, regulates M1/M2 macrophage polarization and NF-kB/Akt pathways. Furthermore, circIFNGR2 enhances the expression of iNOS/TNFa and M1 polarization, and inhibits M2 polarization by sponging miR-939. The RNA-binding protein eIF4A3 is found to enhance the production of circIFNGR2. Importantly, miR-939 attenuates joint damage in collagen-induced arthritis mice, while circIFNGR2 reverses this effect. These findings highlight the pro-inflammatory roles of eIF4A3-induced circIFNGR2 in AS by modulating macrophage-associated inflammation through miR-939.
Review
Clinical Neurology
Naiwen Hu, Dongxia Liu, Na Zhao, Xia Wang, Yanyan Bai, Hongsheng Sun
Summary: The study found significant associations between TNF-238, -308, -857, -1031, and -863 minor alleles and AS susceptibility in the HLA-B27 positive population. However, no association was found between TNF polymorphisms and AS in the HLA-B27-positive patients group and the HLA-B27-positive healthy controls group. Other gene SNPs may play a role in AS susceptibility in the HLA-B27-positive population.
EUROPEAN SPINE JOURNAL
(2021)
Article
Rheumatology
Rodrigo Garcia-Salinas, Santiago Ruta, Jessica Torres Chichande, Sebastian Magri
Summary: This study aimed to evaluate the frequency of HLA-B27 in Argentinean patients with axial spondyloarthritis and analyze its performance as a diagnostic biomarker. The results showed that HLA-B27-positive patients had an earlier age of onset, higher BASFI, and more extra-articular SpA features. However, HLA-B27 had low sensitivity but good specificity for the diagnosis of SpA.
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Xinbo Yang, Lee I. I. Garner, Ivan V. V. Zvyagin, Michael A. A. Paley, Ekaterina A. A. Komech, Kevin M. M. Jude, Xiang Zhao, Ricardo A. A. Fernandes, Lynn M. M. Hassman, Grace L. L. Paley, Christina S. S. Savvides, Simon Brackenridge, Max N. N. Quastel, M. M. Chudakov, Paul Bowness, Wayne M. M. Yokoyama, Andrew J. J. McMichael, Geraldine M. M. Gillespie, K. Christopher Garcia
Summary: The human leucocyte antigen B*27 (HLA-B*27) is strongly associated with inflammatory diseases of the spine and pelvis and the eye. The mechanism by which HLA-B*27 facilitates disease remains unknown, but it may involve the presentation of pathogenic peptides to CD8(+) T cells. In this study, orphan T cell receptors (TCRs) expressing a disease-associated public beta-chain variable region-complementary-determining region 3 beta (BV9-CDR3 beta) motif were isolated from blood and synovial fluid T cells from individuals with ankylosing spondylitis (AS) and from the eye in individuals with acute anterior uveitis (AAU). These TCRs showed consistent alpha-chain variable region (AV21) chain pairing and were clonally expanded in the joint and eye. Using peptide libraries, self-peptides and microbial peptides that activated the AS- and AAU-derived TCRs were identified. Structural analysis revealed that TCR cross-reactivity for peptide-MHC was rooted in a shared binding motif present in both self-antigens and microbial antigens that engages the BV9-CDR3 beta TCRs. These findings suggest that both microbial antigens and self-antigens could play a pathogenic role in HLA-B*27-associated disease.
Review
Immunology
Zi-Yi Song, Duo Yuan, Sheng-Xiao Zhang
Summary: Ankylosing spondylitis is a chronic condition that affects the spine and sacroiliac joints, with multifactorial etiology and pathogenesis that remain elusive. Gut microbiota as an environmental factor plays a critical role in the pathogenesis of AS through various mechanisms.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Adelmo Segota, Tea Schnurrer-Luke-Vrbanic, Viviana Avancini-Dobrovic, Filip Miric
Summary: The aim of this study was to compare four forms of axial spondyloarthritis (axSpA): non-radiographic axial spondyloarthritis (nr-axSpA), ankylosing spondylitis (AS), non-radiographic axial psoriatic arthritis (nr-axPsA) and radiographic axial psoriatic arthritis (r-axPsA). The study analyzed gender differences, human leukocyte antigen (HLA) typing, laboratory values, radiographic and magnetic resonance scans of 137 patients. The key findings included newly detected HLA typing beyond HLA-27 positivity, which could serve as possible biomarkers for early detection of axSpA.
RHEUMATOLOGY INTERNATIONAL
(2023)
Review
Immunology
Maxime Breban, Simon Glatigny, Bilade Cherqaoui, Marie Beaufrere, Marc Lauraine, Aurore Rincheval-Arnold, Sebastien Gaumer, Isabelle Guenal, Luiza M. Araujo
Summary: Studying animal models is crucial in understanding the complex mechanisms of disorders like spondyloarthritis, providing insights into genetic predispositions and potential therapeutic targets. Different animal models, including transgenic rats, Drosophila, and genetically modified mice, have contributed valuable information regarding the pathogenicity and immune involvement in SpA.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sylwia Bialy, Milena Iwaszko, Jerzy Swierkot, Bartosz Bugaj, Katarzyna Kolossa, Slawomir Jeka, Katarzyna Bogunia-Kubik
Summary: This study investigated the relationship between IL5 and IL9 gene variants and susceptibility to AS, clinical parameters, and response to TNF inhibitor therapy. The results demonstrated significant associations between IL5 and IL9 polymorphisms and response to anti-TNF therapy, indicating a significant role for IL-5 and IL-9 in the development and response to treatment of AS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Samaneh Soltani, Mahdi Mahmoudi, Elham Farhadi
Summary: Dendritic cells (DCs) are a subset of mononuclear phagocytes with distinct phenotypic features, playing crucial roles in immune responses to various antigens. Human DCs are classified into blood and cutaneous subsets, with research hindered by their low frequencies and lack of specific markers. DCs arise through lympho-myeloid hematopoiesis and differentiate under the influence of lineage-specific transcription factors.
IMMUNOLOGICAL INVESTIGATIONS
(2021)
Review
Immunology
Mahdi Mahmoudi, Saeed Aslani, Akira Meguro, Maryam Akhtari, Yousef Fatahi, Nobuhisa Mizuki, Farhad Shahram
Summary: Behcet's disease is a systemic and inflammatory disease. Genetic factors, including HLA-B51, have been found to play a critical role in disease predisposition. Other HLA alleles and a number of other genes have also been associated with BD. Immune responses to pathogens and mucosal immunity are suggested to contribute to BD susceptibility.
INTERNATIONAL REVIEWS OF IMMUNOLOGY
(2022)
Article
Immunology
Gelayol Asadi, Fatemeh Rezaei Varmaziar, Mojgan Karimi, Misagh Rajabinejad, Sedigheh Ranjbar, Ali Gorgin Karaji, Farhad Salari, Leila Afshar Hezarkhani, Alireza Rezaiemanesh
Summary: The study observed that in DN patients, there is a significant increase in the expression of lncRNA NEAT-1 and a decrease in miR-183-5p expression, while miR-433-3p expression decreases and ITGA4, SESN1, and SESN3 mRNA expression increases. The dysregulated expression of NEAT-1 and related miRNAs and genes may play a role in the development of DN.
IMMUNOLOGY LETTERS
(2021)
Review
Medicine, Research & Experimental
Hamidreza Ebrahimiyan, Shayan Mostafaei, Saeed Aslani, Seyedeh Tahereh Faezi, Elham Farhadi, Ahmadreza Jamshidi, Mahdi Mahmoudi
Summary: In this study, a meta-analysis was performed to investigate the association between ITGAM gene rs1143679 SNP and MBL gene rs1800451 SNP with SLE risk. The results showed a significant positive association between rs1143679 and SLE risk, while rs1800451 was significantly associated with decreased susceptibility to SLE.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Cell Biology
Alireza Rezaiemanesh, Mahdi Mahmoudi, Ali Akbar Amirzargar, Mahdi Vojdanian, Farhad Babaie, Jila Mahdavi, Misagh Rajabinejad, Ahmad Reza Jamshidi, Mohammad Hossein Nicknam
Summary: ER stress in macrophages from AS patients plays a role in the increased production of IL-23. The autophagy pathway is not involved in the modulation of IL-23 production by AS macrophages.
Article
Immunology
Misagh Rajabinejad, Gelayol Asadi, Sedigheh Ranjbar, Fatemeh Rezaei Varmaziar, Mojgan Karimi, Farhad Salari, Ali Gorgin Karaji, Alireza Rezaiemanesh, Leila Afshar Hezarkhani
Summary: The MALAT1-H19/miR-19b-3p axis may be involved in the development of DN, and these molecules could be useful biomarkers for DN. Dysregulated expression of SEMA4C, PLXNB2, and ATG16L1, targeted by miR-19b-3p and miR-125a-5p, showed that they probably play a role in the development of DN.
IMMUNOLOGY LETTERS
(2022)
Article
Multidisciplinary Sciences
Donya Ashjari, Negin Karamali, Misagh Rajabinejad, Seyedeh Sara Hassani, Leila Afshar Hezarkhani, Daryoush Afshari, Ali Gorgin Karaji, Farhad Salari, Alireza Rezaiemanesh
Summary: This study found that the transcript levels of MALAT1 and CXCR4 were significantly upregulated, while miR-1-3p was downregulated in patients with diabetic neuropathy. A significant correlation was also found between MALAT1 and CXCR4, suggesting a possible involvement of the MALAT1/miR-1-3p/CXCR4 axis in the pathogenesis of diabetic neuropathy.
Article
Immunology
Zahra Mahmoudi, Negin Karamali, Seyed Askar Roghani, Shirin Assar, Mehran Pournazari, Parviz Soufivand, Farhad Salari, Alireza Rezaiemanesh
Summary: The study investigated the gene expression levels of MALAT1, H19, miR-199a-5p, and miR-1-3p in RA patients. MALAT1 and H19 may serve as potential biomarkers for distinguishing RA patients from controls.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Rheumatology
Alaleh Ghasemi, Ali Farazmand, Vahideh Hassanzadeh, Shiva Poursani, Samaneh Soltani, Maryam Akhtari, Maassoumeh Akhlaghi, Elham Farhadi, Ahmadreza Jamshidi, Mahdi Mahmoudi
Summary: The study found that the expression levels of KAT2B and ESCO2 genes were upregulated in peripheral blood mononuclear cells of RA patients, suggesting a potential correlation with the development of RA.
CLINICAL RHEUMATOLOGY
(2023)
Article
Medical Laboratory Technology
Seyedeh Sara Hassani, Negin Karamali, Misagh Rajabinejad, Donya Ashjari, Leila Afshar Hezarkhani, Ali Gorgin Karaji, Farhad Salari, Alireza Rezaiemanesh
Summary: This study found that the expression levels of NEAT1 and BiP genes were significantly increased, while miR-199a-5p expression was significantly decreased in patients with diabetic neuropathy. These findings suggest that the axis of NEAT1, miR-199a-5p, and BiP may play a role in the pathogenesis of diabetic neuropathy.
LABORATORY MEDICINE
(2023)
Review
Immunology
Sara Assadiasl, Misagh Rajabinejad, Narjes Soleimanifar, Farideh Makiyan, Esfandiar Azizi, Alireza Rezaiemanesh, Mohammad Hossein Nicknam
Summary: Rheumatoid arthritis and ankylosing spondylitis are two common rheumatic disorders characterized by persistent inflammatory joint disease. This review provides an overview of the most important signaling pathways controlled by miRNAs in these diseases.
INFLAMMOPHARMACOLOGY
(2023)
Article
Immunology
Parisa Feizollahi, Mohammad Hossein Zamanian, Sara Falahi, Farhad Salari, Zahra Mahmoudi, Elham Faryadi, Ali Gorgin Karaji, Alireza Rezaiemanesh
Summary: This study investigated the association between three SNPs in the coding region of IFIH1 and DDX58 genes and susceptibility to COVID-19 in the Kermanshah population, Iran. The results showed that the rs10813831(A>G) polymorphism in the DDX58 gene may be associated with the severity of COVID-19.
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2023)
Article
Immunology
Hamidreza Ebrahimian, Maryam Akhtari, Maassoumeh Akhlaghi, Elham Farhadi, Ahmadreza Jamshidi, Gholam Hossein Alishiri, Mahdi Mahmoudi, Mahmood Tavallaie
Summary: This study investigated the expression of TP53, BAX, FOXO1, and RB1 genes in peripheral blood mononuclear cells (PBMCs) from rheumatoid arthritis (RA) patients. It was found that the expression levels of these genes were significantly reduced in RA PBMCs. TP53 and FOXO1 expression were negatively correlated with miR-16-5p, miR-335-5p, and miR-34a-5p. The study suggests that the abnormal expression of these genes may be associated with the development and severity of RA.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Otorhinolaryngology
Sara Falahi, Parisa Feizolahi, Ali Monshizadeh, Zahra Mahmoudi, Jila Mahdavi, Farhad Salari, Ali Gorgin Karaji, Alireza Rezaiemanesh
Summary: This study aimed to evaluate the potential correlation of ANRIL gene single nucleotide polymorphisms (SNPs) with allergic rhinitis (AR) risk in the Kurdish population of Kermanshah, Iran. The results showed that ANRIL gene rs1333048 and rs10757278 polymorphisms might not be associated with susceptibility to AR in the Kurdish population of Kermanshah, Iran.
THERAPEUTIC ADVANCES IN ALLERGY AND RHINOLOGY
(2023)
Article
Rheumatology
Negin Karamali, Zahra Mahmoudi, Seyed Askar Roghani, Shirin Assar, Mehran Pournazari, Parviz Soufivand, Ali Gorgin Karaji, Alireza Rezaiemanesh
Summary: This study investigated the changes in expression of peripheral blood ncRNAs and SYVN1-SEL1L affected by DMARDs treatment in newly diagnosed RA patients. The results showed that NEAT1, miR-19b-3p, miR-125a-5p, and SYVN1 were significantly upregulated in RA patients compared to healthy controls. Additionally, the expression of miR-19b-3p, miR-125a-5p, and SYVN1 increased after treatment with DMARDs and methylprednisolone. NEAT1 was found to be positively correlated with SYVN1.
CLINICAL RHEUMATOLOGY
(2023)
