Palmitate-induced ER stress and inhibition of protein synthesis in cultured myotubes does not require Toll-like receptor 4

Resveratrol Ameliorates Palmitate-Induced Inflammation in Skeletal Muscle Cells by Attenuating Oxidative Stress and JNK/NF-κB Pathway in a SIRT1-Independent Mechanism

(2017) Asie Sadeghi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Caspase-12 is involved in stretch-induced apoptosis mediated endoplasmic reticulum stress

(2016) Qiang Zhang et al.   APOPTOSIS

Reduced Lower-Limb Muscle Strength and Volume in Patients With Type 2 Diabetes in Relation to Neuropathy, Intramuscular Fat, and Vitamin D Levels

(2016) Monirah M. Almurdhi et al.   DIABETES CARE

Palmitate activates mTOR/p70S6K through AMPK inhibition and hypophosphorylation of raptor in skeletal muscle cells: Reversal by oleate is similar to metformin

(2015) Bumsup Kwon et al.   BIOCHIMIE

Leptin Rapidly Induces the Expression of Metabolic and Myokine Genes in C2C12 Muscle Cells to Regulate Nutrient Partition and Oxidation

(2015) Yuriy Nozhenko et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy

(2015) Scott M. Ebert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic Reticulum Stress Interacts With Inflammation in Human Diseases

(2015) Stewart Siyan Cao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Muscle wasting in disease: molecular mechanisms and promising therapies

(2015) Shenhav Cohen et al.   NATURE REVIEWS DRUG DISCOVERY

Muscle ectopic fat deposition contributes to anabolic resistance in obese sarcopenic old rats through eIF2α activation

(2014) Nicolas Tardif et al.   AGING CELL

p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization

(2014) Daniel K. Fox et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Toll-like Receptor 4-mediated Endoplasmic Reticulum Stress in Intestinal Crypts Induces Necrotizing Enterocolitis

(2014) Amin Afrazi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells

(2014) Alexandra K. Leamy et al.   JOURNAL OF LIPID RESEARCH

Docosahexaenoic acid prevents palmitate-induced activation of proteolytic systems in C2C12 myotubes

(2014) Myra E. Woodworth-Hobbs et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Insulin Resistance is Associated with MCP1-Mediated Macrophage Accumulation in Skeletal Muscle in Mice and Humans

(2014) David Patsouris et al.   PLoS One

A Molecular Web: Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress

(2014) Namrata Chaudhari et al.   Frontiers in Cellular Neuroscience

Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism

(2013) L. Salvadó et al.   DIABETOLOGIA

A sustained increase in plasma NEFA upregulates the Toll-like receptor network in human muscle

(2013) Sophie E. Hussey et al.   DIABETOLOGIA

Saturated fatty acid palmitate-induced insulin resistance is accompanied with myotube loss and the impaired expression of health benefit myokine genes in C2C12 myotubes

(2013) Ming Yang et al.   Lipids in Health and Disease

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Toll-Like Receptor 4 Knockout Mice Are Protected against Endoplasmic Reticulum Stress Induced by a High-Fat Diet

(2013) Nicolas Pierre et al.   PLoS One

Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

(2013) Matthew D. Shoulders et al.   Cell Reports

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B

(2012) Connie W. Woo et al.   NATURE CELL BIOLOGY

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress

(2011) Brian F. Teske et al.   MOLECULAR BIOLOGY OF THE CELL

ER Stress Induces Anabolic Resistance in Muscle Cells through PKB-Induced Blockade of mTORC1

(2011) Louise Deldicque et al.   PLoS One

Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress

(2010) Larysa Yuzefovych et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Reversible Ponceau staining as a loading control alternative to actin in Western blots

(2010) Isabel Romero-Calvo et al.   ANALYTICAL BIOCHEMISTRY

FOXO3a mediates signaling crosstalk that coordinates ubiquitin and atrogin-1/MAFbx expression during glucocorticoid-induced skeletal muscle atrophy

(2010) Bin Zheng et al.   FASEB JOURNAL

Novel insights into the regulation of skeletal muscle protein synthesis as revealed by a new nonradioactive in vivo technique

(2010) Craig A. Goodman et al.   FASEB JOURNAL

Toll-like receptor 4 mediates lipopolysaccharide-induced muscle catabolism via coordinate activation of ubiquitin-proteasome and autophagy-lysosome pathways

(2010) Alexander Doyle et al.   FASEB JOURNAL

Caspase-3 Cleaves Specific 19 S Proteasome Subunits in Skeletal Muscle Stimulating Proteasome Activity

(2010) Xiaonan H. Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Transcription Factor ATF4 Promotes Skeletal Myofiber Atrophy during Fasting

(2010) Scott M. Ebert et al.   MOLECULAR ENDOCRINOLOGY

Endotoxin causes functional endoplasmic reticulum failure, possibly mediated by mitochondria

(2009) Andrey V. Kozlov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

SUnSET, a nonradioactive method to monitor protein synthesis

(2009) Enrico K Schmidt et al.   NATURE METHODS

Dyslipidemia in type 2 diabetes mellitus

(2009) Arshag D Mooradian   Nature Reviews Endocrinology

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain

(2008) Tomohiro Kawamoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Regulation of caspase-3 activity by insulin in skeletal muscle cells involves both PI3-kinase and MEK-1/2

(2008) Yongmei Gao et al.   JOURNAL OF APPLIED PHYSIOLOGY

Slower rescue of ER homeostasis by the unfolded protein response pathway associated with common variable immunodeficiency

(2008) Juliana S. Kuribayashi et al.   MOLECULAR IMMUNOLOGY

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY