Muscle wasting in disease: molecular mechanisms and promising therapies

Trim32 reduces PI3K–Akt–FoxO signaling in muscle atrophy by promoting plakoglobin–PI3K dissociation

(2014) Shenhav Cohen et al.   JOURNAL OF CELL BIOLOGY

Clenbuterol toxicity: a NSW Poisons Information Centre experience

(2014) Jonathan Brett et al.   MEDICAL JOURNAL OF AUSTRALIA

Acute peripheral tissue effects of ghrelin on interstitial levels of glucose, glycerol, and lactate: a microdialysis study in healthy human subjects

(2013) Esben Thyssen Vestergaard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Phosphodiesterase-4 Inhibitor Therapy for Lung Diseases

(2013) Bianca Beghè et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

MST1, a key player, in enhancing fast skeletal muscle atrophy

(2013) Bin Wei et al.   BMC BIOLOGY

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

(2013) Francesco S. Loffredo et al.   CELL

Stat3 Activation Links a C/EBPδ to Myostatin Pathway to Stimulate Loss of Muscle Mass

(2013) Liping Zhang et al.   Cell Metabolism

Mechanisms stimulating muscle wasting in chronic kidney disease: the roles of the ubiquitin-proteasome system and myostatin

(2013) Sandhya S. Thomas et al.   Clinical and Experimental Nephrology

Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models

(2013) F. Demontis et al.   Disease Models & Mechanisms

Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle

(2013) Tizhong Shan et al.   FASEB JOURNAL

The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy

(2013) V. Proserpio et al.   GENES & DEVELOPMENT

Myostatin/activin pathway antagonism: Molecular basis and therapeutic potential

(2013) H.Q. Han et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

SIRT1 Protein, by Blocking the Activities of Transcription Factors FoxO1 and FoxO3, Inhibits Muscle Atrophy and Promotes Muscle Growth

(2013) Donghoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of resistance exercise contraction mode and protein supplementation on members of the STARS signalling pathway

(2013) Kristian Vissing et al.   JOURNAL OF PHYSIOLOGY-LONDON

Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial

(2013) Adrian S Dobs et al.   LANCET ONCOLOGY

An Antibody Blocking Activin Type II Receptors Induces Strong Skeletal Muscle Hypertrophy and Protects from Atrophy

(2013) E. Lach-Trifilieff et al.   MOLECULAR AND CELLULAR BIOLOGY

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

(2013) Paola Magnaghi et al.   Nature Chemical Biology

BMP signaling controls muscle mass

(2013) Roberta Sartori et al.   NATURE GENETICS

Increased Smad signaling and reduced MRF expression in skeletal muscle from obese subjects

(2013) Rani Watts et al.   Obesity

Myostatin Suppression of Akirin1 Mediates Glucocorticoid-Induced Satellite Cell Dysfunction

(2013) Yanjun Dong et al.   PLoS One

PPARβ/δ Regulates Glucocorticoid- and Sepsis-Induced FOXO1 Activation and Muscle Wasting

(2013) Estibaliz Castillero et al.   PLoS One

Rel A/p65 is required for cytokine-induced myotube atrophy

(2012) Takuo Yamaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

cAMP signaling in skeletal muscle adaptation: hypertrophy, metabolism, and regeneration

(2012) Rebecca Berdeaux et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A PGC-1α Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy

(2012) Jorge L. Ruas et al.   CELL

Exercise Training Attenuates MuRF-1 Expression in the Skeletal Muscle of Patients With Chronic Heart Failure Independent of Age

(2012) Stephan Gielen et al.   CIRCULATION

Cellular and molecular mechanisms of muscle atrophy

(2012) P. Bonaldo et al.   Disease Models & Mechanisms

The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins

(2012) Rosanna Piccirillo et al.   EMBO JOURNAL

Development of proteasome inhibitors as research tools and cancer drugs

(2012) Alfred L. Goldberg   JOURNAL OF CELL BIOLOGY

Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy

(2012) Shenhav Cohen et al.   JOURNAL OF CELL BIOLOGY

Satellite cell senescence underlies myopathy in a mouse model of limb-girdle muscular dystrophy 2H

(2012) Elena Kudryashova et al.   JOURNAL OF CLINICAL INVESTIGATION

Myostatin inhibition induces muscle fibre hypertrophy prior to satellite cell activation

(2012) Qian Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Safety, Pharmacokinetics, and Effects of LGD-4033, a Novel Nonsteroidal Oral, Selective Androgen Receptor Modulator, in Healthy Young Men

(2012) Shehzad Basaria et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Chronic hypobaric hypoxia mediated skeletal muscle atrophy: role of ubiquitin–proteasome pathway and calpains

(2012) Pooja Chaudhary et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The E3 Ubiquitin Ligase TRAF6 Intercedes in Starvation-Induced Skeletal Muscle Atrophy through Multiple Mechanisms

(2012) P. K. Paul et al.   MOLECULAR AND CELLULAR BIOLOGY

Genomic and Proteomic Profiling Reveals Reduced Mitochondrial Function and Disruption of the Neuromuscular Junction Driving Rat Sarcopenia

(2012) C. Ibebunjo et al.   MOLECULAR AND CELLULAR BIOLOGY

Ghrelin Treatment of Cachectic Patients with Chronic Obstructive Pulmonary Disease: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

(2012) Keisuke Miki et al.   PLoS One

Dexamethasone-induced skeletal muscle atrophy was associated with upregulation of myostatin promoter activity

(2012) Jian Qin et al.   RESEARCH IN VETERINARY SCIENCE

Therapeutic potential of anamorelin, a novel, oral ghrelin mimetic, in patients with cancer-related cachexia: a multicenter, randomized, double-blind, crossover, pilot study

(2012) José M. Garcia et al.   SUPPORTIVE CARE IN CANCER

Modulation of reactive oxygen species in skeletal muscle by myostatin is mediated through NF-κB

(2011) Sandhya Sriram et al.   AGING CELL

Posttranslational modifications control FoxO3 activity during denervation

(2011) Enrico Bertaggia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Clenbuterol suppresses proteasomal and lysosomal proteolysis and atrophy-related genes in denervated rat soleus muscles independently of Akt

(2011) Dawit A. P. Gonçalves et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Antibody-directed myostatin inhibition enhances muscle mass and function in tumor-bearing mice

(2011) Kate T. Murphy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Inhibition of IkappaB kinase alpha (IKKα) or IKKbeta (IKKβ) plus forkhead box O (Foxo) abolishes skeletal muscle atrophy

(2011) S.A. Reed et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The proteasome inhibitor MG132 reduces immobilization-induced skeletal muscle atrophy in mice

(2011) Annabelle Z Caron et al.   BMC MUSCULOSKELETAL DISORDERS

Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease

(2011) Klaus F. Rabe   BRITISH JOURNAL OF PHARMACOLOGY

Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog

(2011) Michael Rera et al.   Cell Metabolism

Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle

(2011) Noriaki Shimizu et al.   Cell Metabolism

Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice

(2011) C. Zhang et al.   DIABETOLOGIA

A humanized anti-IL-6 antibody (ALD518) in non-small cell lung cancer

(2011) Trevor J Bayliss et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease

(2011) Liping Zhang et al.   FASEB JOURNAL

Acute antibody-directed myostatin inhibition attenuates disuse muscle atrophy and weakness in mice

(2011) Kate T. Murphy et al.   JOURNAL OF APPLIED PHYSIOLOGY

Striated muscle activator of Rho signalling (STARS) is a PGC-1α/oestrogen-related receptor-α target gene and is upregulated in human skeletal muscle after endurance exercise

(2011) Marita A. Wallace et al.   JOURNAL OF PHYSIOLOGY-LONDON

Prevention of muscle disuse atrophy by MG132 proteasome inhibitor

(2011) Cecile Jamart et al.   MUSCLE & NERVE

Striking Denervation of Neuromuscular Junctions without Lumbar Motoneuron Loss in Geriatric Mouse Muscle

(2011) Ruth Jinfen Chai et al.   PLoS One

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

(2011) T.-F. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ACT-ONE trial, a multicentre, randomised, double-blind, placebo-controlled, dose-finding study of the anabolic/catabolic transforming agent, MT-102 in subjects with cachexia related to stage III and IV non-small cell lung cancer and colorectal cancer:

(2011) Andrew J. Stewart Coats et al.   Journal of Cachexia Sarcopenia and Muscle

The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial

(2011) James T. Dalton et al.   Journal of Cachexia Sarcopenia and Muscle

Myostatin blockage using actRIIB antagonism in mice bearing the Lewis lung carcinoma results in the improvement of muscle wasting and physical performance

(2011) Sílvia Busquets et al.   Journal of Cachexia Sarcopenia and Muscle

Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models

(2011) Stefano Schiaffino et al.   Skeletal Muscle

Review of muscle wasting associated with chronic kidney disease

(2010) Biruh T Workeneh et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Diaphragm Muscle Fiber Weakness in Pulmonary Hypertension

(2010) Frances S. de Man et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

The cathepsin L gene is a direct target of FOXO1 in skeletal muscle

(2010) Yoshihiro Yamazaki et al.   BIOCHEMICAL JOURNAL

Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

(2010) Xiaolan Zhou et al.   CELL

Gene Expression Profiling in Vastus Lateralis Muscle During an Acute Exacerbation of COPD

(2010) Tim Crul et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Genetic Deletion of Myostatin From the Heart Prevents Skeletal Muscle Atrophy in Heart Failure

(2010) Joerg Heineke et al.   CIRCULATION

Consensus definition of sarcopenia, cachexia and pre-cachexia: Joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics”

(2010) M. Muscaritoli et al.   CLINICAL NUTRITION

Remodeling of the neuromuscular junction precedes sarcopenia related alterations in myofibers

(2010) Michael R. Deschenes et al.   EXPERIMENTAL GERONTOLOGY

Antibody-directed myostatin inhibition in 21-mo-old mice reveals novel roles for myostatin signaling in skeletal muscle structure and function

(2010) Kate T. Murphy et al.   FASEB JOURNAL

Mechanisms involved in the enhancement of mammalian target of rapamycin signalling and hypertrophy in skeletal muscle of myostatin-deficient mice

(2010) Christopher Lipina et al.   FEBS LETTERS

Sepsis increases the expression and activity of the transcription factor Forkhead Box O 1 (FOXO1) in skeletal muscle by a glucocorticoid-dependent mechanism

(2010) Ira J. Smith et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Muscle Wasting in Aged, Sarcopenic Rats Is Associated with Enhanced Activity of the Ubiquitin Proteasome Pathway

(2010) Mikael Altun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxisome Proliferator-activated Receptor γ Coactivator 1α or 1β Overexpression Inhibits Muscle Protein Degradation, Induction of Ubiquitin Ligases, and Disuse Atrophy

(2010) Jeffrey J. Brault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-3 Cleaves Specific 19 S Proteasome Subunits in Skeletal Muscle Stimulating Proteasome Activity

(2010) Xiaonan H. Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JunB transcription factor maintains skeletal muscle mass and promotes hypertrophy

(2010) Anna Raffaello et al.   JOURNAL OF CELL BIOLOGY

The TWEAK–Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice

(2010) Ashwani Mittal et al.   JOURNAL OF CELL BIOLOGY

JunB-CBF  signaling is essential to maintain sarcomeric Z-disc structure and when defective leads to heart failure

(2010) B. Meder et al.   JOURNAL OF CELL SCIENCE

Sepsis downregulates myostatin mRNA levels without altering myostatin protein levels in skeletal muscle

(2010) Ira J. Smith et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Effects of Testosterone on Muscle Strength, Physical Function, Body Composition, and Quality of Life in Intermediate-Frail and Frail Elderly Men: A Randomized, Double-Blind, Placebo-Controlled Study

(2010) Upendram Srinivas-Shankar et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

XIAP Reduces Muscle Proteolysis Induced by CKD

(2010) J. Hu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Myostatin Decreases with Aerobic Exercise and Associates with Insulin Resistance

(2010) DUSTIN S. HITTEL et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

PGC-1β-Regulated mitochondrial biogenesis and function in myotubes is mediated by NRF-1 and ERRα

(2010) Di Shao et al.   MITOCHONDRION

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

(2010) Janel O. Johnson et al.   NEURON

Tumor Necrosis Factor-α Regulates Distinct Molecular Pathways and Gene Networks in Cultured Skeletal Muscle Cells

(2010) Shephali Bhatnagar et al.   PLoS One

The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

(2010) Armin Hatzelmann et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Atrophy and hypertrophy signalling of the quadriceps and diaphragm in COPD

(2010) M. Doucet et al.   THORAX

Recombinant Myostatin (GDF-8) Propeptide Enhances the Repair and Regeneration of Both Muscle and Bone in a Model of Deep Penetrant Musculoskeletal Injury

(2010) Mark W. Hamrick et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

(2009) Anne Ulrike Trendelenburg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Smad2 and 3 transcription factors control muscle mass in adulthood

(2009) Roberta Sartori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Follistatin induces muscle hypertrophy through satellite cell proliferation and inhibition of both myostatin and activin

(2009) Hélène Gilson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effect of proteasome inhibitors on endotoxin-induced diaphragm dysfunction

(2009) G. S. Supinski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia

(2009) Margaret E. Benny Klimek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanisms Involved in 3′,5′-Cyclic Adenosine Monophosphate-Mediated Inhibition of the Ubiquitin-Proteasome System in Skeletal Muscle

(2009) Dawit A. P. Gonçalves et al.   ENDOCRINOLOGY

Atrophy and hypertrophy signalling in the diaphragm of patients with COPD

(2009) D. Testelmans et al.   EUROPEAN RESPIRATORY JOURNAL

Nonsteroidal selective androgen receptor modulator Ostarine™in cancer cachexia

(2009) Mihail F Zilbermint et al.   Future Oncology

Pharmacodynamic hormonal effects of anamorelin, a novel oral ghrelin mimetic and growth hormone secretagogue in healthy volunteers

(2009) José M. Garcia et al.   GROWTH HORMONE & IGF RESEARCH

Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component

(2009) Elena Kudryashova et al.   HUMAN MOLECULAR GENETICS

The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity

(2009) I Akpan et al.   INTERNATIONAL JOURNAL OF OBESITY

Absence of caspase-3 protects against denervation-induced skeletal muscle atrophy

(2009) Pamela J. Plant et al.   JOURNAL OF APPLIED PHYSIOLOGY

SIRT1 Controls the Transcription of the Peroxisome Proliferator-activated Receptor-γ Co-activator-1α (PGC-1α) Gene in Skeletal Muscle through the PGC-1α Autoregulatory Loop and Interaction with MyoD

(2009) Ramon Amat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation

(2009) Shenhav Cohen et al.   JOURNAL OF CELL BIOLOGY

Myostatin Inhibition Enhances the Effects of Exercise on Performance and Metabolic Outcomes in Aged Mice

(2009) N. K. LeBrasseur et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A placebo-controlled, double-blind trial of infliximab for cancer-associated weight loss in elderly and/or poor performance non-small cell lung cancer patients (N01C9)

(2009) Aminah Jatoi et al.   LUNG CANCER

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Increased muscle PGC-1  expression protects from sarcopenia and metabolic disease during aging

(2009) T. Wenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Follistatin Gene Delivery Enhances Muscle Growth and Strength in Nonhuman Primates

(2009) J. Kota et al.   Science Translational Medicine

Peripheral muscle dysfunction in idiopathic pulmonary arterial hypertension

(2009) V. Mainguy et al.   THORAX

The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene

(2008) David S. Waddell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation and function of JunB in cell proliferation

(2008) Marc Piechaczyk et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

AMPK and PPARδ Agonists Are Exercise Mimetics

(2008) Vihang A. Narkar et al.   CELL

Cachexia: A new definition

(2008) William J. Evans et al.   CLINICAL NUTRITION

Skeletal muscle proteolysis in aging

(2008) Lydie Combaret et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

The initiation factor eIF3-f is a major target for Atrogin1/MAFbx function in skeletal muscle atrophy

(2008) Julie Lagirand-Cantaloube et al.   EMBO JOURNAL

Sirt1 increases skeletal muscle precursor cell proliferation

(2008) Christopher R. Rathbone et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Identification of a Novel Pool of Extracellular Pro-myostatin in Skeletal Muscle

(2008) Sarah B. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of glucocorticoid-induced myopathy

(2008) O Schakman et al.   JOURNAL OF ENDOCRINOLOGY

The role of exercise and PGC1α in inflammation and chronic disease

(2008) Christoph Handschin et al.   NATURE

Sirtuins — novel therapeutic targets to treat age-associated diseases

(2008) Siva Lavu et al.   NATURE REVIEWS DRUG DISCOVERY

Rapid Disuse Atrophy of Diaphragm Fibers in Mechanically Ventilated Humans

(2008) Sanford Levine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiac cachexia: A systematic overview

(2008) Stephan von Haehling et al.   PHARMACOLOGY & THERAPEUTICS

Role of β-Adrenoceptor Signaling in Skeletal Muscle: Implications for Muscle Wasting and Disease

(2008) Gordon S. Lynch et al.   PHYSIOLOGICAL REVIEWS

Signaling in Muscle Atrophy and Hypertrophy

(2008) Marco Sandri   PHYSIOLOGY

Growth factor delivery methods in the management of sports injuries: the state of play

(2007) L Creaney et al.   BRITISH JOURNAL OF SPORTS MEDICINE

Exercise Training Promotes SIRT1 Activity in Aged Rats

(2007) Nicola Ferrara et al.   REJUVENATION RESEARCH