Pharmacoperones as Novel Therapeutics for Diverse Protein Conformational Diseases

Shaping proteostasis at the cellular, tissue, and organismal level

(2017) Ambre J. Sala et al.   JOURNAL OF CELL BIOLOGY

Cytosolic Proteostasis Networks of the Mitochondrial Stress Response

(2017) Davide D’Amico et al.   TRENDS IN BIOCHEMICAL SCIENCES

With the Help of MOM: Mitochondrial Contributions to Cellular Quality Control

(2017) Ralf J. Braun et al.   TRENDS IN CELL BIOLOGY

New Insights into the Physiological Role of Endoplasmic Reticulum-Associated Degradation

(2017) Ling Qi et al.   TRENDS IN CELL BIOLOGY

Protein misfolding in neurodegenerative diseases: implications and strategies

(2017) Patrick Sweeney et al.   Translational Neurodegeneration

Drug Library Screening for the Identification of Ionophores That Correct the Mistrafficking Disorder Associated with Oxalosis Kidney Disease

(2017) Shurong Hou et al.   SLAS Discovery

The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches

(2016) Andreas C. Joerger et al.   Annual Review of Biochemistry

Cellular Homeostasis and Aging

(2016) F. Ulrich Hartl   Annual Review of Biochemistry

Pathologic endoplasmic reticulum stress induced by glucotoxic insults inhibits adipocyte differentiation and induces an inflammatory phenotype

(2016) Michele Longo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response

(2016) Hyun-Eui Kim et al.   CELL

Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicity

(2016) Marc Brehme et al.   Disease Models & Mechanisms

ALS‐linked protein disulfide isomerase variants cause motor dysfunction

(2016) Ute Woehlbier et al.   EMBO JOURNAL

Progress and potential of non-inhibitory small molecule chaperones for the treatment of Gaucher disease and its implications for Parkinson disease

(2016) Olive Jung et al.   Expert Review of Proteomics

Glycosylation Quality Control by the Golgi Structure

(2016) Xiaoyan Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

A New Glucocerebrosidase Chaperone Reduces  -Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism

(2016) E. Aflaki et al.   JOURNAL OF NEUROSCIENCE

Receptor antagonism/agonism can be uncoupled from pharmacoperone activity

(2016) Jo Ann Janovick et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations

(2016) Gudio Veit et al.   MOLECULAR BIOLOGY OF THE CELL

Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

(2016) Yi-Fan Lin et al.   NATURE

Mitonuclear communication in homeostasis and stress

(2016) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Treatment of Fabry’s Disease with the Pharmacologic Chaperone Migalastat

(2016) Dominique P. Germain et al.   NEW ENGLAND JOURNAL OF MEDICINE

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

Rapamycin in aging and disease: maximizing efficacy while minimizing side effects

(2016) Simon C. Johnson et al.   Oncotarget

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Development of a Phenotypic High-Content Assay to Identify Pharmacoperone Drugs for the Treatment of Primary Hyperoxaluria Type 1 by High-Throughput Screening

(2015) Franck Madoux et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

UPRmt-mediated cytoprotection and organismal aging

(2015) Anna M. Schulz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Better to burn out than it is to rust: coordinating cellular redox states during aging and stress

(2015) C. Rongo   EMBO JOURNAL

Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments

(2015) J. Kirstein et al.   EMBO JOURNAL

Aberrant disulphide bonding contributes to the ER retention of alpha1-antitrypsin deficiency variants

(2015) Riccardo Ronzoni et al.   HUMAN MOLECULAR GENETICS

Inhibiting cytosolic translation and autophagy improves health in mitochondrial disease

(2015) Min Peng et al.   HUMAN MOLECULAR GENETICS

The unpredictability of prolonged activation of stress response pathways

(2015) Lilian T. Lamech et al.   JOURNAL OF CELL BIOLOGY

Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking

(2015) Graeme W. Carlile et al.   Journal of Cystic Fibrosis

RNA Interference Screen to Identify Kinases That Suppress Rescue of ΔF508-CFTR

(2015) Agata M. Trzcińska-Daneluti et al.   MOLECULAR & CELLULAR PROTEOMICS

A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death

(2015) Xiaowen Wang et al.   NATURE

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

(2015) Lidia Wrobel et al.   NATURE

Pharmacological folding chaperones act as allosteric ligands of Frizzled4

(2015) Serena F Generoso et al.   Nature Chemical Biology

New roles for mitochondrial proteases in health, ageing and disease

(2015) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

N-linked sugar-regulated protein folding and quality control in the ER

(2015) Abla Tannous et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice

(2015) Simon C. Johnson et al.   Frontiers in Genetics

A Phenotypic High Throughput Screening Assay for the Identification of Pharmacoperones for the Gonadotropin Releasing Hormone Receptor

(2014) P. Michael Conn et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome

(2014) Wen-Xing Ding et al.   Autophagy

Inefficient SRP Interaction with a Nascent Chain Triggers a mRNA Quality Control Pathway

(2014) Andrey L. Karamyshev et al.   CELL

Pathogenesis of Human Mitochondrial Diseases Is Modulated by Reduced Activity of the Ubiquitin/Proteasome System

(2014) Alexandra Segref et al.   Cell Metabolism

Mechanisms of protein-folding diseases at a glance

(2014) J. S. Valastyan et al.   Disease Models & Mechanisms

Chaperoning G Protein-Coupled Receptors: From Cell Biology to Therapeutics

(2014) Ya-Xiong Tao et al.   ENDOCRINE REVIEWS

Mutant p53 reactivation by small molecules makes its way to the clinic

(2014) Vladimir J.N. Bykov et al.   FEBS LETTERS

Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling

(2014) P. van Oosten-Hawle et al.   GENES & DEVELOPMENT

A Small Molecule Agonist THIQ as a Novel Pharmacoperone for Intracellularly Retained Melanocortin-4 Receptor Mutants

(2014) Hui Huang et al.   International Journal of Biological Sciences

Mitochondrial quality control in the myocardium: Cooperation between protein degradation and mitophagy

(2014) Babette C. Hammerling et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A GCase Chaperone Improves Motor Function in a Mouse Model of Synucleinopathy

(2014) Franziska Richter et al.   Neurotherapeutics

Protein Homeostasis at the Plasma Membrane

(2014) Pirjo M. Apaja et al.   PHYSIOLOGY

Some gating potentiators, including VX-770, diminish  F508-CFTR functional expression

(2014) G. Veit et al.   Science Translational Medicine

Potentiator ivacaftor abrogates pharmacological correction of  F508 CFTR in cystic fibrosis

(2014) D. M. Cholon et al.   Science Translational Medicine

Macrophage Models of Gaucher Disease for Evaluating Disease Pathogenesis and Candidate Drugs

(2014) E. Aflaki et al.   Science Translational Medicine

Proteostasis impairment in protein-misfolding and -aggregation diseases

(2014) Mark S. Hipp et al.   TRENDS IN CELL BIOLOGY

A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease

(2014) Marc Brehme et al.   Cell Reports

Ipsen 5i is a Novel Potent Pharmacoperone for Intracellularly Retained Melanocortin-4 Receptor Mutants

(2014) Ya-Xiong Tao et al.   Frontiers in Endocrinology

A Brief History of G-Protein Coupled Receptors (Nobel Lecture)

(2013) Robert J. Lefkowitz   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Extracellular Chaperones and Proteostasis

(2013) Amy R. Wyatt et al.   Annual Review of Biochemistry

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

(2013) Seok Min Jin et al.   Autophagy

Regulation of proteasome activity in health and disease

(2013) Marion Schmidt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial protein quality control in health and disease

(2013) Michael J Baker et al.   BRITISH JOURNAL OF PHARMACOLOGY

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

(2013) Rebecca C. Taylor et al.   CELL

Regulation of Organismal Proteostasis by Transcellular Chaperone Signaling

(2013) Patricija van Oosten-Hawle et al.   CELL

Historical landmarks of autophagy research

(2013) Yoshinori Ohsumi   CELL RESEARCH

Nephrogenic Diabetes Insipidus: Essential Insights into the Molecular Background and Potential Therapies for Treatment

(2013) Hanne B. Moeller et al.   ENDOCRINE REVIEWS

Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson’s disease

(2013) JIANHUA JIANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Ubiquitination-dependent quality control of hERG K+ channel with acquired and inherited conformational defect at the plasma membrane

(2013) Pirjo M. Apaja et al.   MOLECULAR BIOLOGY OF THE CELL

Transitioning pharmacoperones to therapeutic use: In vivo proof-of-principle and design of high throughput screens

(2013) P. Michael Conn et al.   PHARMACOLOGICAL RESEARCH

“Pharmacoperone”: What's in a word?

(2013) P. Michael Conn et al.   PHARMACOLOGICAL RESEARCH

Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy

(2013) J. A. Janovick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome

(2013) S. C. Johnson et al.   SCIENCE

Novel pharmacological strategies to treat cystic fibrosis

(2013) John W. Hanrahan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Protein disulfide isomerases in neurodegeneration: From disease mechanisms to biomedical applications

(2012) Catherine I. Andreu et al.   FEBS LETTERS

The impact of the unfolded protein response on human disease

(2012) Shiyu Wang et al.   JOURNAL OF CELL BIOLOGY

Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer

(2012) Sören Lehmann et al.   JOURNAL OF CLINICAL ONCOLOGY

Chemical Chaperones Curcumin and 4-Phenylbutyric Acid Improve Secretion of Mutant Factor H R127H by Fibroblasts from a Factor H-Deficient Patient

(2012) J. A. T. Albuquerque et al.   JOURNAL OF IMMUNOLOGY

BiP prevents rod opsin aggregation

(2012) Dimitra Athanasiou et al.   MOLECULAR BIOLOGY OF THE CELL

The Delicate Balance Between Secreted Protein Folding and Endoplasmic Reticulum-Associated Degradation in Human Physiology

(2012) Christopher J. Guerriero et al.   PHYSIOLOGICAL REVIEWS

High Throughput Screening for Small Molecule Therapy for Gaucher Disease Using Patient Tissue as the Source of Mutant Glucocerebrosidase

(2012) Ehud Goldin et al.   PLoS One

The Pharmacological Chaperone AT2220 Increases Recombinant Human Acid α-Glucosidase Uptake and Glycogen Reduction in a Mouse Model of Pompe Disease

(2012) Richie Khanna et al.   PLoS One

Pharmacological chaperones for human  -N-acetylgalactosaminidase

(2012) N. E. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flagging and docking: dual roles for N-glycans in protein quality control and cellular proteostasis

(2012) Daniel N. Hebert et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ouabain Mimics Low Temperature Rescue of F508del-CFTR in Cystic Fibrosis Epithelial Cells

(2012) Donglei Zhang et al.   Frontiers in Pharmacology

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

Identification of a NBD1-Binding Pharmacological Chaperone that Corrects the Trafficking Defect of F508del-CFTR

(2011) Heidi M. Sampson et al.   CHEMISTRY & BIOLOGY

A pharmacogenetic approach to identify mutant forms of α-galactosidase a that respond to a pharmacological chaperone for Fabry disease

(2011) Xiaoyang Wu et al.   HUMAN MUTATION

The Cytosolic Chaperone Hsc70 Promotes Traffic to the Cell Surface of Intracellular Retained Melanocortin-4 Receptor Mutants

(2011) Eirini Meimaridou et al.   MOLECULAR ENDOCRINOLOGY

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

ATP7A-related copper transport diseases—emerging concepts and future trends

(2011) Stephen G. Kaler   Nature Reviews Neurology

The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α

(2011) Claudio Hetz et al.   PHYSIOLOGICAL REVIEWS

Therapeutic Rescue of Misfolded Mutants: Validation of Primary High Throughput Screens for Identification of Pharmacoperone Drugs

(2011) Jo Ann Janovick et al.   PLoS One

The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System

(2011) James Shorter   PLoS One

Rescue of expression and signaling of human luteinizing hormone G protein-coupled receptor mutants with an allosterically binding small-molecule agonist

(2011) C. L. Newton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809

(2011) F. Van Goor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for theF508del-CFTRmutation

(2011) J P Clancy et al.   THORAX

CFTR: folding, misfolding and correcting the ΔF508 conformational defect

(2011) Gergely L. Lukacs et al.   TRENDS IN MOLECULAR MEDICINE

Golgi Glycosylation and Human Inherited Diseases

(2011) H. H. Freeze et al.   Cold Spring Harbor Perspectives in Biology

Ubiquitin–Proteasome System and mitochondria — Reciprocity

(2010) Nurit Livnat-Levanon et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Disulfide bonds in ER protein folding and homeostasis

(2010) Matthias J Feige et al.   CURRENT OPINION IN CELL BIOLOGY

The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology

(2010) Ya-Xiong Tao   ENDOCRINE REVIEWS

The pharmacological chaperone isofagomine increases the activity of the Gaucher disease L444P mutant form of β-glucosidase

(2010) Richie Khanna et al.   FEBS Journal

A single nucleotide polymorphism in the CCR3 gene ablates receptor export to the plasma membrane

(2010) Emma L. Wise et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

ANKRD13C Acts as a Molecular Chaperone for G Protein-coupled Receptors

(2010) Audrey Parent et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein homeostasis and aging in neurodegeneration

(2010) Peter M. Douglas et al.   JOURNAL OF CELL BIOLOGY

Quality control for unfolded proteins at the plasma membrane

(2010) Pirjo M. Apaja et al.   JOURNAL OF CELL BIOLOGY

Pharmacological Chaperones Restore Function to MC4R Mutants Responsible for Severe Early-Onset Obesity

(2010) P. Rene et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Heat Shock Response: Life on the Verge of Death

(2010) Klaus Richter et al.   MOLECULAR CELL

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Obesity-Linked Variants of Melanocortin-4 Receptor Are Misfolded in the Endoplasmic Reticulum and Can Be Rescued to the Cell Surface by a Chemical Chaperone

(2010) Susana Granell et al.   MOLECULAR ENDOCRINOLOGY

Pharmacochaperoning of the A1 Adenosine Receptor Is Contingent on the Endoplasmic Reticulum

(2010) L. Malaga-Dieguez et al.   MOLECULAR PHARMACOLOGY

Correction of the  Phe508 Cystic Fibrosis Transmembrane Conductance Regulator Trafficking Defect by the Bioavailable Compound Glafenine

(2010) R. Robert et al.   MOLECULAR PHARMACOLOGY

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

Cellular strategies for controlling protein aggregation

(2010) Jens Tyedmers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fabry disease

(2010) Dominique P Germain   Orphanet Journal of Rare Diseases

Fabry disease: a review of current management strategies

(2010) A. Mehta et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane

(2010) T. Okiyoneda et al.   SCIENCE

PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

(2009) Jeremy M.R. Lambert et al.   CANCER CELL

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Dominant pro-vasopressin mutants that cause diabetes insipidus form disulfide-linked fibrillar aggregates in the endoplasmic reticulum

(2009) J. Birk et al.   JOURNAL OF CELL SCIENCE

Functional characterization and pharmacological rescue of melanocortin-4 receptor mutations identified from obese patients

(2009) Zhen-Chuan Fan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The pharmacological chaperone 1-deoxygalactonojirimycin increases α-galactosidase A levels in Fabry patient cell lines

(2009) E. R. Benjamin et al.   JOURNAL OF INHERITED METABOLIC DISEASE

The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response

(2009) Sana Basseri et al.   JOURNAL OF LIPID RESEARCH

The Pharmacological Chaperone N-butyldeoxynojirimycin Enhances Enzyme Replacement Therapy in Pompe Disease Fibroblasts

(2009) Caterina Porto et al.   MOLECULAR THERAPY

The Pharmacological Chaperone 1-Deoxygalactonojirimycin Reduces Tissue Globotriaosylceramide Levels in a Mouse Model of Fabry Disease

(2009) Richie Khanna et al.   MOLECULAR THERAPY

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis

(2009) J M R Lambert et al.   ONCOGENE

Lysosomal Storage Disorders in the Newborn

(2009) O. Staretz-Chacham et al.   PEDIATRICS

Inefficient Quality Control of Thermosensitive Proteins on the Plasma Membrane

(2009) Michael J. Lewis et al.   PLoS One

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Golgi linked protein glycosylation and associated diseases

(2009) Daniel Ungar   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

CFTR Delivery to 25% of Surface Epithelial Cells Restores Normal Rates of Mucus Transport to Human Cystic Fibrosis Airway Epithelium

(2009) Liqun Zhang et al.   PLOS BIOLOGY

Mistranslation-Induced Protein Misfolding as a Dominant Constraint on Coding-Sequence Evolution

(2008) D. Allan Drummond et al.   CELL

The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases

(2008) Konstanze F Winklhofer et al.   EMBO JOURNAL

Failure of bone morphogenetic protein receptor trafficking in pulmonary arterial hypertension: potential for rescue

(2008) A. Sobolewski et al.   HUMAN MOLECULAR GENETICS

Getting In and Out from Calnexin/Calreticulin Cycles

(2008) Julio J. Caramelo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria

(2008) Angel L. Pey et al.   JOURNAL OF CLINICAL INVESTIGATION

Preclinical Efficacy and Safety of 1-Deoxygalactonojirimycin in Mice for Fabry Disease

(2008) S. Ishii et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Chemical Rescue of ΔF508-CFTR Mimics Genetic Repair in Cystic Fibrosis Bronchial Epithelial Cells

(2008) Om V. Singh et al.   MOLECULAR & CELLULAR PROTEOMICS

Increased plasma membrane expression of human follicle-stimulating hormone receptor by a small molecule thienopyr(im)idine

(2008) Jo Ann Janovick et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Constitutive activation of G protein-coupled receptors and diseases: Insights into mechanisms of activation and therapeutics

(2008) Y TAO   PHARMACOLOGY & THERAPEUTICS

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

(2008) F. M. Boeckler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

A counterintuitive approach to treat enzyme deficiencies: use of enzyme inhibitors for restoring mutant enzyme activity

(2007) Jian-Qiang Fan   BIOLOGICAL CHEMISTRY

A day in the life of a G protein-coupled receptor: the contribution to function of G protein-coupled receptor dimerization

(2007) G Milligan   BRITISH JOURNAL OF PHARMACOLOGY