Pharmacological folding chaperones act as allosteric ligands of Frizzled4

Frizzled-7 as a Potential Therapeutic Target in Colorectal Cancer

(2015) Koji Ueno et al.   NEOPLASIA

ER Reorganization is Remarkably Induced in COS-7 Cells Accumulating Transmembrane Protein Receptors Not Competent for Export from the Endoplasmic Reticulum

(2014) Massimo D’Agostino et al.   JOURNAL OF MEMBRANE BIOLOGY

Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex

(2013) J. Ke et al.   GENES & DEVELOPMENT

The cytosolic chaperone  -crystallin B rescues folding and compartmentalization of misfolded multispan transmembrane proteins

(2013) M. D'Agostino et al.   JOURNAL OF CELL SCIENCE

On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

(2013) Reggy Ekkebus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of the human smoothened receptor bound to an antitumour agent

(2013) Chong Wang et al.   NATURE

Assembly of a π–π stack of ligands in the binding site of an acetylcholine-binding protein

(2013) Mariano Stornaiuolo et al.   Nature Communications

A disorder-to-order structural transition in the COOH-tail of Fz4 determines misfolding of the L501fsX533-Fz4 mutant

(2013) Valentina Lemma et al.   Scientific Reports

Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling

(2013) H Jung et al.   Oncogenesis

Norrin/Frizzled4 Signaling in Retinal Vascular Development and Blood Brain Barrier Plasticity

(2012) Yanshu Wang et al.   CELL

Wnt/beta-Catenin Signaling and Small Molecule Inhibitors

(2012) Andrey Voronkov et al.   CURRENT PHARMACEUTICAL DESIGN

Drugging Wnt signalling in cancer

(2012) Paul Polakis   EMBO JOURNAL

Structure–Function Dissection of the Frizzled Receptor in Drosophila melanogaster Suggests Different Mechanisms of Action in Planar Polarity and Canonical Wnt Signaling

(2012) David Strutt et al.   GENETICS

Transient transfection coupled to baculovirus infection for rapid protein expression screening in insect cells

(2012) Stephan Radner et al.   JOURNAL OF STRUCTURAL BIOLOGY

Wnt/ -catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled

(2012) D. V. F. Tauriello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors

(2012) A. Gurney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Wnt Recognition by Frizzled

(2012) C. Y. Janda et al.   SCIENCE

Targeting Wnt Pathways in Disease

(2012) Z. F. Zimmerman et al.   Cold Spring Harbor Perspectives in Biology

Frizzled and LRP5/6 Receptors for Wnt/ -Catenin Signaling

(2012) B. T. MacDonald et al.   Cold Spring Harbor Perspectives in Biology

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Frizzled 4 Regulates Stemness and Invasiveness of Migrating Glioma Cells Established by Serial Intracranial Transplantation

(2011) X. Jin et al.   CANCER RESEARCH

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Chaperone-assisted protein folding: the path to discovery from a personal perspective

(2011) F Ulrich Hartl   NATURE MEDICINE

Rescue of expression and signaling of human luteinizing hormone G protein-coupled receptor mutants with an allosterically binding small-molecule agonist

(2011) C. L. Newton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GABA acts as a ligand chaperone in the early secretory pathway to promote cell surface expression of GABAA receptors

(2010) Randa S. Eshaq et al.   BRAIN RESEARCH

International Union of Basic and Clinical Pharmacology. LXXX. The Class Frizzled Receptors

(2010) G. Schulte   PHARMACOLOGICAL REVIEWS

β-Catenin Phosphorylated at Serine 45 Is Spatially Uncoupled from β-Catenin Phosphorylated in the GSK3 Domain: Implications for Signaling

(2010) Meghan T. Maher et al.   PLoS One

MetAlign: Interface-Driven, Versatile Metabolomics Tool for Hyphenated Full-Scan Mass Spectrometry Data Preprocessing

(2009) Arjen Lommen   ANALYTICAL CHEMISTRY

Discovery and Characterization of a Small Molecule Inhibitor of the PDZ Domain of Dishevelled

(2009) David Grandy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic Nicotine Selectively Enhances  4 2* Nicotinic Acetylcholine Receptors in the Nigrostriatal Dopamine Pathway

(2009) C. Xiao et al.   JOURNAL OF NEUROSCIENCE

Functional Rescue of β1-Adrenoceptor Dimerization and Trafficking by Pharmacological Chaperones

(2009) Hiroyuki Kobayashi et al.   TRAFFIC

Enhanced cell-surface stability of rescued ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) by pharmacological chaperones

(2008) Karoly Varga et al.   BIOCHEMICAL JOURNAL

Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling

(2008) Ximei Wu et al.   CELL