RNA Interference Screen to Identify Kinases That Suppress Rescue of ΔF508-CFTR

Some gating potentiators, including VX-770, diminish  F508-CFTR functional expression

(2014) G. Veit et al.   Science Translational Medicine

Potentiator ivacaftor abrogates pharmacological correction of  F508 CFTR in cystic fibrosis

(2014) D. M. Cholon et al.   Science Translational Medicine

Protein Homeostasis as a Therapeutic Target for Diseases of Protein Conformation

(2013) Barbara Calamini et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Regulated recycling of mutant CFTR is partially restored by pharmacological treatment

(2013) J. P. Holleran et al.   JOURNAL OF CELL SCIENCE

Modification of the salivary secretion assay in F508del mice — The murine equivalent of the human sweat test

(2013) Karoline Droebner et al.   Journal of Cystic Fibrosis

A functional CFTR assay using primary cystic fibrosis intestinal organoids

(2013) Johanna F Dekkers et al.   NATURE MEDICINE

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

(2013) T. Sato et al.   SCIENCE

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

(2012) Marc L. Mendillo et al.   CELL

Correction of Both NBD1 Energetics and Domain Interface Is Required to Restore ΔF508 CFTR Folding and Function

(2012) Wael M. Rabeh et al.   CELL

The small heat shock proteins family: The long forgotten chaperones

(2012) C. Garrido et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Use of Kinase Inhibitors to Correct ΔF508-CFTR Function

(2012) Agata M. Trzcińska-Daneluti et al.   MOLECULAR & CELLULAR PROTEOMICS

IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin

(2012) Wei-Chieh Chiang et al.   MOLECULAR BIOLOGY OF THE CELL

Small heat shock proteins target mutant cystic fibrosis transmembrane conductance regulator for degradation via a small ubiquitin-like modifier–dependent pathway

(2012) Annette Ahner et al.   MOLECULAR BIOLOGY OF THE CELL

Suppressors of Cytokine Signaling (SOCS) Proteins and JAK/STAT Pathways

(2011) Taiga Tamiya et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB

(2011) D. Maag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for theF508del-CFTRmutation

(2011) J P Clancy et al.   THORAX

Role of epithelial HCO3− transport in mucin secretion: lessons from cystic fibrosis

(2010) Paul M. Quinton   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

RAF protein-serine/threonine kinases: Structure and regulation

(2010) Robert Roskoski   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Roles of Fibroblast Growth Factor Receptors in Carcinogenesis

(2010) E. M. Haugsten et al.   MOLECULAR CANCER RESEARCH

Correction of the  Phe508 Cystic Fibrosis Transmembrane Conductance Regulator Trafficking Defect by the Bioavailable Compound Glafenine

(2010) R. Robert et al.   MOLECULAR PHARMACOLOGY

Modulation of Akt and ERK1/2 Pathways by Resveratrol in Chronic Myelogenous Leukemia (CML) Cells Results in the Downregulation of Hsp70

(2010) Soumyajit Banerjee Mustafi et al.   PLoS One

Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane

(2010) T. Okiyoneda et al.   SCIENCE

Suppressors of Cytokine Signaling Modulate JAK/STAT-Mediated Cell Responses During Atherosclerosis

(2009) Guadalupe Ortiz-Muñoz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology

(2009) Sergiy Kostenko et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Induction of Overexpression of the 27- and 70-kDa Heat Shock Proteins by Bicyclol Attenuates Concanavalin A-Induced Liver Injury through Suppression of Nuclear Factor- B in Mice

(2009) X.-Q. Bao et al.   MOLECULAR PHARMACOLOGY

CFTR Is a Negative Regulator of NFκB Mediated Innate Immune Response

(2009) Neeraj Vij et al.   PLoS One

CFTR Delivery to 25% of Surface Epithelial Cells Restores Normal Rates of Mucus Transport to Human Cystic Fibrosis Airway Epithelium

(2009) Liqun Zhang et al.   PLOS BIOLOGY

CFTR Function and Prospects for Therapy

(2008) John R. Riordan   Annual Review of Biochemistry

MAP3Ks as central regulators of cell fate during development

(2008) Evisabel A. Craig et al.   DEVELOPMENTAL DYNAMICS

Proteasome-Dependent Pharmacological Rescue of Cystic Fibrosis Transmembrane Conductance Regulator Revealed by Mutation of Glycine 622

(2008) C. Norez et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

High-content Functional Screen to Identify Proteins that Correct F508del-CFTR Function

(2008) Agata M. Trzcińska-Daneluti et al.   MOLECULAR & CELLULAR PROTEOMICS

Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function

(2008) A. W. R. Serohijos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA