Protein Homeostasis at the Plasma Membrane

Extracellular Chaperones and Proteostasis

(2013) Amy R. Wyatt et al.   Annual Review of Biochemistry

The Yeast Alix Homolog Bro1 Functions as a Ubiquitin Receptor for Protein Sorting into Multivesicular Endosomes

(2013) Natasha Pashkova et al.   DEVELOPMENTAL CELL

Ubiquitination of HLA-DO by MARCH family E3 ligases

(2013) Martin Jahnke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Insights into MLC pathogenesis: GlialCAM is an MLC1 chaperone required for proper activation of volume-regulated anion currents

(2013) Xavier Capdevila-Nortes et al.   HUMAN MOLECULAR GENETICS

Ubiquitination of the N-terminal Region of Caveolin-1 Regulates Endosomal Sorting by the VCP/p97 AAA-ATPase

(2013) Philipp Kirchner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanism of 17-Allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL Receptor Tyrosine Kinase Degradation

(2013) Gnana Prakasam Krishnamoorthy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane-associated RING-CH (MARCH) 8 mediates the ubiquitination and lysosomal degradation of the transferrin receptor

(2013) H. Fujita et al.   JOURNAL OF CELL SCIENCE

Alternative fates of newly formed PrPSc upon prion conversion on the plasma membrane

(2013) R. Goold et al.   JOURNAL OF CELL SCIENCE

Ubiquitination-dependent quality control of hERG K+ channel with acquired and inherited conformational defect at the plasma membrane

(2013) Pirjo M. Apaja et al.   MOLECULAR BIOLOGY OF THE CELL

The Ribosome as a Hub for Protein Quality Control

(2013) Sebastian Pechmann et al.   MOLECULAR CELL

Mechanism-based corrector combination restores ΔF508-CFTR folding and function

(2013) Tsukasa Okiyoneda et al.   Nature Chemical Biology

Diversity in the origins of proteostasis networks — a driver for protein function in evolution

(2013) Evan T. Powers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deubiquitylases From Genes to Organism

(2013) Michael J. Clague et al.   PHYSIOLOGICAL REVIEWS

Quality Control and Substrate-Dependent Downregulation of the Nutrient Transporter Fur4

(2013) Justin M. Keener et al.   TRAFFIC

The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress

(2013) Yingying Zhao et al.   eLife

Ubiquitin and Membrane Protein Turnover: From Cradle to Grave

(2012) Jason A. MacGurn et al.   Annual Review of Biochemistry

Amyloid-β Oligomers are Sequestered by both Intracellular and Extracellular Chaperones

(2012) Priyanka Narayan et al.   BIOCHEMISTRY

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

Cleaning Up: ER-Associated Degradation to the Rescue

(2012) Jeffrey L. Brodsky   CELL

ALIX Is a Lys63-Specific Polyubiquitin Binding Protein that Functions in Retrovirus Budding

(2012) Dara P. Dowlatshahi et al.   DEVELOPMENTAL CELL

Governance of Endocytic Trafficking and Signaling by Reversible Ubiquitylation

(2012) Michael J. Clague et al.   DEVELOPMENTAL CELL

Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking

(2012) Sang-Oh Han et al.   EMBO REPORTS

Ubiquitination of Human Leukocyte Antigen (HLA)-DM by Different Membrane-associated RING-CH (MARCH) Protein Family E3 Ligases Targets Different Endocytic Pathways

(2012) Martin Jahnke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ALIX binds a YPX3L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting

(2012) Michael R. Dores et al.   JOURNAL OF CELL BIOLOGY

The role of ubiquitylation in receptor endocytosis and endosomal sorting

(2012) K. Haglund et al.   JOURNAL OF CELL SCIENCE

Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions

(2012) Sylvie Urbé et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome

(2012) David A. Tumbarello et al.   NATURE CELL BIOLOGY

Genetics of Clusterin Isoform Expression and Alzheimer's Disease Risk

(2012) I-Fang Ling et al.   PLoS One

Cell Surface Cdc37 Participates in Extracellular HSP90 Mediated Cancer Cell Invasion

(2012) Avraam El Hamidieh et al.   PLoS One

Mitochondrial quality control: an integrated network of pathways

(2012) Fabian Fischer et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular Mechanisms of Ubiquitin-Dependent Membrane Traffic

(2011) James H. Hurley et al.   Annual Review of Biophysics

UBAP1 Is a Component of an Endosome-Specific ESCRT-I Complex that Is Essential for MVB Sorting

(2011) Flavia Stefani et al.   CURRENT BIOLOGY

Protein quality control at the plasma membrane

(2011) Tsukasa Okiyoneda et al.   CURRENT OPINION IN CELL BIOLOGY

The ESCRT Pathway

(2011) William M. Henne et al.   DEVELOPMENTAL CELL

The Deubiquitinating Enzyme USP-46 Negatively Regulates the Degradation of Glutamate Receptors to Control Their Abundance in the Ventral Nerve Cord of Caenorhabditis elegans

(2011) J. R. Kowalski et al.   JOURNAL OF NEUROSCIENCE

MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation

(2011) Craig A. Eyster et al.   MOLECULAR BIOLOGY OF THE CELL

Hul5 HECT ubiquitin ligase plays a major role in the ubiquitylation and turnover of cytosolic misfolded proteins

(2011) Nancy N. Fang et al.   NATURE CELL BIOLOGY

Shaping development with ESCRTs

(2011) Tor Erik Rusten et al.   NATURE CELL BIOLOGY

Derlin-Dependent Retrograde Transport from Endosomes to the Golgi Apparatus

(2011) Hope Dang et al.   TRAFFIC

A brief survey of mRNA surveillance

(2011) Ambro van Hoof et al.   TRENDS IN BIOCHEMICAL SCIENCES

Endosomal transport via ubiquitination

(2011) Robert C. Piper et al.   TRENDS IN CELL BIOLOGY

β-arrestin-mediated receptor trafficking and signal transduction

(2011) Sudha K. Shenoy et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Chaperonin-Catalyzed Rescue of Kinetically Trapped States in Protein Folding

(2010) Kausik Chakraborty et al.   CELL

The deubiquitinating enzyme USP10 regulates the endocytic recycling of CFTR in airway epithelial cells

(2010) Jennifer M. Bomberger et al.   Channels

Modeling general proteostasis: proteome balance in health and disease

(2010) Daniela M Roth et al.   CURRENT OPINION IN CELL BIOLOGY

VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo

(2010) Xuefeng Ren et al.   EMBO JOURNAL

Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation

(2010) Arnold Hayer et al.   JOURNAL OF CELL BIOLOGY

Quality control for unfolded proteins at the plasma membrane

(2010) Pirjo M. Apaja et al.   JOURNAL OF CELL BIOLOGY

Multiple Interactions between the ESCRT Machinery and Arrestin-Related Proteins: Implications for PPXY-Dependent Budding

(2010) S. Rauch et al.   JOURNAL OF VIROLOGY

Ubr1 and Ubr2 Function in a Quality Control Pathway for Degradation of Unfolded Cytosolic Proteins

(2010) Nadinath B. Nillegoda et al.   MOLECULAR BIOLOGY OF THE CELL

Protein Quality Control in the Cytosol and the Endoplasmic Reticulum: Brothers in Arms

(2010) Alexander Buchberger et al.   MOLECULAR CELL

Membrane-Associated RING-CH Proteins Associate with Bap31 and Target CD81 and CD44 to Lysosomes

(2010) Eric Bartee et al.   PLoS One

Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2

(2010) T. Mund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hsp 70/Hsp 90 organizing protein as a nitrosylation target in cystic fibrosis therapy

(2010) N. V. Marozkina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane

(2010) T. Okiyoneda et al.   SCIENCE

DNA polymerase proofreading: Multiple roles maintain genome stability

(2009) Linda J. Reha-Krantz   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Fidelity at the Molecular Level: Lessons from Protein Synthesis

(2009) Hani S. Zaher et al.   CELL

RNA polymerase fidelity and transcriptional proofreading

(2009) Jasmin F Sydow et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The deubiquitinases USP33 and USP20 coordinate β2 adrenergic receptor recycling and resensitization

(2009) Magali Berthouze et al.   EMBO JOURNAL

Dual degradation mechanisms ensure disposal of NHE6 mutant protein associated with neurological disease

(2009) Ingrid Roxrud et al.   EXPERIMENTAL CELL RESEARCH

Ubiquitination Regulates Proteolytic Processing of G Protein-coupled Receptors after Their Sorting to Lysosomes

(2009) James N. Hislop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane traffic

(2009) Rina Glozman et al.   JOURNAL OF CELL BIOLOGY

Derlin-dependent accumulation of integral membrane proteins at cell surfaces

(2009) B. Schaheen et al.   JOURNAL OF CELL SCIENCE

Stable Isotope Labeling by Amino Acids in Cell Culture and Differential Plasma Membrane Proteome Quantitation Identify New Substrates for the MARCH9 Transmembrane E3 Ligase

(2009) Simon Hör et al.   MOLECULAR & CELLULAR PROTEOMICS

Recruitment of the ESCRT Machinery to a Putative Seven-Transmembrane-Domain Receptor Is Mediated by an Arrestin-Related Protein

(2009) A. Herrador et al.   MOLECULAR AND CELLULAR BIOLOGY

Misfolded Membrane Proteins Are Specifically Recognized by the Transmembrane Domain of the Hrd1p Ubiquitin Ligase

(2009) Brian K. Sato et al.   MOLECULAR CELL

The ubiquitylation machinery of the endoplasmic reticulum

(2009) Christian Hirsch et al.   NATURE

Ubiquitin-binding domains — from structures to functions

(2009) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90

(2009) Martin Hessling et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons

(2009) J. Howitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1

(2009) J. W. Heck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2

(2009) S. K. Shenoy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase

(2009) E. S. Ehrlich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient Internalization of MHC I Requires Lysine-11 and Lysine-63 Mixed Linkage Polyubiquitin Chains

(2009) Jessica M. Boname et al.   TRAFFIC

Monitoring Protein Conformation along the Pathway of Chaperonin-Assisted Folding

(2008) Shruti Sharma et al.   CELL

Arrestin-Related Ubiquitin-Ligase Adaptors Regulate Endocytosis and Protein Turnover at the Cell Surface

(2008) Charles H. Lin et al.   CELL

Arrestin-like proteins mediate ubiquitination and endocytosis of the yeast metal transporter Smf1

(2008) Elina Nikko et al.   EMBO REPORTS

The trafficking and regulation of membrane receptors by the RING-CH ubiquitin E3 ligases

(2008) James A. Nathan et al.   EXPERIMENTAL CELL RESEARCH

N-Glycan-mediated Quality Control in the Endoplasmic Reticulum Is Required for the Expression of Correctly Folded δ-Opioid Receptors at the Cell Surface

(2008) Piia M. H. Markkanen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor

(2008) Ingrid Roxrud et al.   JOURNAL OF CELL BIOLOGY

CHIP Deficiency Decreases Longevity, with Accelerated Aging Phenotypes Accompanied by Altered Protein Quality Control

(2008) J.-N. Min et al.   MOLECULAR AND CELLULAR BIOLOGY

MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation

(2008) A. De Gassart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viral and cellular MARCH ubiquitin ligases and cancer

(2008) Xiaoli Wang et al.   SEMINARS IN CANCER BIOLOGY