Of dogs and hookworms: man’s best friend and his parasites as a model for translational biomedical research

Revisiting the Ancylostoma Caninum Secretome Provides New Information on Hookworm-Host Interactions

(2017) Taylor Morante et al.   PROTEOMICS

Making sense of genomes of parasitic worms: Tackling bioinformatic challenges

(2016) Pasi K. Korhonen et al.   BIOTECHNOLOGY ADVANCES

Characterization of parasite-specific indels and their proposed relevance for selective anthelminthic drug targeting

(2016) Qi Wang et al.   INFECTION GENETICS AND EVOLUTION

The hookworm Ancylostoma ceylanicum intestinal transcriptome provides a platform for selecting drug and vaccine candidates

(2016) Junfei Wei et al.   Parasites & Vectors

Adult hookworms (Necator spp.) collected from researchers working with wild western lowland gorillas

(2016) Barbora Kalousová et al.   Parasites & Vectors

The omic approach to parasitic trematode research—a review of techniques and developments within the past 5 years

(2016) Orçun Haçarız et al.   PARASITOLOGY RESEARCH

Micro-proteomics with iterative data analysis: Proteome analysis in C. elegans at the single worm level

(2016) Dalila Bensaddek et al.   PROTEOMICS

Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma

(2016) S. Navarro et al.   Science Translational Medicine

The Effect of In Vitro Cultivation on the Transcriptome of Adult Brugia malayi

(2016) Cristina Ballesteros et al.   PLoS Neglected Tropical Diseases

Hookworm infection

(2016) Alex Loukas et al.   Nature Reviews Disease Primers

A novel isothermal microcalorimetry tool to assess drug effects on Ancylostoma ceylanicum and Necator americanus

(2015) Dayana Flores et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Out of southern East Asia: the natural history of domestic dogs across the world

(2015) Guo-Dong Wang et al.   CELL RESEARCH

A recombinant fusion protein derived from dog hookworm inhibits autoantibody-induced dermal-epidermal separationex vivo

(2015) Annette Kemmer et al.   EXPERIMENTAL DERMATOLOGY

Morphological Variability and Molecular Identification ofUncinariaspp. (Nematoda: Ancylostomatidae) from Grizzly and Black Bears: New Species or Phenotypic Plasticity?

(2015) Stefano Catalano et al.   JOURNAL OF PARASITOLOGY

Anthelmintic Drug Discovery: Into the Future

(2015) Timothy G. Geary et al.   JOURNAL OF PARASITOLOGY

The genome and transcriptome of the zoonotic hookworm Ancylostoma ceylanicum identify infection-specific gene families

(2015) Erich M Schwarz et al.   NATURE GENETICS

Mucosal tolerance of the hookwormAncylostoma caninumin the gut of naturally infected wild dogs

(2015) C. C. Constantinoiu et al.   PARASITE IMMUNOLOGY

Identifying the immunomodulatory components of helminths

(2015) C. Shepherd et al.   PARASITE IMMUNOLOGY

Re-evaluation of the species of hookworms infecting dogs in Central Vietnam

(2015) Dinh Ng-Nguyen et al.   Parasites & Vectors

Cell-specific proteomic analysis inCaenorhabditis elegans

(2015) Kai P. Yuet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anthelmintic resistance in nematodes of beef cattle in south-west Western Australia

(2015) J.L. Cotter et al.   VETERINARY PARASITOLOGY

Widespread anthelmintic resistance in European farmed ruminants: a systematic review

(2015) H. Rose et al.   VETERINARY RECORD

Caenorhabditis elegans is a useful model for anthelmintic discovery

(2015) Andrew R. Burns et al.   Nature Communications

New tools for NTD vaccines: A case study of quality control assays for product development of the human hookworm vaccineNa-APR-1M74

(2015) Mark S Pearson et al.   Human Vaccines & Immunotherapeutics

Pan-phylum Comparison of Nematode Metabolic Potential

(2015) Rahul Tyagi et al.   PLoS Neglected Tropical Diseases

The Newest “Omics”—Metagenomics and Metabolomics—Enter the Battle against the Neglected Tropical Diseases

(2015) Geoffrey A. Preidis et al.   PLoS Neglected Tropical Diseases

A Proteomic Analysis of the Body Wall, Digestive Tract, and Reproductive Tract of Brugia malayi

(2015) C. Paul Morris et al.   PLoS Neglected Tropical Diseases

The role of wildlife in the transmission of parasitic zoonoses in peri-urban and urban areas

(2015) Ute Mackenstedt et al.   International Journal for Parasitology-Parasites and Wildlife

Metabolomic analysis of Entamoeba: applications and implications

(2014) Ghulam Jeelani et al.   CURRENT OPINION IN MICROBIOLOGY

Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases

(2014) Sandeep Chhabra et al.   FASEB JOURNAL

Immunity to gastrointestinal nematodes: mechanisms and myths

(2014) Richard K. Grencis et al.   IMMUNOLOGICAL REVIEWS

Probing of a Human Proteome Microarray With a Recombinant Pathogen Protein Reveals a Novel Mechanism by Which Hookworms Suppress B-Cell Receptor Signaling

(2014) Leon Tribolet et al.   JOURNAL OF INFECTIOUS DISEASES

Secreted Proteomes of Different Developmental Stages of the Gastrointestinal NematodeNippostrongylus brasiliensis

(2014) Javier Sotillo et al.   MOLECULAR & CELLULAR PROTEOMICS

Genome of the human hookworm Necator americanus

(2014) Yat T Tang et al.   NATURE GENETICS

Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion

(2014) Fei Chen et al.   NATURE IMMUNOLOGY

Production and analysis of immunomodulatory excretory-secretory products from the mouse gastrointestinal nematode Heligmosomoides polygyrus bakeri

(2014) Rajesh M Valanparambil et al.   Nature Protocols

Mucosal immune responses following intestinal nematode infection

(2014) C. Zaph et al.   PARASITE IMMUNOLOGY

Role of Macrophages in the Altered Epithelial Function during a Type 2 Immune Response Induced by Enteric Nematode Infection

(2014) Luigi Notari et al.   PLoS One

Humans and Great Apes Cohabiting the Forest Ecosystem in Central African Republic Harbour the Same Hookworms

(2014) Hideo Hasegawa et al.   PLoS Neglected Tropical Diseases

Anthelmintics – From Discovery to Resistance

(2014) Adrian J. Wolstenholme et al.   International Journal for Parasitology-Drugs and Drug Resistance

Extending Public Health: The Rockefeller Sanitary Commission and Hookworm in the American South

(2013) Cheryl Elman et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Paleoparasitology: the origin of human parasites

(2013) Adauto Araujo et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

Hookworm Excretory/Secretory Products Induce Interleukin-4 (IL-4)+IL-10+CD4+T Cell Responses and Suppress Pathology in a Mouse Model of Colitis

(2013) Ivana Ferreira et al.   INFECTION AND IMMUNITY

Ancylostoma ceylanicum, a re-emerging but neglected parasitic zoonosis

(2013) Rebecca J. Traub   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Helminth therapy and multiple sclerosis

(2013) J.O. Fleming   INTERNATIONAL JOURNAL FOR PARASITOLOGY

The genomic signature of dog domestication reveals adaptation to a starch-rich diet

(2013) Erik Axelsson et al.   NATURE

Understanding the role of antibodies in murine infections withHeligmosomoides(polygyrus)bakeri: 35 years ago, now and 35 years ahead

(2013) N. L. Harris et al.   PARASITE IMMUNOLOGY

TIMPs of parasitic helminths – a large-scale analysis of high-throughput sequence datasets

(2013) Cinzia Cantacessi et al.   Parasites & Vectors

The genomics of selection in dogs and the parallel evolution between dogs and humans

(2013) Guo-dong Wang et al.   Nature Communications

First report of Ancylostoma ceylanicum in wild canids

(2013) Felicity A. Smout et al.   International Journal for Parasitology-Parasites and Wildlife

Human soil-transmitted helminths

(2012) Jozef Vercruysse et al.   CURRENT OPINION IN INFECTIOUS DISEASES

The hookworm pharmacopoeia for inflammatory diseases

(2012) Severine Navarro et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Translatability of helminth therapy in inflammatory bowel diseases

(2012) Joel V. Weinstock et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Inflammatory bowel disease in Asia: A systematic review

(2012) Lani Prideaux et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Biochemistry and Evolution of Anaerobic Energy Metabolism in Eukaryotes

(2012) M. Muller et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Susceptibility or resistance of praziquantel in human schistosomiasis: a review

(2012) Wei Wang et al.   PARASITOLOGY RESEARCH

Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus

(2012) Lisa A. Reynolds et al.   Seminars in Immunopathology

Epidemiological and Genetic Data Supporting the Transmission of Ancylostoma ceylanicum among Human and Domestic Animals

(2012) Romano Ngui et al.   PLoS Neglected Tropical Diseases

Hygiene Hypothesis and Autoimmune Diseases

(2011) Graham A. W. Rook   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Acquired hookworm immunity in the golden hamster (Mesocricetus auratus) elicited by living Necator americanus third-stage infective larvae

(2011) Jian Xue et al.   EXPERIMENTAL PARASITOLOGY

Immune modulation and modulators in Heligmosomoides polygyrus infection

(2011) Rick M. Maizels et al.   EXPERIMENTAL PARASITOLOGY

Protection against Nippostrongylus brasiliensis infection in mice is independent of GM-CSF

(2011) Doris S C Shim et al.   IMMUNOLOGY AND CELL BIOLOGY

Hookworm products ameliorate dextran sodium sulfate-induced colitis in BALB/c mice

(2011) Guilherme Grossi Lopes Cançado et al.   INFLAMMATORY BOWEL DISEASES

Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of Venom Allergen-Like (VAL) proteins

(2011) James P. Hewitson et al.   Journal of Proteomics

Ac-AP-12, a novel factor Xa anticoagulant peptide from the esophageal glands of adult Ancylostoma caninum

(2011) Desheng Jiang et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The Caenorhabditis elegans intermediate-size transcriptome shows high degree of stage-specific expression

(2011) Yunfei Wang et al.   NUCLEIC ACIDS RESEARCH

RNA and protein synthesis is required for Ancylostoma caninum larval activation

(2011) Dilyan I. Dryanovski et al.   VETERINARY PARASITOLOGY

A Deep Sequencing Approach to Comparatively Analyze the Transcriptome of Lifecycle Stages of the Filarial Worm, Brugia malayi

(2011) Young-Jun Choi et al.   PLoS Neglected Tropical Diseases

Induction of CD4+CD25+FOXP3+ Regulatory T Cells during Human Hookworm Infection Modulates Antigen-Mediated Lymphocyte Proliferation

(2011) Natasha Delaqua Ricci et al.   PLoS Neglected Tropical Diseases

The domestic dog: man's best friend in the genomic era

(2011) Adam R Boyko   GENOME BIOLOGY

Man's Best Friend Becomes Biology's Best in Show: Genome Analyses in the Domestic Dog

(2010) Heidi G. Parker et al.   Annual Review of Genetics

Characterizing Ancylostoma caninum transcriptome and exploring nematode parasitic adaptation

(2010) Zhengyuan Wang et al.   BMC GENOMICS

The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an update

(2010) H. Okada et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Hookworms of dogs and cats as agents of cutaneous larva migrans

(2010) Dwight D. Bowman et al.   TRENDS IN PARASITOLOGY

Massively Parallel Sequencing and Analysis of the Necator americanus Transcriptome

(2010) Cinzia Cantacessi et al.   PLoS Neglected Tropical Diseases

The mitochondrial genomes of Ancylostoma caninum and Bunostomum phlebotomum – two hookworms of animal health and zoonotic importance

(2009) Aaron R Jex et al.   BMC GENOMICS

Helminth immunoregulation: The role of parasite secreted proteins in modulating host immunity

(2009) James P. Hewitson et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The mucosal response to secondary infection with Ancylostoma ceylanicum in hamsters immunized by abbreviated primary infection

(2009) L. ALKAZMI et al.   PARASITE IMMUNOLOGY

The Schistosomiasis Control Initiative (SCI): rationale, development and implementation from 2002–2008

(2009) A. FENWICK et al.   PARASITOLOGY

The Hookworm Tissue Inhibitor of Metalloproteases (Ac-TMP-1) Modifies Dendritic Cell Function and Induces Generation of CD4 and CD8 Suppressor T Cells

(2009) Carmen Cuéllar et al.   PLoS Neglected Tropical Diseases

Improved insights into the transcriptomes of the human hookworm Necator americanus — Fundamental and biotechnological implications

(2008) Elida M. Rabelo et al.   BIOTECHNOLOGY ADVANCES

Therapeutic potential of helminth soluble proteins in TNBS-induced colitis in mice

(2008) Nathalie E. Ruyssers et al.   INFLAMMATORY BOWEL DISEASES

Acetylcholine receptor subunit genes from Ancylostoma caninum: Altered transcription patterns associated with pyrantel resistance

(2008) Steven R. Kopp et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Helminth infections: the great neglected tropical diseases

(2008) Peter J. Hotez et al.   JOURNAL OF CLINICAL INVESTIGATION

Epidemiological and clinical characteristics of hookworm-related cutaneous larva migrans

(2008) Jörg Heukelbach et al.   LANCET INFECTIOUS DISEASES

Early stage-specific immune responses in primary experimental human hookworm infection

(2008) Stefan M. Geiger et al.   MICROBES AND INFECTION

Proteomics Analysis of the Excretory/Secretory Component of the Blood-feeding Stage of the Hookworm,Ancylostoma caninum

(2008) Jason Mulvenna et al.   MOLECULAR & CELLULAR PROTEOMICS

The secretome of the filarial parasite, Brugia malayi: Proteomic profile of adult excretory–secretory products

(2008) James P. Hewitson et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The genome of Brugia malayi — All worms are not created equal

(2008) Alan L. Scott et al.   PARASITOLOGY INTERNATIONAL

Parasites as probes for prehistoric human migrations?

(2008) Adauto Araujo et al.   TRENDS IN PARASITOLOGY

Identification of gender-regulated genes in Ancylostoma braziliense by real-time RT-PCR

(2008) Ana Flávia D.V. Costa et al.   VETERINARY PARASITOLOGY

PCR-based coprodiagnostic tools reveal dogs as reservoirs of zoonotic ancylostomiasis caused by Ancylostoma ceylanicum in temple communities in Bangkok

(2008) Rebecca J. Traub et al.   VETERINARY PARASITOLOGY

Transcriptional Changes in the Hookworm, Ancylostoma caninum, during the Transition from a Free-Living to a Parasitic Larva

(2008) Bennett J. D. Datu et al.   PLoS Neglected Tropical Diseases

Stage- and Gender-Specific Proteomic Analysis of Brugia malayi Excretory-Secretory Products

(2008) Yovany Moreno et al.   PLoS Neglected Tropical Diseases

Hookworm Vaccines

(2007) S. Plotkin et al.   CLINICAL INFECTIOUS DISEASES

The canine hookworm genome: Analysis and classification of Ancylostoma caninum survey sequences

(2007) Sahar Abubucker et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY