Immunity to gastrointestinal nematodes: mechanisms and myths

Tuning of Antigen Sensitivity by T Cell Receptor-Dependent Negative Feedback Controls T Cell Effector Function in Inflamed Tissues

(2014) Tetsuya Honda et al.   IMMUNITY

Oral Tolerance Can Be Established via Gap Junction Transfer of Fed Antigens from CX3CR1+ Macrophages to CD103+ Dendritic Cells

(2014) Elisa Mazzini et al.   IMMUNITY

Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection

(2014) Kara J Filbey et al.   IMMUNOLOGY AND CELL BIOLOGY

Goblet Cell-Derived Resistin-Like Molecule   Augments CD4+ T Cell Production of IFN-  and Infection-Induced Intestinal Inflammation

(2014) M. G. Nair et al.   JOURNAL OF IMMUNOLOGY

IL-33, a Potent Inducer of Adaptive Immunity to Intestinal Nematodes

(2014) N. E. Humphreys et al.   JOURNAL OF IMMUNOLOGY

Pathogen-Related Differences in the Abundance of Presented Antigen Are Reflected in CD4+ T Cell Dynamic Behavior and Effector Function in the Lung

(2014) P. Torabi-Parizi et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells Limit Induction of Protective Immunity and Promote Immune Pathology following Intestinal Helminth Infection

(2014) D. V. Sawant et al.   JOURNAL OF IMMUNOLOGY

Type 2 Innate Lymphoid Cells Drive CD4+ Th2 Cell Responses

(2014) A. S. Mirchandani et al.   JOURNAL OF IMMUNOLOGY

A role for the pattern recognition receptor Nod2 in promoting recruitment of CD103+ dendritic cells to the colon in response to Trichuris muris infection

(2014) R Bowcutt et al.   Mucosal Immunology

Whipworm genome and dual-species transcriptome analyses provide molecular insights into an intimate host-parasite interaction

(2014) Bernardo J Foth et al.   NATURE GENETICS

Role of Macrophages in the Altered Epithelial Function during a Type 2 Immune Response Induced by Enteric Nematode Infection

(2014) Luigi Notari et al.   PLoS One

Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity

(2014) S. P. Spencer et al.   SCIENCE

Inducible Deletion of CD28 Prior to Secondary Nippostrongylus brasiliensis Infection Impairs Worm Expulsion and Recall of Protective Memory CD4+ T Cell Responses

(2014) Hlumani Ndlovu et al.   PLoS Pathogens

Foxp3+ Regulatory T Cells Delay Expulsion of Intestinal Nematodes by Suppression of IL-9-Driven Mast Cell Activation in BALB/c but Not in C57BL/6 Mice

(2014) Birte Blankenhaus et al.   PLoS Pathogens

Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection

(2013) Hiramani Dhungana et al.   AGING CELL

Innate lymphoid cells and allergic inflammation

(2013) Brian S Kim et al.   CURRENT OPINION IN IMMUNOLOGY

Resident commensals shaping immunity

(2013) Deniz Erturk-Hasdemir et al.   CURRENT OPINION IN IMMUNOLOGY

Dendritic cell subsets in the intestinal lamina propria: Ontogeny and function

(2013) Emma K. Persson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

ICOS controls Foxp3+regulatory T-cell expansion, maintenance and IL-10 production during helminth infection

(2013) Stephen A. Redpath et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Thymic Stromal Lymphopoietin-Mediated Extramedullary Hematopoiesis Promotes Allergic Inflammation

(2013) Mark C. Siracusa et al.   IMMUNITY

Control of T Helper 2 Responses by Transcription Factor IRF4-Dependent Dendritic Cells

(2013) Yan Gao et al.   IMMUNITY

Participation of MyD88 and Interleukin-33 as Innate Drivers of Th2 Immunity to Trichinella spiralis

(2013) Lisa K. Scalfone et al.   INFECTION AND IMMUNITY

The skin is an important bulwark of acquired immunity against intestinal helminths

(2013) Kazushige Obata-Ninomiya et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

(2013) Stephen J. Jenkins et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A role for IL-25 and IL-33–driven type-2 innate lymphoid cells in atopic dermatitis

(2013) Maryam Salimi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFN- -Mediated Induction of an Apical IL-10 Receptor on Polarized Intestinal Epithelia

(2013) D. J. Kominsky et al.   JOURNAL OF IMMUNOLOGY

Type 2 innate lymphoid cells constitutively express arginase-I in the naïve and inflamed lung

(2013) Jennifer K. Bando et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lung-resident CD4+ T cells are sufficient for IL-4Rα-dependent recall immunity to Nippostrongylus brasiliensis infection

(2013) S G Thawer et al.   Mucosal Immunology

Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria

(2013) Matthew R. Hepworth et al.   NATURE

Type 2 innate lymphoid cells control eosinophil homeostasis

(2013) Jesse C. Nussbaum et al.   NATURE

TH2, allergy and group 2 innate lymphoid cells

(2013) Paula Licona-Limón et al.   NATURE IMMUNOLOGY

Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1

(2013) Chauncey J Spooner et al.   NATURE IMMUNOLOGY

The role of the immune system in governing host-microbe interactions in the intestine

(2013) Eric M Brown et al.   NATURE IMMUNOLOGY

Trichuris muris research revisited: a journey through time

(2013) REBECCA J. M. HURST et al.   PARASITOLOGY

Requirement for Core 2 O-Glycans for Optimal Resistance to Helminth Infection

(2013) Sarah C. Mullaly et al.   PLoS One

Macrophages as IL-25/IL-33-Responsive Cells Play an Important Role in the Induction of Type 2 Immunity

(2013) Zhonghan Yang et al.   PLoS One

Small Intestinal Nematode Infection of Mice Is Associated with Increased Enterobacterial Loads alongside the Intestinal Tract

(2013) Sebastian Rausch et al.   PLoS One

Patent Human Infections with the Whipworm, Trichuris trichiura, Are Not Associated with Alterations in the Faecal Microbiota

(2013) Philip Cooper et al.   PLoS One

Regulation of the immune system by biodiversity from the natural environment: An ecosystem service essential to health

(2013) G. A. Rook   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

(2013) M. Shan et al.   SCIENCE

Special aspects of interleukin-33 and the IL-33 receptor complex

(2013) Michael U. Martin   SEMINARS IN IMMUNOLOGY

Controlling the frontier: Regulatory T-cells and intestinal homeostasis

(2013) Julia Bollrath et al.   SEMINARS IN IMMUNOLOGY

Intestinal macrophages: well educated exceptions from the rule

(2013) Ehud Zigmond et al.   TRENDS IN IMMUNOLOGY

Loss of the TGFβ-Activating Integrin αvβ8 on Dendritic Cells Protects Mice from Chronic Intestinal Parasitic Infection via Control of Type 2 Immunity

(2013) John J. Worthington et al.   PLoS Pathogens

Immune Regulation during Helminth Infections

(2013) Natasha M. Girgis et al.   PLoS Pathogens

IL-22 Mediates Goblet Cell Hyperplasia and Worm Expulsion in Intestinal Helminth Infection

(2013) Jan-Eric Turner et al.   PLoS Pathogens

IL-1β Suppresses Innate IL-25 and IL-33 Production and Maintains Helminth Chronicity

(2013) Mario M. Zaiss et al.   PLoS Pathogens

Development of CD4 T Cell Dependent Immunity Against N. brasiliensis Infection

(2013) Marina Harvie et al.   Frontiers in Immunology

The Microbiome in Infectious Disease and Inflammation

(2012) Kenya Honda et al.   Annual Review of Immunology

Immunoregulation by the gut microbiota

(2012) Junko Nishio et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rapid and specific alterations of goblet cell mucin in rat airway and small intestine associated with resistance against Nippostrongylus brasiliensis reinfection

(2012) Daigo Tsubokawa et al.   EXPERIMENTAL PARASITOLOGY

Epithelial Cell-Specific Act1 Adaptor Mediates Interleukin-25-Dependent Helminth Expulsion through Expansion of Lin−c-Kit+ Innate Cell Population

(2012) Zizhen Kang et al.   IMMUNITY

Regulation of TGFβ in the immune system: An emerging role for integrins and dendritic cells

(2012) John J. Worthington et al.   IMMUNOBIOLOGY

Alterations in the Porcine Colon Microbiota Induced by the Gastrointestinal Nematode Trichuris suis

(2012) Robert W. Li et al.   INFECTION AND IMMUNITY

A role for IL-22 in the relationship between intestinal helminths, gut microbiota and mucosal immunity

(2012) Jacqueline M. Leung et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection

(2012) Marsha Wills-Karp et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Thymic Stromal Lymphopoietin-Dependent Basophils Promote Th2 Cytokine Responses following Intestinal Helminth Infection

(2012) Paul R. Giacomin et al.   JOURNAL OF IMMUNOLOGY

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

(2012) Jeremiah R. McDole et al.   NATURE

Transcription factor RORα is critical for nuocyte development

(2012) See Heng Wong et al.   NATURE IMMUNOLOGY

Worm Burden-Dependent Disruption of the Porcine Colon Microbiota by Trichuris suis Infection

(2012) Sitao Wu et al.   PLoS One

Mast cells orchestrate type 2 immunity to helminths through regulation of tissue-derived cytokines

(2012) M. R. Hepworth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms

(2012) L.-Y. Hung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice

(2012) K. Yasuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus

(2012) Lisa A. Reynolds et al.   Seminars in Immunopathology

Trichuris muris: a model of gastrointestinal parasite infection

(2012) Joanna E. Klementowicz et al.   Seminars in Immunopathology

Life on the edge: the balance between macrofauna, microflora and host immunity

(2012) Allison J. Bancroft et al.   TRENDS IN PARASITOLOGY

Serine Protease(s) Secreted by the Nematode Trichuris muris Degrade the Mucus Barrier

(2012) Sumaira Z. Hasnain et al.   PLoS Neglected Tropical Diseases

Therapeutic Helminth Infection of Macaques with Idiopathic Chronic Diarrhea Alters the Inflammatory Signature and Mucosal Microbiota of the Colon

(2012) Mara Jana Broadhurst et al.   PLoS Pathogens

Basophils in allergic immune responses

(2011) David Voehringer   CURRENT OPINION IN IMMUNOLOGY

Modulation of immune homeostasis by commensal bacteria

(2011) Ivaylo I Ivanov et al.   CURRENT OPINION IN MICROBIOLOGY

γδ T cells play a protective role during infection with Nippostrongylus brasiliensis by promoting goblet cell function in the small intestine

(2011) Kyoko Inagaki-Ohara et al.   IMMUNOLOGY

Functional relevance of T helper 17 (Th17) cells and the IL-17 cytokine family in inflammatory bowel disease

(2011) Gheorghe Hundorfean et al.   INFLAMMATORY BOWEL DISEASES

Muc5ac: a critical component mediating the rejection of enteric nematodes

(2011) Sumaira Z. Hasnain et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Strongyloides ratti Infection Induces Expansion of Foxp3 + Regulatory T Cells That Interfere with Immune Response and Parasite Clearance in BALB/c Mice

(2011) Birte Blankenhaus et al.   JOURNAL OF IMMUNOLOGY

Chronic Helminth Infection Promotes Immune Regulation In Vivo through Dominance of CD11cloCD103- Dendritic Cells

(2011) K. A. Smith et al.   JOURNAL OF IMMUNOLOGY

Basophils in immune responses against helminths

(2011) David Voehringer   MICROBES AND INFECTION

Mucin dynamics and enteric pathogens

(2011) Michael A. McGuckin et al.   NATURE REVIEWS MICROBIOLOGY

Arginase-1-expressing macrophages are dispensable for resistance to infection with the gastrointestinal helminth Trichuris muris

(2011) R. BOWCUTT et al.   PARASITE IMMUNOLOGY

The IL-33/ST2 pathway — A new therapeutic target in cardiovascular disease

(2011) Ashley M. Miller et al.   PHARMACOLOGY & THERAPEUTICS

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Chronic Helminth Infections Protect Against Allergic Diseases by Active Regulatory Processes

(2010) Hermelijn H. Smits et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Helminths and dendritic cells: Sensing and regulating via pattern recognition receptors, Th2 and Treg responses

(2010) Bart Everts et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T cells in human geohelminth infection suppress immune responses to BCG andPlasmodium falciparum

(2010) Linda J. Wammes et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mucin Gene Deficiency in Mice Impairs Host Resistance to an Enteric Parasitic Infection

(2010) Sumaira Z. Hasnain et al.   GASTROENTEROLOGY

Colonic transcriptional profiling in resistance and susceptibility to trichuriasis

(2010) S. E. Levison et al.   INFLAMMATORY BOWEL DISEASES

Alteration of the murine gut microbiota during infection with the parasitic helminth Heligmosomoides polygyrus

(2010) Seth T. Walk et al.   INFLAMMATORY BOWEL DISEASES

Polyparasitism and its impact on the immune system

(2010) Taniawati Supali et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway

(2010) John R. Grainger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chronic Systemic Infection Exacerbates Ischemic Brain Damage via a CCL5 (Regulated on Activation, Normal T-Cell Expressed and Secreted)-Mediated Proinflammatory Response in Mice

(2010) A. Denes et al.   JOURNAL OF NEUROSCIENCE

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses

(2010) Steven A. Saenz et al.   NATURE

Sensing the outside world: TSLP regulates barrier immunity

(2010) Steven F Ziegler et al.   NATURE IMMUNOLOGY

Changes in the mucosal barrier during acute and chronic Trichuris muris infection

(2010) S. Z. HASNAIN et al.   PARASITE IMMUNOLOGY

Accumulation of eosinophils in intestine-draining mesenteric lymph nodes occurs after Trichuris muris infection

(2010) M. SVENSSON et al.   PARASITE IMMUNOLOGY

Regulation of colonic epithelial cell turnover by IDO contributes to the innate susceptibility of SCID mice to Trichuris muris infection

(2010) L. V. BELL et al.   PARASITE IMMUNOLOGY

Systemically dispersed innate IL-13-expressing cells in type 2 immunity

(2010) A. E. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploitation of the Intestinal Microflora by the Parasitic Nematode Trichuris muris

(2010) K. S. Hayes et al.   SCIENCE

Innate immune cell populations function as initiators and effectors in Th2 cytokine responses

(2010) Steven A. Saenz et al.   TRENDS IN IMMUNOLOGY

Expulsion of Trichuris muris is associated with increased expression of angiogenin 4 in the gut and increased acidity of mucins within the goblet cell

(2009) Riccardo D'Elia et al.   BMC GENOMICS

Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3+cells

(2009) Sebastian Rausch et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T-cell-specific deletion of gp130 renders the highly susceptible IL-10-deficient mouse resistant to intestinal nematode infection

(2009) Nicolas Fasnacht et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-1-dependent, IL-1R1-independent resistance to gastrointestinal nematodes

(2009) Neil E. Humphreys et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Role of T cell TGF-β signaling in intestinal cytokine responses and helminthic immune modulation

(2009) M. Nedim Ince et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dynamics of CD11c+ dendritic cell subsets in lymph nodes draining the site of intestinal nematode infection

(2009) Adam Balic et al.   IMMUNOLOGY LETTERS

Intestinal epithelial cell secretion of RELM-β protects against gastrointestinal worm infection

(2009) De'Broski R. Herbert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis

(2009) Betsy C. Taylor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Disruption of Th2 Immunity Results in a Gender-Specific Expansion of IL-13 Producing Accessory NK Cells during Helminth Infection

(2009) M. R. Hepworth et al.   JOURNAL OF IMMUNOLOGY

Rapid Dendritic Cell Mobilization to the Large Intestinal Epithelium Is Associated with Resistance to Trichuris muris Infection

(2009) S. M. Cruickshank et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells: A Role in the Control of Helminth-Driven Intestinal Pathology and Worm Survival

(2009) R. D'Elia et al.   JOURNAL OF IMMUNOLOGY

Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

(2009) Kazuyo Moro et al.   NATURE

Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function

(2009) J. C. Massacand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of basophils in helminth infection

(2009) David Voehringer   TRENDS IN PARASITOLOGY

Functional Analysis of Effector and Regulatory T Cells in a Parasitic Nematode Infection

(2008) S. Rausch et al.   INFECTION AND IMMUNITY

Mucins in the mucosal barrier to infection

(2008) S K Linden et al.   Mucosal Immunology