Hookworm infection

New Vaccines for the World's Poorest People

(2016) Peter J. Hotez et al.   Annual Review of Medicine

The Global Burden of Anemia

(2016) Nicholas J. Kassebaum   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Immune polarization by hookworms: taking cues from T helper type 2, type 2 innate lymphoid cells and alternatively activated macrophages

(2016) Meera G. Nair et al.   IMMUNOLOGY

Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

(2016) François Gerbe et al.   NATURE

Efficacy and reinfection with soil-transmitted helminths 18-weeks post-treatment with albendazole-ivermectin, albendazole-mebendazole, albendazole-oxantel pamoate and mebendazole

(2016) Benjamin Speich et al.   Parasites & Vectors

Multi-parallel qPCR provides increased sensitivity and diagnostic breadth for gastrointestinal parasites of humans: field-based inferences on the impact of mass deworming

(2016) Alice V. Easton et al.   Parasites & Vectors

Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma

(2016) S. Navarro et al.   Science Translational Medicine

Modeling the economic and epidemiologic impact of hookworm vaccine and mass drug administration (MDA) in Brazil, a high transmission setting

(2016) Sarah M. Bartsch et al.   VACCINE

Advancing a vaccine to prevent hookworm disease and anemia

(2016) Peter J. Hotez et al.   VACCINE

Human anthelminthic vaccines: Rationale and challenges

(2016) Peter J. Hotez et al.   VACCINE

Productivity Loss Related to Neglected Tropical Diseases Eligible for Preventive Chemotherapy: A Systematic Literature Review

(2016) Edeltraud J. Lenk et al.   PLoS Neglected Tropical Diseases

The Global Economic and Health Burden of Human Hookworm Infection

(2016) Sarah M. Bartsch et al.   PLoS Neglected Tropical Diseases

The Hygiene Hypothesis and Its Inconvenient Truths about Helminth Infections

(2016) Neima Briggs et al.   PLoS Neglected Tropical Diseases

Human helminth therapy to treat inflammatory disorders- where do we stand?

(2015) Helena Helmby   BMC IMMUNOLOGY

The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation

(2015) Mario M. Zaiss et al.   IMMUNITY

Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease

(2015) John Croese et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015)   LANCET

What impact will the achievement of the current World Health Organisation targets for anthelmintic treatment coverage in children have on the intensity of soil transmitted helminth infections?

(2015) JE Truscott et al.   Parasites & Vectors

Identification of human intestinal parasites affecting an asymptomatic peri-urban Argentinian population using multi-parallel quantitative real-time polymerase chain reaction

(2015) Rubén O. Cimino et al.   Parasites & Vectors

Feasibility of controlling hookworm infection through preventive chemotherapy: a simulation study using the individual-based WORMSIM modelling framework

(2015) Luc E. Coffeng et al.   Parasites & Vectors

An economic evaluation of expanding hookworm control strategies to target the whole community

(2015) Hugo C. Turner et al.   Parasites & Vectors

Infection with Soil-Transmitted Helminths Is Associated with Increased Insulin Sensitivity

(2015) Aprilianto E. Wiria et al.   PLoS One

Helminth infection, fecundity, and age of first pregnancy in women

(2015) A. D. Blackwell et al.   SCIENCE

Experimental hookworm infection and escalating gluten challenges are associated with increased microbial richness in celiac subjects

(2015) Paul Giacomin et al.   Scientific Reports

Expression, purification, and characterization of theNecator americanusaspartic protease-1 (Na-APR-1 (M74)) antigen, a component of the bivalent human hookworm vaccine

(2015) Christopher A Seid et al.   Human Vaccines & Immunotherapeutics

Assessment of Efficacy and Quality of Two Albendazole Brands Commonly Used against Soil-Transmitted Helminth Infections in School Children in Jimma Town, Ethiopia

(2015) Sileshi Belew et al.   PLoS Neglected Tropical Diseases

Randomized, Controlled, Assessor-Blind Clinical Trial To Assess the Efficacy of Single- versus Repeated-Dose Albendazole To Treat Ascaris lumbricoides, Trichuris trichiura, and Hookworm Infection

(2014) A. A. Adegnika et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases

(2014) Sandeep Chhabra et al.   FASEB JOURNAL

Use of an Sm-p80-Based Therapeutic Vaccine to Kill Established Adult Schistosome Parasites in Chronically Infected Baboons

(2014) S. Karmakar et al.   JOURNAL OF INFECTIOUS DISEASES

Impact of Experimental Hookworm Infection on the Human Gut Microbiota

(2014) Cinzia Cantacessi et al.   JOURNAL OF INFECTIOUS DISEASES

Controlling Soil-Transmitted Helminths: Time to Think Inside the Box?

(2014) John M. Hawdon   JOURNAL OF PARASITOLOGY

Helminth therapy or elimination: epidemiological, immunological, and clinical considerations

(2014) Linda J Wammes et al.   LANCET INFECTIOUS DISEASES

Genome of the human hookworm Necator americanus

(2014) Yat T Tang et al.   NATURE GENETICS

Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion

(2014) Fei Chen et al.   NATURE IMMUNOLOGY

Global numbers of infection and disease burden of soil transmitted helminth infections in 2010

(2014) Rachel L Pullan et al.   Parasites & Vectors

Application of PCR-based methods for diagnosis of intestinal parasitic infections in the clinical laboratory

(2014) JACO J. VERWEIJ   PARASITOLOGY

Host protective roles of type 2 immunity: Parasite killing and tissue repair, flip sides of the same coin

(2014) Judith E. Allen et al.   SEMINARS IN IMMUNOLOGY

Do shoes reduce hookworm infection in school-aged children on Pemba Island, Zanzibar? A pragmatic trial

(2014) C. Bird et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Water, Sanitation, Hygiene, and Soil-Transmitted Helminth Infection: A Systematic Review and Meta-Analysis

(2014) Eric C. Strunz et al.   PLOS MEDICINE

Health-Related Quality of Life among School Children with Parasitic Infections: Findings from a National Cross-Sectional Survey in Côte d'Ivoire

(2014) Eveline Hürlimann et al.   PLoS Neglected Tropical Diseases

Risk Factors for Soil-Transmitted Helminth Infections during the First 3 Years of Life in the Tropics; Findings from a Birth Cohort

(2014) Stefanie K. Menzies et al.   PLoS Neglected Tropical Diseases

Micronutrient Supplementation and Deworming in Children with Geohelminth Infections

(2014) Selvi Rajagopal et al.   PLoS Neglected Tropical Diseases

Helminth Colonization Is Associated with Increased Diversity of the Gut Microbiota

(2014) Soo Ching Lee et al.   PLoS Neglected Tropical Diseases

Advances with the Chinese anthelminthic drug tribendimidine in clinical trials and laboratory investigations

(2013) Shu-Hua Xiao et al.   ACTA TROPICA

Rapid Re-Infection with Soil-Transmitted Helminths after Triple-Dose Albendazole Treatment of School-Aged Children in Yunnan, People's Republic of China

(2013) Peiling Yap et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Hookworm Excretory/Secretory Products Induce Interleukin-4 (IL-4)+IL-10+CD4+T Cell Responses and Suppress Pathology in a Mouse Model of Colitis

(2013) Ivana Ferreira et al.   INFECTION AND IMMUNITY

Ancylostoma ceylanicum, a re-emerging but neglected parasitic zoonosis

(2013) Rebecca J. Traub   INTERNATIONAL JOURNAL FOR PARASITOLOGY

The skin is an important bulwark of acquired immunity against intestinal helminths

(2013) Kazushige Obata-Ninomiya et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Health-Education Package to Prevent Worm Infections in Chinese Schoolchildren

(2013) Franziska A. Bieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Helminth Infections

(2013) Peter Hotez et al.   OBSTETRICS AND GYNECOLOGY

Risk Factors Associated with the Development of Atopic Sensitization in Indonesia

(2013) Firdaus Hamid et al.   PLoS One

Phylogenetic Characterization of β-Tubulins and Development of Pyrosequencing Assays for Benzimidazole Resistance in Cattle Nematodes

(2013) Janina Demeler et al.   PLoS One

Prevalence, Types, Risk Factors and Clinical Correlates of Anaemia in Older People in a Rural Ugandan Population

(2013) Joseph O. Mugisha et al.   PLoS One

Mini-FLOTAC, an Innovative Direct Diagnostic Technique for Intestinal Parasitic Infections: Experience from the Field

(2013) Beatrice Divina Barda et al.   PLoS Neglected Tropical Diseases

Activity of Oxantel Pamoate Monotherapy and Combination Chemotherapy against Trichuris muris and Hookworms: Revival of an Old Drug

(2013) Jennifer Keiser et al.   PLoS Neglected Tropical Diseases

Impact of Six Rounds of Mass Drug Administration on Brugian Filariasis and Soil-Transmitted Helminth Infections in Eastern Indonesia

(2013) Taniawati Supali et al.   PLoS Neglected Tropical Diseases

How Effective Is School-Based Deworming for the Community-Wide Control of Soil-Transmitted Helminths?

(2013) Roy M. Anderson et al.   PLoS Neglected Tropical Diseases

Association between Response to Albendazole Treatment and β-Tubulin Genotype Frequencies in Soil-transmitted Helminths

(2013) Aïssatou Diawara et al.   PLoS Neglected Tropical Diseases

Microbial Translocation Across the GI Tract

(2012) Jason M. Brenchley et al.   Annual Review of Immunology

The hookworm pharmacopoeia for inflammatory diseases

(2012) Severine Navarro et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Generalized urticaria induced by the Na-ASP-2 hookworm vaccine: Implications for the development of vaccines against helminths

(2012) David J. Diemert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inflammatory bowel disease in Asia: A systematic review

(2012) Lani Prideaux et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus

(2012) Lisa A. Reynolds et al.   Seminars in Immunopathology

Effect of Sanitation on Soil-Transmitted Helminth Infection: Systematic Review and Meta-Analysis

(2012) Kathrin Ziegelbauer et al.   PLOS MEDICINE

Low Efficacy of Single-Dose Albendazole and Mebendazole against Hookworm and Effect on Concomitant Helminth Infection in Lao PDR

(2012) Phonepasong Ayé Soukhathammavong et al.   PLoS Neglected Tropical Diseases

Evidence of Microbial Translocation Associated with Perturbations in T Cell and Antigen-Presenting Cell Homeostasis in Hookworm Infections

(2012) Palakkal Jovvian George et al.   PLoS Neglected Tropical Diseases

Mechanistic and Single-Dose In Vivo Therapeutic Studies of Cry5B Anthelmintic Action against Hookworms

(2012) Yan Hu et al.   PLoS Neglected Tropical Diseases

Characterising the Mucosal and Systemic Immune Responses to Experimental Human Hookworm Infection

(2012) Soraya Gaze et al.   PLoS Pathogens

Assessing the Impact of a School-based Safe Water Intervention on Household Adoption of Point-of-Use Water Treatment Practices in Southern India

(2011) Matthew C. Freeman et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Epidemiology of Hookworm Infection in Kintampo North Municipality, Ghana: Patterns of Malaria Coinfection, Anemia, and Albendazole Treatment Failure

(2011) Debbie Humphries et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Ancylostoma caninum: Calibration and comparison of diagnostic accuracy of flotation in tube, McMaster and FLOTAC in faecal samples of dogs

(2011) Giuseppe Cringoli et al.   EXPERIMENTAL PARASITOLOGY

Hookworm products ameliorate dextran sodium sulfate-induced colitis in BALB/c mice

(2011) Guilherme Grossi Lopes Cançado et al.   INFLAMMATORY BOWEL DISEASES

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

Vaccinomics for the Major Blood Feeding Helminths of Humans

(2011) Alex Loukas et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Effect of Hookworm Infection on Wheat Challenge in Celiac Disease – A Randomised Double-Blinded Placebo Controlled Trial

(2011) A. James Daveson et al.   PLoS One

Efficacy of Single-Dose and Triple-Dose Albendazole and Mebendazole against Soil-Transmitted Helminths and Taenia spp.: A Randomized Controlled Trial

(2011) Peter Steinmann et al.   PLoS One

Life Quality Impairment Caused by Hookworm-Related Cutaneous Larva Migrans in Resource-Poor Communities in Manaus, Brazil

(2011) Angela Schuster et al.   PLoS Neglected Tropical Diseases

A Comparison of the Sensitivity and Fecal Egg Counts of the McMaster Egg Counting and Kato-Katz Thick Smear Methods for Soil-Transmitted Helminths

(2011) Bruno Levecke et al.   PLoS Neglected Tropical Diseases

Induction of CD4+CD25+FOXP3+ Regulatory T Cells during Human Hookworm Infection Modulates Antigen-Mediated Lymphocyte Proliferation

(2011) Natasha Delaqua Ricci et al.   PLoS Neglected Tropical Diseases

Assessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemic

(2011) Jozef Vercruysse et al.   PLoS Neglected Tropical Diseases

Blunting the knife: development of vaccines targeting digestive proteases of blood-feeding helminth parasites

(2010) Mark S. Pearson et al.   BIOLOGICAL CHEMISTRY

Impact on diarrhoeal illness of a community educational intervention to improve drinking water quality in rural communities in Puerto Rico

(2010) Paul R Hunter et al.   BMC PUBLIC HEALTH

Experimental hookworm infection: a randomized placebo-controlled trial in asthma

(2010) J. R. Feary et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Molecular Cloning, Biochemical Characterization, and Partial Protective Immunity of the Heme-Binding Glutathione S-Transferases from the Human Hookworm Necator americanus

(2010) B. Zhan et al.   INFECTION AND IMMUNITY

Water, sanitation and hygiene for the prevention of diarrhoea

(2010) Sandy Cairncross et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

The mucosal response of hamsters to a low-intensity superimposed secondary infection with the hookworm Ancylostoma ceylanicum

(2010) L.M.M. Alkazmi et al.   JOURNAL OF HELMINTHOLOGY

Developing vaccines to combat hookworm infection and intestinal schistosomiasis

(2010) Peter J. Hotez et al.   NATURE REVIEWS MICROBIOLOGY

Hookworm Control as a Strategy to Prevent Iron Deficiency

(2010) Rebecca J. Stoltzfus et al.   NUTRITION REVIEWS

Self-rated quality of life and school performance in relation to helminth infections: case study from Yunnan, People's Republic of China

(2010) Kathrin Ziegelbauer et al.   Parasites & Vectors

Discovery of a highly synergistic anthelmintic combination that shows mutual hypersusceptibility

(2010) Y. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hookworms of dogs and cats as agents of cutaneous larva migrans

(2010) Dwight D. Bowman et al.   TRENDS IN PARASITOLOGY

Impact of hookworm infection and deworming on anaemia in non-pregnant populations: a systematic review

(2010) Jennifer L. Smith et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Immunologic Profiles of Persons Recruited for a Randomized, Placebo-Controlled Clinical Trial of Hookworm Infection

(2009) Daniel Blount et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

A spot-check of the efficacies of albendazole or levamisole, against soil-transmitted helminthiases in young Ungujan children, reveals low frequencies of cure

(2009) J. R. Stothard et al.   ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY

Safety of hookworm infection in individuals with measurable airway responsiveness: a randomized placebo-controlled feasibility study

(2009) J. Feary et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Antigen-driven basophil activation is indicative of early Necator americanus infection in IgE-seronegative patients

(2009) Franco H. Falcone et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Proteolytic Degradation of Hemoglobin in the Intestine of the Human HookwormNecator americanus

(2009) Najju Ranjit et al.   JOURNAL OF INFECTIOUS DISEASES

Does Deworming Improve Growth and School Performance in Children?

(2009) David Taylor-Robinson et al.   PLoS Neglected Tropical Diseases

Geohelminth infections: a review of the role of IgE and assessment of potential risks of anti-IgE treatment

(2008) P. J. Cooper et al.   ALLERGY

Hookworm and Poverty

(2008) Peter Hotez   Annals of the New York Academy of Sciences

Multivalent anthelminthic vaccine to prevent hookworm and schistosomiasis

(2008) Peter J Hotez et al.   Expert Review of Vaccines

Review series on helminths, immune modulation and the hygiene hypothesis: Immunity against helminths and immunological phenomena in modern human populations: coevolutionary legacies?

(2008) Joseph A. Jackson et al.   IMMUNOLOGY

Therapeutic potential of helminth soluble proteins in TNBS-induced colitis in mice

(2008) Nathalie E. Ruyssers et al.   INFLAMMATORY BOWEL DISEASES

Efficacy of Current Drugs Against Soil-Transmitted Helminth Infections

(2008) Jennifer Keiser et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Early stage-specific immune responses in primary experimental human hookworm infection

(2008) Stefan M. Geiger et al.   MICROBES AND INFECTION

Proteomics Analysis of the Excretory/Secretory Component of the Blood-feeding Stage of the Hookworm,Ancylostoma caninum

(2008) Jason Mulvenna et al.   MOLECULAR & CELLULAR PROTEOMICS

Mucosal antibody responses in experimental hookworm infection

(2008) R. D. BUNGIRO et al.   PARASITE IMMUNOLOGY

Hookworm,Ascaris lumbricoidesinfection and polyparasitism associated with poor cognitive performance in Brazilian schoolchildren

(2008) Anne Jardim-Botelho et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Tropical Anemia: One of Africa's Great Killers and a Rationale for Linking Malaria and Neglected Tropical Disease Control to Achieve a Common Goal

(2008) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases

Tribendimidine and Albendazole for Treating Soil-Transmitted Helminths, Strongyloides stercoralis and Taenia spp.: Open-Label Randomized Trial

(2008) Peter Steinmann et al.   PLoS Neglected Tropical Diseases

Hookworm-Related Anaemia among Pregnant Women: A Systematic Review

(2008) Simon Brooker et al.   PLoS Neglected Tropical Diseases

The evaluation of recombinant hookworm antigens as vaccines in hamsters (Mesocricetus auratus) challenged with human hookworm, Necator americanus

(2007) Shuhua Xiao et al.   EXPERIMENTAL PARASITOLOGY