Targeting the Endoplasmic Reticulum Unfolded Protein Response to Counteract the Oxidative Stress-Induced Endothelial Dysfunction

Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases

(2018) Maria Angela Incalza et al.   VASCULAR PHARMACOLOGY

Physiological/pathological ramifications of transcription factors in the unfolded protein response

(2017) Jaeseok Han et al.   GENES & DEVELOPMENT

Regulation of Calcium Homeostasis by ER Redox: A Close-Up of the ER/Mitochondria Connection

(2017) Alexander L. Chernorudskiy et al.   JOURNAL OF MOLECULAR BIOLOGY

Protective effects of hydrogen sulfide against angiotensin II-induced endoplasmic reticulum stress in HUVECs

(2017) Heng-Jing Hu et al.   Molecular Medicine Reports

Regulating Secretory Proteostasis through the Unfolded Protein Response: From Function to Therapy

(2017) Lars Plate et al.   TRENDS IN CELL BIOLOGY

The Endoplasmic Reticulum Unfolded Protein Response in Neurodegenerative Disorders and Its Potential Therapeutic Significance

(2017) Paolo Remondelli et al.   Frontiers in Molecular Neuroscience

Curcumin Improves Palmitate-Induced Insulin Resistance in Human Umbilical Vein Endothelial Cells by Maintaining Proteostasis in Endoplasmic Reticulum

(2017) Mao Ye et al.   Frontiers in Pharmacology

Endothelial cells, endoplasmic reticulum stress and oxysterols

(2017) F. Luchetti et al.   Redox Biology

Piceatannol attenuates homocysteine-induced endoplasmic reticulum stress and endothelial cell damage via heme oxygenase-1 expression

(2016) Jin-Sang Kil et al.   AMINO ACIDS

Paeonol protects against endoplasmic reticulum stress-induced endothelial dysfunction via AMPK/PPARδ signaling pathway

(2016) Ker-Woon Choy et al.   BIOCHEMICAL PHARMACOLOGY

Salidroside protects against homocysteine-induced injury in human umbilical vein endothelial cells via the regulation of endoplasmic reticulum stress

(2016) Lin Zhu et al.   Cardiovascular Therapeutics

Identification of a microRNA (miR-663a) induced by ER stress and its target gene PLOD3 by a combined microRNome and proteome approach

(2016) Giuseppina Amodio et al.   CELL BIOLOGY AND TOXICOLOGY

Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load

(2016) L. K. Walsh et al.   CLINICAL SCIENCE

Endothelium-Derived Hyperpolarizing Factors: A Potential Therapeutic Target for Vascular Dysfunction in Obesity and Insulin Resistance

(2016) Guanghong Jia et al.   DIABETES

Inhibition of endoplasmic reticulum stress improves coronary artery function in type 2 diabetic mice

(2016) Soo-Kyoung Choi et al.   EXPERIMENTAL PHYSIOLOGY

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Inhibition of endoplasmic reticulum stress improves coronary artery function in the spontaneously hypertensive rats

(2016) Soo-Kyoung Choi et al.   Scientific Reports

Homocysteine-Induced Endothelial Dysfunction

(2015) Wai Keung Christopher Lai et al.   ANNALS OF NUTRITION AND METABOLISM

ER stress mediates homocysteine-induced endothelial dysfunction: Modulation of IKCa and SKCa channels

(2015) Xiang-Chong Wang et al.   ATHEROSCLEROSIS

Berberine improves endothelial function by inhibiting endoplasmic reticulum stress in the carotid arteries of spontaneously hypertensive rats

(2015) Limei Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endoplasmic reticulum stress involved in high-fat diet and palmitic acid-induced vascular damages and fenofibrate intervention

(2015) Yunxia Lu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and AngiogenesisNovelty and Significance

(2015) Francesco Villa et al.   CIRCULATION RESEARCH

Endoplasmic reticulum stress and Nrf2 signaling in cardiovascular diseases

(2015) Luciano Cominacini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium

(2015) Yan Zhao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction

(2015) Jia Li et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein/NLRP3 inflammasome activation with regulation of AMPK in endothelial cells

(2015) Junna Song et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Salubrinal protects cardiomyocytes against apoptosis in a rat myocardial infarction model via suppressing the dephosphorylation of eukaryotic translation initiation factor 2α

(2015) RUI-JUN LI et al.   Molecular Medicine Reports

Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?

(2015) Yan He et al.   MOLECULES

Ilexgenin A inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP/NLRP3 inflammasome activation in an AMPK dependent manner

(2015) Yi Li et al.   PHARMACOLOGICAL RESEARCH

Black tea protects against hypertension-associated endothelial dysfunction through alleviation of endoplasmic reticulum stress

(2015) Wai San Cheang et al.   Scientific Reports

Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease

(2014) Stewart Siyan Cao et al.   ANTIOXIDANTS & REDOX SIGNALING

Metformin Protects Endothelial Function in Diet-Induced Obese Mice by Inhibition of Endoplasmic Reticulum Stress Through 5′ Adenosine Monophosphate–Activated Protein Kinase–Peroxisome Proliferator–Activated Receptor δ Pathway

(2014) Wai San Cheang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Ox-LDL induces endothelial cell apoptosis via the LOX-1-dependent endoplasmic reticulum stress pathway

(2014) Dan Hong et al.   ATHEROSCLEROSIS

Pathophysiology of circulating xanthine oxidoreductase: New emerging roles for a multi-tasking enzyme

(2014) Maria Giulia Battelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

New functions of mitochondria associated membranes in cellular signaling

(2014) Alexander R. van Vliet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction

(2014) Maria Galán et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Sugarcoating ER Stress

(2014) Lisa Vincenz et al.   CELL

Isoform- and Species-specific Control of Inositol 1,4,5-Trisphosphate (IP3) Receptors by Reactive Oxygen Species

(2014) Száva Bánsághi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox controls UPR to control redox

(2014) D. Eletto et al.   JOURNAL OF CELL SCIENCE

Endoplasmic Reticulum Stress-Activated Transcription Factor ATF6  Requires the Disulfide Isomerase PDIA5 To Modulate Chemoresistance

(2014) A. Higa et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein Disulfide Isomerase A6 Controls the Decay of IRE1α Signaling via Disulfide-Dependent Association

(2014) Davide Eletto et al.   MOLECULAR CELL

The Urokinase Receptor Takes Control of Cell Migration by Recruiting Integrins and FPR1 on the Cell Surface

(2014) Anna Gorrasi et al.   PLoS One

Getting RIDD of RNA: IRE1 in cell fate regulation

(2014) M. Maurel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Stress-responsive regulation of mitochondria through the ER unfolded protein response

(2014) T. Kelly Rainbolt et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death

(2014) S Win et al.   Cell Death & Disease

Mitochondria, endothelial cell function, and vascular diseases

(2014) Xiaoqiang Tang et al.   Frontiers in Physiology

Suppression of endoplasmic reticulum stress improves endothelium-dependent contractile responses in aorta of the spontaneously hypertensive rat

(2013) Kathryn M. Spitler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Aberrant Endoplasmic Reticulum Stress in Vascular Smooth Muscle Increases Vascular Contractility and Blood Pressure in Mice Deficient of AMP-Activated Protein Kinase-α2 In Vivo

(2013) Bin Liang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of inositol 1,4,5-trisphosphate receptors during endoplasmic reticulum stress

(2013) Santeri Kiviluoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Reduced Endoplasmic Reticulum Stress Might Alter the Course of Heart Failure Via Caspase-12 and JNK Pathways

(2013) Yu Liu et al.   CANADIAN JOURNAL OF CARDIOLOGY

Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity

(2013) C. Atkins et al.   CANCER RESEARCH

Nrf2 and Nrf1 signaling and ER stress crosstalk: implication for proteasomal degradation and autophagy

(2013) Hadi Digaleh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting endoplasmic reticulum stress in metabolic disease

(2013) Stewart Siyan Cao et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Endoplasmic Reticulum stress reduces COPII vesicle formation and modifies Sec23a cycling at ERESs

(2013) Giuseppina Amodio et al.   FEBS LETTERS

Linking endothelial dysfunction with endothelial cell activation

(2013) James K. Liao   JOURNAL OF CLINICAL INVESTIGATION

Targeting the unfolded protein response in disease

(2013) Claudio Hetz et al.   NATURE REVIEWS DRUG DISCOVERY

Sigma-1 Receptor Chaperone at the ER-Mitochondrion Interface Mediates the Mitochondrion-ER-Nucleus Signaling for Cellular Survival

(2013) Tomohisa Mori et al.   PLoS One

Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

(2013) J. A. Moreno et al.   Science Translational Medicine

Endoplasmic Reticulum Stress Is Involved in Cardiac Damage and Vascular Endothelial Dysfunction in Hypertensive Mice

(2012) Modar Kassan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Blockade of XBP1 splicing by inhibition of IRE1  is a promising therapeutic option in multiple myeloma

(2012) N. Mimura et al.   BLOOD

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

Free radical biology of the cardiovascular system

(2012) Alex F. Chen et al.   CLINICAL SCIENCE

A Novel Role for Epidermal Growth Factor Receptor Tyrosine Kinase and Its Downstream Endoplasmic Reticulum Stress in Cardiac Damage and Microvascular Dysfunction in Type 1 Diabetes Mellitus

(2012) Maria Galán et al.   HYPERTENSION

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

(2012) Jeffrey M. Axten et al.   JOURNAL OF MEDICINAL CHEMISTRY

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

(2012) Likun Wang et al.   Nature Chemical Biology

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

(2012) B. C. S. Cross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing

(2012) M Ri et al.   Blood Cancer Journal

From form to function: the role of Nox4 in the cardiovascular system

(2012) Feng Chen et al.   Frontiers in Physiology

Nitric oxide: Orchestrator of endothelium-dependent responses

(2011) Michel Félétou et al.   ANNALS OF MEDICINE

Ero1α Regulates Ca2+ Fluxes at the Endoplasmic Reticulum–Mitochondria Interface (MAM)

(2011) Tiziana Anelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

(2011) Maruf M U Ali et al.   EMBO JOURNAL

Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice

(2011) Cheng Ji et al.   HEPATOLOGY

Potent and Selective Inhibitors of the Inositol-requiring Enzyme 1 Endoribonuclease

(2011) Kori Volkmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

(2011) P. Tsaytler et al.   SCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Rescue of ER oxidoreductase function through polyphenolic phytochemical intervention: Implications for subcellular traffic and neurodegenerative disorders

(2010) Rituraj Pal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

(2010) I. Papandreou et al.   BLOOD

Activation of AMP-Activated Protein Kinase Inhibits Oxidized LDL-Triggered Endoplasmic Reticulum Stress In Vivo

(2010) Y. Dong et al.   DIABETES

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

(2010) Ana Ricobaraza et al.   HIPPOCAMPUS

A Small Molecule Inhibitor of Endoplasmic Reticulum Oxidation 1 (ERO1) with Selectively Reversible Thiol Reactivity

(2010) Jaime D. Blais et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

(2010) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Enhanced Signaling Downstream of Ribonucleic Acid-Activated Protein Kinase-Like Endoplasmic Reticulum Kinase Potentiates Lipotoxic Endoplasmic Reticulum Stress in Human Islets

(2010) Laurence Ladrière et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

PERK Activation at Low Glucose Concentration Is Mediated by SERCA Pump Inhibition and Confers Preemptive Cytoprotection to Pancreatic β-Cells

(2010) Claire E. Moore et al.   MOLECULAR ENDOCRINOLOGY

Activation of PERK Signaling Attenuates Aβ-Mediated ER Stress

(2010) Do Yeon Lee et al.   PLoS One

Mechanisms and Implications of Reactive Oxygen Species Generation During the Unfolded Protein Response: Roles of Endoplasmic Reticulum Oxidoreductases, Mitochondrial Electron Transport, and NADPH Oxidase

(2009) Célio X.C. Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

Metformin Prevents Progression of Heart Failure in Dogs

(2009) Hideyuki Sasaki et al.   CIRCULATION

Regulation of GADD153 induced by mechanical stress in cardiomyocytes

(2009) W. P. Cheng et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Role of peroxynitrite in the redox regulation of cell signal transduction pathways

(2009) Lucas Liaudet   Frontiers in Bioscience-Landmark

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis

(2009) Ebru Erbay et al.   NATURE MEDICINE

Role of SERCA1 Truncated Isoform in the Proapoptotic Calcium Transfer from ER to Mitochondria during ER Stress

(2008) Mounia Chami et al.   MOLECULAR CELL

ERdj5 Is Required as a Disulfide Reductase for Degradation of Misfolded Proteins in the ER

(2008) R. Ushioda et al.   SCIENCE