Curcumin Improves Palmitate-Induced Insulin Resistance in Human Umbilical Vein Endothelial Cells by Maintaining Proteostasis in Endoplasmic Reticulum

Restoration of autophagy in endothelial cells from patients with diabetes mellitus improves nitric oxide signaling

(2016) Jessica L. Fetterman et al.   ATHEROSCLEROSIS

Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells

(2016) Xu Li et al.   Autophagy

Curcumin and insulin resistance-Molecular targets and clinical evidences

(2016) Angélica Saraí Jiménez-Osorio et al.   BIOFACTORS

Palmitic acid but not palmitoleic acid induces insulin resistance in a human endothelial cell line by decreasing SERCA pump expression

(2016) J. Gustavo Vazquez-Jimenez et al.   CELLULAR SIGNALLING

Insulin Signaling and Heart Failure

(2016) Christian Riehle et al.   CIRCULATION RESEARCH

Associations between autophagy, the ubiquitin-proteasome system and endoplasmic reticulum stress in hypoxia-deoxygenation or ischemia-reperfusion

(2016) Tao Fan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anti-diabetic effect of 3-hydroxy-2-naphthoic acid, an endoplasmic reticulum stress-reducing chemical chaperone

(2016) Sun-mi Park et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Curcumin inhibits lipolysis via suppression of ER stress in adipose tissue and prevents hepatic insulin resistance

(2016) Lulu Wang et al.   JOURNAL OF LIPID RESEARCH

Insulin Resistance and Endothelial Dysfunction Constitute a Common Therapeutic Target in Cardiometabolic Disorders

(2016) A. Janus et al.   MEDIATORS OF INFLAMMATION

Interference with Akt signaling pathway contributes curcumin-induced adipocyte insulin resistance

(2016) Deling Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Impaired macrophage autophagy induces systemic insulin resistance in obesity

(2016) Young-Ho Kang et al.   Oncotarget

Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway

(2016) Jiaqi Liu et al.   Cell and Bioscience

Proteasome inhibitors, including curcumin, improve pancreatic β-cell function and insulin sensitivity in diabetic mice

(2016) S Weisberg et al.   Nutrition & Diabetes

Proteasome Dysfunction Associated to Oxidative Stress and Proteotoxicity in Adipocytes Compromises Insulin Sensitivity in Human Obesity

(2015) Alberto Díaz-Ruiz et al.   ANTIOXIDANTS & REDOX SIGNALING

Palmitate induces insulin resistance in human HepG2 hepatocytes by enhancing ubiquitination and proteasomal degradation of key insulin signaling molecules

(2015) Megumi Ishii et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

TRAM1 protect HepG2 cells from palmitate induced insulin resistance through ER stress-JNK pathway

(2015) Zhuqi Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Curcumin ameliorates testicular damage in diabetic rats by suppressing cellular stress-mediated mitochondria and endoplasmic reticulum-dependent apoptotic death

(2015) Kahkashan Rashid et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The interplay between autophagy and the ubiquitin–proteasome system in cardiac proteotoxicity

(2015) Changhua Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Curcumin: A Natural Product for Diabetes and its Complications

(2015) Seyed Nabavi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

BAIBA attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK–PPARδ-dependent pathway in mice

(2015) Tae Woo Jung et al.   DIABETOLOGIA

Role of the ubiquitin-proteasome system and autophagy in regulation of insulin sensitivity in serum-starved 3T3-L1 adipocytes

(2015) Yemin Zhang et al.   ENDOCRINE JOURNAL

Experimental evidence for curcumin and its analogs for management of diabetes mellitus and its associated complications

(2015) Susana Rivera-Mancía et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Curcumin ameliorates streptozotocin-induced liver damage through modulation of endoplasmic reticulum stress-mediated apoptosis in diabetic rats

(2015) R. Afrin et al.   FREE RADICAL RESEARCH

Curcumin accelerates reendothelialization and ameliorates intimal hyperplasia in balloon-injured rat carotid artery via the upregulation of endothelial cell autophagy

(2015) DONGDONG CHEN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Inhibition of SCD1 impairs palmitate-derived autophagy at the step of autophagosome-lysosome fusion in pancreatic β-cells

(2015) Justyna Janikiewicz et al.   JOURNAL OF LIPID RESEARCH

Curcumin: A pleiotropic phytonutrient in diabetic complications

(2015) Manish Kumar Jeenger et al.   NUTRITION

Proteasome inhibition in skeletal muscle cells unmasks metabolic derangements in type 2 diabetes

(2014) Lubna Al-Khalili et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Endothelial Dysfunction, Obesity and Insulin Resistance

(2014) Dolores Prieto et al.   Current Vascular Pharmacology

Endoplasmic reticulum stress and endothelial dysfunction

(2014) Stefania Lenna et al.   IUBMB LIFE

Palmitate Induces ER Stress and Autophagy in H9c2 Cells: Implications for Apoptosis and Adiponectin Resistance

(2014) Min Park et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Metformin Attenuates Palmitate-Induced Endoplasmic Reticulum Stress, Serine Phosphorylation of IRS-1 and Apoptosis in Rat Insulinoma Cells

(2014) Laura Simon-Szabó et al.   PLoS One

Mitochondria, endothelial cell function, and vascular diseases

(2014) Xiaoqiang Tang et al.   Frontiers in Physiology

Endothelial dysfunction as a nexus for endothelial cell-cardiomyocyte miscommunication

(2014) Thorsten M. Leucker et al.   Frontiers in Physiology

Activation of PPAR  Ameliorates Hepatic Insulin Resistance and Steatosis in High Fructose-Fed Mice Despite Increased Endoplasmic Reticulum Stress

(2013) S. M. H. Chan et al.   DIABETES

Palmitate induces apoptosis in mouse aortic endothelial cells and endothelial dysfunction in mice fed high-calorie and high-cholesterol diets

(2013) Yunxia Lu et al.   LIFE SCIENCES

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Curcumin is a direct inhibitor of glucose transport in adipocytes

(2013) Allan Green et al.   PHYTOMEDICINE

Impaired myocardial autophagy linked to energy metabolism disorders

(2012) Zi-Lun Li et al.   Autophagy

Rapamycin activates autophagy in Hutchinson-Gilford progeria syndrome

(2012) John J. Graziotto et al.   Autophagy

Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damage

(2012) Jing Han et al.   Autophagy

Curcumin Extract for Prevention of Type 2 Diabetes

(2012) S. Chuengsamarn et al.   DIABETES CARE

The intersecting roles of endoplasmic reticulum stress, ubiquitin–proteasome system, and autophagy in the pathogenesis of proteinuric kidney disease

(2012) Andrey V. Cybulsky   KIDNEY INTERNATIONAL

Curcumin Prevents High Fat Diet Induced Insulin Resistance and Obesity via Attenuating Lipogenesis in Liver and Inflammatory Pathway in Adipocytes

(2012) Weijuan Shao et al.   PLoS One

Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice

(2011) Kimberley M. Mellor et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Curcumin supplementation could improve diabetes-induced endothelial dysfunction associated with decreased vascular superoxide production and PKC inhibition

(2010) Sirada Rungseesantivanon et al.   BMC Complementary and Alternative Medicine

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Autophagy: A Potential Link between Obesity and Insulin Resistance

(2010) Patrice Codogno et al.   Cell Metabolism

Autophagy is activated by proteasomal inhibition and involved in aggresome clearance in cultured astrocytes

(2010) Sven B. Jänen et al.   GLIA

Altered Autophagy in Human Adipose Tissues in Obesity

(2010) Julia Kovsan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Glycogen synthase kinase 3β mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1

(2010) Sanhua Leng et al.   JOURNAL OF ENDOCRINOLOGY

The role of autophagy in pancreatic β-cell and diabetes

(2009) Yoshio Fujitani et al.   Autophagy

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

(2009) Viktor I. Korolchuk et al.   MOLECULAR CELL

Autophagy-Mediated Insulin Receptor Down-Regulation Contributes to Endoplasmic Reticulum Stress-Induced Insulin Resistance

(2009) L. Zhou et al.   MOLECULAR PHARMACOLOGY

Curcumin Inhibits the Proteasome Activity in Human Colon Cancer Cells In vitro and In vivo

(2008) V. Milacic et al.   CANCER RESEARCH