Catalytic asymmetric construction of spiropyrrolidines via 1,3-dipolar cycloaddition of azomethine ylides

Asymmetric [3 + 2] Cycloaddition of 3-Amino Oxindole-Based Azomethine Ylides and α,β-Enones with Divergent Diastereocontrol on the Spiro[pyrrolidine-oxindoles]

(2017) Guodong Zhu et al.   ORGANIC LETTERS

Organocatalytic asymmetric [3+2] cycloaddition of N-2,2,2-trifluoroethylisatin ketimines with 3-alkenyl-5-arylfuran-2(3H)-ones

(2016) Zhen-Hua Wang et al.   CHEMICAL COMMUNICATIONS

Catalytic asymmetric chemoselective 1,3-dipolar cycloadditions of an azomethine ylide with isatin-derived imines: diastereo- and enantioselective construction of a spiro[imidazolidine-2,3′-oxindole] framework

(2016) Yue-Ming Wang et al.   CHEMICAL COMMUNICATIONS

Enantioselective Synthesis of Polysubstituted Spiro-nitroprolinates Mediated by a (R,R)-Me-DuPhos·AgF-Catalyzed 1,3-Dipolar Cycloaddition

(2016) Alberto Cayuelas et al.   ORGANIC LETTERS

Thiourea–Quaternary Ammonium Salt Catalyzed Asymmetric 1, 3-Dipolar Cycloaddition of Imino Esters To Construct Spiro[pyrrolidin-3,3′-oxindoles]

(2016) Jia-Xing Zhang et al.   ORGANIC LETTERS

Diastereo- and Enantioselective Synthesis of Chiral Pyrrolidine-Fused SpirooxindolesviaOrganocatalytic [3+2] 1,3-Dipolar Cycloaddition of Azomethine Ylides with Maleimides

(2015) Hong-Wu Zhao et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic asymmetric construction of spiro[pyrrolidine-2,3′-oxindole] scaffolds through chiral phosphoric acid-catalyzed 1,3-dipolar cycloaddition involving 3-amino oxindoles

(2015) Guodong Zhu et al.   CHEMICAL COMMUNICATIONS

The copper-catalyzed asymmetric construction of a dispiropyrrolidine skeleton via 1,3-dipolar cycloaddition of azomethine ylides to α-alkylidene succinimides

(2015) Wu-Lin Yang et al.   CHEMICAL COMMUNICATIONS

The asymmetric synthesis of CF3-containing spiro[pyrrolidin-3,2′-oxindole] through the organocatalytic 1,3-dipolar cycloaddition reaction

(2015) Mingxia Ma et al.   CHEMICAL COMMUNICATIONS

Recent Advances of Catalytic Asymmetric 1,3-Dipolar Cycloadditions

(2015) Takuya Hashimoto et al.   CHEMICAL REVIEWS

Enantiodivergent Synthesis of Bis-Spiropyrrolidines via Sequential Interrupted and Completed (3 + 2) Cycloadditions

(2015) Egoitz Conde et al.   JOURNAL OF ORGANIC CHEMISTRY

Diastereo- and Enantioselective Construction of 3,3′-Pyrrolidinyldispirooxindole Framework via Catalytic Asymmetric 1,3-Dipolar Cycloadditions

(2015) Wei Dai et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Construction of Spirocyclic Pyrrolidine-thia(oxa)zolidinediones via N,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with 5-Alkylidene Thia(oxa)zolidine-2,4-diones

(2015) Wu-Lin Yang et al.   ORGANIC LETTERS

Catalytic Asymmetric exo-Selective 1,3-Dipolar Cycloaddition of Azomethine Ylides and Ethyl Cyclopropylidene Acetate for Construction of 5-aza-Spiro[2,4]heptane Motif

(2015) Qinghua Li et al.   ACTA CHIMICA SINICA

Catalytic Enantioselective 1,3-Dipolar Cycloadditions of Azomethine Ylides for Biology-Oriented Synthesis

(2014) Rishikesh Narayan et al.   ACCOUNTS OF CHEMICAL RESEARCH

PyBidine-Cu(OTf)2-Catalyzed Asymmetric [3+2] Cycloaddition with Imino Esters: Harmony of Cu-Lewis Acid and Imidazolidine-NH Hydrogen Bonding in Concerto Catalysis

(2014) Takayoshi Arai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in the catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides

(2014) Javier Adrio et al.   CHEMICAL COMMUNICATIONS

Highly Enantioselective Construction of Polycyclic Spirooxindoles by Organocatalytic 1,3-Dipolar Cycloaddition of 2-Cyclohexenone Catalyzed by Proline-Sulfonamide

(2014) Jun-An Xiao et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficient construction of highly functionalized spiro[γ-butyrolactone-pyrrolidin-3,3′-oxindole] tricyclic skeletons via an organocatalytic 1,3-dipolar cycloaddition

(2013) Long Wang et al.   CHEMICAL COMMUNICATIONS

exo-Selective construction of spiro-[butyrolactone-pyrrolidine] via 1,3-dipolar cycloaddition of azomethine ylides with α-methylene-γ-butyrolactone catalyzed by Cu(i)/DTBM-BIPHEP

(2013) Qing-Hua Li et al.   CHEMICAL COMMUNICATIONS

Organocatalytic asymmetric multicomponent cascade reaction via 1,3-proton shift and [3+2] cycloaddition: an efficient strategy for the synthesis of oxindole derivatives

(2013) Li Tian et al.   CHEMICAL COMMUNICATIONS

Thiazolidinone–Peptide Hybrids as Dengue Virus Protease Inhibitors with Antiviral Activity in Cell Culture

(2013) Christoph Nitsche et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biomimetic Asymmetric 1,3-Dioplar Cycloaddition: Amino Acid Precursors in Biosynthesis Serve as Latent Azomethine Ylides

(2013) Chang Guo et al.   ORGANIC LETTERS

Synthesis of a Spiroindolinone Pyrrolidinecarboxamide MDM2 Antagonist

(2013) Lianhe Shu et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Stereoselective Construction of Spiro(butyrolactonepyrrolidines) by Highly Efficient Copper(I)/TF-BiphamPhos-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition

(2012) Tang-Lin Liu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Asymmetric exo′-Selective [3+2] Cycloaddition for Constructing Stereochemically Diversified Spiro[pyrrolidin-3,3′-oxindole]s

(2012) Atsuko Awata et al.   CHEMISTRY-A EUROPEAN JOURNAL

Scaffold-Inspired Enantioselective Synthesis of Biologically Important Spiro[pyrrolidin-3,2′-oxindoles] with Structural Diversity through Catalytic Isatin-Derived 1,3-Dipolar Cycloadditions

(2012) Feng Shi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Asymmetric Construction of Spirocycles Containing Pyrrolidine Motifs and Spiro Quaternary Stereogenic Centers via 1,3-Dipolar Cycloaddition of Azomethine Ylides with 2-Alkylidene-Cycloketones

(2011) Tang-Lin Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Stereoselective construction of a 5-aza-spiro[2,4]heptane motif via catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides and ethyl cyclopropylidene acetate

(2011) Tang-Lin Liu et al.   CHEMICAL COMMUNICATIONS

Highly efficient construction of spirocyclic chromanone–pyrrolidines via Cu(i)/TF–BiphamPhos-catalyzed asymmetric 1,3-dipolar cycloaddition

(2011) Tang-Lin Liu et al.   CHEMICAL COMMUNICATIONS

Novel dipolarophiles and dipoles in the metal-catalyzed enantioselective 1,3-dipolar cycloaddition of azomethine ylides

(2011) Javier Adrio et al.   CHEMICAL COMMUNICATIONS

Structure-Based Design of a New Series ofd-Glutamic Acid Based Inhibitors of Bacterial UDP-N-acetylmuramoyl-l-alanine:d-glutamate Ligase (MurD)

(2011) Tihomir Tomašić et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enantioselective synthesis of the spirotryprostatin A scaffold

(2011) Andrey P. Antonchick et al.   TETRAHEDRON

Synthesis of novel β-lactam fused spiroisoxazolidine chromanones and tetralones as potent antimicrobial agent for human and plant pathogens

(2010) Natarajan Arumugam et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A facile 1,3-dipolar cycloaddition of azomethine ylides to 2-arylidene-1,3-indanediones: Synthesis of dispiro-oxindolylpyrrolothiazoles and their antimycobacterial evaluation

(2010) Shanmugavel Uma Maheswari et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, antibacterial activity evaluation and QSAR studies of novel dispiropyrrolidines

(2010) K. Karthikeyan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of novel spiro-pyrrolothiazolyloxindoles and their antitubercular evaluation

(2010) Pitchaimani Prasanna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Novel 5-Benzylidenerhodanine and 5-Benzylidenethiazolidine-2,4-dione Inhibitors of MurD Ligase

(2010) Nace Zidar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products

(2010) Andrey P. Antonchick et al.   Nature Chemistry

Catalytic asymmetric 1,3-dipolar cycloaddition of N-unprotected 2-oxoindolin-3-ylidene derivatives and azomethine ylides for the construction of spirooxindole-pyrrolidines

(2010) Tang-Lin Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

New Chiral Ferrocenyl P,S-Ligands for Highly Diastereo-/Enantioselective Catalytic [3 + 2] Cycloaddition of Azomethine Ylides with Cyclic and Acyclic Enones

(2010) Cheng Zhang et al.   ORGANIC LETTERS

HighlyEndo-Selective and Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Ylide with α-Enones Catalyzed by a Silver(I)/ThioClickFerrophos Complex

(2010) Ichiro Oura et al.   ORGANIC LETTERS

Discovery and structure-guided drug design of inhibitors of 11β-hydroxysteroid-dehydrogenase type I based on a spiro-carboxamide scaffold

(2009) Franck Lepifre et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties

(2009) So-Young Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors

(2009) Kevin B. Sippy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A highly atom economic, chemo-, regio- and stereoselective synthesis and evaluation of spiro-pyrrolothiazoles as antitubercular agents

(2009) Subramanian Vedhanarayanan Karthikeyan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A facile synthesis and antimycobacterial evaluation of novel spiro-pyrido-pyrrolizines and pyrrolidines

(2009) Raju Ranjith Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel three-component domino reactions of ketones, isatin and amino acids: Synthesis and discovery of antimycobacterial activity of highly functionalised novel dispiropyrrolidines

(2009) Raju Suresh Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Organocatalytic Synthesis of Spiro[pyrrolidin-3,3′-oxindoles] with High Enantiopurity and Structural Diversity

(2009) Xiao-Hua Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of novel spiropyrrolizidines as potent antimicrobial agents for human and plant pathogens

(2008) Govindasami Periyasami et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of spiro[chroman-2,4′-piperidin]-4-one derivatives as acetyl-CoA carboxylase inhibitors

(2008) Pundlik Shinde et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enantioselective Copper-Catalyzed 1,3-Dipolar Cycloadditions

(2008) Levi M. Stanley et al.   CHEMICAL REVIEWS

Advances in Matrix Metalloproteinase Inhibitors Based on Pyrrolidine Scaffold

(2008) Wen-Fang Xu et al.   CURRENT MEDICINAL CHEMISTRY

Discovery of Antimycobacterial Spiro-piperidin-4-ones: An Atom Economic, Stereoselective Synthesis, and Biological Intervention

(2008) Raju Ranjith Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Evaluation of Novel Inhibitors of Pim-1 and Pim-2 Protein Kinases

(2008) Zuping Xia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Catalytic Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides with α,β-Unsaturated Ketones

(2008) Jorge Hernández-Toribio et al.   ORGANIC LETTERS

Seven new prenylated indole diketopiperazine alkaloids from holothurian-derived fungus Aspergillus fumigatus

(2008) Fazuo Wang et al.   TETRAHEDRON