An update on the genetic architecture of hyperuricemia and gout

Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci

(2014) Vinicius Tragante et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Twenty-eight loci that influence serum urate levels: analysis of association with gout

(2014) A J Phipps-Green et al.   ANNALS OF THE RHEUMATIC DISEASES

Copy number polymorphisms near SLC2A9 are associated with serum uric acid concentrations

(2014) Robert B Scharpf et al.   BMC GENETICS

Mendelian Randomization Provides No Evidence for a Causal Role of Serum Urate in Increasing Serum Triglyceride Levels

(2014) H. Rasheed et al.   Circulation-Cardiovascular Genetics

The ras responsive transcription factor RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease

(2014) J. A. Bonomo et al.   HUMAN MOLECULAR GENETICS

Abundant local interactions in the 4p16.1 region suggest functional mechanisms underlying SLC2A9 associations with human serum uric acid

(2014) Wen-Hua Wei et al.   HUMAN MOLECULAR GENETICS

Gout: Joints and beyond, epidemiology, clinical features, treatment and co-morbidities

(2014) Philip C. Robinson et al.   MATURITAS

Pleiotropic genes for metabolic syndrome and inflammation

(2014) Aldi T. Kraja et al.   MOLECULAR GENETICS AND METABOLISM

Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense

(2014) Y Itahana et al.   ONCOGENE

Expression of SLC2A9 Isoforms in the Kidney and Their Localization in Polarized Epithelial Cells

(2014) Toru Kimura et al.   PLoS One

The Genetic Basis of Gout

(2014) Tony R. Merriman et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Influence of the ABCG2 gout risk 141 K allele on urate metabolism during a fructose challenge

(2014) Nicola Dalbeth et al.   ARTHRITIS RESEARCH & THERAPY

Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9

(2014) Brian J DeBosch et al.   Nature Communications

Population-specific influence ofSLC2A9genotype on the acute hyperuricaemic response to a fructose load

(2013) Nicola Dalbeth et al.   ANNALS OF THE RHEUMATIC DISEASES

Sugar-sweetened beverage consumption: a risk factor for prevalent gout withSLC2A9genotype-specific effects on serum urate and risk of gout

(2013) Caitlin Batt et al.   ANNALS OF THE RHEUMATIC DISEASES

Effect of Genetic Polymorphisms on Development of Gout

(2013) W. Urano et al.   JOURNAL OF RHEUMATOLOGY

Mendelian randomization analysis associates increased serum urate, due to genetic variation in uric acid transporters, with improved renal function

(2013) Kim Hughes et al.   KIDNEY INTERNATIONAL

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

(2013) Sonja I Berndt et al.   NATURE GENETICS

Association of TLR4 Gene rs2149356 Polymorphism with Primary Gouty Arthritis in a Case-Control Study

(2013) Yu-Feng Qing et al.   PLoS One

Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules

(2013) O. M. Woodward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyperuricaemia in the Pacific: why the elevated serum urate levels?

(2013) Anna L. Gosling et al.   RHEUMATOLOGY INTERNATIONAL

Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects

(2013) Tanya J Flynn et al.   ARTHRITIS RESEARCH & THERAPY

Association of the lipoprotein receptor-related protein 2 gene with gout and non-additive interaction with alcohol consumption

(2013) Humaira Rasheed et al.   ARTHRITIS RESEARCH & THERAPY

Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts

(2013) T. M. Palmer et al.   BMJ-British Medical Journal

Nature Versus Nurture in Gout: A Twin Study

(2012) Eswar Krishnan et al.   AMERICAN JOURNAL OF MEDICINE

A urate gene-by-diuretic interaction and gout risk in participants with hypertension: results from the ARIC study

(2012) Mara A McAdams-DeMarco et al.   ANNALS OF THE RHEUMATIC DISEASES

Association between gout and polymorphisms in GCKR in male Han Chinese

(2012) Jing Wang et al.   HUMAN GENETICS

Meta-analysis confirms a role for deletion in FCGR3B in autoimmune phenotypes

(2012) Cushla McKinney et al.   HUMAN MOLECULAR GENETICS

Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations

(2012) Yukinori Okada et al.   NATURE GENETICS

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

(2012) Anna Köttgen et al.   NATURE GENETICS

The genetics of hyperuricaemia and gout

(2012) Anthony M. Reginato et al.   Nature Reviews Rheumatology

National prevalence of gout derived from administrative health data in Aotearoa New Zealand

(2012) D. Winnard et al.   RHEUMATOLOGY

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

The renal urate transporter SLC17A1 locus: confirmation of association with gout

(2012) Jade E Hollis-Moffatt et al.   ARTHRITIS RESEARCH & THERAPY

Decreased extra-renal urate excretion is a common cause of hyperuricemia

(2012) Kimiyoshi Ichida et al.   Nature Communications

Population Heterogeneity in the Genetic Control of Serum Urate

(2011) Tony R. Merriman   SEMINARS IN NEPHROLOGY

Multiple Genetic Loci Influence Serum Urate Levels and Their Relationship With Gout and Cardiovascular Disease Risk Factors

(2010) Qiong Yang et al.   Circulation-Cardiovascular Genetics

Bayesian methods for instrumental variable analysis with genetic instruments (‘Mendelian randomization’): example with urate transporter SLC2A9 as an instrumental variable for effect of urate levels on metabolic syndrome

(2010) Paul M McKeigue et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

The genetic basis of hyperuricaemia and gout

(2010) Tony R. Merriman et al.   JOINT BONE SPINE

Mechanisms of inflammation in gout

(2010) Nathalie Busso et al.   ARTHRITIS RESEARCH & THERAPY

Sodium-dependent phosphate cotransporter type 1 sequence polymorphisms in male patients with gout

(2009) W. Urano et al.   ANNALS OF THE RHEUMATIC DISEASES

Role of the urate transporterSLC2A9gene in susceptibility to gout in New Zealand Māori, Pacific Island, and Caucasian case-control sample sets

(2009) Jade E. Hollis-Moffatt et al.   ARTHRITIS AND RHEUMATISM

Solute carrier family 2, member 9 and uric acid homeostasis

(2009) Chris Cheeseman   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

A prospective study of gout and cancer

(2009) Paolo Boffetta et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Recent insights into the pathogenesis of hyperuricaemia and gout

(2009) P. L. Riches et al.   HUMAN MOLECULAR GENETICS

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy

(2009) F. Preitner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

(2009) O. M. Woodward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations

(2009) Melanie Kolz et al.   PLoS Genetics

Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions

(2009) Soumya Raychaudhuri et al.   PLoS Genetics

Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study

(2008) Abbas Dehghan et al.   LANCET

SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

(2008) Veronique Vitart et al.   NATURE GENETICS

SLC2A9 influences uric acid concentrations with pronounced sex-specific effects

(2008) Angela Döring et al.   NATURE GENETICS

Crystal ball gazing: new therapeutic targets for hyperuricaemia and gout

(2008) N. Dalbeth et al.   RHEUMATOLOGY

SLC2A9 Is a High-Capacity Urate Transporter in Humans

(2008) Mark J Caulfield et al.   PLOS MEDICINE