A New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue

Behavioural changes observed in demyelination model shares similarities with white matter abnormalities in humans

(2015) Nathalia Serra-de-Oliveira et al.   BEHAVIOURAL BRAIN RESEARCH

Impaired Energy Metabolism and Disturbed Dopamine and Glutamate Signalling in the Striatum and Prefrontal Cortex of the Spontaneously Hypertensive Rat Model of Attention-Deficit Hyperactivity Disorder

(2015) Jacqueline J. Dimatelis et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

(2015) Pierre J. Magistretti et al.   NEURON

Glial cells as key players in schizophrenia pathology: recent insights and concepts of therapy

(2015) Hans-Gert Bernstein et al.   SCHIZOPHRENIA RESEARCH

The emerging functions of oligodendrocytes in regulating neuronal network behaviour

(2014) Livia de Hoz et al.   BIOESSAYS

Minocycline rescues decrease in neurogenesis, increase in microglia cytokines and deficits in sensorimotor gating in an animal model of schizophrenia

(2014) Daniele Mattei et al.   BRAIN BEHAVIOR AND IMMUNITY

Aquaporin-4 Knockout Exacerbates Corticosterone-Induced Depression by Inhibiting Astrocyte Function and Hippocampal Neurogenesis

(2014) Hui Kong et al.   CNS Neuroscience & Therapeutics

Myelination, oligodendrocytes, and serious mental illness

(2014) V. Haroutunian et al.   GLIA

Reduced connexin 43 immunolabeling in the orbitofrontal cortex in alcohol dependence and depression

(2014) José Javier Miguel-Hidalgo et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Evidence for morphological alterations in prefrontal white matter glia in schizophrenia and bipolar disorder

(2014) Christa Hercher et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Astrocytic abnormalities and global DNA methylation patterns in depression and suicide

(2014) C Nagy et al.   MOLECULAR PSYCHIATRY

Reactive Gliosis and the Multicellular Response to CNS Damage and Disease

(2014) Joshua E. Burda et al.   NEURON

Grey matter reduction associated with posttraumatic stress disorder and traumatic stress

(2014) Lei Li et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Astrocytic Dysfunction and Addiction

(2014) Michael D. Scofield et al.   NEUROSCIENTIST

Imipramine and fluoxetine inhibit LPS-induced activation and affect morphology of microglial cells in the rat glial culture

(2014) Ewa Obuchowicz et al.   Pharmacological Reports

Spatial properties of astrocyte gap junction coupling in the rat hippocampus

(2014) S. Anders et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

DISC1 (Disrupted-in-Schizophrenia-1) Regulates Differentiation of Oligodendrocytes

(2014) Tsuyoshi Hattori et al.   PLoS One

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

(2014) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes contribute to gamma oscillations and recognition memory

(2014) H. S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Riluzole in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice

(2014) Masanori Ohashi et al.   PSYCHOPHARMACOLOGY

Cognitive Impairments in Alcohol-Dependent Subjects

(2014) Florent Bernardin et al.   Frontiers in Psychiatry

Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence

(2013) Richard L. Bell et al.   ADDICTION BIOLOGY

FGF2 blocks PTSD symptoms via an astrocyte-based mechanism

(2013) Liang Xia et al.   BEHAVIOURAL BRAIN RESEARCH

From Pathophysiology to Novel Antidepressant Drugs: Glial Contributions to the Pathology and Treatment of Mood Disorders

(2013) Gerard Sanacora et al.   BIOLOGICAL PSYCHIATRY

Forebrain Engraftment by Human Glial Progenitor Cells Enhances Synaptic Plasticity and Learning in Adult Mice

(2013) Xiaoning Han et al.   Cell Stem Cell

Targeting Glia Cells: Novel Perspectives for the Treatment of Neuropsychiatric Diseases

(2013) B. Benedetto et al.   Current Neuropharmacology

Glial cell modulators attenuate methamphetamine self-administration in therat

(2013) Sarah E. Snider et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Deficits in Adult Neurogenesis, Contextual Fear Conditioning, and Spatial Learning in a Gfap Mutant Mouse Model of Alexander Disease

(2013) T. L. Hagemann et al.   JOURNAL OF NEUROSCIENCE

S100B-immunopositive astrocytes and oligodendrocytes in the hippocampus are differentially afflicted in unipolar and bipolar depression: A postmortem study

(2013) Tomasz Gos et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Glutamate transporters: A key piece in the glutamate puzzle of major depressive disorder

(2013) Adriana Medina et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Astrocyte-derived ATP modulates depressive-like behaviors

(2013) Xiong Cao et al.   NATURE MEDICINE

A behavioral neuroenergetics theory of ADHD

(2013) Peter R. Killeen et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Astrogliopathology

(2013) Alexei Verkhratsky et al.   NEUROSCIENTIST

Reinstatement of nicotine seeking is mediated by glutamatergic plasticity

(2013) C. D. Gipson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased expression of glial fibrillary acidic protein in prefrontal cortex in psychotic illness

(2013) Abigail H. Feresten et al.   SCHIZOPHRENIA RESEARCH

Origin and differentiation of microglia

(2013) Florent Ginhoux et al.   Frontiers in Cellular Neuroscience

Microglia in Neuronal Circuits

(2013) Long-Jun Wu et al.   NEURAL PLASTICITY

BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities

(2013) G Quesseveur et al.   Translational Psychiatry

Antidepressant Effects of Fibroblast Growth Factor-2 in Behavioral and Cellular Models of Depression

(2012) Maha Elsayed et al.   BIOLOGICAL PSYCHIATRY

Coverage of Blood Vessels by Astrocytic Endfeet Is Reduced in Major Depressive Disorder

(2012) Grazyna Rajkowska et al.   BIOLOGICAL PSYCHIATRY

Astrocyte decrease in the subgenual cingulate and callosal genu in schizophrenia

(2012) Matthew Roy Williams et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes

(2012) Wouter Beumer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Properties and Fate of Oligodendrocyte Progenitor Cells in the Corpus Callosum, Motor Cortex, and Piriform Cortex of the Mouse

(2012) L. E. Clarke et al.   JOURNAL OF NEUROSCIENCE

Alexander Disease

(2012) A. Messing et al.   JOURNAL OF NEUROSCIENCE

Minocycline benefits negative symptoms in early schizophrenia: a randomised double-blind placebo-controlled clinical trial in patients on standard treatment

(2012) Imran B Chaudhry et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion

(2012) T M Ma et al.   MOLECULAR PSYCHIATRY

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

(2012) Ursula Fünfschilling et al.   NATURE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Aquaporin-4 Deficiency Impairs Synaptic Plasticity and Associative Fear Memory in the Lateral Amygdala: Involvement of Downregulation of Glutamate Transporter-1 Expression

(2012) Yan-Kun Li et al.   NEUROPSYCHOPHARMACOLOGY

Lithium and GSK3-β Promoter Gene Variants Influence White Matter Microstructure in Bipolar Disorder

(2012) Francesco Benedetti et al.   NEUROPSYCHOPHARMACOLOGY

Neuroimmunophilin GPI-1046 reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats

(2012) Y. Sari et al.   NEUROSCIENCE

Meta-analysis of fMRI studies of timing in attention-deficit hyperactivity disorder (ADHD)

(2012) Heledd Hart et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Astrocyte-Specific Disruption of SynCAM1 Signaling Results in ADHD-Like Behavioral Manifestations

(2012) Ursula S. Sandau et al.   PLoS One

Antidepressant Acts on Astrocytes Leading to an Increase in the Expression of Neurotrophic/Growth Factors: Differential Regulation of FGF-2 by Noradrenaline

(2012) Naoto Kajitani et al.   PLoS One

Prolonged myelination in human neocortical evolution

(2012) D. J. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic psychosocial stress and citalopram modulate the expression of the glial proteins GFAP and NDRG2 in the hippocampus

(2012) Carolina Araya-Callís et al.   PSYCHOPHARMACOLOGY

A Critical Period for Social Experience-Dependent Oligodendrocyte Maturation and Myelination

(2012) M. Makinodan et al.   SCIENCE

Genetic and functional analyses identify DISC1 as a novel callosal agenesis candidate gene

(2011) Nathan Osbun et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Evidence that Microglia Mediate the Neurobiological Effects of Chronic Psychological Stress on the Medial Prefrontal Cortex

(2011) M. Hinwood et al.   CEREBRAL CORTEX

Riluzole and gabapentinoids activate glutamate transporters to facilitate glutamate-induced glutamate release from cultured astrocytes

(2011) Masaru Yoshizumi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

GSK3β negatively regulates oligodendrocyte differentiation and myelination in vivo

(2011) Kasum Azim et al.   GLIA

A morphometric study of glia and neurons in the anterior cingulate cortex in mood disorder

(2011) Rebecca A. Gittins et al.   JOURNAL OF AFFECTIVE DISORDERS

Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide

(2011) Angela W Corona et al.   Journal of Neuroinflammation

Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?

(2011) Johann Steiner et al.   Journal of Neuroinflammation

NMDA Receptor Signaling in Oligodendrocyte Progenitors Is Not Required for Oligodendrogenesis and Myelination

(2011) L. M. De Biase et al.   JOURNAL OF NEUROSCIENCE

Regulation of Oligodendrocyte Development and Myelination by Glucose and Lactate

(2011) J. E. Rinholm et al.   JOURNAL OF NEUROSCIENCE

Altered White Matter Microstructure in Children With Attention-Deficit/Hyperactivity Disorder

(2011) Bonnie J. Nagel et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Fibroblast growth factor-2 alters the nature of extinction

(2011) B. M. Graham et al.   LEARNING & MEMORY

GFAP mutations, age at onset, and clinical subtypes in Alexander disease

(2011) M. Prust et al.   NEUROLOGY

NG2-glia as Multipotent Neural Stem Cells: Fact or Fantasy?

(2011) William D. Richardson et al.   NEURON

Addiction: Pulling at the Neural Threads of Social Behaviors

(2011) Nora D. Volkow et al.   NEURON

Astrocyte and Glutamate Markers in the Superficial, Deep and White Matter Layers of the Anterior Cingulate Gyrus in Schizophrenia

(2011) Pavel Katsel et al.   NEUROPSYCHOPHARMACOLOGY

Minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in BDNF levels in the hippocampus at baseline

(2011) Shiho Arakawa et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Scaling of Brain Metabolism with a Fixed Energy Budget per Neuron: Implications for Neuronal Activity, Plasticity and Evolution

(2011) Suzana Herculano-Houzel   PLoS One

Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytes

(2011) Igor Allaman et al.   PSYCHOPHARMACOLOGY

Expression of mutant human DISC1 in mice supports abnormalities in differentiation of oligodendrocytes

(2011) Pavel Katsel et al.   SCHIZOPHRENIA RESEARCH

Microglial activation in a neuroinflammational animal model of schizophrenia — a pilot study

(2011) Georg Juckel et al.   SCHIZOPHRENIA RESEARCH

Atypical Default Network Connectivity in Youth with Attention-Deficit/Hyperactivity Disorder

(2010) Damien A. Fair et al.   BIOLOGICAL PSYCHIATRY

Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice

(2010) Shau-Kwaun Chen et al.   CELL

The association of myelin oligodendrocyte glycoprotein gene and white matter volume in obsessive–compulsive disorder

(2010) Murad Atmaca et al.   JOURNAL OF AFFECTIVE DISORDERS

Alexander Disease Mutant Glial Fibrillary Acidic Protein Compromises Glutamate Transport in Astrocytes

(2010) Rujin Tian et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Predominant Enhancement of Glucose Uptake in Astrocytes versus Neurons during Activation of the Somatosensory Cortex

(2010) J. Chuquet et al.   JOURNAL OF NEUROSCIENCE

Animal models of neuropsychiatric disorders

(2010) Eric J Nestler et al.   NATURE NEUROSCIENCE

Amygdala Transcriptome and Cellular Mechanisms Underlying Stress-Enhanced Fear Learning in a Rat Model of Posttraumatic Stress Disorder

(2010) Igor Ponomarev et al.   NEUROPSYCHOPHARMACOLOGY

Glycogen synthesis in brain and astrocytes is inhibited by chronic lithium treatment

(2010) Andréa de Almeida Souza et al.   NEUROSCIENCE LETTERS

Expression and Functions of Fibroblast Growth Factor 2 (FGF-2) in Hippocampal Formation

(2010) Sabrina Zechel et al.   NEUROSCIENTIST

Enhanced synaptic connectivity and epilepsy in C1q knockout mice

(2010) Yunxiang Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes and human cognition: Modeling information integration and modulation of neuronal activity

(2010) Alfredo Pereira et al.   PROGRESS IN NEUROBIOLOGY

fMRI activation in the amygdala and the orbitofrontal cortex in unmedicated subjects with major depressive disorder

(2010) Jennifer D. Townsend et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Ethanol disrupts NMDA receptor and astroglial EAAT2 modulation of Kv2.1 potassium channels in hippocampus

(2009) Patrick J. Mulholland et al.   ALCOHOL

Abnormal Amygdala-Prefrontal Effective Connectivity to Happy Faces Differentiates Bipolar from Major Depression

(2009) Jorge Renner Cardoso de Almeida et al.   BIOLOGICAL PSYCHIATRY

Review of Alexander disease: Beyond the classical concept of leukodystrophy

(2009) Yukio Sawaishi   BRAIN & DEVELOPMENT

Effects of glutamate receptor activation on NG2-glia in the rat optic nerve

(2009) Nicola Hamilton et al.   JOURNAL OF ANATOMY

A Double-Blind, Randomized Study of Minocycline for the Treatment of Negative and Cognitive Symptoms in Early-Phase Schizophrenia

(2009) Yechiel Levkovitz et al.   JOURNAL OF CLINICAL PSYCHIATRY

Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain

(2009) Frederico A.C. Azevedo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Uniquely Hominid Features of Adult Human Astrocytes

(2009) N. A. Oberheim et al.   JOURNAL OF NEUROSCIENCE

A New Role for FGF2 as an Endogenous Inhibitor of Anxiety

(2009) J. A. Perez et al.   JOURNAL OF NEUROSCIENCE

Histone methylation and decreased expression of TrkB.T1 in orbital frontal cortex of suicide completers

(2009) C Ernst et al.   MOLECULAR PSYCHIATRY

Training induces changes in white-matter architecture

(2009) Jan Scholz et al.   NATURE NEUROSCIENCE

The glutamate homeostasis hypothesis of addiction

(2009) Peter W. Kalivas   NATURE REVIEWS NEUROSCIENCE

Glutamate elicits release of BDNF from basal forebrain astrocytes in a process dependent on metabotropic receptors and the PLC pathway

(2009) Ying Y. Jean et al.   Neuron Glia Biology

Chronic lithium treatment decreases NG2 cell proliferation in rat dentate hilus, amygdala and corpus callosum

(2009) Karin Orre et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

(2009) M Bryant Howren et al.   PSYCHOSOMATIC MEDICINE

Subcortical oligodendrocyte- and astrocyte-associated gene expression in subjects with schizophrenia, major depression and bipolar disorder

(2009) Kevin Barley et al.   SCHIZOPHRENIA RESEARCH

Downregulation of oligodendrocyte transcripts is associated with impaired prefrontal cortex function in rats

(2009) Justin R. Gregg et al.   SCHIZOPHRENIA RESEARCH

Energy-Efficient Action Potentials in Hippocampal Mossy Fibers

(2009) H. Alle et al.   SCIENCE

Stereologic investigation of the posterior part of the hippocampus in schizophrenia

(2008) Andrea Schmitt et al.   ACTA NEUROPATHOLOGICA

Microglia Activation in Recent-Onset Schizophrenia: A Quantitative (R)-[11C]PK11195 Positron Emission Tomography Study

(2008) Bart N. van Berckel et al.   BIOLOGICAL PSYCHIATRY

Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors

(2008) Mounira Banasr et al.   BIOLOGICAL PSYCHIATRY

Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression

(2008) Wayne C. Drevets et al.   Brain Structure & Function

Riluzole in the Treatment of Mood and Anxiety Disorders

(2008) Christopher Pittenger et al.   CNS DRUGS

Interleukin-1 (IL-1): A central regulator of stress responses

(2008) Inbal Goshen et al.   FRONTIERS IN NEUROENDOCRINOLOGY

GLT-1 upregulation impairs prepulse inhibition of the startle reflex in adult rats

(2008) Michele Bellesi et al.   GLIA

Decreased functional coupling of the amygdala and supragenual cingulate is related to increased depression in unmedicated individuals with current major depressive disorder

(2008) Scott C. Matthews et al.   JOURNAL OF AFFECTIVE DISORDERS

Gap Junctions Couple Astrocytes and Oligodendrocytes

(2008) Jennifer L. Orthmann-Murphy et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Infusion of gliotoxins or a gap junction blocker in the prelimbic cortex increases alcohol preference in Wistar rats

(2008) J Miguel-Hidalgo et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole

(2008) M Banasr et al.   MOLECULAR PSYCHIATRY

A glimmer of light for neuropsychiatric disorders

(2008) Steven E. Hyman   NATURE

Abnormal Indices of Cell Cycle Activity in Schizophrenia and their Potential Association with Oligodendrocytes

(2008) Pavel Katsel et al.   NEUROPSYCHOPHARMACOLOGY

Cortical expression of glial fibrillary acidic protein and glutamine synthetase is decreased in schizophrenia

(2008) Amy E. Steffek et al.   SCHIZOPHRENIA RESEARCH

Altered Emotional Interference Processing in Affective and Cognitive-Control Brain Circuitry in Major Depression

(2007) Christina L. Fales et al.   BIOLOGICAL PSYCHIATRY

Increased MCP-1 and microglia in various regions of the human alcoholic brain

(2007) Jun He et al.   EXPERIMENTAL NEUROLOGY

Neocortical glial cell numbers in human brains

(2007) D.P. Pelvig et al.   NEUROBIOLOGY OF AGING

Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide

(2006) Johann Steiner et al.   JOURNAL OF PSYCHIATRIC RESEARCH