Opioid receptors: drivers to addiction?

Focusing on the Opioid System for Addiction Biomarker Discovery

(2018) Raoul Belzeaux et al.   TRENDS IN MOLECULAR MEDICINE

Selective kappa opioid antagonists for treatment of addiction, are we there yet?

(2017) Mohamed A. Helal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting delta opioid receptors for pain treatment: drugs in phase I and II clinical development

(2017) Viola Spahn et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Resting-State Neuroimaging and Neuropsychological Findings in Opioid Use Disorder during Abstinence: A Review

(2017) Hada Fong-ha Ieong et al.   Frontiers in Human Neuroscience

Social Laughter Triggers Endogenous Opioid Release in Humans

(2017) Sandra Manninen et al.   JOURNAL OF NEUROSCIENCE

Effects of acute and repeated treatment with the biased mu opioid receptor agonist TRV130 (oliceridine) on measures of antinociception, gastrointestinal function, and abuse liability in rodents

(2017) Ahmad A Altarifi et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1

(2017) A H Smith et al.   MOLECULAR PSYCHIATRY

Functional selectivity of GPCR-directed drug action through location bias

(2017) Roshanak Irannejad et al.   Nature Chemical Biology

Fractionating impulsivity: neuropsychiatric implications

(2017) Jeffrey W. Dalley et al.   NATURE REVIEWS NEUROSCIENCE

Integration of optogenetics with complementary methodologies in systems neuroscience

(2017) Christina K. Kim et al.   NATURE REVIEWS NEUROSCIENCE

Pathway- and Cell-Specific Kappa-Opioid Receptor Modulation of Excitation-Inhibition Balance Differentially Gates D1 and D2 Accumbens Neuron Activity

(2017) Hugo A. Tejeda et al.   NEURON

Genetic variation in the behavioral effects of buprenorphine in female mice derived from a murine model of the OPRM1 A118G polymorphism

(2017) Caroline A. Browne et al.   NEUROPHARMACOLOGY

κ-Opioid Receptor Activation in Dopamine Neurons Disrupts Behavioral Inhibition

(2017) Antony D Abraham et al.   NEUROPSYCHOPHARMACOLOGY

Opioid Release after High-Intensity Interval Training in Healthy Human Subjects

(2017) Tiina Saanijoki et al.   NEUROPSYCHOPHARMACOLOGY

Endogenous Opiates and Behavior: 2015

(2017) Richard J. Bodnar   PEPTIDES

A unique natural selective kappa -opioid receptor agonist, salvinorin A, and its roles in human therapeutics

(2017) André Cruz et al.   PHYTOCHEMISTRY

A nontoxic pain killer designed by modeling of pathological receptor conformations

(2017) V. Spahn et al.   SCIENCE

Granger causality reveals a dominant role of memory circuit in chronic opioid dependence

(2016) Yi Zhang et al.   ADDICTION BIOLOGY

Kappa opioid receptor antagonism and chronic antidepressant treatment have beneficial activities on social interactions and grooming deficits during heroin abstinence

(2016) L. Lalanne et al.   ADDICTION BIOLOGY

Differential behavioral and molecular alterations upon protracted abstinence from cocaine versus morphine, nicotine, THC and alcohol

(2016) Jérôme A.J. Becker et al.   ADDICTION BIOLOGY

Reward and Aversion

(2016) Hailan Hu   Annual Review of Neuroscience

Existing and Future Drugs for the Treatment of the Dark Side of Addiction

(2016) George F. Koob et al.   Annual Review of Pharmacology and Toxicology

Design of Next-Generation G Protein–Coupled Receptor Drugs: Linking Novel Pharmacology and In Vivo Animal Models

(2016) Sophie J. Bradley et al.   Annual Review of Pharmacology and Toxicology

Morphine-induced antinociception and reward in “humanized” mice expressing the mu opioid receptor A118G polymorphism

(2016) Angela N. Henderson-Redmond et al.   BRAIN RESEARCH BULLETIN

Naltrexone: A Pan-Addiction Treatment?

(2016) Elias Aboujaoude et al.   CNS DRUGS

Kappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials

(2016) William A. Carlezon et al.   DEPRESSION AND ANXIETY

Update on pharmacotherapy for treatment of opioid use disorder

(2016) Daniel Ayanga et al.   EXPERT OPINION ON PHARMACOTHERAPY

Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility

(2016) Nurulain T. Zaveri   JOURNAL OF MEDICINAL CHEMISTRY

Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2

(2016) András Váradi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuroimaging the Effectiveness of Substance Use Disorder Treatments

(2016) Elizabeth A. Cabrera et al.   Journal of Neuroimmune Pharmacology

Role of Ventral Subiculum in Context-Induced Relapse to Alcohol Seeking after Punishment-Imposed Abstinence

(2016) N. J. Marchant et al.   JOURNAL OF NEUROSCIENCE

Designing the ideal opioid

(2016) Brigitte L. Kieffer   NATURE

Structure-based discovery of opioid analgesics with reduced side effects

(2016) Aashish Manglik et al.   NATURE

Social touch modulates endogenous μ-opioid system activity in humans

(2016) Lauri Nummenmaa et al.   NEUROIMAGE

Dopamine and Opioid Neurotransmission in Behavioral Addictions: A Comparative PET Study in Pathological Gambling and Binge Eating

(2016) Joonas Majuri et al.   NEUROPSYCHOPHARMACOLOGY

Low μ-Opioid Receptor Status in Alcohol Dependence Identified by Combined Positron Emission Tomography and Post-Mortem Brain Analysis

(2016) Derik Hermann et al.   NEUROPSYCHOPHARMACOLOGY

Opioid Abuse in Chronic Pain — Misconceptions and Mitigation Strategies

(2016) Nora D. Volkow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treatment of Opioid-Use Disorders

(2016) Marc A. Schuckit   NEW ENGLAND JOURNAL OF MEDICINE

Relationship between Nonmedical Prescription-Opioid Use and Heroin Use

(2016) Wilson M. Compton et al.   NEW ENGLAND JOURNAL OF MEDICINE

Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome

(2016) Anna E. Mechling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct cortical and striatal actions of a β-arrestin–biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties

(2016) Nikhil M. Urs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nicotine-specific and non-specific effects of cigarette smoking on endogenous opioid mechanisms

(2016) Emily B. Nuechterlein et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

New Technologies for Elucidating Opioid Receptor Function

(2016) Michael R. Bruchas et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Allostatic Mechanisms of Opioid Tolerance Beyond Desensitization and Downregulation

(2016) Catherine M. Cahill et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit

(2016) Nicole A. Crowley et al.   Cell Reports

Depression and substance use comorbidity: What we have learned from animal studies

(2016) Enoch Ng et al.   AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE

A gene-by-sex interaction for nicotine reward: evidence from humanized mice and epidemiology

(2016) R E Bernardi et al.   Translational Psychiatry

BOLD Imaging in Awake Wild-Type and Mu-Opioid Receptor Knock-Out Mice Reveals On-Target Activation Maps in Response to Oxycodone

(2016) Kelsey Moore et al.   Frontiers in Neuroscience

A Trigger for Opioid Misuse: Chronic Pain and Stress Dysregulate the Mesolimbic Pathway and Kappa Opioid System

(2016) Nicolas Massaly et al.   Frontiers in Neuroscience

The Prescription Opioid and Heroin Crisis: A Public Health Approach to an Epidemic of Addiction

(2015) Andrew Kolodny et al.   Annual Review of Public Health

A Novel Anxiogenic Role for the Delta Opioid Receptor Expressed in GABAergic Forebrain Neurons

(2015) Paul Chu Sin Chung et al.   BIOLOGICAL PSYCHIATRY

A Pharmacogenetic Determinant of Mu-Opioid Receptor Antagonist Effects on Alcohol Reward and Consumption: Evidence from Humanized Mice

(2015) Ainhoa Bilbao et al.   BIOLOGICAL PSYCHIATRY

Cis-Expression Quantitative Trait Loci Mapping Reveals Replicable Associations with Heroin Addiction in OPRM1

(2015) Dana B. Hancock et al.   BIOLOGICAL PSYCHIATRY

The dark side of emotion: The addiction perspective

(2015) George F. Koob   EUROPEAN JOURNAL OF PHARMACOLOGY

Generation of aKOR-Creknockin mouse strain to study cells involved in kappa opioid signaling

(2015) Xiaoyun Cai et al.   GENESIS

Mouse Model of OPRM1 (A118G) Polymorphism Increases Sociability and Dominance and Confers Resilience to Social Defeat

(2015) L. A. Briand et al.   JOURNAL OF NEUROSCIENCE

Obesity Is Associated with Decreased  -Opioid But Unaltered Dopamine D2 Receptor Availability in the Brain

(2015) H. K. Karlsson et al.   JOURNAL OF NEUROSCIENCE

Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons

(2015) J. M. Ehrich et al.   JOURNAL OF NEUROSCIENCE

Structural insights into µ-opioid receptor activation

(2015) Weijiao Huang et al.   NATURE

Propagation of conformational changes during μ-opioid receptor activation

(2015) Rémy Sounier et al.   NATURE

Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward

(2015) Ream Al-Hasani et al.   NEURON

Spatiotemporal Control of Opioid Signaling and Behavior

(2015) Edward R. Siuda et al.   NEURON

Dynorphin, Dysphoria and Dependence: the Stress of Addiction

(2015) Charles Chavkin et al.   NEUROPSYCHOPHARMACOLOGY

Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats

(2015) Nathan J Marchant et al.   NEUROPSYCHOPHARMACOLOGY

Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism

(2015) J Elliott Robinson et al.   NEUROPSYCHOPHARMACOLOGY

Dissociating Motivational From Physiological Withdrawal in Alcohol Dependence: Role of Central Amygdala κ-Opioid Receptors

(2015) Jessica L Kissler et al.   NEUROPSYCHOPHARMACOLOGY

Blunted Endogenous Opioid Release Following an Oral Amphetamine Challenge in Pathological Gamblers

(2015) Inge Mick et al.   NEUROPSYCHOPHARMACOLOGY

Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment

(2015) Nicole A. Crowley et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

μ-Opioid receptor 6-transmembrane isoform: A potential therapeutic target for new effective opioids

(2015) Marino Convertino et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Understanding opioid reward

(2015) Howard L. Fields et al.   TRENDS IN NEUROSCIENCES

Brain Circuits Encoding Reward from Pain Relief

(2015) Edita Navratilova et al.   TRENDS IN NEUROSCIENCES

Associations ofOPRM1A118G and alcohol sensitivity with intravenous alcohol self-administration in young adults

(2014) Christian S. Hendershot et al.   ADDICTION BIOLOGY

A mu–delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks

(2014) Eric Erbs et al.   Brain Structure & Function

The role of opioid processes in reward and decision-making

(2014) Vincent Laurent et al.   BRITISH JOURNAL OF PHARMACOLOGY

The role of δ-opioid receptors in learning and memory underlying the development of addiction

(2014) Paul Klenowski et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward

(2014) Yijun Cui et al.   NATURE NEUROSCIENCE

Alcohol: A stimulant activating brain stress responsive systems with persistent neuroadaptation

(2014) Yan Zhou et al.   NEUROPHARMACOLOGY

Mouse Model of the OPRM1 (A118G) Polymorphism: Differential Heroin Self-Administration Behavior Compared with Wild-Type Mice

(2014) Yong Zhang et al.   NEUROPSYCHOPHARMACOLOGY

Distinct Mu, Delta and Kappa Opioid Receptor Mechanisms Underlie Low Sociability and Depressive-Like Behaviors During Heroin Abstinence

(2014) Pierre-Eric Lutz et al.   NEUROPSYCHOPHARMACOLOGY

Autistic-Like Syndrome in Mu Opioid Receptor Null Mice is Relieved by Facilitated mGluR4 Activity

(2014) Jérôme AJ Becker et al.   NEUROPSYCHOPHARMACOLOGY

Expression of mu opioid receptor in dorsal diencephalic conduction system: New insights for the medial habenula

(2014) O. Gardon et al.   NEUROSCIENCE

Disruption of the Na+ion binding site as a mechanism for positive allosteric modulation of the mu-opioid receptor

(2014) Kathryn E. Livingston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation

(2014) Julie A. Harris et al.   Frontiers in Neural Circuits

Genetics of Opiate Addiction

(2014) Brian Reed et al.   Current Psychiatry Reports

The Structural Basis of G-Protein-Coupled Receptor Signaling (Nobel Lecture)

(2013) Brian Kobilka   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The multiple facets of opioid receptor function: implications for addiction

(2013) Pierre-Eric Lutz et al.   CURRENT OPINION IN NEUROBIOLOGY

Addiction: failure of control over maladaptive incentive habits

(2013) David Belin et al.   CURRENT OPINION IN NEUROBIOLOGY

Personalized Medicine and Opioid Analgesic Prescribing for Chronic Pain: Opportunities and Challenges

(2013) Stephen Bruehl et al.   JOURNAL OF PAIN

Cartography and Connectomes

(2013) David C. Van Essen   NEURON

Kappa opioid receptor activation decreases inhibitory transmission and antagonizes alcohol effects in rat central amygdala

(2013) Nicholas W. Gilpin et al.   NEUROPHARMACOLOGY

Addiction as a stress surfeit disorder

(2013) George F. Koob et al.   NEUROPHARMACOLOGY

15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuse

(2013) Pauline Charbogne et al.   NEUROPHARMACOLOGY

Opioids and their receptors: Are we there yet?

(2013) Gavril W. Pasternak   NEUROPHARMACOLOGY

Ablation of Kappa-Opioid Receptors from Brain Dopamine Neurons has Anxiolytic-Like Effects and Enhances Cocaine-Induced Plasticity

(2013) Ashlee Van't Veer et al.   NEUROPSYCHOPHARMACOLOGY

Kappa Opioid Receptors on Dopaminergic Neurons Are Necessary for Kappa-Mediated Place Aversion

(2013) Vladimir I Chefer et al.   NEUROPSYCHOPHARMACOLOGY

Prefrontal Cortical Kappa-Opioid Receptor Modulation of Local Neurotransmission and Conditioned Place Aversion

(2013) Hugo A Tejeda et al.   NEUROPSYCHOPHARMACOLOGY

Delta opioid receptors in brain function and diseases

(2013) Paul Chu Sin Chung et al.   PHARMACOLOGY & THERAPEUTICS

The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence

(2013) Jeffrey M. Witkin et al.   PHARMACOLOGY & THERAPEUTICS

Pharmacogenetics of OPRM1

(2013) Richard C. Crist et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Discovery of positive allosteric modulators and silent allosteric modulators of the  -opioid receptor

(2013) N. T. Burford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dose-Related Behavioral, Subjective, Endocrine, and Psychophysiological Effects of the κ Opioid Agonist Salvinorin A in Humans

(2012) Mohini Ranganathan et al.   BIOLOGICAL PSYCHIATRY

Ligand-directed signalling within the opioid receptor family

(2012) Amynah A Pradhan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Restructuring G-Protein- Coupled Receptor Activation

(2012) Martin Audet et al.   CELL

The genetics of the opioid system and specific drug addictions

(2012) Orna Levran et al.   HUMAN GENETICS

Structure of the δ-opioid receptor bound to naltrindole

(2012) Sébastien Granier et al.   NATURE

Structure of the human κ-opioid receptor in complex with JDTic

(2012) Huixian Wu et al.   NATURE

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

(2012) Aaron A. Thompson et al.   NATURE

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

(2012) Aashish Manglik et al.   NATURE

Input-specific control of reward and aversion in the ventral tegmental area

(2012) Stephan Lammel et al.   NATURE

The pain of social disconnection: examining the shared neural underpinnings of physical and social pain

(2012) Naomi I. Eisenberger   NATURE REVIEWS NEUROSCIENCE

κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction

(2012) Eduardo R. Butelman et al.   TRENDS IN NEUROSCIENCES

Opioid receptors: distinct roles in mood disorders

(2012) Pierre-Eric Lutz et al.   TRENDS IN NEUROSCIENCES

G Protein–Coupled Receptor Deorphanizations

(2011) Olivier Civelli et al.   Annual Review of Pharmacology and Toxicology

The dynorphin/κ-opioid receptor system and its role in psychiatric disorders

(2011) H. A. Tejeda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Temporal dynamics and genetic control of transcription in the human prefrontal cortex

(2011) Carlo Colantuoni et al.   NATURE

Opiate versus psychostimulant addiction: the differences do matter

(2011) Aldo Badiani et al.   NATURE REVIEWS NEUROSCIENCE

Selective p38α MAPK Deletion in Serotonergic Neurons Produces Stress Resilience in Models of Depression and Addiction

(2011) Michael R. Bruchas et al.   NEURON

New Medications for Substance Use Disorders: Challenges and Opportunities

(2011) Nora D Volkow et al.   NEUROPSYCHOPHARMACOLOGY

Functional Selectivity at the  -Opioid Receptor: Implications for Understanding Opioid Analgesia and Tolerance

(2011) K. M. Raehal et al.   PHARMACOLOGICAL REVIEWS

Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects

(2011) S. Majumdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epistatic effects between variants of kappa-opioid receptor gene and A118G of mu-opioid receptor gene increase susceptibility to addiction in Indian population

(2011) Deepak Kumar et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The delta opioid receptor: an evolving target for the treatment of brain disorders

(2011) Amynah A. Pradhan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Impaired Emotional-Like Behavior and Serotonergic Function During Protracted Abstinence from Chronic Morphine

(2010) Celia Goeldner et al.   BIOLOGICAL PSYCHIATRY

Deletion of the δ Opioid Receptor Gene Impairs Place Conditioning But Preserves Morphine Reinforcement

(2010) Julie Le Merrer et al.   BIOLOGICAL PSYCHIATRY

OPRM1 gene variants modulate amphetamine-induced euphoria in humans

(2010) A. M. Dlugos et al.   GENES BRAIN AND BEHAVIOR

Ligand-Directed Trafficking of the  -Opioid Receptor In Vivo: Two Paths Toward Analgesic Tolerance

(2010) A. A. A. Pradhan et al.   JOURNAL OF NEUROSCIENCE

A genetic determinant of the striatal dopamine response to alcohol in men

(2010) V A Ramchandani et al.   MOLECULAR PSYCHIATRY

The habenula: from stress evasion to value-based decision-making

(2010) Okihide Hikosaka   NATURE REVIEWS NEUROSCIENCE

The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors

(2009) M.R. Bruchas et al.   BRAIN RESEARCH

Single-nucleotide polymorphism (A118G) in exon 1 ofOPRM1gene causes alteration in downstream signaling by mu-opioid receptor and may contribute to the genetic risk for addiction

(2009) Ishani Deb et al.   JOURNAL OF NEUROCHEMISTRY

Neurocircuitry of Addiction

(2009) George F Koob et al.   NEUROPSYCHOPHARMACOLOGY

Reward Processing by the Opioid System in the Brain

(2009) Julie Le Merrer et al.   PHYSIOLOGICAL REVIEWS

Mu and Delta Opioid Receptors Oppositely Regulate Motor Impulsivity in the Signaled Nose Poke Task

(2009) Mary C. Olmstead et al.   PLoS One

Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior

(2009) S. D. Mague et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking

(2009) Benjamin B. Land et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Common Human μ-Opioid Receptor Genetic Variant Diminishes the Receptor Signaling Efficacy in Brain Regions Processing the Sensory Information of Pain

(2008) Bruno Georg Oertel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin  -Opioid System

(2008) B. B. Land et al.   JOURNAL OF NEUROSCIENCE

Addiction and the Brain Antireward System

(2007) George F. Koob et al.   Annual Review of Psychology