Disruption of the Na+ion binding site as a mechanism for positive allosteric modulation of the mu-opioid receptor

Positive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medications

(2014) N T Burford et al.   BRITISH JOURNAL OF PHARMACOLOGY

Molecular control of δ-opioid receptor signalling

(2014) Gustavo Fenalti et al.   NATURE

Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100

(2014) Nellie E Byun et al.   NEUROPSYCHOPHARMACOLOGY

The 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor

(2014) Jennifer L. Miller-Gallacher et al.   PLoS One

Allosteric sodium in class A GPCR signaling

(2014) Vsevolod Katritch et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Dynamic Process of β2-Adrenergic Receptor Activation

(2013) Rie Nygaard et al.   CELL

Activation and allosteric modulation of a muscarinic acetylcholine receptor

(2013) Andrew C. Kruse et al.   NATURE

Emerging paradigms in GPCR allostery: implications for drug discovery

(2013) Denise Wootten et al.   NATURE REVIEWS DRUG DISCOVERY

Development of allosteric modulators of GPCRs for treatment of CNS disorders

(2013) Hilary Highfield Nickols et al.   NEUROBIOLOGY OF DISEASE

Discovery of positive allosteric modulators and silent allosteric modulators of the  -opioid receptor

(2013) N. T. Burford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of a Sodium Ion Binding Site in the Allosteric Modulation of the A2A Adenosine G Protein-Coupled Receptor

(2013) Hugo Gutiérrez-de-Terán et al.   STRUCTURE

New concepts in pharmacological efficacy at 7TM receptors: IUPHAR Review 2

(2012) Terry Kenakin   BRITISH JOURNAL OF PHARMACOLOGY

Allosteric Modulator ORG27569 Induces CB1 Cannabinoid Receptor High Affinity Agonist Binding State, Receptor Internalization, and GiProtein-independent ERK1/2 Kinase Activation

(2012) Kwang H. Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

(2012) Aashish Manglik et al.   NATURE

Bridging the gap: bitopic ligands of G-protein-coupled receptors

(2012) J. Robert Lane et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A Monod-Wyman-Changeux Mechanism Can Explain G Protein-coupled Receptor (GPCR) Allosteric Modulation

(2011) Meritxell Canals et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational changes in the G protein Gs induced by the β2 adrenergic receptor

(2011) Ka Young Chung et al.   NATURE

Allosteric modulation of G protein-coupled receptors: A pharmacological perspective

(2010) Peter Keov et al.   NEUROPHARMACOLOGY

Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation

(2009) L. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous Regulators of G Protein Signaling Differentially Modulate Full and Partial  -Opioid Agonists at Adenylyl Cyclase as Predicted by a Collision Coupling Model

(2008) M. J. Clark et al.   MOLECULAR PHARMACOLOGY