Clonal evolution of colorectal cancer in IBD

Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease

(2016) Rona Yaeger et al.   GASTROENTEROLOGY

Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease−Associated Colorectal Cancers

(2016) Ana I. Robles et al.   GASTROENTEROLOGY

The continuing uncertainty about cancer risk in inflammatory bowel disease

(2016) Hans-Olov Adami et al.   GUT

Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus

(2016) Pierre Martinez et al.   Nature Communications

Paneth Cell-Rich Regions Separated by a Cluster of Lgr5+ Cells Initiate Crypt Fission in the Intestinal Stem Cell Niche

(2016) Alistair J. Langlands et al.   PLOS BIOLOGY

Forty-Year Analysis of Colonoscopic Surveillance Program for Neoplasia in Ulcerative Colitis: An Updated Overview

(2015) Chang-Ho Ryan Choi et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Chromoendoscopy for Surveillance in Inflammatory Bowel Disease Does Not Increase Neoplasia Detection Compared With Conventional Colonoscopy With Random Biopsies: Results From a Large Retrospective Study

(2015) E Mooiweer et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer

(2015) Lukas E. Dow et al.   CELL

Incidence of Interval Colorectal Cancer Among Inflammatory Bowel Disease Patients Undergoing Regular Colonoscopic Surveillance

(2015) Erik Mooiweer et al.   Clinical Gastroenterology and Hepatology

SCENIC International Consensus Statement on Surveillance and Management of Dysplasia in Inflammatory Bowel Disease

(2015) Loren Laine et al.   GASTROENTEROLOGY

The role of endoscopy in inflammatory bowel disease

(2015) Amandeep K. Shergill et al.   GASTROINTESTINAL ENDOSCOPY

Outcome of “indefinite for dysplasia” in inflammatory bowel disease: correlation with DNA flow cytometry and other risk factors of colorectal cancer

(2015) Won-Tak Choi et al.   HUMAN PATHOLOGY

Microenvironmental control of stem cell fate in intestinal homeostasis and disease

(2015) Sujata Biswas et al.   JOURNAL OF PATHOLOGY

Clock-like mutational processes in human somatic cells

(2015) Ludmil B Alexandrov et al.   NATURE GENETICS

The global burden of IBD: from 2015 to 2025

(2015) Gilaad G. Kaplan   Nature Reviews Gastroenterology & Hepatology

Systematic review with meta-analysis: the declining risk of colorectal cancer in ulcerative colitis

(2014) C. Castaño-Milla et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead

(2014) Aleksandar D. Kostic et al.   GASTROENTEROLOGY

Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity

(2014) Andriy Marusyk et al.   NATURE

Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging

(2014) Laila Ritsma et al.   NATURE

Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis

(2014) Jamie M J Weaver et al.   NATURE GENETICS

5-Aminosalicylates Reduce the Risk of Colorectal Neoplasia in Patients with Ulcerative Colitis: An Updated Meta-Analysis

(2014) Li-Na Zhao et al.   PLoS One

Synchronous colorectal cancer: Clinical, pathological and molecular implications

(2014) Alfred King-Yin Lam   WORLD JOURNAL OF GASTROENTEROLOGY

Microbial genomic analysis reveals the essential role of inflammation in bacteria-induced colorectal cancer

(2014) Janelle C. Arthur et al.   Nature Communications

Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing

(2014) Laura C. Greaves et al.   PLoS Genetics

Histological evaluation in ulcerative colitis

(2014) T. C. DeRoche et al.   Gastroenterology Report

Large chromosome deletions, duplications, and gene conversion events accumulate with age in normal human colon crypts

(2013) John C. F. Hsieh et al.   AGING CELL

Temporal and Spatial Evolution of Somatic Chromosomal Alterations: A Case-Cohort Study of Barrett's Esophagus

(2013) X. Li et al.   Cancer Prevention Research

Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion

(2013) Hugo J. Snippert et al.   EMBO REPORTS

Colonic mucosa-associated diffusely adherentafaC+ Escherichia coliexpressinglpfAandpksare increased in inflammatory bowel disease and colon cancer

(2013) Maelle Prorok-Hamon et al.   GUT

Clonal Expansions and Short Telomeres Are Associated with Neoplasia in Early-onset, but not Late-onset, Ulcerative Colitis

(2013) Jesse J. Salk et al.   INFLAMMATORY BOWEL DISEASES

IL-16 Induces Intestinal Inflammation via PepT1 Upregulation in a Pufferfish Model: New Insights into the Molecular Mechanism of Inflammatory Bowel Disease

(2013) P. Wang et al.   JOURNAL OF IMMUNOLOGY

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Fusobacterium Is Associated with Colorectal Adenomas

(2013) Amber N. McCoy et al.   PLoS One

Defining Stem Cell Dynamics in Models of Intestinal Tumor Initiation

(2013) L. Vermeulen et al.   SCIENCE

NSAIDs Modulate Clonal Evolution in Barrett's Esophagus

(2013) Rumen L. Kostadinov et al.   PLoS Genetics

Pan-colonic field defects are detected by CGH in the colons of UC patients with dysplasia/cancer

(2012) Lisa A. Lai et al.   CANCER LETTERS

Transition from Colitis to Cancer: High Wnt Activity Sustains the Tumor-Initiating Potential of Colon Cancer Stem Cell Precursors

(2012) A. K. Shenoy et al.   CANCER RESEARCH

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

(2012) Sarah Schwitalla et al.   CELL

Risk of Colorectal Cancer in Patients With Ulcerative Colitis: A Meta-analysis of Population-Based Cohort Studies

(2012) Tine Jess et al.   Clinical Gastroenterology and Hepatology

Prospective study of the progression of low-grade dysplasia in ulcerative colitis using current cancer surveillance guidelines

(2012) Timothy L. Zisman et al.   INFLAMMATORY BOWEL DISEASES

Age at diagnosis of inflammatory bowel disease influences early development of colorectal cancer in inflammatory bowel disease patients: a nationwide, long-term survey

(2012) J. E. Baars et al.   JOURNAL OF GASTROENTEROLOGY

Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials

(2012) Annemijn M Algra et al.   LANCET ONCOLOGY

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

(2012) Shiro Yui et al.   NATURE MEDICINE

Wnt5a Potentiates TGF-  Signaling to Promote Colonic Crypt Regeneration After Tissue Injury

(2012) H. Miyoshi et al.   SCIENCE

Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota

(2012) J. C. Arthur et al.   SCIENCE

Inflammation and colorectal cancer: colitis-associated neoplasia

(2012) Sergei I. Grivennikov   Seminars in Immunopathology

Review article: colorectal neoplasia in patients with primary sclerosing cholangitis and inflammatory bowel disease

(2011) J. Torres et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Ulcerative Colitis-Associated Colorectal Cancer Arises in a Field of Short Telomeres, Senescence, and Inflammation

(2011) R. A. Risques et al.   CANCER RESEARCH

Field Cancerization in the Intestinal Epithelium of Patients With Crohn's Ileocolitis

(2011) Susan Galandiuk et al.   GASTROENTEROLOGY

Invasive potential of gut mucosa-derived fusobacterium nucleatum positively correlates with IBD status of the host

(2011) Jaclyn Strauss et al.   INFLAMMATORY BOWEL DISEASES

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

(2011) Hua Tian et al.   NATURE

Pathogenesis and biomarkers of carcinogenesis in ulcerative colitis

(2011) Sigrun Thorsteinsdottir et al.   Nature Reviews Gastroenterology & Hepatology

Biomarker-based prediction of inflammatory bowel disease-related colorectal cancer: a case–control study

(2011) Monique M. Gerrits et al.   CELLULAR ONCOLOGY

Methylation Status of Genes in Non-Neoplastic Mucosa From Patients With Ulcerative Colitis-Associated Colorectal Cancer

(2010) Megan M Garrity-Park et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

(2010) Hugo J. Snippert et al.   CELL

Colitis-associated DNA aneuploidy and dysplasia in Crohnʼs disease and risk of colorectal cancer

(2010) Sverre Söderlund et al.   INFLAMMATORY BOWEL DISEASES

Robustness and Evolvability

(2010) Joanna Masel et al.   TRENDS IN GENETICS

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

(2009) Julia Bollrath et al.   CANCER CELL

A Prospective Cohort Study Shows Unique Epigenetic, Genetic, and Prognostic Features of Synchronous Colorectal Cancers

(2009) Katsuhiko Nosho et al.   GASTROENTEROLOGY

Mesalamine Inhibits Epithelial β-Catenin Activation in Chronic Ulcerative Colitis

(2009) Jeffrey B. Brown et al.   GASTROENTEROLOGY

Endoscopic and pathological aspects of colitis-associated dysplasia

(2009) Fiona D. M. van Schaik et al.   Nature Reviews Gastroenterology & Hepatology

Clonal expansions in ulcerative colitis identify patients with neoplasia

(2009) J. J. Salk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lectin–epithelial interactions in the human colon

(2008) Jonathan M. Rhodes et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Degeneration of the Pericryptal Myofibroblast Sheath by Proinflammatory Cytokines in Inflammatory Bowel Diseases

(2008) Caroline Francoeur et al.   GASTROENTEROLOGY

Clonality, Founder Mutations, and Field Cancerization in Human Ulcerative Colitis–Associated Neoplasia

(2008) Simon J. Leedham et al.   GASTROENTEROLOGY

5-aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis

(2008) Margie L. Clapper et al.   INFLAMMATORY BOWEL DISEASES

NF-κB in inflammatory bowel disease

(2008) I. Atreya et al.   JOURNAL OF INTERNAL MEDICINE

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Cancer as an overhealing wound: an old hypothesis revisited

(2008) Matthias Schäfer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY